Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.
paper
Cited
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- Authors
- Bardy, Cedric; van den Hurk, Mark; Eames, Tameji; Marchand, Cynthia; Hernandez, Ruben V; Kellogg, Mariko; Gorris, Mark; Galet, Ben; Palomares, Vanessa; Brown, Joshua; Bang, Anne G; Mertens, Jerome; Bรถhnke, Lena; Boyer, Leah; Simon, Suzanne; Gage, Fred H
- Year
- 2015
- Journal
- Proceedings of the National Academy of Sciences of the United States of America
- PMID
- 25870293
- DOI
- 10.1073/pnas.1504393112
- PMCID
- PMC4443325
Human cell reprogramming technologies offer access to live human neurons from patients and provide a new alternative for modeling neurological disorders in vitro. Neural electrical activity is the essence of nervous system function in vivo. Therefore, we examined neuronal activity in media widely used to culture neurons. We found that classic basal media, as well as serum, impair action potential generation and synaptic communication. To overcome this problem, we designed a new neuronal medium (BrainPhys basal + serum-free supplements) in which we adjusted the concentrations of inorganic salts, neuroactive amino acids, and energetic substrates. We then tested that this medium adequately supports neuronal activity and survival of human neurons in culture. Long-term exposure to this physiological medium also improved the proportion of neurons that were synaptically active. The medium was designed to culture human neurons but also proved adequate for rodent neurons. The improvement in BrainPhys basal medium to support neurophysiological activity is an important step toward reducing the gap between brain physiological conditions in vivo and neuronal models in vitro.
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| FPGA Realization of Hodgkin-Huxley Neuronal Model. | Shama F et al. | โ | 2020 | โ |
| Genetic predispositions of Parkinson's disease revealed in patient-derived brain cells. | Tran J et al. | โ | 2020 | โ |
| hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. | Miranda CC et al. | โ | 2020 | โ |
| HIV and opiates dysregulate K<sup>+</sup>- Cl<sup>-</sup> cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice. | Barbour AJ et al. | โ | 2020 | โ |
| Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models. | Hedegaard A et al. | โ | 2020 | โ |
| Human Cerebrospinal Fluid Promotes Neuronal Circuit Maturation of Human Induced Pluripotent Stem Cell-Derived 3D Neural Aggregates. | Izsak J et al. | โ | 2020 | โ |
| Human Induced Pluripotent Stem Cell-Derived Neural Cells from Alzheimer's Disease Patients Exhibited Different Susceptibility to Oxidative Stress. | Zhang L et al. | โ | 2020 | โ |
| Human in vitro systems for examining synaptic function and plasticity in the brain. | Lee K et al. | โ | 2020 | โ |
| Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium. | Jacob F et al. | โ | 2020 | โ |
| Inย Vitro Differentiated Human Stem Cell-Derived Neurons Reproduce Synaptic Synchronicity Arising during Neurodevelopment. | Rosa F et al. | โ | 2020 | โ |
| Limitations and Promise of Retinal Tissue From Human Pluripotent Stem Cells for Developing Therapies of Blindness. | Singh RK et al. | โ | 2020 | โ |
| Maturation of Human Pluripotent Stem Cell-Derived Cerebellar Neurons in the Absence of Co-culture. | Silva TP et al. | โ | 2020 | โ |
| Modeling Brain Disorders Using Induced Pluripotent Stem Cells. | Vadodaria KC et al. | โ | 2020 | โ |
| Modeling genetic epilepsies in a dish. | Niu W et al. | โ | 2020 | โ |
| Modelling Lyssavirus Infections in Human Stem Cell-Derived Neural Cultures. | Sundaramoorthy V et al. | โ | 2020 | โ |
