The tachykinin receptor 3 is associated with alcohol and cocaine dependence.
- Authors
- Foroud, Tatiana; Wetherill, Leah Flury; Kramer, John; Tischfield, Jay A; Nurnberger, John I; Schuckit, Marc A; Xuei, Xiaoling; Edenberg, Howard J
- Year
- 2008
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 18422838
- DOI
- 10.1111/j.1530-0277.2008.00663.x
- PMCID
- PMC2430628
BACKGROUND: A broad region on chromosome 4q was previously linked to the phenotype of alcohol dependence in the Collaborative Study on the Genetics of Alcoholism sample. A strong positional candidate gene was identified within this region: tachykinin receptor 3 gene (TACR3), which encodes tachykinin receptor 3 (NK3R), the receptor for the tachykinin 3 (neurokinin B) peptide. Pharmacological studies have provided evidence that the administration of NK3R agonists attenuates the intake of alcohol and NK3R can also mediate the acute and chronic behavioral effects of cocaine. METHODS: Thirty SNPs were genotyped throughout TACR3. Family based association analysis was performed in 219 European American families to detect an association with alcohol dependence. Subsequent analyses were performed to evaluate the evidence of association with other definitions of alcohol dependence as well as cocaine dependence. RESULTS: Seven of the 9 SNPs in the 3' region of TACR3 provided significant evidence of association with alcohol dependence (p <or= 0.05). Further analyses suggest that the evidence of association is strongest among those subjects with more severe alcohol dependence (defined by ICD-10) and those with co-morbid cocaine dependence. Haplotype analyses further strengthen the evidence of association in the 3' region of the gene. CONCLUSIONS: These results indicate that sequence variations in TACR3 contribute to the variation in more severe alcohol dependent individuals and those who are also cocaine dependent.
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| Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes. | Zoubková H et al. | — | 2019 | → |
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| More than Meets the Eye: Eye Color and Alcoholism. | Eissenberg JC | — | 2016 | → |
| Assessment of Tachykinin Receptor 3' Gene Polymorphism rs3733631 in Rosacea. | Karpouzis A et al. | — | 2015 | → |
| Clinically relevant genetic biomarkers from the brain in alcoholism with representation on high resolution chromosome ideograms. | Manzardo AM et al. | — | 2015 | → |
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| Central hypogonadotropic hypogonadism: genetic complexity of a complex disease. | Marino M et al. | — | 2014 | → |
| Extended access oxycodone self-administration and neurotransmitter receptor gene expression in the dorsal striatum of adult C57BL/6 J mice. | Zhang Y et al. | — | 2014 | → |
| Genetics and genomics of alcohol sensitivity. | Morozova TV et al. | — | 2014 | → |
| Genetics of alcohol dependence: a review of clinical studies. | Samochowiec J et al. | — | 2014 | → |
| Genetics of alcoholism. | Edenberg HJ et al. | — | 2014 | → |
| Genetics of alcoholism. | Iyer-Eimerbrink PA et al. | — | 2014 | → |
| Modest long-term ethanol consumption affects expression of neurotransmitter receptor genes in the rat nucleus accumbens. | Jonsson S et al. | — | 2014 | → |
| Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. | Yan J et al. | — | 2014 | → |
| Decreased methylation of the NK3 receptor coding gene (TACR3) after cocaine-induced place preference in marmoset monkeys. | Barros M et al. | — | 2013 | → |
| Pharmacokinetics and central nervous system effects of the novel dual NK1 /NK3 receptor antagonist GSK1144814 in alcohol-intoxicated volunteers. | te Beek ET et al. | — | 2013 | → |
| Sensitization of hypervigilance effects of cocaine can be induced by NK3 receptor activation in marmoset monkeys. | Melamed JL et al. | — | 2013 | → |
| Implications of central immune signaling caused by drugs of abuse: mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence. | Coller JK et al. | — | 2012 | → |
| Is there still a future for neurokinin 3 receptor antagonists as potential drugs for the treatment of psychiatric diseases? | Griebel G et al. | — | 2012 | → |
| Mutational analysis of TAC3 and TACR3 genes in patients with idiopathic central pubertal disorders. | Tusset C et al. | — | 2012 | → |
| The genetic basis of alcoholism: multiple phenotypes, many genes, complex networks. | Morozova TV et al. | — | 2012 | → |
| Alcohol research: past, present, and future. | Gunzerath L et al. | — | 2011 | → |
| A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. | Kalsi G et al. | — | 2010 | → |
| Candidate genes for alcohol preference identified by expression profiling in alcohol-preferring and -nonpreferring reciprocal congenic rats. | Liang T et al. | — | 2010 | → |
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| Substance P inhibits GABAB receptor signalling in the ventral tegmental area. | Xia YF et al. | — | 2010 | → |
| Opiate and cocaine addiction: from bench to clinic and back to the bench. | Kreek MJ et al. | — | 2009 | → |
| TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. | Topaloglu AK et al. | — | 2009 | → |