PGC1α and mitochondrial metabolism--emerging concepts and relevance in ageing and neurodegenerative disorders.
paper
Cited
Public
Unavailable
- Authors
- Austin, Shane; St-Pierre, Julie
- Year
- 2012
- Journal
- Journal of cell science
- PMID
- 23277535
- DOI
- 10.1242/jcs.113662
PGC1α is a transcriptional coactivator that is a central inducer of mitochondrial biogenesis in cells. Recent work highlighted that PGC1α can also modulate the composition and functions of individual mitochondria. Therefore, it is emerging that PGC1α is controlling global oxidative metabolism by performing two types of remodelling: (1) cellular remodelling through mitochondrial biogenesis, and (2) organelle remodelling through alteration in the intrinsic properties of mitochondria. The elevated oxidative metabolism associated with increased PGC1α activity could be accompanied by an increase in reactive oxygen species (ROS) that are primarily generated by mitochondria. However, increasing evidence suggests that this is not the case, as PGC1α is also a powerful regulator of ROS removal by increasing the expression of numerous ROS-detoxifying enzymes. Therefore, PGC1α, by controlling both the induction of mitochondrial metabolism and the removal of its ROS by-products, would elevate oxidative metabolism and minimize the impact of ROS on cell physiology. In this Commentary, we discuss how the biogenesis and remodelling of mitochondria that are elicited by PGC1α contribute to an increase in oxidative metabolism and the preservation of ROS homeostasis. Finally, we examine the importance of these findings in ageing and neurodegenerative disorders, conditions that are associated with impaired mitochondrial functions and ROS balance.
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| Quercetin Attenuates Diabetic Peripheral Neuropathy by Correcting Mitochondrial Abnormality via Activation of AMPK/PGC-1α Pathway <i>in vivo</i> and <i>in vitro</i>. | Zhang Q et al. | — | 2021 | → |
| Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals. | Hana CA et al. | — | 2021 | → |
| Sex-dependent effects of amyloid precursor-like protein 2 in the SOD1-G37R transgenic mouse model of MND. | Truong PH et al. | — | 2021 | → |
| Testosterone treatment is associated with reduced adipose tissue dysfunction and nonalcoholic fatty liver disease in obese hypogonadal men. | Maseroli E et al. | — | 2021 | → |
| The consequences of a high-calorie diet background before calorie restriction on skeletal muscles in a mouse model. | Maldonado M et al. | — | 2021 | → |
| The Protective Mechanism of SIRT1 in the Regulation of Mitochondrial Biogenesis and Mitochondrial Autophagy in Alzheimer's Disease. | Ye F et al. | — | 2021 | → |
| The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases. | Yan J et al. | — | 2021 | → |
| Time restricted feeding and mental health: a review of possible mechanisms on affective and cognitive disorders. | Currenti W et al. | — | 2021 | → |
| Twist1 signaling in age-dependent decline in angiogenesis and lung regeneration. | Hendee K et al. | — | 2021 | → |
| A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. | Piers TM et al. | — | 2020 | → |
| A looming role of mitochondrial calcium in dictating the lung epithelial integrity and pathophysiology of lung diseases. | Ray A et al. | — | 2020 | → |
| AMPK-SIRT1-PGC1α Signal Pathway Influences the Cognitive Function of Aged Rats in Sevoflurane-Induced Anesthesia. | Yang XY et al. | — | 2020 | → |
| Antioxidant-Conjugated Peptide Attenuated Metabolic Reprogramming in Pulmonary Hypertension. | Varghese MV et al. | — | 2020 | → |
| Associations of Peripheral Artery Disease With Calf Skeletal Muscle Mitochondrial DNA Heteroplasmy. | Gonzalez-Freire M et al. | — | 2020 | → |
| Astrocytes resolve ER stress through mitochondrial fusion facilitated by biotin availability. | Anand RS et al. | — | 2020 | → |
| Cardiac Dysfunction after Burn Injury: Role of the AMPK-SIRT1-PGC1α-NFE2L2-ARE Pathway. | Wen JJ et al. | — | 2020 | → |
| Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. | Shah DS et al. | — | 2020 | → |
| Combination therapy with astaxanthin and epidermal neural crest stem cells improves motor impairments and activates mitochondrial biogenesis in a rat model of spinal cord injury. | Mohaghegh Shalmani L et al. | — | 2020 | → |
| Crosstalk between mitochondrial metabolism and oxidoreductive homeostasis: a new perspective for understanding the effects of bioactive dietary compounds. | Di Giacomo M et al. | — | 2020 | → |
| Derangement of Metabolic and Lysosomal Gene Profiles in Response to Dexamethasone Treatment in Sarcoidosis. | Talreja J et al. | — | 2020 | → |
| Dysregulated metabolic pathways in age-related macular degeneration. | Zhang M et al. | — | 2020 | → |
| Effect of Probiotics and Multi-Component Feed Additives on Microbiota, Gut Barrier and Immune Responses in Broiler Chickens During Subclinical Necrotic Enteritis. | Emami NK et al. | — | 2020 | → |
