Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma.
paper
Cited
Public
Unavailable
- Authors
- Asakage, Takahiro; Yokoyama, Akira; Haneda, Tatsumasa; Yamazaki, Mitsuo; Muto, Manabu; Yokoyama, Tetsuji; Kato, Hoichi; Igaki, Hiroyasu; Tsujinaka, Toshimasa; Kumagai, Yoshiya; Yokoyama, Masako; Omori, Tai; Watanabe, Hiroshi
- Year
- 2007
- Journal
- Carcinogenesis
- PMID
- 17071628
- DOI
- 10.1093/carcin/bgl206
The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol. The inactive ALDH2 encoded by ALDH2*1/*2 and the less-active ADH1B encoded by ADH1B*1/*1 increase the risk of esophageal squamous cell carcinoma in East Asian drinkers. This case-control study involved 96 Japanese men with oral and pharyngeal squamous cell carcinoma (hypopharyngeal cancer in 43 patients and oral/oropharyngeal cancer in 53) and 642 cancer-free Japanese men. The risk of the cancers overall and of hypopharyngeal cancer was increased 3.61- and 10.08-fold, respectively, by ALDH2*1/*2 among moderate-to-heavy drinkers (9+ units/week; one unit = 22 g of ethanol), but the risk of oral/oropharyngeal cancer was not significantly affected by the ALDH2 genotype. The results obtained with a simple alcohol flushing questionnaire were essentially comparable with those obtained by ALDH2 genotyping. Among moderate-to-heavy drinkers, men with the less-active ADH1B*1/*1 had a significantly higher risk of the cancers overall, of hypopharyngeal cancer, and of oral/oropharyngeal cancer (OR = 5.56, 7.21 and 4.24, respectively). In view of the linkage disequilibrium between ADH1B and ADH1C, the ADH1C genotype does not significantly affect cancer risk. The significant independent risk factors for oral and pharyngeal cancer overall among moderate-to-heavy drinkers were inactive ALDH2*1/*2, less-active ADH1B*1/*1, frequent drinking of strong alcohol beverages straight, smoking, and lower intake of green-yellow vegetables. Educating these risks for cancer of the upper aerodigestive tract could be a useful new strategic approach to the prevention of these cancers in Japanese.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The genetics of substance dependence. | 2012 | 22703173 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic risk stratification and preventive strategies for double primary HNSCC and ESCC: a single-center cohort study. | Naito S et al. | — | 2026 | → |
| The expanding cancer landscape in chronic pancreatitis. | Quammie S et al. | — | 2026 | → |
| Survival Outcomes of the Patients With Advanced Hypopharyngeal Squamous Cell Carcinoma Treated With Chemoradiotherapy and Total Pharyngolaryngectomy Based on Reports of Head and Neck Cancer Registry of Japan. | Horichi Y et al. | — | 2025 | → |
| Treatment strategies and prognosis of superficial laryngo-pharyngeal cancer: a literature review. | Ohno K et al. | — | 2025 | → |
| ALDH2 mutations and defense against genotoxic aldehydes in cancer and inherited bone marrow failure syndromes. | Woo AY et al. | — | 2024 | → |
| Association between alcohol dehydrogenase polymorphisms (rs1229984, rs1573496, rs1154460, and rs284787) and susceptibility to head and neck cancers: A systematic review and meta-analysis. | Imani MM et al. | — | 2024 | → |
| Survival Outcome Superiority of Total Pharyngolaryngectomy Compared with Chemoradiotherapy for T4aM0 Hypopharyngeal Squamous Cell Carcinoma: A Nationwide Database Study of Japan. | Omura G et al. | — | 2024 | → |
| Translational research in head and neck cancer: Molecular and immunological updates. | Kumai T et al. | — | 2024 | → |
| Biosensor development for low-level acetaldehyde gas detection using mesoporous carbon electrode printed on a porous polyimide film. | Shitanda I et al. | — | 2023 | → |
| Comparison of Survival Outcomes Between Larynx-Preserving Open Partial Pharyngectomy and Radiotherapy or Chemoradiotherapy in Patients with Hypopharyngeal Squamous Cell Carcinoma: A Single-Center Retrospective Analysis with Inverse Probability of Treatment Weighting Adjustments. | Eguchi K et al. | — | 2023 | → |
| Fibrinogen-to-lymphocyte Ratio Predicts the Outcomes of Hypopharyngeal Squamous Cell Carcinoma Treated With Definitive Radiotherapy. | Sato K et al. | — | 2023 | → |
| Human umbilical cord mesenchymal stem cells: Heralding an effective treatment against esophageal cancer? | ArefNezhad R et al. | — | 2023 | → |
| Mediation analysis unveils a carcinogenic effect of ADH1B rs1229984 through mechanisms other than change in drinking intensity: oesophageal cancer case-control study. | Sugimoto Y et al. | — | 2023 | → |
