Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system.
paper
Cited
Public
Unavailable
- Authors
- Dani, John A; Bertrand, Daniel
- Year
- 2007
- Journal
- Annual review of pharmacology and toxicology
- PMID
- 17009926
- DOI
- 10.1146/annurev.pharmtox.47.120505.105214
Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from numerous subunit combinations that compose channel-receptor complexes with varied functional and pharmacological characteristics. Structural and functional diversity and the broad presynaptic, postsynaptic, and nonsynaptic locations of nAChRs underlie their mainly modulatory roles throughout the mammalian brain. Presynaptic and preterminal nicotinic receptors enhance neurotransmitter release, postsynaptic nAChRs contribute a small minority of fast excitatory transmission, and nonsynaptic nAChRs modulate many neurotransmitter systems by influencing neuronal excitability. Nicotinic receptors have roles in development and synaptic plasticity, and nicotinic mechanisms participate in learning, memory, and attention. Decline, disruption, or alterations of nicotinic cholinergic mechanisms contribute to dysfunctions such as epilepsy, schizophrenia, Parkinson's disease, autism, dementia with Lewy bodies, Alzheimer's disease, and addiction.
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| Modulation of cholinergic activity through lynx prototoxins: Implications for cognition and anxiety regulation. | Anderson KR et al. | β | 2020 | β |
| Molecular characterization and expression profiles of nicotinic acetylcholine receptors in Bradysia odoriphaga. | Shan T et al. | β | 2020 | β |
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| More than Smoke and Patches: The Quest for Pharmacotherapies to Treat Tobacco Use Disorder. | Moerke MJ et al. | β | 2020 | β |
| Nanoscopic Visualization of Restricted Nonvolume Cholinergic and Monoaminergic Transmission with Genetically Encoded Sensors. | Zhu PK et al. | β | 2020 | β |
| New insights in the mode of action of (+)-erythravine and (+)-11Ξ±-hydroxy-erythravine alkaloids. | Gelfuso EA et al. | β | 2020 | β |
| Nicotinic acetylcholine receptors and nicotine addiction: A brief introduction. | Wittenberg RE et al. | β | 2020 | β |
| Non-neuronal Role of Acetylcholinesterase in Bone Development and Degeneration. | Luo X et al. | β | 2020 | β |
| PCB52 exposure alters the neurotransmission ligand-receptors in male offspring and contributes to sex-specific neurodevelopmental toxicity. | Zhao D et al. | β | 2020 | β |
| Prenatal exposure to nicotine disrupts synaptic network formation by inhibiting spontaneous correlated wave activity. | Momose-Sato Y et al. | β | 2020 | β |
| Progress in nicotinic receptor structural biology. | Gharpure A et al. | β | 2020 | β |
| Rational Design of Ξ±-Conotoxin RegIIA Analogues Selectively Inhibiting the Human Ξ±3Ξ²2 Nicotinic Acetylcholine Receptor through Computational Scanning. | Xu Q et al. | β | 2020 | β |
| Recent findings in the pharmacology of inhaled nicotine: Preclinical and clinical in vivo studies. | Jackson A et al. | β | 2020 | β |
| Research progress of <sup>18</sup>F labeled small molecule positron emission tomography (PET) imaging agents. | Zhang M et al. | β | 2020 | β |
| RIC3, the cholinergic anti-inflammatory pathway, and neuroinflammation. | Ben-David Y et al. | β | 2020 | β |
| Role of the Ξ±7 Nicotinic Acetylcholine Receptor in the Pathophysiology of Atherosclerosis. | Vieira-Alves I et al. | β | 2020 | β |
| Selective Expression of Nicotinic Receptor Sub-unit mRNA in Early Human Fetal Forebrain. | Alzu'bi A et al. | β | 2020 | β |
| Structure-Function of Neuronal Nicotinic Acetylcholine Receptor Inhibitors Derived From Natural Toxins. | Ho TNT et al. | β | 2020 | β |
| The role of nicotinic acetylcholine receptors in alcohol-related behaviors. | Miller CN et al. | β | 2020 | β |
| The Role of Smoking and Nicotine in the Transmission and Pathogenesis of COVID-19. | Sifat AE et al. | β | 2020 | β |
| Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models. | MΓΌller TE et al. | β | 2020 | β |
| Anatomy and Physiology of Neurons in Layer 9 of the Chicken Optic Tectum. | Kloos M et al. | β | 2019 | β |
| Cellular, Synaptic and Network Effects of Acetylcholine in the Neocortex. | Colangelo C et al. | β | 2019 | β |
| Characterization of nAChRs in <i>Nematostella vectensis</i> supports neuronal and non-neuronal roles in the cnidarian-bilaterian common ancestor. | Faltine-Gonzalez DZ et al. | β | 2019 | β |
