Selective acceleration of auditory processing in chronic alcoholics during abstinence.
- Authors
- Pekkonen, E; Ahveninen, J; Jääskeläinen, I P; Seppä, K; Näätänen, R; Sillanaukee, P
- Year
- 1998
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 9622438
- DOI
- 10.1111/j.1530-0277.1998.tb04299.x
Simultaneous auditory processing between the hemispheres was studied with a whole-head magnetometer in 13 abstinent chronic alcoholics and 10 healthy control subjects. Auditory stimuli were presented monaurally with interstimulus intervals of 0.5 and 2.5 sec in different blocks. The N100m response, which contributes to stimulus detection, was significantly accelerated in the hemisphere ipsilateral to the ear stimulated in abstinent alcoholics. The MMNm response reflecting automatic stimulus-change detection peaked earlier in alcoholics, and the ipsilateral N100m latency correlated significantly with the abstinence duration. These results suggest that auditory processing is accelerated in the auditory cortex ipsilateral to the stimulated ear in chronic abstinent alcoholics and that the accelerated processing is at least partly reversible. This may be caused by the hyperexcitation in the brain related to the ethanol withdrawal.
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| Advances in Electrophysiological Research. | 2015 | 26259089 |
| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
External
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|---|---|---|---|---|
| Auditory mismatch detection, distraction, and attentional reorientation (MMN-P3a-RON) in neurological and psychiatric disorders: A review. | Justo-Guillén E et al. | — | 2019 | → |
| Advances in Electrophysiological Research. | Kamarajan C et al. | — | 2015 | → |
| Event-related potentials in substance use disorders: a narrative review based on articles from 1984 to 2012. | Campanella S et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| The mismatch negativity (MMN)--a unique window to disturbed central auditory processing in ageing and different clinical conditions. | Näätänen R et al. | — | 2012 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Mismatch negativity: no difference between controls and abstinent alcoholics. | Fein G et al. | — | 2004 | → |
| Abnormal CNV in chronic heavy drinkers. | Chao LL et al. | — | 2003 | → |
| Electrophysiological evidence of abnormal activation of the cerebral network of involuntary attention in alcoholism. | Polo MD et al. | — | 2003 | → |
| Mismatch negativity in subjects at high risk for alcoholism. | Zhang XL et al. | — | 2001 | → |
| Global field power of auditory N1 correlates with impaired verbal-memory performance in human alcoholics. | Ahveninen J et al. | — | 2000 | → |
| Increased distractibility by task-irrelevant sound changes in abstinent alcoholics. | Ahveninen J et al. | — | 2000 | → |
| Mismatch negativity and auditory sensory memory in chronic alcoholics. | Polo MD et al. | — | 1999 | → |
| Post-withdrawal changes in middle-latency auditory evoked potentials in abstinent human alcoholics. | Ahveninen J et al. | — | 1999 | → |
| Suppression of mismatch negativity by backward masking predicts impaired working-memory performance in alcoholics. | Ahveninen J et al. | — | 1999 | → |