G protein-coupled inwardly rectifying K+ channels (GIRKs) mediate postsynaptic but not presynaptic transmitter actions in hippocampal neurons.
paper
Cited
Public
Unavailable
- Authors
- LΓΌscher, C; Jan, L Y; Stoffel, M; Malenka, R C; Nicoll, R A
- Year
- 1997
- Journal
- Neuron
- PMID
- 9331358
- DOI
- 10.1016/s0896-6273(00)80381-5
To study the role of G protein-coupled, inwardly rectifying K+ (GIRK) channels in mediating neurotransmitter actions in hippocampal neurons, we have examined slices from transgenic mice lacking the GIRK2 gene. The outward currents evoked by agonists for GABA(B) receptors, 5HT1A receptors, and adenosine A1 receptors were essentially absent in mutant mice, while the inward current evoked by muscarinic receptor activation was unaltered. In contrast, the presynaptic inhibitory action of a number of presynaptic receptors on excitatory and inhibitory terminals was unaltered in mutant mice. These included GABA(B), adenosine, muscarinic, metabotropic glutamate, and NPY receptors on excitatory synapses and GABA(B) and opioid receptors on inhibitory synapses. These findings suggest that a number of G protein-coupled receptors activate the same class of postsynaptic K+ channel, which contains GIRK2. In addition, the GIRK2 channels play no role in the inhibition mediated by presynaptic G protein-coupled receptors, suggesting that the same receptor can couple to different effector systems according to its subcellular location in the neuron.
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| De novo synaptogenesis induced by GABA in the developing mouse cortex. | Oh WC et al. | β | 2016 | β |
| Development- and experience-dependent plasticity in the dorsomedial habenula. | Koppensteiner P et al. | β | 2016 | β |
| Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine. | Jacobson LH et al. | β | 2016 | β |
| Effects of serotonin in the hippocampus: how SSRIs and multimodal antidepressants might regulate pyramidal cell function. | Dale E et al. | β | 2016 | β |
| GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition. | Shamseldin HE et al. | β | 2016 | β |
| G Protein-Gated K<sup>+</sup> Channel Ablation in Forebrain Pyramidal Neurons Selectively Impairs Fear Learning. | Victoria NC et al. | β | 2016 | β |
| Learning Universal Computations with Spikes. | Thalmeier D et al. | β | 2016 | β |
| Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. | Schwenk J et al. | β | 2016 | β |
| Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. | Goitia B et al. | β | 2016 | β |
| Neuromodulation of the Feedforward Dentate Gyrus-CA3 Microcircuit. | Prince LY et al. | β | 2016 | β |
| Possible involvement of ATP-sensitive potassium channels in the antidepressant-like effect of baclofen in mouse forced swimming test. | Nazari SK et al. | β | 2016 | β |
| Serotonin and Antidepressant SSRIs Inhibit Rat Neuroendocrine Dopamine Neurons: Parallel Actions in the Lactotrophic Axis. | Lyons DJ et al. | β | 2016 | β |
| Serotonin modulates the excitatory synaptic transmission in the dentate granule cells. | Nozaki K et al. | β | 2016 | β |
| Sodium salicylate reduces the level of GABAB receptors in the rat's inferior colliculus. | Butt S et al. | β | 2016 | β |
| Somatostatin in the rat rostral ventrolateral medulla: Origins and mechanism of action. | Bou Farah L et al. | β | 2016 | β |
| The Emergence of a Circuit Model for Addiction. | LΓΌscher C | β | 2016 | β |
| The external globus pallidus: progress and perspectives. | Hegeman DJ et al. | β | 2016 | β |
| The Neurobiological Mechanisms of Gamma-Hydroxybutyrate Dependence and Withdrawal and Their Clinical Relevance: A Review. | Kamal RM et al. | β | 2016 | β |
| VTA dopamine neuron plasticity - the unusual suspects. | Xin W et al. | β | 2016 | β |
| A1 adenosine receptor-mediated GIRK channels contribute to the resting conductance of CA1 neurons in the dorsal hippocampus. | Kim CS et al. | β | 2015 | β |
| Altered Ξ³-aminobutyric acid neurotransmission in major depressive disorder: a critical review of the supporting evidence and the influence of serotonergic antidepressants. | Pehrson AL et al. | β | 2015 | β |
| A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of GΞ± and GΞ²Ξ³. | Yakubovich D et al. | β | 2015 | β |
| Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction. | Mayfield J et al. | β | 2015 | β |
| Compartmental distribution of GABAB receptor-mediated currents along the somatodendritic axis of hippocampal principal cells. | Degro CE et al. | β | 2015 | β |
| Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT1A Receptor-Mediated Signaling and Results in a Depression-Resistant Behavior. | Llamosas N et al. | β | 2015 | β |
| Evidence for an excitatory GABAA response in human motor cortex in idiopathic generalised epilepsy. | Silbert BI et al. | β | 2015 | β |
| Expression of the 5-HT1A serotonin receptor in the hippocampus is required for social stress resilience and the antidepressant-like effects induced by the nicotinic partial agonist cytisine. | Mineur YS et al. | β | 2015 | β |
| Functional Selectivity and Antidepressant Activity of Serotonin 1A Receptor Ligands. | Chilmonczyk Z et al. | β | 2015 | β |
| GIRK Channel Plasticity and Implications for Drug Addiction. | Marron Fernandez de Velasco E et al. | β | 2015 | β |
| GIRK Channels: A Potential Link Between Learning and Addiction. | Tipps ME et al. | β | 2015 | β |
| Localization and Targeting of GIRK Channels in Mammalian Central Neurons. | LujΓ‘n R et al. | β | 2015 | β |
| Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons. | Montalbano A et al. | β | 2015 | β |
| R-Baclofen Reverses a Social Behavior Deficit and Elevated Protein Synthesis in a Mouse Model of Fragile X Syndrome. | Qin M et al. | β | 2015 | β |
| Regulation of neuronal communication by G protein-coupled receptors. | Huang Y et al. | β | 2015 | β |
| RGS-Insensitive G Proteins as In Vivo Probes of RGS Function. | Neubig RR | β | 2015 | β |
| RGS Redundancy and Implications in GPCR-GIRK Signaling. | Doupnik CA | β | 2015 | β |
| Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine. | Leiser SC et al. | β | 2015 | β |
| Spatiotemporal control of opioid signaling and behavior. | Siuda ER et al. | β | 2015 | β |
| The Roles of GΞ²Ξ³ and GΞ± in Gating and Regulation of GIRK Channels. | Dascal N et al. | β | 2015 | β |
| 5-Hydroxytryptamine1A receptor-activation hyperpolarizes pyramidal cells and suppresses hippocampal gamma oscillations via Kir3 channel activation. | Johnston A et al. | β | 2014 | β |
| Activity-dependent serotonergic excitation of callosal projection neurons in the mouse prefrontal cortex. | Stephens EK et al. | β | 2014 | β |
| A kinetic model for the frequency dependence of cholinergic modulation at hippocampal GABAergic synapses. | Stone E et al. | β | 2014 | β |