| Chemical conversion of nicotinamide into type I positive allosteric modulator of Ξ±7 nAChRs. | Li X et al. | β | 2019 | β |
| Cholinergic system and exploratory behavior are changed after weekly-binge ethanol exposure in zebrafish. | Bernardo HT et al. | β | 2019 | β |
| Cigarette smoke exposure effects on the brainstem expression of nicotinic acetylcholine receptors (nAChRs), and on cardiac, respiratory and sleep physiologies. | Vivekanandarajah A et al. | β | 2019 | β |
| Co-activation of selective nicotinic acetylcholine receptors is required to reverse beta amyloid-induced Ca<sup>2+</sup> hyperexcitation. | Sun JL et al. | β | 2019 | β |
| Cognitive Enhancer Effects of Low Memantine Doses Are Facilitated by an Alpha7 Nicotinic Acetylcholine Receptor Agonist in Scopolamine-Induced Amnesia in Rats. | Bali ZK et al. | β | 2019 | β |
| Combining CDP-choline and galantamine, an optimized Ξ±7 nicotinic strategy, to ameliorate sensory gating to speech stimuli in schizophrenia. | Choueiry J et al. | β | 2019 | β |
| Combining CDP-choline and galantamine: Effects of a selective Ξ±7 nicotinic acetylcholine receptor agonist strategy on P50 sensory gating of speech sounds in healthy volunteers. | Choueiry J et al. | β | 2019 | β |
| Distinctive single-channel properties of Ξ±4Ξ²2-nicotinic acetylcholine receptor isoforms. | Weltzin MM et al. | β | 2019 | β |
| Drug Discovery on Natural Products: From Ion Channels to nAChRs, from Nature to Libraries, from Analytics to Assays. | Otvos RA et al. | β | 2019 | β |
| Embelin Improves the Spatial Memory and Hippocampal Long-Term Potentiation in a Rat Model of Chronic Cerebral Hypoperfusion. | Bhuvanendran S et al. | β | 2019 | β |
| Enhanced Sensory-Cognitive Processing by Activation of Nicotinic Acetylcholine Receptors. | Gil SM et al. | β | 2019 | β |
| Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook. | Singh L et al. | β | 2019 | β |
| Evolution of vertebrate nicotinic acetylcholine receptors. | Pedersen JE et al. | β | 2019 | β |
| Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. | Bali ZK et al. | β | 2019 | β |
| Gene editing vectors for studying nicotinic acetylcholine receptors in cholinergic transmission. | Peng C et al. | β | 2019 | β |
| Growth and neurite stimulating effects of the neonicotinoid pesticide clothianidin on human neuroblastoma SH-SY5Y cells. | Hirano T et al. | β | 2019 | β |
| <i>CHRNA2</i> and Nocturnal Frontal Lobe Epilepsy: Identification and Characterization of a Novel Loss of Function Mutation. | Villa C et al. | β | 2019 | β |
| Impaired Expression of Neuregulin 1 and Nicotinic Acetylcholine Receptor Ξ²4 Subunit in Diverticular Disease. | Barrenschee M et al. | β | 2019 | β |
| Inhibition of N-acylethanolamine acid amidase reduces nicotine-induced dopamine activation and reward. | Sagheddu C et al. | β | 2019 | β |
| Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration. | Kim J et al. | β | 2019 | β |
| Involvement of the Cholinergic Parameters and Glial Cells in Learning Delay Induced by Glutaric Acid: Protection by N-Acetylcysteine. | Rodrigues FS et al. | β | 2019 | β |
| Is there a role for antibodies targeting muscarinic acetylcholine receptors in the pathogenesis of schizophrenia? | Ryan AE et al. | β | 2019 | β |
| Mechanism Underlying Organophosphate Paraoxon-Induced Kinetic Tremor. | Iha HA et al. | β | 2019 | β |
| NAChR Ξ±4Ξ²2 Subtype and their Relation with Nicotine Addiction, Cognition, Depression and Hyperactivity Disorder. | Laikowski MM et al. | β | 2019 | β |
| Neonatal Nicotine Exposure Primes Midbrain Neurons to a Dopaminergic Phenotype and Increases Adult Drug Consumption. | Romoli B et al. | β | 2019 | β |
| Nicotine excites VIP interneurons to disinhibit pyramidal neurons in auditory cortex. | Askew CE et al. | β | 2019 | β |
| Nicotine Gateway Effects on Adolescent Substance Use. | Ren M et al. | β | 2019 | β |
| Nicotine increases sleep spindle activity. | O'Reilly C et al. | β | 2019 | β |
| Nicotine modulates the facial stimulation-evoked responses in cerebellar granule cell layer in vivo in mice. | Xu YH et al. | β | 2019 | β |
| Potential roles of 5-HT<sub>3</sub> receptor (5-HT<sub>3</sub>R) antagonists in modulating the effects of nicotine. | Zulkifli MH et al. | β | 2019 | β |
| Structure and function of dual-source cholinergic modulation in early vision. | Krueger J et al. | β | 2019 | β |
| Targeting the <i>Ξ±</i>4<i>Ξ²</i>2- and <i>Ξ±</i>7-Subtypes of Nicotinic Acetylcholine Receptors for Smoking Cessation Medication Development. | Ramachandran Nair L et al. | β | 2019 | β |
