The genetics of alcohol dependence: Twin and SNP-based heritability, and genome-wide association study based on AUDIT scores.
paper
Cited
Public
Unavailable
- Authors
- Mbarek, Hamdi; Milaneschi, Yuri; Fedko, Iryna O; Hottenga, Jouke-Jan; de Moor, Marleen H M; Jansen, Rick; Gelernter, Joel; Sherva, Richard; Willemsen, Gonneke; Boomsma, Dorret I; Penninx, Brenda W; Vink, Jacqueline M
- Year
- 2015
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 26365420
- DOI
- 10.1002/ajmg.b.32379
Alcohol dependence (AD) is among the most common and costly public health problems contributing to morbidity and mortality throughout the world. In this study, we investigate the genetic basis of AD in a Dutch population using data from the Netherlands Twin Register (NTR) and the Netherlands Study of Depression and Anxiety (NESDA). The presence of AD was ascertained via the Alcohol Use Disorders Identification Test (AUDIT) applying cut-offs with good specificity and sensitivity in identifying those at risk for AD. Twin-based heritability of AD-AUDIT was estimated using structural equation modeling of data in 7,694 MZ and DZ twin pairs. Variance in AD-AUDIT explained by all SNPs was estimated with genome-wide complex trait analysis (GCTA). A genome-wide association study (GWAS) was performed in 7,842 subjects. GWAS SNP effect concordance analysis was performed between our GWAS and a recent AD GWAS using DSM-IV diagnosis. The twin-based heritability of AD-AUDIT was estimated at 60% (55-69%). GCTA showed that common SNPs jointly capture 33% (SE = 0.12, P = 0.002) of this heritability. In the GWAS, the top hits were positioned within four regions (4q31.1, 2p16.1, 6q25.1, 7p14.1) with the strongest association detected for rs55768019 (P = 7.58 × 10(-7) ). This first GWAS of AD using the AUDIT measure found results consistent with previous genetic studies using DSM diagnosis: concordance in heritability estimates and direction of SNPs effect and overlap with top hits from previous GWAS. Thus, the use of appropriate questionnaires may represent cost-effective strategies to phenotype samples in large-scale biobanks or other population-based datasets.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Central amygdala single-nucleus atlas reveals chromatin and gene transcription dynamics in human alcohol use disorder. | Lee CY et al. | — | 2026 | → |
| Pilot evidence of genetic and environmental contributions to problematic pornography use, pornography use frequency, and moral disapproval to pornography. | Borgogna NC et al. | — | 2026 | → |
| A Systematic Investigation of the Common Genetic Architecture of Substance Use Traits and the Relationship with Mental Health. | Pasman JA et al. | — | 2025 | → |
| GRIK1 genotype and effect of topiramate for alcohol use: a systematic review. | Kotake K et al. | — | 2025 | → |
| Human genetics and epigenetics of alcohol use disorder. | Zhou H et al. | — | 2024 | → |
| Genetic and Cultural Transmission of Alcohol Use Disorder in Swedish Twin Pedigrees. | Maes HH et al. | — | 2023 | → |
| Genetic associations between alcohol phenotypes and life satisfaction: a genomic structural equation modelling approach. | Bountress KE et al. | — | 2023 | → |
| Associations between electronic devices use and common mental traits: A gene-environment interaction model using the UK Biobank data. | Ye J et al. | — | 2022 | → |
| Common and distinguishing genetic factors for substance use behavior and disorder: an integrated analysis of genomic and transcriptomic studies from both human and animal studies. | Chang XW et al. | — | 2022 | → |
| Genome-wide association mapping of ethanol sensitivity in the Diversity Outbred mouse population. | Parker CC et al. | — | 2022 | → |
| Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. | Clarke TK et al. | — | 2021 | → |
| <i>LRRK2</i> Gene Variants Associated With a Higher Risk for Alcohol Dependence in Multiethnic Populations. | Oliveira PRS et al. | — | 2021 | → |
| The Aldehyde Dehydrogenase ALDH2*2 Allele, Associated with Alcohol Drinking Behavior, Dates Back to Prehistoric Times. | Lin CL et al. | — | 2021 | → |
| Whole Genome Interpretation for a Family of Five. | Corpas M et al. | — | 2021 | → |
| Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans. | Parker CC et al. | — | 2020 | → |
| Neighborhood Deprivation Moderates Shared and Unique Environmental Influences on Hazardous Drinking: Findings from a Cross-Sectional Co-Twin Study. | Rhew IC et al. | — | 2020 | → |