| Alcohol modulation of G-protein-gated inwardly rectifying potassium channels: from binding to therapeutics. | Bodhinathan K et al. | β | 2014 | β |
| Differential effects of genetically-encoded GΞ²Ξ³ scavengers on receptor-activated and basal Kir3.1/Kir3.4 channel current in rat atrial myocytes. | Kienitz MC et al. | β | 2014 | β |
| Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells. | Kirizs T et al. | β | 2014 | β |
| Distinct roles for Cav2.1-2.3 in activity-dependent synaptic dynamics. | Ricoy UM et al. | β | 2014 | β |
| Elevated serotonergic signaling amplifies synaptic noise and facilitates the emergence of epileptiform network oscillations. | Puzerey PA et al. | β | 2014 | β |
| Firing modes of dopamine neurons drive bidirectional GIRK channel plasticity. | Lalive AL et al. | β | 2014 | β |
| GABAergic neurotransmission and new strategies of neuromodulation to compensate synaptic dysfunction in early stages of Alzheimer's disease. | Nava-Mesa MO et al. | β | 2014 | β |
| Genetics of alcoholism. | Edenberg HJ et al. | β | 2014 | β |
| Infraslow EEG changes in infantile spasms. | Myers KA et al. | β | 2014 | β |
| Inward rectifier potassium (Kir) current in dopaminergic periglomerular neurons of the mouse olfactory bulb. | Borin M et al. | β | 2014 | β |
| Kir3 channel signaling complexes: focus on opioid receptor signaling. | Nagi K et al. | β | 2014 | β |
| Learning-induced modulation of the GABAB-mediated inhibitory synaptic transmission: mechanisms and functional significance. | Kfir A et al. | β | 2014 | β |
| Ligand-directed trafficking of receptor stimulus. | Chilmonczyk Z et al. | β | 2014 | β |
| New insights into the therapeutic potential of Girk channels. | LujΓ‘n R et al. | β | 2014 | β |
| Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. | Wang W et al. | β | 2014 | β |
| Recruitment of GΞ²Ξ³ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1. | Kahanovitch U et al. | β | 2014 | β |
| RGS7/GΞ²5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. | Ostrovskaya O et al. | β | 2014 | β |
| Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction. | Pehrson AL et al. | β | 2014 | β |
| Silencing synapses with DREADDs. | Zhu H et al. | β | 2014 | β |
| Suprachiasmatic nucleus function and circadian entrainment are modulated by G protein-coupled inwardly rectifying (GIRK) channels. | Hablitz LM et al. | β | 2014 | β |
| Tethered protein display identifies a novel Kir3.2 (GIRK2) regulator from protein scaffold libraries. | Bagriantsev SN et al. | β | 2014 | β |
| Adult neurogenesis produces neurons with unique GABAergic synapses in the olfactory bulb. | Valley MT et al. | β | 2013 | β |
| Amyloid-Ξ² induces synaptic dysfunction through G protein-gated inwardly rectifying potassium channels in the fimbria-CA3 hippocampal synapse. | Nava-Mesa MO et al. | β | 2013 | β |
| Association of Rgs7/GΞ²5 complexes with Girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. | Fajardo-Serrano A et al. | β | 2013 | β |
| Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons. | Sun YG et al. | β | 2013 | β |
| Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment. | Saenz del Burgo L et al. | β | 2013 | β |
| Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting parvalbumin interneurons. | Booker SA et al. | β | 2013 | β |
| Differential maturation of GIRK2-expressing neurons in the mouse cerebellum. | Aguado C et al. | β | 2013 | β |
| GABAB receptor activation attenuates the stimulant but not mesolimbic dopamine response to ethanol in FAST mice. | Holstein SE et al. | β | 2013 | β |
| GABAB receptors resist acute desensitization in both postsynaptic and presynaptic compartments of periaqueductal gray neurons. | Liu J et al. | β | 2013 | β |
| Genetics and alcoholism. | Edenberg HJ et al. | β | 2013 | β |
| Glial adenosine kinase--a neuropathological marker of the epileptic brain. | Aronica E et al. | β | 2013 | β |
| Hypoxia-inducible factor signalling mechanisms in the central nervous system. | Corcoran A et al. | β | 2013 | β |
| Inward-rectifying potassium (Kir) channels regulate pacemaker activity in spinal nociceptive circuits during early life. | Li J et al. | β | 2013 | β |
| Ion channels in the central regulation of energy and glucose homeostasis. | Sohn JW | β | 2013 | β |
| Modulation of the arcuate nucleus-medial preoptic nucleus lordosis regulating circuit: a role for GABAB receptors. | Sinchak K et al. | β | 2013 | β |
| Neurochemical and behavioral features in genetic absence epilepsy and in acutely induced absence seizures. | Bazyan AS et al. | β | 2013 | β |
| Relationship between transcranial magnetic stimulation measures of intracortical inhibition and spectroscopy measures of GABA and glutamate+glutamine. | Tremblay S et al. | β | 2013 | β |
| Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior. | Altieri SC et al. | β | 2013 | β |
| Role of GIRK channels on the noradrenergic transmission in vivo: an electrophysiological and neurochemical study on GIRK2 mutant mice. | Torrecilla M et al. | β | 2013 | β |
| Synaptic and cellular profile of neurons in the lateral habenula. | Meye FJ et al. | β | 2013 | β |
| The K(+) channel GIRK2 is both necessary and sufficient for peripheral opioid-mediated analgesia. | Nockemann D et al. | β | 2013 | β |
| Variable dendritic integration in hippocampal CA3 pyramidal neurons. | Makara JK et al. | β | 2013 | β |
| 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii. | Austgen JR et al. | β | 2012 | β |
| Cocaine-induced adaptations in metabotropic inhibitory signaling in the mesocorticolimbic system. | Hearing MC et al. | β | 2012 | β |
| Combination therapy of ifenprodil with piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis. | Bhattacharya P et al. | β | 2012 | β |
| Deficits in cognition and synaptic plasticity in a mouse model of Down syndrome ameliorated by GABAB receptor antagonists. | Kleschevnikov AM et al. | β | 2012 | β |
| Discovering genes involved in alcohol dependence and other alcohol responses: role of animal models. | Buck KJ et al. | β | 2012 | β |
| Dysfunctional hippocampal inhibition in the Ts65Dn mouse model of Down syndrome. | Best TK et al. | β | 2012 | β |
| Excision of Trpv6 gene leads to severe defects in epididymal Ca2+ absorption and male fertility much like single D541A pore mutation. | Weissgerber P et al. | β | 2012 | β |
| Family-based genome-wide association study of frontal ΞΈ oscillations identifies potassium channel gene KCNJ6. | Kang SJ et al. | β | 2012 | β |
| Functional localization of neurotransmitter receptors and synaptic inputs to mature neurons of the medial superior olive. | Couchman K et al. | β | 2012 | β |
| GABA(B) receptor GTP-binding is decreased in the prefrontal cortex but not the hippocampus of aged rats. | McQuail JA et al. | β | 2012 | β |