| The Pharmacology of Visual Hallucinations in Synucleinopathies. | Russo M et al. | β | 2019 | β |
| Therapeutic Effect of Agmatine on Neurological Disease: Focus on Ion Channels and Receptors. | Barua S et al. | β | 2019 | β |
| To flourish or perish: evolutionary TRiPs into the sensory biology of plant-herbivore interactions. | Startek JB et al. | β | 2019 | β |
| A genetically encoded fluorescent acetylcholine indicator for in vitro and in vivo studies. | Jing M et al. | β | 2018 | β |
| Alpha 7 nicotinic receptors attenuate neurite development through calcium activation of calpain at the growth cone. | King JR et al. | β | 2018 | β |
| Altered release and uptake of gamma-aminobutyric acid in the cerebellum of dystrophin-deficient mice. | Pereira da Silva JD et al. | β | 2018 | β |
| Analysis of <i>in situ</i> Transcriptomes Reveals Divergent Adaptive Response to Hyper- and Hypo-Salinity in the Hong Kong Oyster, <i>Crassostrea hongkongensis</i>. | Xiao S et al. | β | 2018 | β |
| Attention and working memory deficits in a perinatal nicotine exposure mouse model. | Zhang L et al. | β | 2018 | β |
| Autoimmune autonomic ganglionopathy: an update on diagnosis and treatment. | Nakane S et al. | β | 2018 | β |
| Beyond the Channel: Metabotropic Signaling by Nicotinic Receptors. | Kabbani N et al. | β | 2018 | β |
| Cholinergic modulation of spatial learning, memory and navigation. | Solari N et al. | β | 2018 | β |
| Cognitive correlates of Ξ±4Ξ²2 nicotinic acetylcholine receptors in mild Alzheimer's dementia. | Sabri O et al. | β | 2018 | β |
| Cognitive Effects of Nicotine: Recent Progress. | Valentine G et al. | β | 2018 | β |
| Convergent Neuronal Plasticity and Metaplasticity Mechanisms of Stress, Nicotine, and Alcohol. | Ostroumov A et al. | β | 2018 | β |
| Early adolescent nicotine exposure affects later-life hippocampal mu-opioid receptors activity and morphine reward but not physical dependence in male mice. | Kota D et al. | β | 2018 | β |
| Firing responses mediated via distinct nicotinic acetylcholine receptor subtypes in rat prepositus hypoglossi nuclei neurons. | Zhang Y et al. | β | 2018 | β |
| Insights Into Nicotinic Receptor Signaling in Nicotine Addiction: Implications for Prevention and Treatment. | Liu W et al. | β | 2018 | β |
| Is There a Canonical Cortical Circuit for the Cholinergic System? Anatomical Differences Across Common Model Systems. | Coppola JJ et al. | β | 2018 | β |
| Layer- and Cell Type-Specific Modulation of Excitatory Neuronal Activity in the Neocortex. | Radnikow G et al. | β | 2018 | β |
| Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of Ξ±7 nicotinic receptor, glutamate and oxidative stress. | MΓ³naco NM et al. | β | 2018 | β |
| LY2087101 and dFBr share transmembrane binding sites in the (Ξ±4)3(Ξ²2)2 Nicotinic Acetylcholine Receptor. | Deba F et al. | β | 2018 | β |
| Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors. | Fernandez SP et al. | β | 2018 | β |
| Molecular determinants of Ξ±-conotoxin potency for inhibition of human and rat Ξ±6Ξ²4 nicotinic acetylcholine receptors. | Hone AJ et al. | β | 2018 | β |
| Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. | Zoli M et al. | β | 2018 | β |
| Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails. | Abraham N et al. | β | 2018 | β |
| Nicotine and the renin-angiotensin system. | Oakes JM et al. | β | 2018 | β |
| Nicotinic Acetylcholine Receptors Control Encoding and Retrieval of Associative Recognition Memory through Plasticity in the Medial Prefrontal Cortex. | Sabec MH et al. | β | 2018 | β |
| Pharmacological Effects and Regulatory Mechanisms of Tobacco Smoking Effects on Food Intake and Weight Control. | Hu T et al. | β | 2018 | β |
| Pharmacological intervention and abstinence in smokers undergoing cessation treatment: A psychophysiological study. | Cui Y et al. | β | 2018 | β |
| Phase IIb Trial of an Ξ±7 Nicotinic Receptor Partial Agonist With and Without Nicotine Patch for Withdrawal-Associated Cognitive Deficits and Tobacco Abstinence. | Schuster RM et al. | β | 2018 | β |
| Progressive modulation of accumbal neurotransmission and anxiety-like behavior following protracted nicotine withdrawal. | Morud J et al. | β | 2018 | β |
| Proteomic Investigation of Murine Neuronal Ξ±7-Nicotinic Acetylcholine Receptor Interacting Proteins. | Mulcahy MJ et al. | β | 2018 | β |
| Restoring Vision to the Blind with Chemical Photoswitches. | Tochitsky I et al. | β | 2018 | β |
