Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study.
paper
Cited
Public
Unavailable
- Authors
- Fergusson, David M; Horwood, L John; Miller, Allison L; Kennedy, Martin A
- Year
- 2011
- Journal
- The British journal of psychiatry : the journal of mental science
- PMID
- 21282783
- DOI
- 10.1192/bjp.bp.110.085993
- PMCID
- PMC3031653
BACKGROUND: Recent meta-analyses have raised concerns about the replicability of gene × environment interactions involving the serotonin transporter gene (5-HTTLPR) in moderating the associations between adverse life events and mental disorders. AIMS: To use data gathered over the course of a 30-year longitudinal study of a New Zealand birth cohort to test the hypothesis that the presence of short ('s') alleles of 5-HTTLPR are associated with an increased response to life stress. METHOD: Participants were 893 individuals from the Christchurch Health and Development Study who had complete data on: the 5-HTTLPR genotype; psychiatric disorders up to the age of 30; and exposure to childhood and adult adverse life events. RESULTS: A series of 104 regression models were fitted to four mental health outcomes (depressive symptoms, major depression, anxiety disorder and suicidal ideation) observed at ages 18, 21, 25 and 30 using 13 measures of life-course stress that spanned childhood and adult stressors. Both multiplicative and additive models were fitted to the data. No evidence was found that would support the hypothesis that 's' alleles of 5-HTTLPR are associated with increased responsivity to life stressors. CONCLUSIONS: The present findings add to the evidence suggesting that it is unlikely that there is a stable gene × environment interaction involving 5-HTTLPR, life stress and mental disorders.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Tryptophan Metabolism in Developmental Origins of Health and Disease. | de Souza SL et al. | — | 2026 | → |
| Adverse childhood experience and depression: the role of gut microbiota. | Bai Y et al. | — | 2024 | → |
| Individual differences in social homeostasis. | Bales KL et al. | — | 2023 | → |
| HPA Axis Responsiveness Associates with Central Serotonin Transporter Availability in Human Obesity and Non-Obesity Controls. | Schinke C et al. | — | 2022 | → |
| Preliminary Evidence That the Short Allele of 5-HTTLPR Moderates the Association of Psychiatric Symptom Severity on Suicide Attempt: The Example in Obsessive-Compulsive Disorder. | Harika-Germaneau G et al. | — | 2022 | → |
| Children's Mental Health in Southwestern Ontario during Summer 2020 of the COVID-19 Pandemic. | Mactavish A et al. | — | 2021 | → |
| Genetic Architecture of Depression: Where Do We Stand Now? | Unal-Aydin P et al. | — | 2021 | → |
| Lifetime and 1-Month Prevalence of Mental Disorders in Hebei Province, China: A Community-Based Cross-Sectional Study. | Sun L et al. | — | 2021 | → |
| An integrative analysis of 5HTT-mediated mechanism of hyperactivity to non-threatening voices. | Chen C et al. | — | 2020 | → |
| Biomarkers of suicidal behaviors: A comprehensive critical review. | Capuzzi E et al. | — | 2020 | → |
| Does single gene expression omnibus data mining analysis apply for only tumors and not mental illness? A preliminary study on bipolar disorder based on bioinformatics methodology. | You X et al. | — | 2020 | → |
| GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway. | Hou X et al. | — | 2020 | → |
| Influence of psychosocial stress on activation in human brain regions: moderation by the 5-HTTLPR genetic locus. | Sun X et al. | — | 2020 | → |
| The Multifaceted Effects of Serotonin Transporter Polymorphism (5-HTTLPR) on Anxiety, Implicit Moral Attitudes, and Harmful Behaviors. | Martínez RM et al. | — | 2020 | → |
| The role of 5-HTTLPR in autism spectrum disorder: New evidence and a meta-analysis of this polymorphism in Latin American population with psychiatric disorders. | Nuñez-Rios DL et al. | — | 2020 | → |
| Associations between schizophrenia genetic risk, anxiety disorders and manic/hypomanic episode in a longitudinal population cohort study. | Richards A et al. | — | 2019 | → |
| Genetic, epigenetic and posttranscriptional mechanisms for treatment of major depression: the 5-HT1A receptor gene as a paradigm | Albert PR et al. | — | 2019 | → |
| Sometimes It's Good to be Short: The Serotonin Transporter Gene, Positive Parenting, and Adolescent Depression. | Little K et al. | — | 2019 | → |
| Uncovering the Genetic Architecture of Major Depression. | McIntosh AM et al. | — | 2019 | → |
| Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression. | Culverhouse RC et al. | — | 2018 | → |
| Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium. | Peyrot WJ et al. | — | 2018 | → |
| Family History as an Important Factor for Stratifying Participants in Genetic Studies of Major Depression. | Zalar B et al. | — | 2018 | → |
| Gene-environment interactions between stress and 5-HTTLPR in depression: A meta-analytic update. | Bleys D et al. | — | 2018 | → |
| High anxiety trait: A vulnerable phenotype for stress-induced depression. | Weger M et al. | — | 2018 | → |
| Childhood quality influences genetic sensitivity to environmental influences across adulthood: A life-course Gene × Environment interaction study. | Keers R et al. | — | 2017 | → |
| Disruptive Behavior Disorders in Children 0 to 6 Years Old. | Tandon M et al. | — | 2017 | → |
| How Good Were Candidate Gene Guesses in Schizophrenia Genetics? | Sullivan PF | — | 2017 | → |
| Microsatellite polymorphisms associated with human behavioural and psychological phenotypes including a gene-environment interaction. | Bagshaw AT et al. | — | 2017 | → |
| Modifiable predictors of depression following childhood maltreatment: a systematic review and meta-analysis. | Braithwaite EC et al. | — | 2017 | → |