| Monitoring neuronal activity with voltage-sensitive fluorophores. | Kirk MJ et al. | โ | 2020 | โ |
| Multimodal Analysis of STRADA Function in Brain Development. | Dang LT et al. | โ | 2020 | โ |
| Organoid and pluripotent stem cells in Parkinson's disease modeling: an expert view on their value to drug discovery. | Marotta N et al. | โ | 2020 | โ |
| Pannexin 1 Regulates Dendritic Protrusion Dynamics in Immature Cortical Neurons. | Sanchez-Arias JC et al. | โ | 2020 | โ |
| Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. | Frew J et al. | โ | 2020 | โ |
| Procedures for Culturing and Genetically Manipulating Murine Hippocampal Postnatal Neurons. | Moutin E et al. | โ | 2020 | โ |
| Retinal Ganglion Cells With a Glaucoma OPTN(E50K) Mutation Exhibit Neurodegenerative Phenotypes when Derived from Three-Dimensional Retinal Organoids. | VanderWall KB et al. | โ | 2020 | โ |
| Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. | Smits LM et al. | โ | 2020 | โ |
| Sliced Human Cortical Organoids for Modeling Distinct Cortical Layer Formation. | Qian X et al. | โ | 2020 | โ |
| Sustained hedgehog signaling in medulloblastoma tumoroids is attributed to stromal astrocytes and astrocyte-derived extracellular matrix. | Cheng Y et al. | โ | 2020 | โ |
| TGF-ฮฒ1 Suppresses Proliferation and Induces Differentiation in Human iPSC Neural <i>in vitro</i> Models. | Izsak J et al. | โ | 2020 | โ |
| The Promise and Perils of Compound Discovery Screening with Inducible Pluripotent Cell-Derived Neurons. | Sharlow ER et al. | โ | 2020 | โ |
| Three-dimensionality shapes the dynamics of cortical interconnected to hippocampal networks. | Brofiga M et al. | โ | 2020 | โ |
| Using human induced pluripotent stem cells (hiPSCs) to investigate the mechanisms by which Apolipoprotein E (APOE) contributes to Alzheimer's disease (AD) risk. | Raman S et al. | โ | 2020 | โ |
| An Autaptic Culture System for Standardized Analyses of iPSC-Derived Human Neurons. | Rhee HJ et al. | โ | 2019 | โ |
| A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency. | Zhang XM et al. | โ | 2019 | โ |
| Cell Culture Medium Formulation and Its Implications in Cancer Metabolism. | Ackermann T et al. | โ | 2019 | โ |
| Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications. | Doss MX et al. | โ | 2019 | โ |
| Detection of all adult Tau isoforms in a 3D culture model of iPSC-derived neurons. | Miguel L et al. | โ | 2019 | โ |
| Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a neurogenic niche. | Zheng Y et al. | โ | 2019 | โ |
| Dual modulation of neuron-specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons. | Birtele M et al. | โ | 2019 | โ |
| Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes. | Patel AM et al. | โ | 2019 | โ |
| Early Actions of Neurotransmitters During Cortex Development and Maturation of Reprogrammed Neurons. | Ojeda J et al. | โ | 2019 | โ |
| Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures. | Bansal R et al. | โ | 2019 | โ |
| Human iPSC application in Alzheimer's disease and Tau-related neurodegenerative diseases. | Tcw J | โ | 2019 | โ |
| <i>In Vitro</i> Modeling of the Bipolar Disorder and Schizophrenia Using Patient-Derived Induced Pluripotent Stem Cells with Copy Number Variations of <i>PCDH1</i>5 and <i>RELN</i>. | Ishii T et al. | โ | 2019 | โ |
| L-type voltage-gated calcium channel regulation of in vitro human cortical neuronal networks. | Plumbly W et al. | โ | 2019 | โ |
| MicroRNAs miR-25, let-7 and miR-124 regulate the neurogenic potential of Mรผller glia in mice. | Wohl SG et al. | โ | 2019 | โ |
| Multifunctionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries. | Marchini A et al. | โ | 2019 | โ |