| Effects of astaxanthin on the protection of muscle health (Review). | Wong SK et al. | — | 2020 | → |
| Effects of resveratrol on the levels of ATP, 5-HT and GAP-43 in the hippocampus of mice exposed to chronic unpredictable mild stress. | Shen JD et al. | — | 2020 | → |
| Emerging model systems and treatment approaches for Leber's hereditary optic neuropathy: Challenges and opportunities. | Bahr T et al. | — | 2020 | → |
| Epigenetic alteration of mitochondrial biogenesis regulatory genes in arsenic exposed individuals (with and without skin lesions) and in skin cancer tissues: A case control study. | Sanyal T et al. | — | 2020 | → |
| ERK signalling: a master regulator of cell behaviour, life and fate. | Lavoie H et al. | — | 2020 | → |
| Excitotoxicity and Overnutrition Additively Impair Metabolic Function and Identity of Pancreatic β-Cells. | Osipovich AB et al. | — | 2020 | → |
| From Obesity to Hippocampal Neurodegeneration: Pathogenesis and Non-Pharmacological Interventions. | Lee TH et al. | — | 2020 | → |
| Heat-induced changes in the expression and localisation of PGC-1α in the mice testis. | Das M et al. | — | 2020 | → |
| Hypoxic tumor microenvironment: Implications for cancer therapy. | Roy S et al. | — | 2020 | → |
| Impact of neural stem cell-derived extracellular vesicles on mitochondrial dysfunction, sirtuin 1 level, and synaptic deficits in Alzheimer's disease. | Li B et al. | — | 2020 | → |
| Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude. | Gangwar A et al. | — | 2020 | → |
| Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. | Zhang Y et al. | — | 2020 | → |
| LncRNA GUARDIN suppresses cellular senescence through a LRP130-PGC1α-FOXO4-p21-dependent signaling axis. | Sun X et al. | — | 2020 | → |
| Lycopene supplementation regulates the gene expression profile and fat metabolism of breeding hens. | Tian H et al. | — | 2020 | → |
| Maternal High Fat Diet and Diabetes Disrupts Transcriptomic Pathways That Regulate Cardiac Metabolism and Cell Fate in Newborn Rat Hearts. | Preston CC et al. | — | 2020 | → |
| Melatonin-Induced PGC-1α Improves Angiogenic Potential of Mesenchymal Stem Cells in Hindlimb Ischemia. | Lee JH et al. | — | 2020 | → |
| Melatonin protects against chronic stress-induced oxidative meiotic defects in mice MII oocytes by regulating SIRT1. | Guo Y et al. | — | 2020 | → |
| Metabolic Reprogramming by Malat1 Depletion in Prostate Cancer. | Nanni S et al. | — | 2020 | → |
| Mitochondrial biology in airway pathogenesis and the role of NRF2. | Cho HY et al. | — | 2020 | → |
| Mitochondrial dysfunction in metabolic syndrome. | Prasun P | — | 2020 | → |
| Mitochondrial Heme Synthesis Enzymes as Therapeutic Targets in Vascular Diseases. | Shetty T et al. | — | 2020 | → |
| Nanoparticle-Mediated Inhibition of Notch Signaling Promotes Mitochondrial Biogenesis and Reduces Subcutaneous Adipose Tissue Expansion in Pigs. | Huang D et al. | — | 2020 | → |
| Natural products, PGC-1 <b><i>α</i></b> , and Duchenne muscular dystrophy. | Suntar I et al. | — | 2020 | → |
| Neuroprotective actions of leptin facilitated through balancing mitochondrial morphology and improving mitochondrial function. | Cheng Y et al. | — | 2020 | → |
| No Change - No Gain; The Effect of Age, Sex, Selected Genes and Training on Physiological and Performance Adaptations in Cross-Country Skiing. | Johansen JM et al. | — | 2020 | → |
| Oxidative Stress in Amyotrophic Lateral Sclerosis: Pathophysiology and Opportunities for Pharmacological Intervention. | Cunha-Oliveira T et al. | — | 2020 | → |
| PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. | Pirooznia SK et al. | — | 2020 | → |
| Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Activates Vascular Endothelial Growth Factor That Protects Against Neuronal Cell Death Following Status Epilepticus through PI3K/AKT and MEK/ERK Signaling. | Huang JB et al. | — | 2020 | → |
| PGC-1α activator-induced fatty acid oxidation in tumor-infiltrating CTLs enhances effects of PD-1 blockade therapy in lung cancer. | Wan H et al. | — | 2020 | → |
| Pharmacological targeting of MCL-1 promotes mitophagy and improves disease pathologies in an Alzheimer's disease mouse model. | Cen X et al. | — | 2020 | → |
| Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion. | Balkhi MY | — | 2020 | → |
| Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer's Disease. | Wong KY et al. | — | 2020 | → |
| Role of cytochrome P450-derived, polyunsaturated fatty acid mediators in diabetes and the metabolic syndrome. | Dos Santos LRB et al. | — | 2020 | → |
| Silent Mating-Type Information Regulation 2 Homolog 1 Attenuates the Neurotoxicity Associated with Alzheimer Disease via a Mechanism Which May Involve Regulation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-α. | Dong YT et al. | — | 2020 | → |
| Teaching the basics of the mechanism of doxorubicin-induced cardiotoxicity: Have we been barking up the wrong tree? | Kalyanaraman B | — | 2020 | → |
