Neurobiology of decision-making: risk and reward.
paper
Cited
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- Authors
- Bechara, A
- Year
- 2001
- Journal
- Seminars in clinical neuropsychiatry
- PMID
- 11447572
- DOI
- 10.1053/scnp.2001.22927
Neurological patients with bilateral ventromedial (VM) lesions of the prefrontal cortex often deny, or they are not aware that they have a problem. Furthermore, they often pursue actions that bring some reward in the immediate run, despite severe long-term consequences such as the loss of job, home, and family. The somatic marker hypothesis, which provides an account of this defect in decision-making, posits that the impairment is the result of defective activation of somatic markers that normally function as covert or overt signposts for helping with the process of making choices that are advantageous to the organism. Failure to enact somatic states results from dysfunction in a neural system in which the VM cortex is one critical region. However, other neural regions, including the amygdala, and somatosensory cortices (SI, SII, and insula) are also hypothesized to be components of that same neural system. Recent evidence reveals that substance abusers suffer from decision-making deficit akin to that seen with patients with VM lesions. Thus, the strategies used to study decision-making in neurological patients have direct implications for understanding several neuropsychiatric disorders including addiction and pathological gambling.
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| Title | Year | PMID |
|---|---|---|
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | 2010 | 20035952 |
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| Brain Neural Underpinnings of Interoception and Decision-Making in Alzheimer's Disease: A Narrative Review. | Sun W et al. | — | 2022 | → |
| Decision-making in suicidal behavior: A systematic review and meta-analysis. | Sastre-Buades A et al. | — | 2021 | → |
| Effectiveness of an Integrated Intervention Program for Alcoholism: Electrophysiological Findings. | Kumar R et al. | — | 2021 | → |
| Heart Rate Variability and Decision-Making: Autonomic Responses in Making Decisions. | Forte G et al. | — | 2021 | → |
| Interoceptive Awareness, Decision-Making and Impulsiveness in Male Patients with Alcohol or Opioid Use Disorder. | Sübay B et al. | — | 2021 | → |
| ADHD desynchronizes brain activity during watching a distracted multi-talker conversation. | Salmi J et al. | — | 2020 | → |
| Prehabilitation in Alcohol Dependence as a Treatment Model for Sustainable Outcomes. A Narrative Review of Literature on the Risks Associated With Detoxification, From Animal Models to Human Translational Research. | Kouimtsidis C et al. | — | 2019 | → |
| Sweating the small stuff: A meta-analysis of skin conductance on the Iowa gambling task. | Simonovic B et al. | — | 2019 | → |
| The Controllability Hypothesis: Near-miss effect points to common neurological machinery in posterior parietal cortex for controllable objects and concepts. | Kruse I | — | 2019 | → |
| Underlying decision making processes on Iowa Gambling Task. | Kumar R et al. | — | 2019 | → |
| Amygdala-orbitofrontal functional connectivity mediates the relationship between sensation seeking and alcohol use among binge-drinking adults. | Crane NA et al. | — | 2018 | → |
| Functional Imaging Changes in the Medial Prefrontal Cortex in Adult ADHD. | Salavert J et al. | — | 2018 | → |
| Presumed structural and functional neural recovery after long-term abstinence from cocaine in male military veterans. | He Q et al. | — | 2018 | → |
| Gambling disorder: Association between duration of illness, clinical, and neurocognitive variables. | Medeiros GC et al. | — | 2017 | → |
| Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats. | Golebiowska J et al. | — | 2017 | → |
| Risky decision-making under risk in schizophrenia: A deliberate choice? | Pedersen A et al. | — | 2017 | → |
| Cognitive deficits in patients with obsessive-compulsive disorder - electroencephalography correlates. | Kamaradova D et al. | — | 2016 | → |
| Motivational Processes Underlying Substance Abuse Disorder. | Meyer PJ et al. | — | 2016 | → |
| Resting-state functional MRI of abnormal baseline brain activity in young depressed patients with and without suicidal behavior. | Cao J et al. | — | 2016 | → |
| Risky Decisions in a Lottery Task Are Associated with an Increase of Cocaine Use. | Wittwer A et al. | — | 2016 | → |
| Attenuated Neural Processing of Risk in Young Adults at Risk for Stimulant Dependence. | Reske M et al. | — | 2015 | → |
| Developmental trajectories of cortical-subcortical interactions underlying the evaluation of trust in adolescence. | Kragel PA et al. | — | 2015 | → |
| The Anterior Insula Tracks Behavioral Entropy during an Interpersonal Competitive Game. | Takahashi H et al. | — | 2015 | → |
| What the orbitofrontal cortex does not do. | Stalnaker TA et al. | — | 2015 | → |
| Cannabis use is quantitatively associated with nucleus accumbens and amygdala abnormalities in young adult recreational users. | Gilman JM et al. | — | 2014 | → |
| Differences in time course activation of dorsolateral prefrontal cortex associated with low or high risk choices in a gambling task. | Bembich S et al. | — | 2014 | → |