| GPCR mediated regulation of synaptic transmission. | Betke KM et al. | β | 2012 | β |
| Heterodimerization of serotonin receptors 5-HT1A and 5-HT7 differentially regulates receptor signalling and trafficking. | Renner U et al. | β | 2012 | β |
| Increased efficiency of the GABAA and GABAB receptor-mediated neurotransmission in the Ts65Dn mouse model of Down syndrome. | Kleschevnikov AM et al. | β | 2012 | β |
| IRK-1 potassium channels mediate peptidergic inhibition of Caenorhabditis elegans serotonin neurons via a G(o) signaling pathway. | Emtage L et al. | β | 2012 | β |
| K(+) channels: function-structural overview. | GonzΓ‘lez C et al. | β | 2012 | β |
| Modulation of cell surface GABA(B) receptors by desensitization, trafficking and regulated degradation. | Benke D et al. | β | 2012 | β |
| Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. | Rueda N et al. | β | 2012 | β |
| Optical control of endogenous proteins with a photoswitchable conditional subunit reveals a role for TREK1 in GABA(B) signaling. | Sandoz G et al. | β | 2012 | β |
| [Optical remote control of native ion channels]. | Sandoz G et al. | β | 2012 | β |
| Potassium channels underlie postsynaptic but not presynaptic GABAB receptor-mediated inhibition on ventrolateral periaqueductal gray neurons. | Liu ZL et al. | β | 2012 | β |
| Presynaptic but not postsynaptic GABA signaling at unitary mossy fiber synapses. | Cabezas C et al. | β | 2012 | β |
| Reversal of disease-related pathologies in the fragile X mouse model by selective activation of GABAB receptors with arbaclofen. | Henderson C et al. | β | 2012 | β |
| Somatic and dendritic GABA(B) receptors regulate neuronal excitability via different mechanisms. | Breton JD et al. | β | 2012 | β |
| Structural elements in the Girk1 subunit that potentiate G protein-gated potassium channel activity. | Wydeven N et al. | β | 2012 | β |
| The influence of cold temperature on cellular excitability of hippocampal networks. | de la PeΓ±a E et al. | β | 2012 | β |
| The level and distribution of the GABA(B)R1 and GABA(B)R2 receptor subunits in the rat's inferior colliculus. | Jamal L et al. | β | 2012 | β |
| The Role of Inhibitory G Proteins and Regulators of G Protein Signaling in the in vivo Control of Heart Rate and Predisposition to Cardiac Arrhythmias. | Ang R et al. | β | 2012 | β |
| Trisomy of the G protein-coupled K+ channel gene, Kcnj6, affects reward mechanisms, cognitive functions, and synaptic plasticity in mice. | Cooper A et al. | β | 2012 | β |
| Activation of presynaptic GABAB receptors modulates GABAergic and glutamatergic inputs to the medial geniculate body. | Luo B et al. | β | 2011 | β |
| Allosteric modulation of family C G-protein-coupled receptors: from molecular insights to therapeutic perspectives. | Urwyler S | β | 2011 | β |
| Baclofen and adenosine inhibition of synaptic transmission at CA3-CA1 synapses display differential sensitivity to K+ channel blockade. | Skov J et al. | β | 2011 | β |
| Cannabidiol inhibits synaptic transmission in rat hippocampal cultures and slices via multiple receptor pathways. | Ledgerwood CJ et al. | β | 2011 | β |
| Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain. | FernΓ‘ndez-Alacid L et al. | β | 2011 | β |
| GABAB receptor-mediated tonic inhibition of noradrenergic A7 neurons in the rat. | Wu Y et al. | β | 2011 | β |
| GABAB receptor modulation of voltage-sensitive calcium channels in spines and dendrites. | Chalifoux JR et al. | β | 2011 | β |
| GABA(B) receptors accentuate neural excitation contrast in rat insular cortex. | Fujita S et al. | β | 2011 | β |
| How inhibition shapes cortical activity. | Isaacson JS et al. | β | 2011 | β |
| Inhibition of G protein-activated inwardly rectifying K+ channels by different classes of antidepressants. | Kobayashi T et al. | β | 2011 | β |
| Ion channels and their molecular environments--glimpses and insights from functional proteomics. | Schulte U et al. | β | 2011 | β |
| Is it possible to improve neurodevelopmental abnormalities in Down syndrome? | Bartesaghi R et al. | β | 2011 | β |
| [Is the GIRK channel a possible target in the development of a novel therapeutic drug of urinary disturbance?]. | Yamamoto G et al. | β | 2011 | β |
| Naringin directly activates inwardly rectifying potassium channels at an overlapping binding site to tertiapin-Q. | Yow TT et al. | β | 2011 | β |
| Optogenetic analysis of GABAB receptor signaling in Caenorhabditis elegans motor neurons. | Schultheis C et al. | β | 2011 | β |
| Role of Kv1 potassium channels in regulating dopamine release and presynaptic D2 receptor function. | Martel P et al. | β | 2011 | β |
| Serotonin 2C receptor activates a distinct population of arcuate pro-opiomelanocortin neurons via TRPC channels. | Sohn JW et al. | β | 2011 | β |
| siRNA-mediated GABA(B) receptor at early fetal rat brain upon acute and chronic ethanol exposure: down regulation of PKA and p-CREB expression. | Naseer MI et al. | β | 2011 | β |
| Sperm GIRK2-containing K+ inward rectifying channels participate in sperm capacitation and fertilization. | Yi YJ et al. | β | 2011 | β |
| 5-HT1A receptor-regulated signal transduction pathways in brain. | Polter AM et al. | β | 2010 | β |
| A Gut Feeling about GABA: Focus on GABA(B) Receptors. | Hyland NP et al. | β | 2010 | β |
| Altered neurotransmission in the mesolimbic reward system of Girk mice. | Arora D et al. | β | 2010 | β |
| A neural switch for active and passive fear. | Gozzi A et al. | β | 2010 | β |
| Cellular basis for opioid potentiation in the rostral ventromedial medulla of rats with persistent inflammatory nociception. | Zhang L et al. | β | 2010 | β |
| Coactivation of GABA receptors inhibits the JNK3 apoptotic pathway via disassembly of GluR6-PSD-95-MLK3 signaling module in KA-induced seizure. | Li C et al. | β | 2010 | β |
| Emerging roles for G protein-gated inwardly rectifying potassium (GIRK) channels in health and disease. | LΓΌscher C et al. | β | 2010 | β |
| Evidence for oligomerization between GABAB receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. | Ciruela F et al. | β | 2010 | β |
| GABAB-GIRK2-mediated signaling in Down syndrome. | Cramer NP et al. | β | 2010 | β |
| GABAB receptor activation protects neurons from apoptosis via IGF-1 receptor transactivation. | Tu H et al. | β | 2010 | β |
| GABAB receptor agonism as a novel therapeutic modality in the treatment of gastroesophageal reflux disease. | Lehmann A et al. | β | 2010 | β |
| GABAB receptor-dependent modulation of network activity in the rat prefrontal cortex in vitro. | Wang Y et al. | β | 2010 | β |
| GABAB receptors modulate NMDA receptor calcium signals in dendritic spines. | Chalifoux JR et al. | β | 2010 | β |
| GABAB receptors: physiological functions and mechanisms of diversity. | Pinard A et al. | β | 2010 | β |