| [The effect of Mexidol on cerebral mitochondriogenesis at a young age and during aging]. | Kirova YI et al. | — | 2020 | → |
| The Effect of Resveratrol on Mitochondrial Function in Myoblasts of Patients with the Common m.3243A>G Mutation. | Motlagh Scholle L et al. | — | 2020 | → |
| The inhibition of eIF5A hypusination by GC7, a preconditioning protocol to prevent brain death-induced renal injuries in a preclinical porcine kidney transplantation model. | Giraud S et al. | — | 2020 | → |
| The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer's Disease and Other Neurodegenerative Disorders. | Wójtowicz S et al. | — | 2020 | → |
| The Pan-Sirtuin Inhibitor MC2494 Regulates Mitochondrial Function in a Leukemia Cell Line. | Carafa V et al. | — | 2020 | → |
| The role of exercise in the reversal of IGF-1 deficiencies in microvascular rarefaction and hypertension. | Norling AM et al. | — | 2020 | → |
| The Underlying Role of Mitophagy in Different Regulatory Mechanisms of Chronic Obstructive Pulmonary Disease. | Liu JY et al. | — | 2020 | → |
| Transcriptional Regulation in Non-Alcoholic Fatty Liver Disease. | Steensels S et al. | — | 2020 | → |
| Vitamin D ameliorates adipose browning in chronic kidney disease cachexia. | Cheung WW et al. | — | 2020 | → |
| Wavelength- and irradiance-dependent changes in intracellular nitric oxide level. | Pope NJ et al. | — | 2020 | → |
| Acetylation of PGC1α by Histone Deacetylase 1 Downregulation Is Implicated in Radiation-Induced Senescence of Brain Endothelial Cells. | Kim SB et al. | — | 2019 | → |
| Advances Towards Therapeutic Approaches for mtDNA Disease. | Al Khatib I et al. | — | 2019 | → |
| Aging and Central Auditory Disinhibition: Is It a Reflection of Homeostatic Downregulation or Metabolic Vulnerability? | Ibrahim BA et al. | — | 2019 | → |
| Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation. | Kanatsu-Shinohara M et al. | — | 2019 | → |
| AMPK Activation of PGC-1α/NRF-1-Dependent SELENOT Gene Transcription Promotes PACAP-Induced Neuroendocrine Cell Differentiation Through Tolerance to Oxidative Stress. | Abid H et al. | — | 2019 | → |
| Anthracycline and Peripartum Cardiomyopathies. | Cowgill JA et al. | — | 2019 | → |
| Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration. | Kuter K et al. | — | 2019 | → |
| Dendritic Cells Require PINK1-Mediated Phosphorylation of BCKDE1α to Promote Fatty Acid Oxidation for Immune Function. | Basit F et al. | — | 2019 | → |
| Dietary Sea Buckthorn Pomace Induces Beige Adipocyte Formation in Inguinal White Adipose Tissue in Lambs. | Zhang T et al. | — | 2019 | → |
| Differential Effects of Yeast NADH Dehydrogenase (Ndi1) Expression on Mitochondrial Function and Inclusion Formation in a Cell Culture Model of Sporadic Parkinson's Disease. | Cronin-Furman EN et al. | — | 2019 | → |
| Effects of Mitochondrial Dysfunction via AMPK/PGC-1 α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine. | Zhang Q et al. | — | 2019 | → |
| Endothelial tip cells in vitro are less glycolytic and have a more flexible response to metabolic stress than non-tip cells. | Yetkin-Arik B et al. | — | 2019 | → |
| ETHE1 overexpression promotes SIRT1 and PGC1α mediated aerobic glycolysis, oxidative phosphorylation, mitochondrial biogenesis and colorectal cancer. | Witherspoon M et al. | — | 2019 | → |
| Fasting as a Therapy in Neurological Disease. | Phillips MCL | — | 2019 | → |
| Fucoidan Suppresses Mitochondrial Dysfunction and Cell Death against 1-Methyl-4-Phenylpyridinum-Induced Neuronal Cytotoxicity via Regulation of PGC-1α Expression. | Han YS et al. | — | 2019 | → |
| Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales. | Oh A et al. | — | 2019 | → |
| Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation. | Liu J et al. | — | 2019 | → |
| Minimal effects of <i>spargel</i> (PGC-1) overexpression in a <i>Drosophila</i> mitochondrial disease model. | George J et al. | — | 2019 | → |
| Mitochondrial Toxicity of Azithromycin Results in Aerobic Glycolysis and DNA Damage of Human Mammary Epithelia and Fibroblasts. | Jiang X et al. | — | 2019 | → |
| Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes. | Lee HJ et al. | — | 2019 | → |
| Nobiletin ameliorates hepatic ischemia and reperfusion injury through the activation of SIRT-1/FOXO3a-mediated autophagy and mitochondrial biogenesis. | Dusabimana T et al. | — | 2019 | → |
| Phenolic compounds from coffee by-products modulate adipogenesis-related inflammation, mitochondrial dysfunction, and insulin resistance in adipocytes, via insulin/PI3K/AKT signaling pathways. | Rebollo-Hernanz M et al. | — | 2019 | → |
| Plumage redness signals mitochondrial function in the house finch. | Hill GE et al. | — | 2019 | → |
| Proinflammatory NFkB signalling promotes mitochondrial dysfunction in skeletal muscle in response to cellular fuel overloading. | Nisr RB et al. | — | 2019 | → |
| Propofol induces impairment of mitochondrial biogenesis through inhibiting the expression of peroxisome proliferator-activated receptor-γ coactivator-1α. | Qin J et al. | — | 2019 | → |