| Additive genetic contribution to symptom dimensions in major depressive disorder. | Pearson R et al. | — | 2016 | → |
| A Genome-Wide Test of the Differential Susceptibility Hypothesis Reveals a Genetic Predictor of Differential Response to Psychological Treatments for Child Anxiety Disorders. | Keers R et al. | — | 2016 | → |
| Genetic and Environmental Influences on the Mental Health of Children: A Twin Study. | Yin P et al. | — | 2016 | → |
| Genetic moderation of the association between adolescent romantic involvement and depression: Contributions of serotonin transporter gene polymorphism, chronic stress, and family discord. | Starr LR et al. | — | 2016 | → |
| Longitudinal Intergenerational Birth Cohort Designs: A Systematic Review of Australian and New Zealand Studies. | Townsend ML et al. | — | 2016 | → |
| Serotonin transporter variants play a role in anxiety sensitivity in South African adolescents. | Hemmings SM et al. | — | 2016 | → |
| The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders. | Smoller JW | — | 2016 | → |
| The Swiss Preschoolers' health study (SPLASHY): objectives and design of a prospective multi-site cohort study assessing psychological and physiological health in young children. | Messerli-Bürgy N et al. | — | 2016 | → |
| Genetic determinants of depression: recent findings and future directions. | Dunn EC et al. | — | 2015 | → |
| I just ran a thousand analyses: benefits of multiple testing in understanding equivocal evidence on gene-environment interactions. | Heininga VE et al. | — | 2015 | → |
| Social support and the serotonin transporter genotype (5-HTTLPR) moderate levels of resilience, sense of coherence, and depression. | Reinelt E et al. | — | 2015 | → |
| An update on the interaction between the serotonin transporter promoter variant (5-HTTLPR), stress and depression, plus an exploration of non-confirming findings. | Sharpley CF et al. | — | 2014 | → |
| Effect of polygenic risk scores on depression in childhood trauma. | Peyrot WJ et al. | — | 2014 | → |
| Gene-environment interaction in postpartum depression: a Chinese clinical study. | Zhang X et al. | — | 2014 | → |
| Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders. | Van der Auwera S et al. | — | 2014 | → |
| Lack of association between the 5-HTTLPR and positive screening for mental disorders among children exposed to urban violence and maltreatment. | Cividanes GC et al. | — | 2014 | → |
| Mind the gap: why many geneticists and psychological scientists have discrepant views about gene-environment interaction (G×E) research. | Duncan LE et al. | — | 2014 | → |
| No association between mean telomere length and life stress observed in a 30 year birth cohort. | Jodczyk S et al. | — | 2014 | → |
| Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder. | Vinberg M et al. | — | 2014 | → |
| The genetics of major depression. | Flint J et al. | — | 2014 | → |
| A mega-analysis of genome-wide association studies for major depressive disorder. | Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium et al. | — | 2013 | → |
| Candidate and non-candidate genes in behavior genetics. | Flint J et al. | — | 2013 | → |
| Effects of environmental manipulations in genetically targeted animal models of affective disorders. | Renoir T et al. | — | 2013 | → |
| G × E interaction and neurodevelopment II. Focus on adversities in paediatric depression: the moderating role of serotonin transporter. | Bellani M et al. | — | 2013 | → |
| Increased risk of major depression by childhood abuse is not modified by CNR1 genotype. | Pearson JF et al. | — | 2013 | → |
| Involvement of genetic and environmental factors in the onset of depression. | Nabeshima T et al. | — | 2013 | → |
| No moderating effect of 5-HTTLPR on associations between antenatal anxiety and infant behavior. | Braithwaite EC et al. | — | 2013 | → |
| Paying attention to all results, positive and negative. | Duncan LE | — | 2013 | → |
| Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression. | Culverhouse RC et al. | — | 2013 | → |
| Role of 5-HTTLPR polymorphism in the development of the inward/outward personality organization: a genetic association study. | Nardi B et al. | — | 2013 | → |
| Testing bidirectional effects between cannabis use and depressive symptoms: moderation by the serotonin transporter gene. | Otten R et al. | — | 2013 | → |
| Testing the diathesis-stress model: 5-HTTLPR, childhood emotional maltreatment, and vulnerability to social anxiety disorder. | Reinelt E et al. | — | 2013 | → |
| The current state of play on the molecular genetics of depression. | Cohen-Woods S et al. | — | 2013 | → |
| Genetic architectures of psychiatric disorders: the emerging picture and its implications. | Sullivan PF et al. | — | 2012 | → |
| Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sample. | Grabe HJ et al. | — | 2012 | → |
| The serotonin transporter gene polymorphism (5HTTLPR) moderates the effect of adolescent environmental conditions on self-esteem in young adulthood: a structural equation modeling approach. | Jonassaint CR et al. | — | 2012 | → |
| Biomarkers in development of psychotropic drugs. | Wiedemann K | — | 2011 | → |
| Blowing in the wind. | Tyrer P | — | 2011 | → |
| Familial clustering of suicide risk: a total population study of 11.4 million individuals. | Tidemalm D et al. | — | 2011 | → |
| MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. | Fergusson DM et al. | — | 2011 | → |
| Serotonin transporter gene polymorphism and psychiatric disorders: is there a link? | Margoob MA et al. | — | 2011 | → |
| The relationship between serotonin transporter gene promoter polymorphism and serum lipid levels at young age in a longitudinal population-representative study. | Tomson K et al. | — | 2011 | → |