| GABA transporter GAT1: a crucial determinant of GABAB receptor activation in cortical circuits? | Gonzalez-Burgos G | β | 2010 | β |
| Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. | Xie K et al. | β | 2010 | β |
| G protein {beta}{gamma} gating confers volatile anesthetic inhibition to Kir3 channels. | Styer AM et al. | β | 2010 | β |
| Hearing loss alters serotonergic modulation of intrinsic excitability in auditory cortex. | Rao D et al. | β | 2010 | β |
| Historical perspective and emergence of the GABAB receptor. | Bowery NG | β | 2010 | β |
| Homeostatic regulation of neuronal excitability by K(+) channels in normal and diseased brains. | Misonou H | β | 2010 | β |
| Identification and characterization of Cs(+) -permeable K(+) channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation. | Ishii H et al. | β | 2010 | β |
| Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine. | Kobayashi T et al. | β | 2010 | β |
| Inwardly rectifying potassium channels: their structure, function, and physiological roles. | Hibino H et al. | β | 2010 | β |
| Late cortical disinhibition in human motor cortex: a triple-pulse transcranial magnetic stimulation study. | Cash RF et al. | β | 2010 | β |
| Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons. | Nassirpour R et al. | β | 2010 | β |
| NMDA receptor-dependent GABAB receptor internalization via CaMKII phosphorylation of serine 867 in GABAB1. | Guetg N et al. | β | 2010 | β |
| Organisation of potassium channels on the neuronal surface. | LujΓ‘n R | β | 2010 | β |
| Plasticity of postsynaptic, but not presynaptic, GABAB receptors in SSADH deficient mice. | Vardya I et al. | β | 2010 | β |
| Serotonin receptor 1A modulates actin dynamics and restricts dendritic growth in hippocampal neurons. | Ferreira TA et al. | β | 2010 | β |
| Substance P inhibits GABAB receptor signalling in the ventral tegmental area. | Xia YF et al. | β | 2010 | β |
| The interaction of intrathecal neostigmine and N-cyclohexyladenosine on anti-allodynic effects in rats with a nerve ligation injury. | Choi DK et al. | β | 2010 | β |
| The mammalian interaural time difference detection circuit is differentially controlled by GABAB receptors during development. | Hassfurth B et al. | β | 2010 | β |
| The roles of GABAB receptors in cortical network activity. | Kohl MM et al. | β | 2010 | β |
| Type B GABA receptors contribute to the restoration of balance during vestibular compensation in mice. | Heskin-Sweezie R et al. | β | 2010 | β |
| Understanding inflammatory pain: ion channels contributing to acute and chronic nociception. | Linley JE et al. | β | 2010 | β |
| Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. | Voigt N et al. | β | 2010 | β |
| Adenosine-evoked hyperpolarization of retinal ganglion cells is mediated by G-protein-coupled inwardly rectifying K+ and small conductance Ca2+-activated K+ channel activation. | Clark BD et al. | β | 2009 | β |
| A mouse model for visualization of GABA(B) receptors. | Casanova E et al. | β | 2009 | β |
| At immature mossy fibers-CA3 connections, activation of presynaptic GABA(B) receptors by endogenously released GABA contributes to synapses silencing. | Safiulina VF et al. | β | 2009 | β |
| Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma. | Rubinstein M et al. | β | 2009 | β |
| GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons. | Gonzalez-Burgos G et al. | β | 2009 | β |
| G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation. | Chung HJ et al. | β | 2009 | β |
| G-protein-coupled-receptor-mediated presynaptic inhibition in the cerebellum. | Stephens GJ | β | 2009 | β |
| Inhibitory effects of the antiepileptic drug ethosuximide on G protein-activated inwardly rectifying K+ channels. | Kobayashi T et al. | β | 2009 | β |
| Mapping a barbiturate withdrawal locus to a 0.44 Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol. | Kozell LB et al. | β | 2009 | β |
| Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels. | Chung HJ et al. | β | 2009 | β |
| New sites of action for GIRK and SK channels. | LujΓ‘n R et al. | β | 2009 | β |
| Strain-dependent hippocampal protein levels of GABA(B)-receptor subunit 2 and NMDA-receptor subunit 1. | Sunyer B et al. | β | 2009 | β |
| Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. | FernΓ‘ndez-Alacid L et al. | β | 2009 | β |
| Supramolecular assemblies and localized regulation of voltage-gated ion channels. | Dai S et al. | β | 2009 | β |
| The GABAB1a isoform mediates heterosynaptic depression at hippocampal mossy fiber synapses. | Guetg N et al. | β | 2009 | β |
| The time course of dopamine transmission in the ventral tegmental area. | Ford CP et al. | β | 2009 | β |
| Tyrosine phosphorylation of Kir3 following kappa-opioid receptor activation of p38 MAPK causes heterologous desensitization. | Clayton CC et al. | β | 2009 | β |
| X11-like protein deficiency is associated with impaired conflict resolution in mice. | Sano Y et al. | β | 2009 | β |
| Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice. | Cruz HG et al. | β | 2008 | β |
| Activity-based probe for specific photoaffinity labeling gamma-aminobutyric acid B (GABAB) receptors on living cells: design, synthesis, and biological evaluation. | Li X et al. | β | 2008 | β |
| Alpha-Ca2+/calmodulin-dependent protein kinase II contributes to the developmental programming of anxiety in serotonin receptor 1A knock-out mice. | Lo Iacono L et al. | β | 2008 | β |
| Analysis of partner of inscuteable (mPins) expression in the developing mouse eye. | Raji B et al. | β | 2008 | β |
| Behavioral characterization of mice lacking GIRK/Kir3 channel subunits. | Pravetoni M et al. | β | 2008 | β |
| Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum. | Aguado C et al. | β | 2008 | β |
| Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars. | Benes FM et al. | β | 2008 | β |
| Co-activation of GABA receptors inhibits the JNK3 apoptotic pathway via the disassembly of the GluR6-PSD95-MLK3 signaling module in cerebral ischemic-reperfusion. | Han D et al. | β | 2008 | β |
| D(1) dopaminergic control of G protein-dependent inward rectifier K(+) (GIRK)-like channel current in pyramidal neurons of the medial prefrontal cortex. | Witkowski G et al. | β | 2008 | β |
| Developmental decrease in short-term facilitation at Schaffer collateral synapses in hippocampus is mGluR1 sensitive. | Speed HE et al. | β | 2008 | β |
| Distribution and neurochemical characterization of neurons expressing GIRK channels in the rat brain. | Saenz del Burgo L et al. | β | 2008 | β |
| Dynamic metabotropic control of intrinsic firing in cerebellar unipolar brush cells. | Russo MJ et al. | β | 2008 | β |
| Heterogeneous expression of gamma-aminobutyric acid and gamma-aminobutyric acid-associated receptors and transporters in the rat suprachiasmatic nucleus. | Belenky MA et al. | β | 2008 | β |