| Reinforcing mitochondrial functions in aging brain: An insight into Parkinson's disease therapeutics. | Chandra G et al. | — | 2019 | → |
| Role of mitochondrial dysfunction on rheumatic diseases. | Vaamonde-García C et al. | — | 2019 | → |
| TEGDMA releasing in resin composites with different filler contents and its correlation with mitochondrial mediated cytotoxicity in human gingival fibroblasts. | Liu B et al. | — | 2019 | → |
| The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease. | Harrison IF et al. | — | 2019 | → |
| The receptor for advanced glycation end-products (RAGE) is an important pattern recognition receptor (PRR) for inflammaging. | Teissier T et al. | — | 2019 | → |
| The Warburg metabolism fuels tumor metastasis. | Lu J | — | 2019 | → |
| Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy. | Hombrebueno JR et al. | — | 2019 | → |
| Activation of cyclin D1 affects mitochondrial mass following traumatic brain injury. | Saha P et al. | — | 2018 | → |
| A functional connection between dyskerin and energy metabolism. | Angrisani A et al. | — | 2018 | → |
| A procession of metabolic alterations accompanying muscle senescence in Manduca sexta. | Wone BWM et al. | — | 2018 | → |
| Assessment of PGC1α-FNDC5 Axis in Granulosa Cells of PCOS Mouse Model. | Bakhshalizadeh S et al. | — | 2018 | → |
| Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells. | Jin G et al. | — | 2018 | → |
| Carbohydrate intake and training efficacy - a randomized cross-over study. | Beaudouin F et al. | — | 2018 | → |
| Cellular and molecular mechanisms of sarcopenia: the S100B perspective. | Riuzzi F et al. | — | 2018 | → |
| Co-expression Analysis of Sirtuins and Related Metabolic Biomarkers in Juveniles of Gilthead Sea Bream (<i>Sparus aurata</i>) With Differences in Growth Performance. | Simó-Mirabet P et al. | — | 2018 | → |
| Combination therapy of lovastatin and AMP-activated protein kinase activator improves mitochondrial and peroxisomal functions and clinical disease in experimental autoimmune encephalomyelitis model. | Singh I et al. | — | 2018 | → |
| Deciphering the Dichotomous Effects of PGC-1α on Tumorigenesis and Metastasis. | Gravel SP | — | 2018 | → |
| Different mitochondrial DNA copy number in liver and mammary gland of lactating cows with divergent genetic background for milk production. | Weikard R et al. | — | 2018 | → |
| Epigallocatechin-3-gallate confers protection against corticosterone-induced neuron injuries via restoring extracellular signal-regulated kinase 1/2 and phosphatidylinositol-3 kinase/protein kinase B signaling pathways. | Zhao X et al. | — | 2018 | → |
| Features of Effective T Cell-Inducing Vaccines against Chronic Viral Infections. | Panagioti E et al. | — | 2018 | → |
| Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson's Disease. | Zhang L et al. | — | 2018 | → |
| Genetic ablation of tau improves mitochondrial function and cognitive abilities in the hippocampus. | Jara C et al. | — | 2018 | → |
| Glia Maturation Factor Dependent Inhibition of Mitochondrial PGC-1α Triggers Oxidative Stress-Mediated Apoptosis in N27 Rat Dopaminergic Neuronal Cells. | Selvakumar GP et al. | — | 2018 | → |
| Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response. | Basit F et al. | — | 2018 | → |
| Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer. | Im YK et al. | — | 2018 | → |
| Metabolic phenotype of skeletal muscle in early critical illness. | Puthucheary ZA et al. | — | 2018 | → |
| MH84 improves mitochondrial dysfunction in a mouse model of early Alzheimer's disease. | Pohland M et al. | — | 2018 | → |
| Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition. | Rai Y et al. | — | 2018 | → |
| Mitochondrial biogenesis and PGC-1α gene expression in male broilers from ascites-susceptible and -resistant lines. | Khodambashi Emami N et al. | — | 2018 | → |
| Mitochondrial energy metabolism and signalling in human glioblastoma cell lines with different PTEN gene status. | Comelli M et al. | — | 2018 | → |
| Mitochondrial Morphology, Function and Homeostasis Are Impaired by Expression of an N-terminal Calpain Cleavage Fragment of Ataxin-3. | Harmuth T et al. | — | 2018 | → |
| Molecular Characterization of Peroxisome Proliferator-Activated Receptor-Gamma Coactivator-1α (PGC1α) and Its Role in Mitochondrial Biogenesis in Blunt Snout Bream (<i>Megalobrama amblycephala</i>). | Song X et al. | — | 2018 | → |
| Oxytocin and excitation/inhibition balance in social recognition. | Lopatina OL et al. | — | 2018 | → |
| Pas Kinase Deficiency Triggers Antioxidant Mechanisms in the Liver. | Dongil P et al. | — | 2018 | → |
| Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha as a Novel Target for Bipolar Disorder and Other Neuropsychiatric Disorders. | Nierenberg AA et al. | — | 2018 | → |
| Protein Kinase A/CREB Signaling Prevents Adriamycin-Induced Podocyte Apoptosis via Upregulation of Mitochondrial Respiratory Chain Complexes. | Xie K et al. | — | 2018 | → |