| Potential influence of socioeconomic status on genetic correlations between alcohol consumption measures and mental health. | Marees AT et al. | — | 2020 | → |
| Substance use: Interplay between polygenic risk and neighborhood environment. | Pasman JA et al. | — | 2020 | → |
| Association Between rs1051730 and Smoking During Pregnancy in Dutch Women. | Mbarek H et al. | — | 2019 | → |
| Beyond genome-wide significance: integrative approaches to the interpretation and extension of GWAS findings for alcohol use disorder. | Salvatore JE et al. | — | 2019 | → |
| Effects of DRD2 splicing-regulatory polymorphism and DRD4 48 bp VNTR on crack cocaine addiction. | Stolf AR et al. | — | 2019 | → |
| Genetic determinants of beverage consumption: Implications for nutrition and health. | Cornelis MC | — | 2019 | → |
| Genome-wide association meta-analysis of cocaine dependence: Shared genetics with comorbid conditions. | Cabana-Domínguez J et al. | — | 2019 | → |
| Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts. | Sanchez-Roige S et al. | — | 2019 | → |
| Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations. | Kranzler HR et al. | — | 2019 | → |
| Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry. | Sanchez-Roige S et al. | — | 2019 | → |
| Genome-wide Association Study of Maximum Habitual Alcohol Intake in >140,000 U.S. European and African American Veterans Yields Novel Risk Loci. | Gelernter J et al. | — | 2019 | → |
| A Whole Methylome Study of Ethanol Exposure in Brain and Blood: An Exploration of the Utility of Peripheral Blood as Proxy Tissue for Brain in Alcohol Methylation Studies. | Clark SL et al. | — | 2018 | → |
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | Prytkova I et al. | — | 2018 | → |
| Genomewide Association Study of Alcohol Dependence and Related Traits in a Thai Population. | Gelernter J et al. | — | 2018 | → |
| Human Genetics of Addiction: New Insights and Future Directions. | Hancock DB et al. | — | 2018 | → |
| Incorporating Functional Genomic Information to Enhance Polygenic Signal and Identify Variants Involved in Gene-by-Environment Interaction for Young Adult Alcohol Problems. | Salvatore JE et al. | — | 2018 | → |
| Lack of association between MTHFR C677T Gene polymorphism with alcohol dependence: A meta-analysis of case-control studies. | Xu R et al. | — | 2018 | → |
| Polygenic risk for alcohol consumption and its association with alcohol-related phenotypes: Do stress and life satisfaction moderate these relationships? | Mies GW et al. | — | 2018 | → |
| Polygenic Risk Score Prediction of Alcohol Dependence Symptoms Across Population-Based and Clinically Ascertained Samples. | Savage JE et al. | — | 2018 | → |
| Problematic alcohol use associates with sodium channel and clathrin linker 1 (SCLT1) in trauma-exposed populations. | Almli LM et al. | — | 2018 | → |
| Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. | Walters RK et al. | — | 2018 | → |
| Comorbidity of Alcohol Use Disorder and Chronic Pain: Genetic Influences on Brain Reward and Stress Systems. | Yeung EW et al. | — | 2017 | → |
| Genetic contributors to variation in alcohol consumption vary by race/ethnicity in a large multi-ethnic genome-wide association study. | Jorgenson E et al. | — | 2017 | → |
| Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117). | Clarke TK et al. | — | 2017 | → |
| Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry | Sanchez-Roige S et al. | — | 2017 | — |
| Lack of associations of the opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) with alcohol dependence: review and meta-analysis of retrospective controlled studies. | Kong X et al. | — | 2017 | → |
| Molecular Genetic Influences on Normative and Problematic Alcohol Use in a Population-Based Sample of College Students. | Webb BT et al. | — | 2017 | → |
| The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene. | Tollenaar MS et al. | — | 2017 | → |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | — | 2017 | → |
| The Impact of Peer Substance Use and Polygenic Risk on Trajectories of Heavy Episodic Drinking Across Adolescence and Emerging Adulthood. | Li JJ et al. | — | 2017 | → |
| Heritability of high sugar consumption through drinks and the genetic correlation with substance use. | Treur JL et al. | — | 2016 | → |