| Modulation of pain transmission by G-protein-coupled receptors. | Pan HL et al. | β | 2008 | β |
| Modulation of the heteromeric Kir4.1-Kir5.1 channel by multiple neurotransmitters via Galphaq-coupled receptors. | Rojas A et al. | β | 2008 | β |
| Molecular targets of anxiety: from membrane to nucleus. | Wu LJ et al. | β | 2008 | β |
| Perisomatic GABA release and thalamocortical integration onto neocortical excitatory cells are regulated by neuromodulators. | Kruglikov I et al. | β | 2008 | β |
| Plasticity of pre- and postsynaptic GABAB receptor function in the paraventricular nucleus in spontaneously hypertensive rats. | Li DP et al. | β | 2008 | β |
| Possible differences between the time courses of presynaptic and postsynaptic GABAB mediated inhibition in the human motor cortex. | Chu J et al. | β | 2008 | β |
| Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice. | Torrecilla M et al. | β | 2008 | β |
| Pre-synaptic GABA receptors inhibit glutamate release through GIRK channels in rat cerebral cortex. | Ladera C et al. | β | 2008 | β |
| Presynaptic metabotropic glutamate and GABAB receptors. | Raiteri M | β | 2008 | β |
| Presynaptic signaling by heterotrimeric G-proteins. | Brown DA et al. | β | 2008 | β |
| The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function. | Tiao JY et al. | β | 2008 | β |
| The use of FRET microscopy to elucidate steady state channel conformational rearrangements and G protein interaction with the GIRK channels. | Raveh A et al. | β | 2008 | β |
| [18F]MPPF as a tool for the in vivo imaging of 5-HT1A receptors in animal and human brain. | Aznavour N et al. | β | 2007 | β |
| Activation of GABA receptors attenuates neuronal apoptosis through inhibiting the tyrosine phosphorylation of NR2A by Src after cerebral ischemia and reperfusion. | Zhang F et al. | β | 2007 | β |
| Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect. | Liu ZW et al. | β | 2007 | β |
| Adenosine modulates transmission at the hippocampal mossy fibre synapse via direct inhibition of presynaptic calcium channels. | Gundlfinger A et al. | β | 2007 | β |
| A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction. | Lunn ML et al. | β | 2007 | β |
| Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. | Knapp DJ et al. | β | 2007 | β |
| C-Jun N-terminal kinase regulates adenosine A1 receptor-mediated synaptic depression in the rat hippocampus. | Brust TB et al. | β | 2007 | β |
| Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels. | Clancy SM et al. | β | 2007 | β |
| Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons. | Tu H et al. | β | 2007 | β |
| Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. | Fowler CE et al. | β | 2007 | β |
| Functional mapping of GABA(B)-receptor subtypes in the thalamus. | Ulrich D et al. | β | 2007 | β |
| GABA: a pioneer transmitter that excites immature neurons and generates primitive oscillations. | Ben-Ari Y et al. | β | 2007 | β |
| Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes. | Rubinstein M et al. | β | 2007 | β |
| G protein-coupled inwardly rectifying potassium channels in dorsal root ganglion neurons. | Gao XF et al. | β | 2007 | β |
| Group II metabotropic glutamate receptors inhibit glutamate release at thalamocortical synapses in the developing somatosensory cortex. | Mateo Z et al. | β | 2007 | β |
| Inhibition by cocaine of G protein-activated inwardly rectifying K+ channels expressed in Xenopus oocytes. | Kobayashi T et al. | β | 2007 | β |
| Opioid systems in the dentate gyrus. | Drake CT et al. | β | 2007 | β |
| Receptor-specific inhibition of GABAB-activated K+ currents by muscarinic and metabotropic glutamate receptors in immature rat hippocampus. | Sohn JW et al. | β | 2007 | β |
| RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. | LabouΓ¨be G et al. | β | 2007 | β |
| Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. | LeΓ³n-Ponte M et al. | β | 2007 | β |
| Suppression of conditioning to ambiguous cues by pharmacogenetic inhibition of the dentate gyrus. | Tsetsenis T et al. | β | 2007 | β |
| Synaptic activation of GABA(B) receptors regulates neuronal network activity and entrainment. | Brown JT et al. | β | 2007 | β |
| Ts65Dn, a mouse model of Down syndrome, exhibits increased GABAB-induced potassium current. | Best TK et al. | β | 2007 | β |
| Abnormal expression of the G-protein-activated inwardly rectifying potassium channel 2 (GIRK2) in hippocampus, frontal cortex, and substantia nigra of Ts65Dn mouse: a model of Down syndrome. | Harashima C et al. | β | 2006 | β |
| Adenosine A1 receptors decrease thalamic excitation of inhibitory and excitatory neurons in the barrel cortex. | Fontanez DE et al. | β | 2006 | β |
| Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro. | Arrigoni E et al. | β | 2006 | β |
| Antidepressant-like activity of CGP 36742 and CGP 51176, selective GABAB receptor antagonists, in rodents. | Nowak G et al. | β | 2006 | β |
| Compartment-dependent colocalization of Kir3.2-containing K+ channels and GABAB receptors in hippocampal pyramidal cells. | Kulik A et al. | β | 2006 | β |
| Depression of glutamate and GABA release by presynaptic GABAB receptors in the entorhinal cortex in normal and chronically epileptic rats. | Thompson SE et al. | β | 2006 | β |
| Differential compartmentalization and distinct functions of GABAB receptor variants. | Vigot R et al. | β | 2006 | β |
| Effects of the abused inhalant toluene on ethanol-sensitive potassium channels expressed in oocytes. | Del Re AM et al. | β | 2006 | β |
| Functional consequences of presynaptic inhibition during behaviorally relevant activity. | Frerking M et al. | β | 2006 | β |
| Functions of neuronal P2Y receptors. | Hussl S et al. | β | 2006 | β |
| GABA(B) receptors and synaptic modulation. | Kornau HC | β | 2006 | β |
| GABAB receptor stimulation accentuates the locomotor effects of morphine in mice bred for extreme sensitivity to the stimulant effects of ethanol. | Holstein SE et al. | β | 2006 | β |
| Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. | Shaban H et al. | β | 2006 | β |
| GIRK channel activation involves a local rearrangement of a preformed G protein channel complex. | Riven I et al. | β | 2006 | β |
| G-protein-gated inwardly rectifying potassium channels regulate ADP-induced cPLA2 activity in platelets through Src family kinases. | Shankar H et al. | β | 2006 | β |
| Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. | Kobayashi T et al. | β | 2006 | β |
| Inhibition of G protein-activated inwardly rectifying K+ channels by the antidepressant paroxetine. | Kobayashi T et al. | β | 2006 | β |
| Inhibition of mechanosensitivity in visceral primary afferents by GABAB receptors involves calcium and potassium channels. | Page AJ et al. | β | 2006 | β |