| Rollercoaster ride of kynurenines: steering the wheel towards neuroprotection in Alzheimer's disease. | Sharma R et al. | β | 2018 | β |
| The Cholinergic and Adrenergic Autocrine Signaling Pathway Mediates Immunomodulation in Oyster <i>Crassostrea gigas</i>. | Liu Z et al. | β | 2018 | β |
| The cholinergic anti-inflammatory pathway: an innovative treatment strategy for respiratory diseases and their comorbidities. | Yamada M et al. | β | 2018 | β |
| The p38 mitogen activated protein kinase regulates Ξ²-amyloid protein internalization through the Ξ±7 nicotinic acetylcholine receptor in mouse brain. | Ma KG et al. | β | 2018 | β |
| Treatment duration affects cytoprotective efficacy of positive allosteric modulation of Ξ±7 nAChRs after focal ischemia in rats. | Gaidhani N et al. | β | 2018 | β |
| Understanding the implications of the biobehavioral basis of nicotine addiction and its impact on the efficacy of treatment. | Bozinoff N et al. | β | 2018 | β |
| Ξ±7 nicotinic acetylcholine receptors in lung cancer. | Wang S et al. | β | 2018 | β |
| Ξ±-Conotoxins active at Ξ±3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition. | Cuny H et al. | β | 2018 | β |
| Alpha7 nicotinic acetylcholine receptor agonist promotes retinal ganglion cell function via modulating GABAergic presynaptic activity in a chronic glaucomatous model. | Zhou X et al. | β | 2017 | β |
| A protocadherin gene cluster regulatory variant is associated with nicotine withdrawal and the urge to smoke. | Jensen KP et al. | β | 2017 | β |
| A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus). | Huang Y et al. | β | 2017 | β |
| Attenuating Nicotine Reinforcement and Relapse by Enhancing Endogenous Brain Levels of Kynurenic Acid in Rats and Squirrel Monkeys. | Secci ME et al. | β | 2017 | β |
| Cellular and Molecular Targets of Menthol Actions. | Oz M et al. | β | 2017 | β |
| Choline induces opposite changes in pyramidal neuron excitability and synaptic transmission through a nicotinic receptor-independent process in hippocampal slices. | AlbiΓ±ana E et al. | β | 2017 | β |
| Cholinergic agonist reverses H1-induced memory deficit in mice. | Fernandes CE et al. | β | 2017 | β |
| Cholinergic circuits in cognitive flexibility. | Prado VF et al. | β | 2017 | β |
| Cholinergic System and Post-translational Modifications: An Insight on the Role in Alzheimer's Disease. | Ahmed T et al. | β | 2017 | β |
| Compromised neuroplasticity in cigarette smokers under nicotine withdrawal is restituted by the nicotinic Ξ±<sub>4</sub>Ξ²<sub>2</sub>-receptor partial agonist varenicline. | Batsikadze G et al. | β | 2017 | β |
| Discovery of peptide ligands through docking and virtual screening at nicotinic acetylcholine receptor homology models. | Leffler AE et al. | β | 2017 | β |
| Effects of nicotine on homeostatic and hedonic components of food intake. | Stojakovic A et al. | β | 2017 | β |
| Electronic cigarettes: age-specific generation-resolved pulmonary doses. | Manigrasso M et al. | β | 2017 | β |
| Electrophysiological characterization of the M-current in rat hypoglossal motoneurons. | Ghezzi F et al. | β | 2017 | β |
| Embelin Attenuates Intracerebroventricular Streptozotocin-Induced Behavioral, Biochemical, and Neurochemical Abnormalities in Rats. | Arora R et al. | β | 2017 | β |
| Endogenous opioid system: a promising target for future smoking cessation medications. | Norman H et al. | β | 2017 | β |
| Ethnopharmacological uses, phytochemistry, biological activities, and therapeutic applications of Clinacanthus nutans (Burm. f.) Lindau: A comprehensive review. | Kamarudin MNA et al. | β | 2017 | β |
| Impact of ageing on postsynaptic neuronal nicotinic neurotransmission in auditory thalamus. | Sottile SY et al. | β | 2017 | β |
| Interactions between the Kynurenine and the Endocannabinoid System with Special Emphasis on Migraine. | Nagy-GrΓ³cz G et al. | β | 2017 | β |
| Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene. | Wang AL et al. | β | 2017 | β |
| MeCP2-deficient mice have reduced Ξ±4 and Ξ±6 nicotinic receptor mRNA and altered behavioral response to nicotinic agonists. | Leung J et al. | β | 2017 | β |
| Nicotine Elicits Convulsive Seizures by Activating Amygdalar Neurons. | Iha HA et al. | β | 2017 | β |
| Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve. | Prickaerts J et al. | β | 2017 | β |
| Pleiotropic Effects of Loss of the DΞ±1 Subunit in Drosophila melanogaster: Implications for Insecticide Resistance. | Somers J et al. | β | 2017 | β |