| Association between changes in facial flushing and hypertension across drinking behavior patterns in South Korean adults. | Park YS et al. | — | 2022 | → |
| Can gene therapy be used to prevent cancer? Gene therapy for aldehyde dehydrogenase 2 deficiency. | Montel RA et al. | — | 2022 | → |
| Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review. | Rajabi-Moghaddam M et al. | — | 2022 | → |
| The Potential Role of Mitochondrial Acetaldehyde Dehydrogenase 2 in Urological Cancers From the Perspective of Ferroptosis and Cellular Senescence. | Zhu W et al. | — | 2022 | → |
| Association Between the Aldehyde Dehydrogenase-2 rs671 G>A Polymorphism and Head and Neck Cancer Susceptibility: A Meta-Analysis in East Asians. | Du XY et al. | — | 2021 | → |
| Evaluation of synchronous multiple primary superficial laryngo-pharyngeal cancers that were treated by endoscopic laryngo-pharyngeal surgery. | Ohno K et al. | — | 2021 | → |
| Critical review on the use and abuse of alcohol. When the dose makes the difference. | Di Sarno R et al. | — | 2020 | → |
| Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men. | Yokoyama A et al. | — | 2020 | → |
| The Alcohol Use Disorders Identification Test and the risk of metachronous cancer after endoscopic resection of esophageal cancer. | Yokoyama A et al. | — | 2020 | → |
| Usefulness of a dedicated mouthpiece for the Valsalva maneuver to visualize the hypopharynx during transoral endoscopy. | Kato M et al. | — | 2020 | → |
| Association of <i>ADH1B</i> Arg47His polymorphism with the risk of cancer: a meta-analysis. | Tan B et al. | — | 2019 | → |
| Effect of ALDH2 polymorphism on cancer risk in Asians: A meta-analysis. | Zuo W et al. | — | 2019 | → |
| Long-term changes of salivary exoglycosidases and their applicability as chronic alcohol-drinking and dependence markers. | Waszkiewicz N et al. | — | 2019 | → |
| Cigarette smoking, alcohol drinking, and oral cavity and pharyngeal cancer in the Japanese: a population-based cohort study in Japan. | Lu Y et al. | — | 2018 | → |
| Could ALDH2<sup>*</sup>2 be the reason for low incidence and mortality of ovarian cancer for East Asia women? | Yan S et al. | — | 2018 | → |
| Exploring the utility of alcohol flushing as an instrumental variable for alcohol intake in Koreans. | Cho Y et al. | — | 2018 | → |
| Genetic polymorphisms may explain association between alcohol consumption and bladder cancer risk in East Asian men. | Fankhauser CD et al. | — | 2018 | → |
| Impact of alcohol dehydrogenase-aldehyde dehydrogenase polymorphism on clinical outcome in patients with hypopharyngeal cancer. | Avinçsal MO et al. | — | 2018 | → |
| Modified TALK Score for Japanese Patients with Laryngeal and Hypopharyngeal Cancers to Predict the Possibility of Laryngeal Preservation by Concurrent Chemoradiotherapy. | Otsuki N et al. | — | 2018 | → |
| Alcohol abstinence and risk assessment for second esophageal cancer in Japanese men after mucosectomy for early esophageal cancer. | Yokoyama A et al. | — | 2017 | → |
| Alcohol and Cancer: Mechanisms and Therapies. | Ratna A et al. | — | 2017 | → |
| Alcohol and head and neck cancer. | Kawakita D et al. | — | 2017 | → |
| Alcohol consumption and bladder cancer risk with or without the flushing response: The Japan Public Health Center-based Prospective Study. | Masaoka H et al. | — | 2017 | → |
| ALDH2-deficiency as genetic epidemiologic and biochemical model for the carcinogenicity of acetaldehyde. | Lachenmeier DW et al. | — | 2017 | → |
| Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer on the basis of the aldehyde dehydrogenase 2 genotype and alcohol consumption in a Japanese population. | Koyanagi YN et al. | — | 2017 | → |
| Facial flushing after alcohol consumption and the risk of cancer: A meta-analysis. | Zhang J et al. | — | 2017 | → |
| Facial flushing after alcohol intake as a predictor for a high risk of synchronous or metachronous cancer of the upper gastrointestinal tract. | Harada H et al. | — | 2017 | → |
| Prognostic value of ALDH2 polymorphism for patients with oropharyngeal cancer in a Japanese population. | Shinomiya H et al. | — | 2017 | → |
| The prognostic value of TP53 mutations in hypopharyngeal squamous cell carcinoma. | Omura G et al. | — | 2017 | → |
| Aldehyde dehydrogenase 2 (ALDH2) and alcohol dehydrogenase 1B (ADH1B) polymorphisms exacerbate bladder cancer risk associated with alcohol drinking: gene-environment interaction. | Masaoka H et al. | — | 2016 | → |