| Interactions between GABA-B1 receptors and Kir 3 inwardly rectifying potassium channels. | David M et al. | β | 2006 | β |
| Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN. | Wiser O et al. | β | 2006 | β |
| Molecular diversity, trafficking and subcellular localization of GABAB receptors. | Bettler B et al. | β | 2006 | β |
| Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent. | Arrigoni E et al. | β | 2006 | β |
| Opposite regulation of Slick and Slack K+ channels by neuromodulators. | Santi CM et al. | β | 2006 | β |
| Presynaptic GABA(B) receptors regulate retinohypothalamic tract synaptic transmission by inhibiting voltage-gated Ca2+ channels. | Moldavan MG et al. | β | 2006 | β |
| Regulation of synaptic input to hypothalamic presympathetic neurons by GABA(B) receptors. | Chen Q et al. | β | 2006 | β |
| RGS3 and RGS4 differentially associate with G protein-coupled receptor-Kir3 channel signaling complexes revealing two modes of RGS modulation. Precoupling and collision coupling. | JaΓ©n C et al. | β | 2006 | β |
| The mechanistic classification of addictive drugs. | LΓΌscher C et al. | β | 2006 | β |
| The positive allosteric modulator GS39783 enhances GABA(B) receptor-mediated inhibition of cyclic AMP formation in rat striatum in vivo. | Gjoni T et al. | β | 2006 | β |
| Abnormal synaptic plasticity in the Ts1Cje segmental trisomy 16 mouse model of Down syndrome. | Siarey RJ et al. | β | 2005 | β |
| Adenosine and brain function. | Fredholm BB et al. | β | 2005 | β |
| Adenosine postsynaptically modulates supraoptic neuronal excitability. | Ponzio TA et al. | β | 2005 | β |
| beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids. | BradaΓ―a A et al. | β | 2005 | β |
| Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging. | Iwakiri M et al. | β | 2005 | β |
| Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. | Huang CS et al. | β | 2005 | β |
| Complex genetics of interactions of alcohol and CNS function and behavior. | Matthews DB et al. | β | 2005 | β |
| Constitutively active G-protein-gated inwardly rectifying K+ channels in dendrites of hippocampal CA1 pyramidal neurons. | Chen X et al. | β | 2005 | β |
| Depolarization initiates phasic acetylcholine release by relief of a tonic block imposed by presynaptic M2 muscarinic receptors. | Parnas H et al. | β | 2005 | β |
| Differential sensitivity to the motor and hypothermic effects of the GABA B receptor agonist baclofen in various mouse strains. | Jacobson LH et al. | β | 2005 | β |
| Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. | Cryan JF et al. | β | 2005 | β |
| Effects of familial hemiplegic migraine type 1 mutations on neuronal P/Q-type Ca2+ channel activity and inhibitory synaptic transmission. | Cao YQ et al. | β | 2005 | β |
| Endogenous RGS proteins enhance acute desensitization of GABA(B) receptor-activated GIRK currents in HEK-293T cells. | Mutneja M et al. | β | 2005 | β |
| Enhanced serotonin response in the hippocampus of Galphaz protein knock-out mice. | Oleskevich S et al. | β | 2005 | β |
| GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area. | Chen Y et al. | β | 2005 | β |
| Gbetagamma-dependent and Gbetagamma-independent basal activity of G protein-activated K+ channels. | Rishal I et al. | β | 2005 | β |
| Molecular and cellular diversity of neuronal G-protein-gated potassium channels. | Koyrakh L et al. | β | 2005 | β |
| Muscimol and baclofen differentially suppress retinotopic and nonretinotopic responses in visual cortex. | Kasamatsu T et al. | β | 2005 | β |
| Section I. The cholinergic system. | Smythies J | β | 2005 | β |
| Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids. | Marker CL et al. | β | 2005 | β |
| The role of GABA in the early neuronal development. | Jelitai M et al. | β | 2005 | β |
| 5-hydroxytryptamine1A-like receptor activation in the bed nucleus of the stria terminalis: electrophysiological and behavioral studies. | Levita L et al. | β | 2004 | β |
| Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system. | Cruz HG et al. | β | 2004 | β |
| Development of GABAB subunits and functional GABAB receptors in rat cultured hippocampal neurons. | CorrΓͺa SA et al. | β | 2004 | β |
| Distinct properties of presynaptic group II and III metabotropic glutamate receptor-mediated inhibition of perforant pathway-CA1 EPSCs. | Capogna M | β | 2004 | β |
| Ecto-nucleotidases and nucleoside transporters mediate activation of adenosine receptors on hippocampal mossy fibers by P2X7 receptor agonist 2'-3'-O-(4-benzoylbenzoyl)-ATP. | Kukley M et al. | β | 2004 | β |
| Effects of sumatriptan on rat medullary dorsal horn neurons. | Jennings EA et al. | β | 2004 | β |
| Endocannabinoids modulate N-type calcium channels and G-protein-coupled inwardly rectifying potassium channels via CB1 cannabinoid receptors heterologously expressed in mammalian neurons. | Guo J et al. | β | 2004 | β |
| gamma-hydroxybutyrate increases a potassium current and decreases the H-current in hippocampal neurons via GABAB receptors. | Schweitzer P et al. | β | 2004 | β |
| Lamina-specific differences in GABA(B) autoreceptor-mediated regulation of spontaneous GABA release in rat entorhinal cortex. | Bailey SJ et al. | β | 2004 | β |
| Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. | Mao J et al. | β | 2004 | β |
| Molecular structure and physiological functions of GABA(B) receptors. | Bettler B et al. | β | 2004 | β |
| My close encounter with GABA(B) receptors. | Nicoll RA | β | 2004 | β |
| Paradoxical cerebral cortical hyperexcitability following flupirtine overdose. | Hoffmann O et al. | β | 2004 | β |
| Presynaptic GABAB receptors modulate thalamic excitation of inhibitory and excitatory neurons in the mouse barrel cortex. | Porter JT et al. | β | 2004 | β |
| Rapid desensitization of G protein-gated inwardly rectifying K(+) currents is determined by G protein cycle. | Leaney JL et al. | β | 2004 | β |
| Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. | Gassmann M et al. | β | 2004 | β |
| Regulation of neuronal ion channels via P2Y receptors. | Lechner SG et al. | β | 2004 | β |
| Serotonergic regulation of membrane potential in developing rat prefrontal cortex: coordinated expression of 5-hydroxytryptamine (5-HT)1A, 5-HT2A, and 5-HT7 receptors. | Béïque JC et al. | β | 2004 | β |
| Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. | Marker CL et al. | β | 2004 | β |
| Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels. | Benians A et al. | β | 2003 | β |
| Anxiety-related traits in mice with modified genes of the serotonergic pathway. | Lesch KP et al. | β | 2003 | β |
| A pervasive mechanism for analgesia: activation of GIRK2 channels. | Blednov YA et al. | β | 2003 | β |
| CLIP identifies Nova-regulated RNA networks in the brain. | Ule J et al. | β | 2003 | β |