| Quercetin preserves redox status and stimulates mitochondrial function in metabolically-stressed HepG2 cells. | Houghton MJ et al. | — | 2018 | → |
| Regulation of T cell immunity by cellular metabolism. | Hu Z et al. | — | 2018 | → |
| Repetitive TLR3 activation in the lung induces skeletal muscle adaptations and cachexia. | Graber TG et al. | — | 2018 | → |
| SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway. | Ramesh S et al. | — | 2018 | → |
| Sirtuin signaling controls mitochondrial function in glycogen storage disease type Ia. | Cho JH et al. | — | 2018 | → |
| Skeletal muscle from aged American Quarter Horses shows impairments in mitochondrial biogenesis and expression of autophagy markers. | Li C et al. | — | 2018 | → |
| Tauroursodeoxycholic Acid Enhances Mitochondrial Biogenesis, Neural Stem Cell Pool, and Early Neurogenesis in Adult Rats. | Soares R et al. | — | 2018 | → |
| The microRNA-29/PGC1α regulatory axis is critical for metabolic control of cardiac function. | Caravia XM et al. | — | 2018 | → |
| Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function. | Yu G et al. | — | 2018 | → |
| Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation. | Yerra VG et al. | — | 2017 | → |
| Afzelin ameliorates D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure by modulating mitochondrial quality control and dynamics. | Lee SB et al. | — | 2017 | → |
| Comparison of dietary polyphenols for protection against molecular mechanisms underlying nonalcoholic fatty liver disease in a cell model of steatosis. | Rafiei H et al. | — | 2017 | → |
| Dendrobium nobile Lindl. alkaloids regulate metabolism gene expression in livers of mice. | Xu YY et al. | — | 2017 | → |
| Diabetes-induced hepatic oxidative stress: a new pathogenic role for glycated albumin. | Patche J et al. | — | 2017 | → |
| Endoplasmic Reticulum Stress-Induced CHOP Inhibits PGC-1α and Causes Mitochondrial Dysfunction in Diabetic Embryopathy. | Chen X et al. | — | 2017 | → |
| Fateful triad of reactive oxygen species, mitochondrial dysfunction and lipid accumulation is associated with expression outline of the AMP-activated protein kinase pathway in bovine blastocysts. | Prastowo S et al. | — | 2017 | → |
| Genipin protects the liver from ischemia/reperfusion injury by modulating mitochondrial quality control. | Shin JK et al. | — | 2017 | → |
| Glycated human albumin alters mitochondrial respiration in preadipocyte 3T3-L1 cells. | Baret P et al. | — | 2017 | → |
| Hypoxia-induced suppression of c-Myc by HIF-2α in human pulmonary endothelial cells attenuates TFAM expression. | Zarrabi AJ et al. | — | 2017 | → |
| Induction of oxidative metabolism by the p38α/MK2 pathway. | Trempolec N et al. | — | 2017 | → |
| Looking beyond the brain to improve the pathogenic understanding of Parkinson's disease: implications of whole transcriptome profiling of Patients' skin. | Planken A et al. | — | 2017 | → |
| MC1R signaling. Intracellular partners and pathophysiological implications. | Herraiz C et al. | — | 2017 | → |
| MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo. | Sahoo A et al. | — | 2017 | → |
| Mitochondrial dynamics, transport, and quality control: A bottleneck for retinal ganglion cell viability in optic neuropathies. | Ito YA et al. | — | 2017 | → |
| Muscle PGC-1α is required for long-term systemic and local adaptations to a ketogenic diet in mice. | Schnyder S et al. | — | 2017 | → |
| Olive oil bioactive compounds increase body weight, and improve gut health and integrity in gilthead sea bream (Sparus aurata). | Gisbert E et al. | — | 2017 | → |
| Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes. | Huang TY et al. | — | 2017 | → |
| Peroxisome Proliferator-Activated Receptors Associated with Nonalcoholic Fatty Liver Disease. | Wang N et al. | — | 2017 | → |
| Prdm16 is crucial for progression of the multipolar phase during neural differentiation of the developing neocortex. | Inoue M et al. | — | 2017 | → |
| Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy. | Wang F et al. | — | 2017 | → |
| Regulation of longevity by FGF21: Interaction between energy metabolism and stress responses. | Salminen A et al. | — | 2017 | → |
| Regulation of mitochondrial function and endoplasmic reticulum stress by nitric oxide in pluripotent stem cells. | Caballano-Infantes E et al. | — | 2017 | → |
| Sirtuins as modifiers of Parkinson's disease pathology. | Tang BL | — | 2017 | → |
| STUB1 regulates TFEB-induced autophagy-lysosome pathway. | Sha Y et al. | — | 2017 | → |
| Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease. | Martino Adami PV et al. | — | 2017 | → |
| The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore. | Rottenberg H et al. | — | 2017 | → |
| The Peroxisome-Mitochondria Connection: How and Why? | Fransen M et al. | — | 2017 | → |
| The two-century journey of Parkinson disease research. | Przedborski S | — | 2017 | → |