| Neurogranin Expression Is Regulated by Synaptic Activity and Promotes Synaptogenesis in Cultured Hippocampal Neurons. | Garrido-Garcรญa A et al. | โ | 2019 | โ |
| New considerations for hiPSC-based models of neuropsychiatric disorders. | Hoffman GE et al. | โ | 2019 | โ |
| Next-generation disease modeling with direct conversion: a new path to old neurons. | Traxler L et al. | โ | 2019 | โ |
| Pannexin 1 Regulates Network Ensembles and Dendritic Spine Development in Cortical Neurons. | Sanchez-Arias JC et al. | โ | 2019 | โ |
| Past, Present, and Future of Neuronal Models In Vitro. | Keller JM et al. | โ | 2019 | โ |
| Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins. | Kim H et al. | โ | 2019 | โ |
| Reappraisal of Human HOG and MO3.13 Cell Lines as a Model to Study Oligodendrocyte Functioning. | De Kleijn KMA et al. | โ | 2019 | โ |
| Reduced variability of neural progenitor cells and improved purity of neuronal cultures using magnetic activated cell sorting. | Bowles KR et al. | โ | 2019 | โ |
| Regenerative medicine: could Parkinson's be the first neurodegenerative disease to be cured? | Dรญaz ML | โ | 2019 | โ |
| Robust Generation of Person-Specific, Synchronously Active Neuronal Networks Using Purely Isogenic Human iPSC-3D Neural Aggregate Cultures. | Izsak J et al. | โ | 2019 | โ |
| Role of Human-Induced Pluripotent Stem Cell-Derived Spinal Cord Astrocytes in the Functional Maturation of Motor Neurons in a Multielectrode Array System. | Taga A et al. | โ | 2019 | โ |
| Simultaneous voltage and calcium imaging and optogenetic stimulation with high sensitivity and a wide field of view. | Nguyen C et al. | โ | 2019 | โ |
| Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models. | van den Hurk M et al. | โ | 2019 | โ |
| Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells. | Gao L et al. | โ | 2019 | โ |
| Synergistic effects of common schizophrenia risk variants. | Schrode N et al. | โ | 2019 | โ |
| The effect of rho kinase inhibition on morphological and electrophysiological maturity in iPSC-derived neurons. | Harbom LJ et al. | โ | 2019 | โ |
| The Glucocorticoid Receptor Is a Critical Regulator of HIV Latency in Human Microglial Cells. | Alvarez-Carbonell D et al. | โ | 2019 | โ |
| Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform. | Garcia-Leon JA et al. | โ | 2019 | โ |
| All-Optical Assay to Study Biological Neural Networks. | Afshar Saber W et al. | โ | 2018 | โ |
| Ambient but not local lactate underlies neuronal tolerance to prolonged glucose deprivation. | Sobieski C et al. | โ | 2018 | โ |
| A Novel Approach to Primary Cell Culture for <i>Octopus vulgaris</i> Neurons. | Maselli V et al. | โ | 2018 | โ |
| A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells. | Gunhanlar N et al. | โ | 2018 | โ |
| BrainPhysยฎ increases neurofilament levels in CNS cultures, and facilitates investigation of axonal damage after a mechanical stretch-injury in vitro. | Jackson TC et al. | โ | 2018 | โ |
| Digital Multiplierless Realization of Coupled Wilson Neuron Model. | Imani MA et al. | โ | 2018 | โ |
| Fibroblast growth factor 2 regulates activity and gene expression of human post-mitotic excitatory neurons. | Gupta S et al. | โ | 2018 | โ |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | โ | 2018 | โ |
| <i>In vitro</i> Models for Seizure-Liability Testing Using Induced Pluripotent Stem Cells. | Grainger AI et al. | โ | 2018 | โ |
| Ion Beam Assisted E-Beam Deposited TiN Microelectrodes-Applied to Neuronal Cell Culture Medium Evaluation. | Ryynรคnen T et al. | โ | 2018 | โ |