| Conformational rearrangements associated with the gating of the G protein-coupled potassium channel revealed by FRET microscopy. | Riven I et al. | β | 2003 | β |
| Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. | Mitrovic I et al. | β | 2003 | β |
| Contribution of Kir3.1, Kir3.2A and Kir3.2C subunits to native G protein-gated inwardly rectifying potassium currents in cultured hippocampal neurons. | Leaney JL | β | 2003 | β |
| Different actions of gabapentin and baclofen in hippocampus from weaver mice. | Bertrand S et al. | β | 2003 | β |
| Effect of baclofen on alcohol and sucrose self-administration in rats. | Anstrom KK et al. | β | 2003 | β |
| Endogenous 5-HT, released by MDMA through serotonin transporter- and secretory vesicle-dependent mechanisms, reduces hippocampal excitatory synaptic transmission by preferential activation of 5-HT1B receptors located on CA1 pyramidal neurons. | Mlinar B et al. | β | 2003 | β |
| Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector. | Scammell TE et al. | β | 2003 | β |
| GABA(B) receptor-mediated presynaptic inhibition has history-dependent effects on synaptic transmission during physiologically relevant spike trains. | Ohliger-Frerking P et al. | β | 2003 | β |
| GABA(B) receptors inhibit dendrodendritic transmission in the rat olfactory bulb. | Isaacson JS et al. | β | 2003 | β |
| Gabapentin actions on Kir3 currents and N-type Ca2+ channels via GABAB receptors in hippocampal pyramidal cells. | Bertrand S et al. | β | 2003 | β |
| GABA transporter-1 (GAT1)-deficient mice: differential tonic activation of GABAA versus GABAB receptors in the hippocampus. | Jensen K et al. | β | 2003 | β |
| G protein-independent inhibition of GIRK current by adenosine in rat atrial myocytes overexpressing A1 receptors after adenovirus-mediated gene transfer. | BΓΆsche LI et al. | β | 2003 | β |
| Interplay between activation of GIRK current and deactivation of Ih modifies temporal integration of excitatory input in CA1 pyramidal cells. | Takigawa T et al. | β | 2003 | β |
| Modulation of glycine-activated ion channel function by G-protein betagamma subunits. | Yevenes GE et al. | β | 2003 | β |
| Molecular biology and ontogeny of gamma-aminobutyric acid (GABA) receptors in the mammalian central nervous system. | Simeone TA et al. | β | 2003 | β |
| Presynaptic modulation controlling neuronal excitability and epileptogenesis: role of kainate, adenosine and neuropeptide Y receptors. | Malva JO et al. | β | 2003 | β |
| Short-term desensitization of G-protein-activated, inwardly rectifying K+ (GIRK) currents in pyramidal neurons of rat neocortex. | Sickmann T et al. | β | 2003 | β |
| Spinal GABAB receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats. | Chen SR et al. | β | 2003 | β |
| Subcellular localization of adenosine A(1) receptors in nerve terminals and synapses of the rat hippocampus. | Rebola N et al. | β | 2003 | β |
| Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampus. | Kulik A et al. | β | 2003 | β |
| Suppression of epileptiform activity by GABA(B) receptors in wild type and weaver hippocampus 'in vitro'. | Yanovsky Y et al. | β | 2003 | β |
| The dynamics of formation and action of the ternary complex revealed in living cells using a G-protein-gated K+ channel as a biosensor. | Benians A et al. | β | 2003 | β |
| Agonist-specific maturation of GIRK current responses in acutely isolated pyramidal neurons of rat neocortex. | Sickmann T et al. | β | 2002 | β |
| Analysis of the function of GABA(B) receptors on inhibitory afferent neurons of Purkinje cells in the cerebellar cortex of the rat. | Than M et al. | β | 2002 | β |
| Constitutively active and G-protein coupled inward rectifier K+ channels: Kir2.0 and Kir3.0. | Stanfield PR et al. | β | 2002 | β |
| Control of serotonergic neurons in the dorsal raphe nucleus by the lateral hypothalamus. | Celada P et al. | β | 2002 | β |
| Desensitization of mu-opioid receptor-evoked potassium currents: initiation at the receptor, expression at the effector. | Blanchet C et al. | β | 2002 | β |
| Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons. | Bickmeyer U et al. | β | 2002 | β |
| Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. | Ma D et al. | β | 2002 | β |
| GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy. | MuΓ±oz A et al. | β | 2002 | β |
| Gating properties of GIRK channels activated by Galpha(o)- and Galpha(i)-coupled muscarinic m2 receptors in Xenopus oocytes: the role of receptor precoupling in RGS modulation. | Zhang Q et al. | β | 2002 | β |
| G-protein-gated potassium channels containing Kir3.2 and Kir3.3 subunits mediate the acute inhibitory effects of opioids on locus ceruleus neurons. | Torrecilla M et al. | β | 2002 | β |
| Graded contribution of the Gbeta gamma binding domains to GIRK channel activation. | Sadja R et al. | β | 2002 | β |
| International Union of Pharmacology. XXXIII. Mammalian gamma-aminobutyric acid(B) receptors: structure and function. | Bowery NG et al. | β | 2002 | β |
| Modulation of hippocampal glutamatergic transmission by ATP is dependent on adenosine a(1) receptors. | Masino SA et al. | β | 2002 | β |
| Molecular determinants for activation of G-protein-coupled inward rectifier K+ (GIRK) channels by extracellular acidosis. | Mao J et al. | β | 2002 | β |
| Neuromodulatory role of serotonin in the ferret thalamus. | Monckton JE et al. | β | 2002 | β |
| Phasic and tonic attenuation of EPSPs by inward rectifier K+ channels in rat hippocampal pyramidal cells. | Takigawa T et al. | β | 2002 | β |
| Recombinant GABA(B) receptors formed from GABA(B1) and GABA(B2) subunits selectively inhibit N-type Ca(2+) channels in NG108-15 cells. | Easter A et al. | β | 2002 | β |
| Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. | Gross C et al. | β | 2002 | β |
| Somatostatin inhibits thalamic network oscillations in vitro: actions on the GABAergic neurons of the reticular nucleus. | Sun QQ et al. | β | 2002 | β |
| The neural cell adhesion molecule regulates cell-surface delivery of G-protein-activated inwardly rectifying potassium channels via lipid rafts. | Delling M et al. | β | 2002 | β |
| Cloning and functional expression of GABA(B) receptors from Drosophila. | Mezler M et al. | β | 2001 | β |
| Coupling Gbetagamma-dependent activation to channel opening via pore elements in inwardly rectifying potassium channels. | Sadja R et al. | β | 2001 | β |
| Differential regulation of GABA release and neuronal excitability mediated by neuropeptide Y1 and Y2 receptors in rat thalamic neurons. | Sun QQ et al. | β | 2001 | β |
| Effects of postsynaptic GABA(B) receptor activation on epileptiform activity in hippocampal slices. | Xiong ZQ et al. | β | 2001 | β |
| Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). | Schuler V et al. | β | 2001 | β |