| Transcriptional and epigenetic regulation of T cell hyporesponsiveness. | Pereira RM et al. | — | 2017 | → |
| Transcriptomic profiling of the human brain reveals that altered synaptic gene expression is associated with chronological aging. | Dillman AA et al. | — | 2017 | → |
| Understanding tumor anabolism and patient catabolism in cancer-associated cachexia. | Schcolnik-Cabrera A et al. | — | 2017 | → |
| Acquired Muscle Weakness in the Surgical Intensive Care Unit: Nosology, Epidemiology, Diagnosis, and Prevention. | Farhan H et al. | — | 2016 | → |
| Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. | Tramutola A et al. | — | 2016 | → |
| A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain. | Bakshi R et al. | — | 2016 | → |
| Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension. | Garcia-Morales LJ et al. | — | 2016 | → |
| Bioenergetic Insufficiencies Due to Metabolic Alterations Regulated by the Inhibitory Receptor PD-1 Are an Early Driver of CD8(+) T Cell Exhaustion. | Bengsch B et al. | — | 2016 | → |
| Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice. | Jia Y et al. | — | 2016 | → |
| Catalytic Coupling of Oxidative Phosphorylation, ATP Demand, and Reactive Oxygen Species Generation. | Bazil JN et al. | — | 2016 | → |
| CCN6 regulates mitochondrial function. | Patra M et al. | — | 2016 | → |
| "Cold training" affects rat liver responses to continuous cold exposure. | Venditti P et al. | — | 2016 | → |
| Combined pharmacological activation of AMPK and PPARδ potentiates the effects of exercise in trained mice. | Manio MC et al. | — | 2016 | → |
| Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease. | Gumeni S et al. | — | 2016 | → |
| Decreased endothelial nitric oxide synthase expression and function contribute to impaired mitochondrial biogenesis and oxidative stress in fetal lambs with persistent pulmonary hypertension. | Afolayan AJ et al. | — | 2016 | → |
| Epoxyeicosatrienoic Acid as Therapy for Diabetic and Ischemic Cardiomyopathy. | Romashko M et al. | — | 2016 | → |
| Estrogenic Endocrine Disrupting Chemicals Influencing NRF1 Regulated Gene Networks in the Development of Complex Human Brain Diseases. | Preciados M et al. | — | 2016 | → |
| Evaluation of Neuropathological Effects of a High-Fat Diet in a Presymptomatic Alzheimer's Disease Stage in APP/PS1 Mice. | Ettcheto M et al. | — | 2016 | → |
| Gly482Ser PGC-1α Gene Polymorphism and Exercise-Related Oxidative Stress in Amyotrophic Lateral Sclerosis Patients. | Pasquinelli A et al. | — | 2016 | → |
| Grifolin inhibits tumor cells adhesion and migration via suppressing interplay between PGC1α and Fra-1 / LSF- MMP2 / CD44 axes. | Luo X et al. | — | 2016 | → |
| Metabolic Adjustments to Short-Term Diurnal Temperature Fluctuation in the Rainbow Trout (Oncorhynchus mykiss). | Callaghan NI et al. | — | 2016 | → |
| Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis. | Auburger G et al. | — | 2016 | → |
| Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. | Xiong ZM et al. | — | 2016 | → |
| MH84: A Novel γ-Secretase Modulator/PPARγ Agonist--Improves Mitochondrial Dysfunction in a Cellular Model of Alzheimer's Disease. | Pohland M et al. | — | 2016 | → |
| Mitochondrial changes and oxidative stress in a mouse model of Zellweger syndrome neuropathogenesis. | Rahim RS et al. | — | 2016 | → |
| Muscle wasting and adipose tissue browning in infantile nephropathic cystinosis. | Cheung WW et al. | — | 2016 | → |
| Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. | Wilfinger N et al. | — | 2016 | → |
| Palmitate-induced Regulation of PPARγ via PGC1α: a Mechanism for Lipid Accumulation in the Liver in Nonalcoholic Fatty Liver Disease. | Maruyama H et al. | — | 2016 | → |
| Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response. | Wang T et al. | — | 2016 | → |
| Pentoxifylline ameliorates non-alcoholic fatty liver disease in hyperglycaemic and dyslipidaemic mice by upregulating fatty acid β-oxidation. | Ye JH et al. | — | 2016 | → |
| Peroxisome proliferator-activated receptor-γ coactivator-1α mediates neuroprotection against excitotoxic brain injury in transgenic mice: role of mitochondria and X-linked inhibitor of apoptosis protein. | Mäkelä J et al. | — | 2016 | → |
| Potential Therapeutic Benefits of Maintaining Mitochondrial Health in Peripheral Neuropathies. | Areti A et al. | — | 2016 | → |
| PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer's disease model. | Katsouri L et al. | — | 2016 | → |
| Rice bran extract improves mitochondrial dysfunction in brains of aged NMRI mice. | Hagl S et al. | — | 2016 | → |
| Sirt1 and the Mitochondria. | Tang BL | — | 2016 | → |
| Skeletal muscle PGC-1α modulates systemic ketone body homeostasis and ameliorates diabetic hyperketonemia in mice. | Svensson K et al. | — | 2016 | → |
| Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin. | Hu Y et al. | — | 2016 | → |
| The Mitochondrial Basis of Aging. | Sun N et al. | — | 2016 | → |