| Positron emission tomography (PET) imaging of nicotine-induced dopamine release in squirrel monkeys using [<sup>18</sup>F]Fallypride. | Naylor JE et al. | β | 2017 | β |
| Presynaptic Neuronal Nicotinic Receptors Differentially Shape Select Inputs to Auditory Thalamus and Are Negatively Impacted by Aging. | Sottile SY et al. | β | 2017 | β |
| Radiosynthesis of (S)-[<sup>18</sup>F]T1: The first PET radioligand for molecular imaging of Ξ±3Ξ²4 nicotinic acetylcholine receptors. | Sarasamkan J et al. | β | 2017 | β |
| Regulation of RIC-3 and of nAChR expression. | Ben-David Y et al. | β | 2017 | β |
| Serotonergic modulation of nicotine-induced kinetic tremor in mice. | Kunisawa N et al. | β | 2017 | β |
| Structural mechanisms for Ξ±-conotoxin activity at the human Ξ±3Ξ²4 nicotinic acetylcholine receptor. | Abraham N et al. | β | 2017 | β |
| Systemic Nicotine Increases Gain and Narrows Receptive Fields in A1 via Integrated Cortical and Subcortical Actions. | Askew C et al. | β | 2017 | β |
| The current agonists and positive allosteric modulators of <i>Ξ±</i>7 nAChR for CNS indications in clinical trials. | Yang T et al. | β | 2017 | β |
| The E Loop of the Transmitter Binding Site Is a Key Determinant of the Modulatory Effects of Physostigmine on Neuronal Nicotinic Ξ±4Ξ²2 Receptors. | Jin X et al. | β | 2017 | β |
| The Protective Effect of Alpha 7 Nicotinic Acetylcholine Receptor Activation on Critical Illness and Its Mechanism. | Ren C et al. | β | 2017 | β |
| The Role of Cholesterol in the Activation of Nicotinic Acetylcholine Receptors. | Baenziger JE et al. | β | 2017 | β |
| Ultrafast and Slow Cholinergic Transmission. Different Involvement of Acetylcholinesterase Molecular Forms. | Dunant Y et al. | β | 2017 | β |
| Uncovering the transcriptomic and epigenomic landscape of nicotinic receptor genes in non-neuronal tissues. | Zhang B et al. | β | 2017 | β |
| Weight of evidence evaluation of a network of adverse outcome pathways linking activation of the nicotinic acetylcholine receptor in honey bees to colony death. | LaLone CA et al. | β | 2017 | β |
| Activity-dependent plasticity in the isolated embryonic avian brainstem following manipulations of rhythmic spontaneous neural activity. | Vincen-Brown MA et al. | β | 2016 | β |
| A Randomized Trial to Assess the Efficacy and Safety of ABT-126, a Selective Ξ±7 Nicotinic Acetylcholine Receptor Agonist, in the Treatment of Cognitive Impairment in Schizophrenia. | Haig GM et al. | β | 2016 | β |
| At-Line Cellular Screening Methodology for Bioactives in Mixtures Targeting the Ξ±7-Nicotinic Acetylcholine Receptor. | Otvos RA et al. | β | 2016 | β |
| Attention and the Cholinergic System: Relevance to Schizophrenia. | Lustig C et al. | β | 2016 | β |
| Basal Forebrain Cholinergic Circuits and Signaling in Cognition and Cognitive Decline. | Ballinger EC et al. | β | 2016 | β |
| Biallelic Variants in UBA5 Reveal that Disruption of the UFM1 Cascade Can Result in Early-Onset Encephalopathy. | Colin E et al. | β | 2016 | β |
| Cholinergic and serotonergic modulation of visual information processing in monkey V1. | Shimegi S et al. | β | 2016 | β |
| Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility. | Sarter M et al. | β | 2016 | β |
| Cholinergic imaging in dementia spectrum disorders. | Roy R et al. | β | 2016 | β |
| Cholinergic Mesopontine Signals Govern Locomotion and Reward through Dissociable Midbrain Pathways. | Xiao C et al. | β | 2016 | β |
| Cholinergic Signaling Controls Conditioned Fear Behaviors and Enhances Plasticity of Cortical-Amygdala Circuits. | Jiang L et al. | β | 2016 | β |
| Contribution of Variants in CHRNA5/A3/B4 Gene Cluster on Chromosome 15 to Tobacco Smoking: From Genetic Association to Mechanism. | Wen L et al. | β | 2016 | β |
| Critical needs in drug discovery for cessation of alcohol and nicotine polysubstance abuse. | Van Skike CE et al. | β | 2016 | β |
| Crucial roles of the CHRNB3-CHRNA6 gene cluster on chromosome 8 in nicotine dependence: update and subjects for future research. | Wen L et al. | β | 2016 | β |
| Design and Synthesis of Nicotinic Acetylcholine Receptor Antagonists and their Effect on Cognitive Impairment. | Jaikhan P et al. | β | 2016 | β |
| Differential Effects of Quercetin and Quercetin Glycosides on Human Ξ±7 Nicotinic Acetylcholine Receptor-Mediated Ion Currents. | Lee BH et al. | β | 2016 | β |
| Differential Ξ±4(+)/(-)Ξ²2 Agonist-binding Site Contributions to Ξ±4Ξ²2 Nicotinic Acetylcholine Receptor Function within and between Isoforms. | Lucero LM et al. | β | 2016 | β |
