Genetic correlation between smoking behaviors and schizophrenia.
paper
Cited
Public
- Authors
- Hartz, Sarah M; Horton, Amy C; Hancock, Dana B; Baker, Timothy B; Caporaso, Neil E; Chen, Li-Shiun; Hokanson, John E; Lutz, Sharon M; Marazita, Mary L; McNeil, Daniel W; Pato, Carlos N; Pato, Michele T; Johnson, Eric O; Bierut, Laura J
- Year
- 2018
- Journal
- Schizophrenia research
- PMID
- 28285025
- DOI
- 10.1016/j.schres.2017.02.022
- PMCID
- PMC5811408
Nicotine dependence is highly comorbid with schizophrenia, and the etiology of the comorbidity is unknown. To determine whether there is a genetic correlation of smoking behavior with schizophrenia, genome-wide association study (GWAS) meta-analysis results from five smoking phenotypes (ever/never smoker (N=74,035), age of onset of smoking (N=28,647), cigarettes smoked per day (CPD, N=38,860), nicotine dependence (N=10,666), and current/former smoker (N=40,562)) were compared to GWAS meta-analysis results from schizophrenia (N=79,845) using linkage disequilibrium (LD) score regression. First, the SNP heritability (h) of each of the smoking phenotypes was computed using LD score regression (ever/never smoker h=0.08, age of onset of smoking h=0.06, CPD h=0.06, nicotine dependence h=0.15, current/former smoker h=0.07, p<0.001 for all phenotypes). The SNP heritability for nicotine dependence was statistically higher than the SNP heritability for the other smoking phenotypes (p<0.0005 for all two-way comparisons). Next, a statistically significant (p<0.05) genetic correlation was observed between schizophrenia and three of the five smoking phenotypes (nicotine dependence r=0.14, CPD r=0.12, and ever/never smoking r=0.10). These results suggest that there is a component of common genetic variation that is shared between smoking behaviors and schizophrenia.
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