| Function of GB1 and GB2 subunits in G protein coupling of GABA(B) receptors. | Margeta-Mitrovic M et al. | β | 2001 | β |
| GABA(A)-dependent chloride influx modulates reversal potential of GABA(B)-mediated IPSPs in hippocampal pyramidal cells. | Lopantsev V et al. | β | 2001 | β |
| GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses. | Hirono M et al. | β | 2001 | β |
| Ligand-induced signal transduction within heterodimeric GABA(B) receptor. | Margeta-Mitrovic M et al. | β | 2001 | β |
| Mutant mice as a model for cerebellar ataxia. | GrΓΌsser-Cornehls U et al. | β | 2001 | β |
| Neuropeptide Y receptors differentially modulate G-protein-activated inwardly rectifying K+ channels and high-voltage-activated Ca2+ channels in rat thalamic neurons. | Sun QQ et al. | β | 2001 | β |
| Random response fluctuations lead to spurious paired-pulse facilitation. | Kim J et al. | β | 2001 | β |
| Redox-dependent gating of G protein-coupled inwardly rectifying K+ channels. | Zeidner G et al. | β | 2001 | β |
| Regulation of a G protein-gated inwardly rectifying K+ channel by a Ca(2+)-independent protein kinase C. | Leaney JL et al. | β | 2001 | β |
| Selective inhibition of local excitatory synaptic transmission by serotonin through an unconventional receptor in the CA1 region of rat hippocampus. | Mlinar B et al. | β | 2001 | β |
| Yeast screen for constitutively active mutant G protein-activated potassium channels. | Yi BA et al. | β | 2001 | β |
| Dominant-negative mutants identify a role for GIRK channels in D3 dopamine receptor-mediated regulation of spontaneous secretory activity. | Kuzhikandathil EV et al. | β | 2000 | β |
| Dual control of dorsal raphe serotonergic neurons by GABA(B) receptors. Electrophysiological and microdialysis studies. | AbellΓ‘n MT et al. | β | 2000 | β |
| GABAB receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia. | Towers S et al. | β | 2000 | β |
| GABA(B) receptors couple to potassium and calcium channels on identified lateral perforant pathway projection neurons. | Wang X et al. | β | 2000 | β |
| GABAB receptors mediate frequency-dependent depression of excitatory potentials in rat perirhinal cortex in vitro. | Ziakopoulos Z et al. | β | 2000 | β |
| GABA spillover activates postsynaptic GABA(B) receptors to control rhythmic hippocampal activity. | Scanziani M | β | 2000 | β |
| gamma-aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes. | Lorente P et al. | β | 2000 | β |
| G-protein mediated gating of inward-rectifier K+ channels. | Mark MD et al. | β | 2000 | β |
| Impaired inhibition of epileptiform activity by baclofen, but not by adenosine in the weaver hippocampus. | Jarolimek W et al. | β | 2000 | β |
| Involvement of G-protein-activated inwardly rectifying K (GIRK) channels in opioid-induced analgesia. | Ikeda K et al. | β | 2000 | β |
| Mouse models of serotonin receptor function: toward a genetic dissection of serotonin systems. | Bonasera SJ et al. | β | 2000 | β |
| Slow synaptic inhibition mediated by metabotropic glutamate receptor activation of GIRK channels. | Dutar P et al. | β | 2000 | β |
| Taurine activates GABA(A) but not GABA(B) receptors in rat hippocampal CA1 area. | del Olmo N et al. | β | 2000 | β |
| The G protein alpha subunit has a key role in determining the specificity of coupling to, but not the activation of, G protein-gated inwardly rectifying K(+) channels. | Leaney JL et al. | β | 2000 | β |
| Different subtypes of GABAB receptors are present at pre- and postsynaptic sites within the rat dorsolateral septal nucleus. | Yamada K et al. | β | 1999 | β |
| Dynamic properties of corticothalamic excitatory postsynaptic potentials and thalamic reticular inhibitory postsynaptic potentials in thalamocortical neurons of the guinea-pig dorsal lateral geniculate nucleus. | von Krosigk M et al. | β | 1999 | β |
| Ethanol actions on multiple ion channels: which are important? | Harris RA | β | 1999 | β |
| Facilitation of synaptic transmission by EGL-30 Gqalpha and EGL-8 PLCbeta: DAG binding to UNC-13 is required to stimulate acetylcholine release. | Lackner MR et al. | β | 1999 | β |
| GABAA-Dependent chloride influx modulates GABAB-mediated IPSPs in hippocampal pyramidal cells. | Lopantsev V et al. | β | 1999 | β |
| GABA(B) receptor isoforms GBR1a and GBR1b, appear to be associated with pre- and post-synaptic elements respectively in rat and human cerebellum. | Billinton A et al. | β | 1999 | β |
| G protein-activated inwardly rectifying K+ (GIRK) currents in dendrites of rat neocortical pyramidal cells. | Takigawa T et al. | β | 1999 | β |
| G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action. | Lewohl JM et al. | β | 1999 | β |
| Immunohistochemical localization of GABA(B) receptors in the rat central nervous system. | Margeta-Mitrovic M et al. | β | 1999 | β |
| Molecular determinants for sodium-dependent activation of G protein-gated K+ channels. | Ho IH et al. | β | 1999 | β |
| Molecular manipulations as tools for enhancing our understanding of 5-HT neurotransmission. | Murphy DL et al. | β | 1999 | β |
| On the mechanism of histaminergic inhibition of glutamate release in the rat dentate gyrus. | Brown RE et al. | β | 1999 | β |
| Role of heteromer formation in GABAB receptor function. | Kuner R et al. | β | 1999 | β |
| Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain. | Bischoff S et al. | β | 1999 | β |
| Transmembrane structure of an inwardly rectifying potassium channel. | Minor DL et al. | β | 1999 | β |
| Antagonists of the receptor-G protein interface block Gi-coupled signal transduction. | Gilchrist A et al. | β | 1998 | β |
| A putative alpha-helical G beta gamma-coupling domain in the second intracellular loop of the 5-HT1A receptor. | Albert PR et al. | β | 1998 | β |
| Evidence that the nucleotide exchange and hydrolysis cycle of G proteins causes acute desensitization of G-protein gated inward rectifier K+ channels. | Chuang HH et al. | β | 1998 | β |
| GABAB receptor-mediated modulation of presynaptic currents and excitatory transmission at a fast central synapse. | Isaacson JS | β | 1998 | β |
| GABAB receptors: drugs meet clones. | Bettler B et al. | β | 1998 | β |
| GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. | Jones KA et al. | β | 1998 | β |
| GABA(B)-receptor subtypes assemble into functional heteromeric complexes. | Kaupmann K et al. | β | 1998 | β |
| G-Protein-coupled modulation of presynaptic calcium currents and transmitter release by a GABAB receptor. | Takahashi T et al. | β | 1998 | β |
| Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. | Kaupmann K et al. | β | 1998 | β |
| Hyperalgesia in mice lacking the Kv1.1 potassium channel gene. | Clark JD et al. | β | 1998 | β |
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