| The Neuro-Immune Pathophysiology of Central and Peripheral Fatigue in Systemic Immune-Inflammatory and Neuro-Immune Diseases. | Morris G et al. | — | 2016 | → |
| The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model. | Valenti D et al. | — | 2016 | → |
| The role of PGC-1α and MRP1 in lead-induced mitochondrial toxicity in testicular Sertoli cells. | Li Z et al. | — | 2016 | → |
| The Role of PGC1α in Cancer Metabolism and its Therapeutic Implications. | Tan Z et al. | — | 2016 | → |
| The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis. | Dvir-Ginzberg M et al. | — | 2016 | → |
| Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis. | Vidali S et al. | — | 2016 | → |
| TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux. | Raturi A et al. | — | 2016 | → |
| TP53 mutation, mitochondria and cancer. | Kamp WM et al. | — | 2016 | → |
| Transcriptome Profiling of Patient-Specific Human iPSC-Cardiomyocytes Predicts Individual Drug Safety and Efficacy Responses In Vitro. | Matsa E et al. | — | 2016 | → |
| Understanding the physiology of the ageing individual: computational modelling of changes in metabolism and endurance. | van Beek JH et al. | — | 2016 | → |
| Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy. | Nehls M | — | 2016 | → |
| Wild ginseng cambial meristematic cells ameliorate hepatic steatosis and mitochondrial dysfunction in high-fat diet-fed mice. | Lee SB et al. | — | 2016 | → |
| Adiponectin prevents reduction of lipid-induced mitochondrial biogenesis via AMPK/ACC2 pathway in chicken adipocyte. | Gan L et al. | — | 2015 | → |
| A novel atlas of gene expression in human skeletal muscle reveals molecular changes associated with aging. | Su J et al. | — | 2015 | → |
| Biodegradable Polymeric Microsphere-Based Drug Delivery for Inductive Browning of Fat. | Jiang C et al. | — | 2015 | → |
| Branched-chain amino acids ameliorate heart failure with cardiac cachexia in rats. | Tanada Y et al. | — | 2015 | → |
| Can Brown Fat Win the Battle Against White Fat? | Elattar S et al. | — | 2015 | → |
| Dietary Fatty Acids and Temperature Modulate Mitochondrial Function and Longevity in Drosophila. | Holmbeck MA et al. | — | 2015 | → |
| Down-regulation of peroxisome proliferator activated receptor γ coactivator 1α induces oxidative stress and toxicity of 1-(4-Chlorophenyl)-benzo-2,5-quinone in HaCaT human keratinocytes. | Xiao W et al. | — | 2015 | → |
| ERK1/2 is a key regulator of Fndc5 and PGC1α expression during neural differentiation of mESCs. | Hosseini Farahabadi SS et al. | — | 2015 | → |
| High-fat diet-induced deregulation of hippocampal insulin signaling and mitochondrial homeostasis deficiences contribute to Alzheimer disease pathology in rodents. | Petrov D et al. | — | 2015 | → |
| Humic Acid Increases Amyloid β-Induced Cytotoxicity by Induction of ER Stress in Human SK-N-MC Neuronal Cells. | Li HH et al. | — | 2015 | → |
| Hypoxia signaling pathways: modulators of oxygen-related organelles. | Schönenberger MJ et al. | — | 2015 | → |
| Inhibition of diethylnitrosamine-initiated alcohol-promoted hepatic inflammation and precancerous lesions by flavonoid luteolin is associated with increased sirtuin 1 activity in mice. | Rafacho BP et al. | — | 2015 | → |
| Inhibition of PGC-1α after chemotherapy-mediated insult confines multiple myeloma cell survival by affecting ROS accumulation. | Cao D et al. | — | 2015 | → |
| Leishmania infantum modulates host macrophage mitochondrial metabolism by hijacking the SIRT1-AMPK axis. | Moreira D et al. | — | 2015 | → |
| Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes. | Abu Bakar MH et al. | — | 2015 | → |
| Natural products from marine organisms with neuroprotective activity in the experimental models of Alzheimer's disease, Parkinson's disease and ischemic brain stroke: their molecular targets and action mechanisms. | Choi DY et al. | — | 2015 | → |
| Neural Stem Cells in the Adult Subventricular Zone Oxidize Fatty Acids to Produce Energy and Support Neurogenic Activity. | Stoll EA et al. | — | 2015 | → |
| New Insights into the Connection Between Histone Deacetylases, Cell Metabolism, and Cancer. | Chiaradonna F et al. | — | 2015 | → |
| Notch signaling as a novel regulator of metabolism. | Bi P et al. | — | 2015 | → |
| Oxidative and energy metabolism as potential clues for clinical heterogeneity in nucleotide excision repair disorders. | Hosseini M et al. | — | 2015 | → |
| Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans. | Blednov YA et al. | — | 2015 | → |
| PGC-1α controls mitochondrial biogenesis and dynamics in lead-induced neurotoxicity. | Dabrowska A et al. | — | 2015 | → |
| Pharmacologic targeting of sirtuin and PPAR signaling improves longevity and mitochondrial physiology in respiratory chain complex I mutant Caenorhabditis elegans. | McCormack S et al. | — | 2015 | → |
| Proteomic analysis and functional characterization of mouse brain mitochondria during aging reveal alterations in energy metabolism. | Stauch KL et al. | — | 2015 | → |
