Genetics of alcoholism.
- Authors
- Iyer-Eimerbrink, Priya A; Nurnberger, John I
- Year
- 2014
- Journal
- Current psychiatry reports
- PMID
- 25399692
- DOI
- 10.1007/s11920-014-0518-0
Alcohol use and alcohol use disorders are substantially heritable. Variants in genes coding for alcohol metabolic enzymes have long been known to influence consumption. More recent studies in family-based samples have implicated GABRA2, nicotinic receptor genes such as CHRNB3, and a number of other specific single genes as associated with alcohol use disorders. The growing use of genetic analyses, in particular studies using polygenic risk scores; neurobiologic pathways; and methods for quantifying gene × gene and gene × environment interactions have also contributed to an evolving understanding of the genetic architecture of alcohol use disorders. Additionally, the study of behavioral traits associated with alcohol dependence such as impulsivity and sensation seeking, and the influences of demographic factors (i.e., sex and ethnicity) have significantly enhanced the genetics of alcoholism literature. This article provides a brief overview of the current topically relevant findings in the field to date and includes areas of research still requiring attention.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity. | 2017 | 28134463 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The Impact of Alcohol-Induced Epigenetic Modifications in the Treatment of Alcohol use Disorders. | Fanfarillo F et al. | — | 2024 | → |
| Young Swiss men's risky single-occasion drinking: Identifying those who do not respond to stricter alcohol policy environments. | Foster S et al. | — | 2022 | → |
| Commentary: Perspectives on alcohol-related gene and environment interplay in diverse populations. | Scott MS | — | 2017 | → |
| Review: Pharmacogenetics of alcoholism treatment: Implications of ethnic diversity. | Cservenka A et al. | — | 2017 | → |
| Assessment of Expression of Genes Coding GABAA Receptors during Chronic and Acute Intoxication of Laboratory Rats with Ethanol. | Osechkina NS et al. | — | 2016 | → |
| More than Meets the Eye: Eye Color and Alcoholism. | Eissenberg JC | — | 2016 | → |
| Alcohol-Induced Blackouts and Other Negative Outcomes During the Transition Out of College. | Wilhite ER et al. | — | 2015 | → |
| [Genius between music and disease: Medical considerations on Ludwig van Beethoven]. | Gasenzer ER et al. | — | 2015 | → |