| Editor's Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity. | LaLone CA et al. | β | 2016 | β |
| Exploring the positive allosteric modulation of human Ξ±7 nicotinic receptors from a single-channel perspective. | Andersen ND et al. | β | 2016 | β |
| Genetic models of focal epilepsies. | Boillot M et al. | β | 2016 | β |
| Genetics of Substance Use Disorders. | Yu C et al. | β | 2016 | β |
| Huperzine A as a neuroprotective and antiepileptic drug: a review of preclinical research. | Damar U et al. | β | 2016 | β |
| Imaging of cerebral Ξ±4Ξ²2* nicotinic acetylcholine receptors with (-)-[(18)F]Flubatine PET: Implementation of bolus plus constant infusion and sensitivity to acetylcholine in human brain. | Hillmer AT et al. | β | 2016 | β |
| Interactions between the endocannabinoid and nicotinic cholinergic systems: preclinical evidence and therapeutic perspectives. | Scherma M et al. | β | 2016 | β |
| Key Structural Determinants in the Agonist Binding Loops of Human Ξ²2 and Ξ²4 Nicotinic Acetylcholine Receptor Subunits Contribute to Ξ±3Ξ²4 Subtype Selectivity of Ξ±-Conotoxins. | Cuny H et al. | β | 2016 | β |
| Maternal bonding styles in smokers and non-smokers: a comparative study. | Csala I et al. | β | 2016 | β |
| Modification of the anabaseine pyridine nucleus allows achieving binding and functional selectivity for the Ξ±3Ξ²4 nicotinic acetylcholine receptor subtype. | Matera C et al. | β | 2016 | β |
| Modulatory compartments in cortex and local regulation of cholinergic tone. | Coppola JJ et al. | β | 2016 | β |
| Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine. | Alberola-Die A et al. | β | 2016 | β |
| N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent rats. | Okamura AM et al. | β | 2016 | β |
| nAChR dysfunction as a common substrate for schizophrenia and comorbid nicotine addiction: Current trends and perspectives. | Parikh V et al. | β | 2016 | β |
| Neuroscience of nicotine for addiction medicine: novel targets for smoking cessation medications. | D'Souza MS | β | 2016 | β |
| Nicotine evokes kinetic tremor by activating the inferior olive via Ξ±7 nicotinic acetylcholine receptors. | Kunisawa N et al. | β | 2016 | β |
| Nicotine-induced acute hyperactivity is mediated by dopaminergic system in a sexually dimorphic manner. | Zhang Y et al. | β | 2016 | β |
| Nicotinic acetylcholine receptor-mediated responses in medial vestibular and prepositus hypoglossi nuclei neurons showing distinct neurotransmitter phenotypes. | Zhang Y et al. | β | 2016 | β |
| Nicotinic Acetylcholine Receptors as Targets for Tobacco Cessation Therapeutics: Cutting-Edge Methodologies to Understand Receptor Assembly and Trafficking. | Fox-Loe AM et al. | β | 2016 | β |
| Nicotinic acetylcholine receptors modulate osteoclastogenesis. | Mandl P et al. | β | 2016 | β |
| Nicotinic cholinergic and dopaminergic receptor mRNA expression in male and female rats with high or low preference for nicotine. | Gozen O et al. | β | 2016 | β |
| Nicotinic receptors in the ventral tegmental area promote uncertainty-seeking. | NaudΓ© J et al. | β | 2016 | β |
| Nicotinic Transmission onto Layer 6 Cortical Neurons Relies on Synaptic Activation of Non-Ξ±7 Receptors. | Hay YA et al. | β | 2016 | β |
| Nicotinic Ξ±7 and Ξ±4Ξ²2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders. | McLean SL et al. | β | 2016 | β |
| Noninvasive evaluation of nicotinic acetylcholine receptor availability in mouse brain using single-photon emission computed tomography with [(123)I]5IA. | Matsuura Y et al. | β | 2016 | β |
| Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (Ξ±4)3(Ξ²2)2 nAChR-Selective Positive Allosteric Modulator. | Hamouda AK et al. | β | 2016 | β |
| Retinal co-mediator acetylcholine evokes muscarinic inhibition of recurrent excitation in frog tectum column. | Baginskas A et al. | β | 2016 | β |
| RIC-3 expression and splicing regulate nAChR functional expression. | Ben-David Y et al. | β | 2016 | β |
| Selective activation of Ξ±7 nicotinic acetylcholine receptors augments hippocampal oscillations. | Stoiljkovic M et al. | β | 2016 | β |
| Sleep Pharmacogenetics: Personalized Sleep-Wake Therapy. | Holst SC et al. | β | 2016 | β |
| SNPs in NRXN1 and CHRNA5 are associated to smoking and regulation of GABAergic and glutamatergic pathways. | PΓ©rez-Rubio G et al. | β | 2016 | β |
| Synthesis, Nicotinic Acetylcholine Binding, and in Vitro and in Vivo Pharmacological Properties of 2'-Fluoro-(carbamoylpyridinyl)deschloroepibatidine Analogues. | Ondachi PW et al. | β | 2016 | β |