| Neonatal mouse cortical but not isogenic human astrocyte feeder layers enhance the functional maturation of induced pluripotent stem cell-derived neurons in culture. | Lischka FW et al. | โ | 2018 | โ |
| Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells. | van den Hurk M et al. | โ | 2018 | โ |
| Reproducible and efficient generation of functionally active neurons from human hiPSCs for preclinical disease modeling. | Xie Y et al. | โ | 2018 | โ |
| Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids. | Oksdath M et al. | โ | 2018 | โ |
| SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. | Liu M et al. | โ | 2018 | โ |
| Single-cell analysis of diversity in human stem cell-derived neurons. | Harbom LJ et al. | โ | 2018 | โ |
| Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models. | Taoufik E et al. | โ | 2018 | โ |
| Synaptic Microcircuit Modeling with 3D Cocultures of Astrocytes and Neurons from Human Pluripotent Stem Cells. | Cvetkovic C et al. | โ | 2018 | โ |
| The telomerase inhibitor AZT enhances differentiation and prevents overgrowth of human pluripotent stem cell-derived neural progenitors. | Hu Y et al. | โ | 2018 | โ |
| Three-Dimensional Retinal Organoids Facilitate the Investigation of Retinal Ganglion Cell Development, Organization and Neurite Outgrowth from Human Pluripotent Stem Cells. | Fligor CM et al. | โ | 2018 | โ |
| Toxicological evaluation of convulsant and anticonvulsant drugs in human induced pluripotent stem cell-derived cortical neuronal networks using an MEA system. | Odawara A et al. | โ | 2018 | โ |
| Uncovering True Cellular Phenotypes: Using Induced Pluripotent Stem Cell-Derived Neurons to Study Early Insults in Neurodevelopmental Disorders. | Fink JJ et al. | โ | 2018 | โ |
| Characteristic analyses of a neural differentiation model from iPSC-derived neuron according to morphology, physiology, and global gene expression pattern. | Kang S et al. | โ | 2017 | โ |
| Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells. | Qi Y et al. | โ | 2017 | โ |
| CRISPR/Cas9-Correctable mutation-related molecular and physiological phenotypes in iPSC-derived Alzheimer's PSEN2 <sup>N141I</sup> neurons. | Ortiz-Virumbrales M et al. | โ | 2017 | โ |
| Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries? | Ledur PF et al. | โ | 2017 | โ |
| Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells. | Fink JJ et al. | โ | 2017 | โ |
| Generating CNS organoids from human induced pluripotent stem cells for modeling neurological disorders. | Brawner AT et al. | โ | 2017 | โ |
| High-Throughput Phenotyping of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Neurons Using Electric Field Stimulation and High-Speed Fluorescence Imaging. | Daily NJ et al. | โ | 2017 | โ |
| Human Cerebrospinal fluid promotes long-term neuronal viability and network function in human neocortical organotypic brain slice cultures. | Schwarz N et al. | โ | 2017 | โ |
| Induced pluripotent stem cell technology: a decade of progress. | Shi Y et al. | โ | 2017 | โ |
| More than a drainage fluid: the role of CSF in signaling in the brain and other effects on brain tissue. | Illes S | โ | 2017 | โ |
| Neuronal Culture Microenvironments Determine Preferences in Bioenergetic Pathway Use. | Sรผnwoldt J et al. | โ | 2017 | โ |
| Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids. | Gabriel E et al. | โ | 2017 | โ |
| Reversal of Phenotypic Abnormalities by CRISPR/Cas9-Mediated Gene Correction in Huntington Disease Patient-Derived Induced Pluripotent Stemย Cells. | Xu X et al. | โ | 2017 | โ |
| Store-Operated Calcium Entry Is Required for mGluR-Dependent Long Term Depression in Cortical Neurons. | Gonzรกlez-Sรกnchez P et al. | โ | 2017 | โ |