| Quercetin protects gastric epithelial cell from oxidative damage in vitro and in vivo. | Hu XT et al. | — | 2015 | → |
| Redox Signaling in Diabetic Nephropathy: Hypertrophy versus Death Choices in Mesangial Cells and Podocytes. | Manda G et al. | — | 2015 | → |
| Regulation of mitochondrial biogenesis and its intersection with inflammatory responses. | Cherry AD et al. | — | 2015 | → |
| Temperature controls oxidative phosphorylation and reactive oxygen species production through uncoupling in rat skeletal muscle mitochondria. | Jarmuszkiewicz W et al. | — | 2015 | → |
| The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. | Chung B et al. | — | 2015 | → |
| The Keap1-Nrf2-antioxidant response element pathway: a review of its regulation by melatonin and the proteasome. | Vriend J et al. | — | 2015 | → |
| Tipping the metabolic scales towards increased longevity in mammals. | Riera CE et al. | — | 2015 | → |
| Transcriptional Regulatory Circuits Controlling Brown Fat Development and Activation. | Seale P | — | 2015 | → |
| Transcription Factor Tfe3 Directly Regulates Pgc-1alpha in Muscle. | Salma N et al. | — | 2015 | → |
| Voluntary Aerobic Exercise Reverses Frailty in Old Mice. | Graber TG et al. | — | 2015 | → |
| Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function. | Stauch KL et al. | — | 2014 | → |
| Antagonistic functions of LMNA isoforms in energy expenditure and lifespan. | Lopez-Mejia IC et al. | — | 2014 | → |
| Development to term of cloned cattle derived from donor cells treated with valproic acid. | Sangalli JR et al. | — | 2014 | → |
| Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene. | Rai M et al. | — | 2014 | → |
| Emerging functional similarities and divergences between Drosophila Spargel/dPGC-1 and mammalian PGC-1 protein. | Mukherjee S et al. | — | 2014 | → |
| Energy metabolism analysis reveals the mechanism of inhibition of breast cancer cell metastasis by PEG-modified graphene oxide nanosheets. | Zhou T et al. | — | 2014 | → |
| (-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic δ-sarcoglycan null mouse striated muscle. | Ramirez-Sanchez I et al. | — | 2014 | → |
| Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness. | Perry MC et al. | — | 2014 | → |
| Expression of mitochondrial regulators PGC1α and TFAM as putative markers of subtype and chemoresistance in epithelial ovarian carcinoma. | Gabrielson M et al. | — | 2014 | → |
| Frataxin deficiency in neonatal rat ventricular myocytes targets mitochondria and lipid metabolism. | Obis È et al. | — | 2014 | → |
| Genetics of oxidative stress in obesity. | Rupérez AI et al. | — | 2014 | → |
| Heart energy metabolism impairment in Western-diet induced obese mice. | Neves FA et al. | — | 2014 | → |
| Impaired mitochondrial function and reduced viability in bone marrow cells of obese mice. | de Oliveira GP et al. | — | 2014 | → |
| In vivo RNA interference models of inducible and reversible Sirt1 knockdown in kidney cells. | Chuang PY et al. | — | 2014 | → |
| Melatonin and ubiquitin: what's the connection? | Vriend J et al. | — | 2014 | → |
| Mutations that affect mitochondrial functions and their association with neurodegenerative diseases. | Dhillon VS et al. | — | 2014 | → |
| Negative regulators of brown adipose tissue (BAT)-mediated thermogenesis. | Sharma BK et al. | — | 2014 | → |
| p53 and mitochondrial function in neurons. | Wang DB et al. | — | 2014 | → |
| PGC-1α buffers ROS-mediated removal of mitochondria during myogenesis. | Baldelli S et al. | — | 2014 | → |
| Post-natal induction of PGC-1α protects against severe muscle dystrophy independently of utrophin. | Chan MC et al. | — | 2014 | → |
| Regulation of mitochondrial function and cellular energy metabolism by protein kinase C-λ/ι: a novel mode of balancing pluripotency. | Mahato B et al. | — | 2014 | → |
| Revisiting the neuropathogenesis of Zellweger syndrome. | Crane DI | — | 2014 | → |
| Sexually-dimorphic targeting of functionally-related genes in COPD. | Glass K et al. | — | 2014 | → |
| Stable isotope tracer analysis in isolated mitochondria from mammalian systems. | Gravel SP et al. | — | 2014 | → |
| Steroid receptor coactivator 1 is an integrator of glucose and NAD+/NADH homeostasis. | Motamed M et al. | — | 2014 | → |
| Synergistic effect of high charge and energy particle radiation and chronological age on biomarkers of oxidative stress and tissue degeneration: a ground-based study using the vertebrate laboratory model organism Oryzias latipes. | Zheng X et al. | — | 2014 | → |
| Syzygium aromaticum L. (Clove) extract regulates energy metabolism in myocytes. | Tu Z et al. | — | 2014 | → |
| Unraveling biochemical pathways affected by mitochondrial dysfunctions using metabolomic approaches. | Demine S et al. | — | 2014 | → |
| Punctum on two different transcription factors regulated by PGC-1α: nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2. | Baldelli S et al. | — | 2013 | → |