| The basolateral amygdala Ξ³-aminobutyric acidergic system in health and disease. | Prager EM et al. | β | 2016 | β |
| The development of novel polypharmacological agents targeting the multiple binding sites of nicotinic acetylcholine receptors. | Reyes-Parada M et al. | β | 2016 | β |
| The NMDA Receptor and Schizophrenia: From Pathophysiology to Treatment. | Balu DT | β | 2016 | β |
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| Differential effects of Ξ±7 nicotinic receptor agonist PHA-543613 on spatial memory performance of rats in two distinct pharmacological dementia models. | Bali ZK et al. | β | 2015 | β |
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| Nicotine Dependence Reveals Distinct Responses from Neurons and Their Resident Nicotinic Receptors in Medial Habenula. | Shih PY et al. | β | 2015 | β |
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| Nicotinic receptor subtype-selective circuit patterns in the subthalamic nucleus. | Xiao C et al. | β | 2015 | β |
| Pathologic role of neuronal nicotinic acetylcholine receptors in epileptic disorders: implication for pharmacological interventions. | Ghasemi M et al. | β | 2015 | β |
| Pinnatoxins E, F and G target multiple nicotinic receptor subtypes. | Hellyer SD et al. | β | 2015 | β |
| Potentiation of Neuronal Nicotinic Receptors by 17Ξ²-Estradiol: Roles of the Carboxy-Terminal and the Amino-Terminal Extracellular Domains. | Jin X et al. | β | 2015 | β |
| Resistance to Inhibitors of Cholinesterase 3 (Ric-3) Expression Promotes Selective Protein Associations with the Human Ξ±7-Nicotinic Acetylcholine Receptor Interactome. | Mulcahy MJ et al. | β | 2015 | β |
| Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment. | Lombardo S et al. | β | 2015 | β |
| Role of Ξ±5-containing nicotinic receptors in neuropathic pain and response to nicotine. | Xanthos DN et al. | β | 2015 | β |
| Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication. | Deardorff WJ et al. | β | 2015 | β |
| Selectivity optimization of substituted 1,2,3-triazoles as Ξ±7 nicotinic acetylcholine receptor agonists. | Arunrungvichian K et al. | β | 2015 | β |
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| Smoking in schizophrenic patients: A critique of the self-medication hypothesis. | Manzella F et al. | β | 2015 | β |
| Sodium tungstate induced neurological alterations in rat brain regions and their response to antioxidants. | Sachdeva S et al. | β | 2015 | β |
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| The multiple roles of the Ξ±7 nicotinic acetylcholine receptor in modulating glutamatergic systems in the normal and diseased nervous system. | Koukouli F et al. | β | 2015 | β |
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| The Ξ±7 nicotinic acetylcholine receptor: A mediator of pathogenesis and therapeutic target in autism spectrum disorders and Down syndrome. | Deutsch SI et al. | β | 2015 | β |
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| Discovery of novel 2-((pyridin-3-yloxy)methyl)piperazines as Ξ±7 nicotinic acetylcholine receptor modulators for the treatment of inflammatory disorders. | Clark RB et al. | β | 2014 | β |
| Discriminative-stimulus effects of NS9283, a nicotinic Ξ±4Ξ²2* positive allosteric modulator, in nicotine-discriminating rats. | Mohler EG et al. | β | 2014 | β |
| Effects of adolescent nicotine exposure and withdrawal on intravenous cocaine self-administration during adulthood in male C57BL/6J mice. | Dickson PE et al. | β | 2014 | β |
| Effects of blockade of Ξ±4Ξ²2 and Ξ±7 nicotinic acetylcholine receptors on cue-induced reinstatement of nicotine-seeking behaviour in rats. | Liu X | β | 2014 | β |
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| Influence of disulfide connectivity on structure and bioactivity of Ξ±-conotoxin TxIA. | Wu Y et al. | β | 2014 | β |
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| Modulation of auditory deviance detection by acute nicotine is baseline and deviant dependent in healthy nonsmokers: a mismatch negativity study. | Knott V et al. | β | 2014 | β |
| Modulation of HCN channels in lateral septum by nicotine. | Kodirov SA et al. | β | 2014 | β |
| Mutations in PCYT1A cause spondylometaphyseal dysplasia with cone-rod dystrophy. | Yamamoto GL et al. | β | 2014 | β |
| Nicotine enhances excitability of medial habenular neurons via facilitation of neurokinin signaling. | Dao DQ et al. | β | 2014 | β |