| Surpassing light-induced cell damage in vitro with novel cell culture media. | Stockley JH et al. | โ | 2017 | โ |
| The AMPA receptor-associated protein Shisa7 regulates hippocampal synaptic function and contextual memory. | Schmitz LJM et al. | โ | 2017 | โ |
| Understanding Parkinson's Disease through the Use of Cell Reprogramming. | Playne R et al. | โ | 2017 | โ |
| Using induced pluripotent stem cells derived neurons to model brain diseases. | McKinney CE | โ | 2017 | โ |
| CNS disease models with human pluripotent stem cells in the CRISPR age. | Muffat J et al. | โ | 2016 | โ |
| Concise Review: Exciting Cells: Modeling Genetic Epilepsies with Patient-Derived Induced Pluripotent Stem Cells. | Tidball AM et al. | โ | 2016 | โ |
| Concise Review: Progress and Challenges in Using Human Stem Cells for Biological and Therapeutics Discovery: Neuropsychiatric Disorders. | Panchision DM | โ | 2016 | โ |
| Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format. | Medda X et al. | โ | 2016 | โ |
| Dishing out mini-brains: Current progress and future prospects in brain organoid research. | Kelava I et al. | โ | 2016 | โ |
| Effective motor neuron differentiation of hiPSCs on a patch made of crosslinked monolayer gelatin nanofibers. | Tang Y et al. | โ | 2016 | โ |
| Efficient derivation of microglia-like cells from human pluripotent stem cells. | Muffat J et al. | โ | 2016 | โ |
| Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. | Mertens J et al. | โ | 2016 | โ |
| Forced cell cycle exit and modulation of GABAA, CREB, and GSK3ฮฒ signaling promote functional maturation of induced pluripotent stem cell-derived neurons. | Telezhkin V et al. | โ | 2016 | โ |
| Functional Comparison of Neuronal Cells Differentiated from Human Induced Pluripotent Stem Cell-Derived Neural Stem Cells under Different Oxygen and Medium Conditions. | Yamazaki K et al. | โ | 2016 | โ |
| Functional properties of in vitro excitatory cortical neurons derived from human pluripotent stem cells. | Livesey MR et al. | โ | 2016 | โ |
| Generation of functional human serotonergic neurons from fibroblasts. | Vadodaria KC et al. | โ | 2016 | โ |
| Human Cerebrospinal Fluid Promotes Neuronal Viability and Activity of Hippocampal Neuronal Circuits In Vitro. | Perez-Alcazar M et al. | โ | 2016 | โ |
| Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA. | Kemp PJ et al. | โ | 2016 | โ |
| Modeling psychiatric disorders: from genomic findings to cellular phenotypes. | Falk A et al. | โ | 2016 | โ |
| Neural Subtype Specification from Human Pluripotent Stem Cells. | Tao Y et al. | โ | 2016 | โ |
| Neurodevelopmental origins of bipolar disorder: iPSC models. | O'Shea KS et al. | โ | 2016 | โ |
| Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology. | Bardy C et al. | โ | 2016 | โ |
| The use of human neurons for novel drug discovery in dementia research. | Vargas-Caballero M et al. | โ | 2016 | โ |
| Modifiers of C9orf72 dipeptide repeat toxicity connect nucleocytoplasmic transport defects to FTD/ALS. | Joviฤiฤ A et al. | โ | 2015 | โ |
| Pluripotent stem cell-based disease modeling: current hurdles and future promise. | Zeltner N et al. | โ | 2015 | โ |
| Programming and Reprogramming Cellular Age in the Era of Induced Pluripotency. | Studer L et al. | โ | 2015 | โ |
| Reconstructing the neuronal milieu intรฉrieur. | Livesey FJ | โ | 2015 | โ |
| Using Patient-Derived Induced Pluripotent Stem Cells to Model and Treat Epilepsies. | Du X et al. | โ | 2015 | โ |
| The influence of medium formulation on phosphomonoester and UDP-hexose levels in cultured human colon tumor cells as observed by 31P NMR spectroscopy. | Shedd SF et al. | โ | 1993 | โ |