| Association of the upregulated expression of focal adhesion kinase with poor prognosis and tumor dissemination in hypopharyngeal cancer. | Omura G et al. | — | 2016 | → |
| Hairpin Ribozyme Genes Curtail Alcohol Drinking: from Rational Design to in vivo Effects in the Rat. | Sapag A et al. | — | 2016 | → |
| Prognostic Value of Drinking Status and Aldehyde Dehydrogenase 2 Polymorphism in Patients With Head and Neck Squamous Cell Carcinoma. | Kawakita D et al. | — | 2016 | → |
| Alcohol dehydrogenase-1B Arg47His polymorphism is associated with head and neck cancer risk in Asian: a meta-analysis. | Zhang Y et al. | — | 2015 | → |
| Association between Glu504Lys polymorphism of ALDH2 gene and cancer risk: a meta-analysis. | Cai Q et al. | — | 2015 | → |
| Disease control and clinicopathological prognostic factors of total pharyngolaryngectomy for hypopharyngeal cancer: a single-center study. | Omura G et al. | — | 2015 | → |
| Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. | Eriksson CJ | — | 2015 | → |
| Gingival condition and tooth-brushing behavior after alcohol consumption. | Mizutani S et al. | — | 2015 | → |
| Relationship between acetaldehyde concentration in mouth air and tongue coating volume. | Yokoi A et al. | — | 2015 | → |
| Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: focusing on mitochondria. | Zhong H et al. | — | 2015 | → |
| Genetic variants in nicotine addiction and alcohol metabolism genes, oral cancer risk and the propensity to smoke and drink alcohol: a replication study in India. | Anantharaman D et al. | — | 2014 | → |
| Negative human papillomavirus status and excessive alcohol consumption are significant risk factors for second primary malignancies in Japanese patients with oropharyngeal carcinoma. | Saito Y et al. | — | 2014 | → |
| Oral health, dental care and mouthwash associated with upper aerodigestive tract cancer risk in Europe: the ARCAGE study. | Ahrens W et al. | — | 2014 | → |
| Salivary alcohol dehydrogenase in non-smoking and smoking alcohol-dependent persons. | Waszkiewicz N et al. | — | 2014 | → |
| Salivary exoglycosidases as markers of alcohol dependence. | Waszkiewicz N et al. | — | 2014 | → |
| Single nucleotide polymorphism at alcohol dehydrogenase-1B is associated with risk of esophageal squamous cell carcinoma. | Ye B et al. | — | 2014 | → |
| Targeting aldehyde dehydrogenase 2: new therapeutic opportunities. | Chen CH et al. | — | 2014 | → |
| Genetic variants at 10q23 are associated with risk of head and neck cancer in a Chinese population. | Yuan Z et al. | — | 2013 | → |
| Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population. | Gao Y et al. | — | 2013 | → |
| Genetic variants at 4q23 and 12q24 are associated with head and neck cancer risk in China. | Yuan H et al. | — | 2013 | → |
| Prognostic value of p16 expression and alcohol consumption in Japanese patients with oropharyngeal squamous cell carcinoma. | Saito Y et al. | — | 2013 | → |
| Telomere shortening in the esophagus of Japanese alcoholics: relationships with chromoendoscopic findings, ALDH2 and ADH1B genotypes and smoking history. | Aida J et al. | — | 2013 | → |
| The pharynx: examination of an area too often ignored during upper endoscopy. | Emura F et al. | — | 2013 | → |
| ADH1C Ile350Val polymorphism and cancer risk: evidence from 35 case-control studies. | Xue Y et al. | — | 2012 | → |
| Alcohol dehydrogenase-1B Arg47His polymorphism and upper aerodigestive tract cancer risk: a meta-analysis including 24,252 subjects. | Guo H et al. | — | 2012 | → |
| A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism. | Cadoni G et al. | — | 2012 | → |
| A variant allele of ADH1B and ALDH2, is associated with the risk of esophageal cancer. | Gu H et al. | — | 2012 | → |
| Gene-environment interactions of novel variants associated with head and neck cancer. | Liang C et al. | — | 2012 | → |
| Incidence of second primary malignancies in patients with treated head and neck cancer: a comprehensive review of literature. | Atienza JA et al. | — | 2012 | → |
| Streptococci-human papilloma virus interaction with ethanol exposure leads to keratinocyte damage. | Schwartz J et al. | — | 2012 | → |
| The genetics of substance dependence. | Wang JC et al. | — | 2012 | → |
| The role of alcohol dehydrogenase genes in head and neck cancers: a systematic review and meta-analysis of ADH1B and ADH1C. | Chang JS et al. | — | 2012 | → |
| Alcohol drinking and esophageal cancer risk: an evaluation based on a systematic review of epidemiologic evidence among the Japanese population. | Oze I et al. | — | 2011 | → |
| Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma. | Brocic M et al. | — | 2011 | → |
| Joint effects of alcohol consumption and polymorphisms in alcohol and oxidative stress metabolism genes on risk of head and neck cancer. | Hakenewerth AM et al. | — | 2011 | → |
| Oral squamous cell cancer: early detection and the role of alcohol and smoking. | Zygogianni AG et al. | — | 2011 | → |
| Sequence Variants and the Risk of Head and Neck Cancer: Pooled Analysis in the INHANCE Consortium. | Chuang SC et al. | — | 2011 | → |
| Alcohol and aldehyde dehydrogenase polymorphisms and a new strategy for prevention and screening for cancer in the upper aerodigestive tract in East Asians. | Yokoyama A et al. | — | 2010 | → |
| A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. | Wei S et al. | — | 2010 | → |
| Association of ALDH2 genotypes with periodontitis progression. | Nishida N et al. | — | 2010 | → |
| Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population. | Oze I et al. | — | 2010 | → |
| DNA polymorphism and risk of esophageal squamous cell carcinoma in a population of North Xinjiang, China. | Ma WJ et al. | — | 2010 | → |
| Formation of acetaldehyde-derived DNA adducts due to alcohol exposure. | Yu HS et al. | — | 2010 | → |
| Impact of smoking on lung cancer risk is stronger in those with the homozygous aldehyde dehydrogenase 2 null allele in a Japanese population. | Park JY et al. | — | 2010 | → |
| Late presentation of esophageal cancer: observations in a multiracial South-East Asian population. | Abdullah M et al. | — | 2010 | → |
| Oral cancer and polymorphism of ethanol metabolising genes. | Marichalar-Mendia X et al. | — | 2010 | → |
| Past and current tendency for facial flushing after a small dose of alcohol is a marker for increased risk of upper aerodigestive tract cancer in Japanese drinkers. | Yokoyama A et al. | — | 2010 | → |
| Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study. | Wang LL et al. | — | 2010 | → |
| Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population. | Garcia SM et al. | — | 2010 | → |
| Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men. | Yokoyama A et al. | — | 2010 | → |
| The epidemiology of hypopharynx and cervical esophagus cancer. | Popescu CR et al. | — | 2010 | → |
| Acetaldehyde as a common denominator and cumulative carcinogen in digestive tract cancers. | Salaspuro M | — | 2009 | → |
| Alcohol and genetic polymorphisms: effect on risk of alcohol-related cancer. | Druesne-Pecollo N et al. | — | 2009 | → |
| Alcohol and the older adult: a comprehensive review. | Heuberger RA | — | 2009 | → |
| Alcohol sensitivity, alcohol use and hypertension in an older Chinese population: the Guangzhou Biobank Cohort Study. | Zhang WS et al. | — | 2009 | → |
| Aldehyde dehydrogenase 2 and head and neck cancer: a meta-analysis implementing a Mendelian randomization approach. | Boccia S et al. | — | 2009 | → |
| Carcinogenicity of acetaldehyde in alcoholic beverages: risk assessment outside ethanol metabolism. | Lachenmeier DW et al. | — | 2009 | → |
| Health risk appraisal models for mass screening for esophageal and pharyngeal cancer: an endoscopic follow-up study of cancer-free Japanese men. | Yokoyama A et al. | — | 2009 | → |
| Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population. | Oze I et al. | — | 2009 | → |
| Oral squamous cell carcinoma: overview of current understanding of aetiopathogenesis and clinical implications. | Scully C et al. | — | 2009 | → |
| Alcohol and laryngeal cancer: an update. | La Vecchia C et al. | — | 2008 | → |
| Dietary risk factors for hypopharyngeal cancer in India. | Heck JE et al. | — | 2008 | → |
| Health risk appraisal models for mass screening of esophageal cancer in Japanese men. | Yokoyama T et al. | — | 2008 | → |
| Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians. | Solomon PR et al. | — | 2008 | → |
| Risk of metachronous squamous cell carcinoma in the upper aerodigestive tract of Japanese alcoholic men with esophageal squamous cell carcinoma: a long-term endoscopic follow-up study. | Yokoyama A et al. | — | 2008 | → |
| Salivary acetaldehyde concentration according to alcoholic beverage consumed and aldehyde dehydrogenase-2 genotype. | Yokoyama A et al. | — | 2008 | → |
| Contribution of the alcohol dehydrogenase-1B genotype and oral microorganisms to high salivary acetaldehyde concentrations in Japanese alcoholic men. | Yokoyama A et al. | — | 2007 | → |