| Review of cognitive performance in hoarding disorder. | Woody SR et al. | — | 2014 | → |
| A multistep general theory of transition to addiction. | Piazza PV et al. | — | 2013 | → |
| Deliberative and spontaneous cognitive processes associated with HIV risk behavior. | Grenard JL et al. | — | 2013 | → |
| Red brain, blue brain: evaluative processes differ in Democrats and Republicans. | Schreiber D et al. | — | 2013 | → |
| Reexamining the validity and reliability of the clinical version of the iowa gambling task: evidence from a normal subject group. | Lin CH et al. | — | 2013 | → |
| COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making. | He Q et al. | — | 2012 | → |
| Cross-sectional and longitudinal abnormalities in brain structure in children with severe mood dysregulation or bipolar disorder. | Adleman NE et al. | — | 2012 | → |
| High impulsivity in rats predicts amphetamine conditioned place preference. | Yates JR et al. | — | 2012 | → |
| "Tell me how do I feel"--emotion recognition and theory of mind in symptomatic mesial temporal lobe epilepsy. | Broicher SD et al. | — | 2012 | → |
| Trends and issues in characterizing early cognitive changes in Parkinson's disease. | Claassen DO et al. | — | 2012 | → |
| Alternation learning in pathological gamblers: an fMRI Study. | Dannon PN et al. | — | 2011 | → |
| A reverse translational approach to quantify approach-avoidance conflict in humans. | Aupperle RL et al. | — | 2011 | → |
| Maturation of limbic corticostriatal activation and connectivity associated with developmental changes in temporal discounting. | Christakou A et al. | — | 2011 | → |
| Neurobiology of decision-making in adolescents. | Shad MU et al. | — | 2011 | → |
| Reduced cortical gray matter volume in male adolescents with substance and conduct problems. | Dalwani M et al. | — | 2011 | → |
| Rodent versions of the iowa gambling task: opportunities and challenges for the understanding of decision-making. | de Visser L et al. | — | 2011 | → |
| Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholics. | Duka T et al. | — | 2011 | → |
| Dysfunctional reward processing in male alcoholics: an ERP study during a gambling task. | Kamarajan C et al. | — | 2010 | → |
| Gambling pathology is associated with dampened cortisol response among men and women. | Paris JJ et al. | — | 2010 | → |
| Neuroscience, power and culture: an introduction. | Vrecko S | — | 2010 | → |
| Non-substance-addictive behaviors in youth: pathological gambling and problematic Internet use. | Brezing C et al. | — | 2010 | → |
| Problem-solving without awareness: an ERP investigation. | Paynter CA et al. | — | 2010 | → |
| Sex differences in salivary cortisol in response to acute stressors among healthy participants, in recreational or pathological gamblers, and in those with posttraumatic stress disorder. | Paris JJ et al. | — | 2010 | → |
| What motivates the adolescent? Brain regions mediating reward sensitivity across adolescence. | Van Leijenhorst L et al. | — | 2010 | → |
| Decision making with and without feedback: the role of intelligence, strategies, executive functions, and cognitive styles. | Brand M et al. | — | 2009 | → |
| Do amnesic patients with Korsakoff's syndrome use feedback when making decisions under risky conditions? An experimental investigation with the Game of Dice Task with and without feedback. | Brand M et al. | — | 2009 | → |
| Gain-loss frequency and final outcome in the Soochow Gambling Task: A Reassessment. | Lin CH et al. | — | 2009 | → |
| Neural mechanism of intertemporal choice: from discounting future gains to future losses. | Xu L et al. | — | 2009 | → |
| Progressive decline of decision-making performances during multiple sclerosis. | Simioni S et al. | — | 2009 | → |
| The effects of insula damage on decision-making for risky gains and losses. | Weller JA et al. | — | 2009 | → |
| To bet or not to bet? The error negativity or error-related negativity associated with risk-taking choices. | Yu R et al. | — | 2009 | → |
| Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th-grade Chinese adolescent smokers. | Xiao L et al. | — | 2008 | → |
| Brain maps of Iowa gambling task. | Lin CH et al. | — | 2008 | → |
| Decision-making impairment is related to serotonin transporter promoter polymorphism in a sample of patients with obsessive-compulsive disorder. | da Rocha FF et al. | — | 2008 | → |
| Informed consent to opioid agonist maintenance treatment: recommended ethical guidelines. | Carter A et al. | — | 2008 | → |
| Pathological gambling: an update on neuropathophysiology and pharmacotherapy. | Iancu I et al. | — | 2008 | → |
| Serotonergic mechanisms in addiction-related memories. | Nic Dhonnchadha BA et al. | — | 2008 | → |
| Source preference and ambiguity aversion: models and evidence from behavioral and neuroimaging experiments. | Chew SH et al. | — | 2008 | → |
| The neurobiology and genetics of impulse control disorders: relationships to drug addictions. | Brewer JA et al. | — | 2008 | → |
| The role of strategies in deciding advantageously in ambiguous and risky situations. | Brand M et al. | — | 2008 | → |
| Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules. | Brand M et al. | — | 2007 | → |
| Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy"). | Quednow BB et al. | — | 2007 | → |
| From vice to virtue: insights from sensitization in the nonhuman primate. | Castner SA et al. | — | 2007 | → |
| Impulsivity, neural deficits, and the addictions: the "oops" factor in relapse. | Adinoff B et al. | — | 2007 | → |
| Is deck B a disadvantageous deck in the Iowa Gambling Task? | Lin CH et al. | — | 2007 | → |
| Location, location: using functional magnetic resonance imaging to pinpoint brain differences relevant to stimulant use. | Aron JL et al. | — | 2007 | → |
| Neuropsychological functioning in kleptomania. | Grant JE et al. | — | 2007 | → |
| Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease. | Brand M et al. | — | 2007 | → |
| Are the insular cortex and cortisol implicated in Parkinsonian features? | Tops M | — | 2006 | → |
| Brain atrophy in long-term abstinent alcoholics who demonstrate impairment on a simulated gambling task. | Fein G et al. | — | 2006 | → |
| Distinct neural mechanisms of risk and ambiguity: a meta-analysis of decision-making. | Krain AL et al. | — | 2006 | → |
| Impaired decision making following 49 h of sleep deprivation. | Killgore WD et al. | — | 2006 | → |
| Lorazepam dose-dependently decreases risk-taking related activation in limbic areas. | Arce E et al. | — | 2006 | → |
| Neurodevelopmental pathways to aggression: a model to understand and target treatment in youth. | Sugden SG et al. | — | 2006 | → |
| Normal performance on a simulated gambling task in treatment-naive alcohol-dependent individuals. | Fein G et al. | — | 2006 | → |
| Odor identification accuracy declines following 24 h of sleep deprivation. | Killgore WD et al. | — | 2006 | → |
| Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation. | Ardouin C et al. | — | 2006 | → |
| Pharmacotherapy of pathological gambling: review of new treatment modalities. | Lowengrub K et al. | — | 2006 | → |
| Response bias and aging on a recognition memory task. | Huh TJ et al. | — | 2006 | → |
| Sex differences in medial and lateral orbitofrontal cortex hypoperfusion in cocaine-dependent men and women. | Adinoff B et al. | — | 2006 | → |
| Stroop performance in pathological gamblers. | Kertzman S et al. | — | 2006 | → |
| The Neurocognitive Mechanisms of Decision-making, Impulse Control, and Loss of Willpower to Resist Drugs. | Noël X et al. | — | 2006 | → |
| The role of emotion in decision-making: a cognitive neuroeconomic approach towards understanding sexual risk behavior. | Gutnik LA et al. | — | 2006 | → |
| Decision-making impairments in patients with pathological gambling. | Brand M et al. | — | 2005 | → |
| Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. | Bechara A | — | 2005 | → |
| Decisions under uncertainty: probabilistic context influences activation of prefrontal and parietal cortices. | Huettel SA et al. | — | 2005 | → |
| Effect of aging on stimulus-reward association learning. | Mell T et al. | — | 2005 | → |
| Genetic studies of pathological gambling: a review of methodology and analyses of data from the Vietnam Era Twin Registry. | Shah KR et al. | — | 2005 | → |
| Neural networks of information processing in posttraumatic stress disorder: a functional magnetic resonance imaging study. | Bryant RA et al. | — | 2005 | → |
| Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures. | Schienle A et al. | — | 2005 | → |
| Psychological processes underlying risky decisions in drug abusers. | Stout JC et al. | — | 2005 | → |
| Relationship between disgust sensitivity, trait anxiety and brain activity during disgust induction. | Schienle A et al. | — | 2005 | → |
| Reward-based decision-making and aging. | Marschner A et al. | — | 2005 | → |
| Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers. | Fishbein DH et al. | — | 2005 | → |
| Impaired decision making related to working memory deficits in individuals with substance addictions. | Bechara A et al. | — | 2004 | → |
| Impairment on a simulated gambling task in long-term abstinent alcoholics. | Fein G et al. | — | 2004 | → |
| Increased sensitivity to error during decision-making in bipolar disorder patients with acute mania. | Minassian A et al. | — | 2004 | → |
| An FMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers. | Potenza MN et al. | — | 2003 | → |
| Decision making by methamphetamine-dependent subjects is associated with error-rate-independent decrease in prefrontal and parietal activation. | Paulus MP et al. | — | 2003 | → |
| Decision making in adolescents with behavior disorders and adults with substance abuse. | Ernst M et al. | — | 2003 | → |
| Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. | Chambers RA et al. | — | 2003 | → |
| Impulsive decision making and working memory. | Hinson JM et al. | — | 2003 | → |
| Neurodevelopment, impulsivity, and adolescent gambling. | Chambers RA et al. | — | 2003 | → |
| Reward anticipation, cognition, and electrodermal activity in the conditioned monkey. | Amiez C et al. | — | 2003 | → |
| Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients. | Franklin TR et al. | — | 2002 | → |
| Gambling: an addictive behavior with health and primary care implications. | Potenza MN et al. | — | 2002 | → |
| Somatic markers, working memory, and decision making. | Hinson JM et al. | — | 2002 | → |