| Nicotine increases impulsivity and decreases willingness to exert cognitive effort despite improving attention in "slacker" rats: insights into cholinergic regulation of cost/benefit decision making. | Hosking JG et al. | β | 2014 | β |
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| Nicotinic modulation of cortical circuits. | Arroyo S et al. | β | 2014 | β |
| Nicotinic receptor antagonists as treatments for nicotine abuse. | Crooks PA et al. | β | 2014 | β |
| Nicotinic receptor modulation to treat alcohol and drug dependence. | Rahman S et al. | β | 2014 | β |
| Optogenetic studies of nicotinic contributions to cholinergic signaling in the central nervous system. | Jiang L et al. | β | 2014 | β |
| Pharmacogenetics of nicotine addiction: role of dopamine. | Herman AI et al. | β | 2014 | β |
| Pozanicline for the treatment of attention-deficit/hyperactivity disorder. | Childress A et al. | β | 2014 | β |
| Preclinical pharmacology of amphetamine: implications for the treatment of neuropsychiatric disorders. | Hutson PH et al. | β | 2014 | β |
| Role of a genetic variant on the 15q25.1 lung cancer susceptibility locus in smoking-associated nasopharyngeal carcinoma. | Ji X et al. | β | 2014 | β |
| Role of nicotinic acetylcholine receptors in regulating dopamine neuron activity. | Faure P et al. | β | 2014 | β |
| Scientific overview: 2013 BBC plenary symposium on tobacco addiction. | De Biasi M et al. | β | 2014 | β |
| Selective ligand behaviors provide new insights into agonist activation of nicotinic acetylcholine receptors. | Marotta CB et al. | β | 2014 | β |
| Short-term plasticity and modulation of synaptic transmission at mammalian inhibitory cholinergic olivocochlear synapses. | Katz E et al. | β | 2014 | β |
| Spatiotemporal specificity in cholinergic control of neocortical function. | MuΓ±oz W et al. | β | 2014 | β |
| Subsynaptic localization of nicotinic acetylcholine receptor subunits: a comparative study in the mouse and rat striatum. | Garção P et al. | β | 2014 | β |
| Surface trafficking of NMDA receptors: gathering from a partner to another. | LadΓ©pΓͺche L et al. | β | 2014 | β |
| Targeting brain Ξ±7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status. | VallΓ©s AS et al. | β | 2014 | β |
| Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. | Wang L et al. | β | 2014 | β |
| The role of alpha-7 nicotinic receptors in food intake behaviors. | McFadden KL et al. | β | 2014 | β |
| The role of nicotinic receptors in shaping and functioning of the glutamatergic system: a window into cognitive pathology. | Molas S et al. | β | 2014 | β |
| Tracking the molecular evolution of calcium permeability in a nicotinic acetylcholine receptor. | Lipovsek M et al. | β | 2014 | β |
| Treadmill exercise ameliorates short-term memory disturbance in scopolamine-induced amnesia rats. | Heo YM et al. | β | 2014 | β |
| Varenicline and cytisine diminish the dysphoric-like state associated with spontaneous nicotine withdrawal in rats. | Igari M et al. | β | 2014 | β |
| Ξ±7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia. | Freedman R | β | 2014 | β |
| ACR-12 ionotropic acetylcholine receptor complexes regulate inhibitory motor neuron activity in Caenorhabditis elegans. | Petrash HA et al. | β | 2013 | β |
| Activation of Ξ±7-containing nicotinic receptors on astrocytes triggers AMPA receptor recruitment to glutamatergic synapses. | Wang X et al. | β | 2013 | β |
| Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities. | Still PC et al. | β | 2013 | β |
| Alpha7 neuronal nicotinic receptors as a drug target in schizophrenia. | Wallace TL et al. | β | 2013 | β |
| Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. | Cohen A et al. | β | 2013 | β |
| A novel differential susceptibility gene: CHRNA4 and moderation of the effect of maltreatment on child personality. | Grazioplene RG et al. | β | 2013 | β |
| Are nicotinic acetylcholine receptors coupled to G proteins? | Kabbani N et al. | β | 2013 | β |
| A tale of two receptors: Dual roles for ionotropic acetylcholine receptors in regulating motor neuron excitation and inhibition. | Philbrook A et al. | β | 2013 | β |
| AΞ² impairs nicotinic regulation of inhibitory synaptic transmission and interneuron excitability in prefrontal cortex. | Chen GJ et al. | β | 2013 | β |
| Biogenesis, trafficking and up-regulation of nicotinic ACh receptors. | Colombo SF et al. | β | 2013 | β |
| Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons. | Sun YG et al. | β | 2013 | β |
| Born to Lead? A Twin Design and Genetic Association Study of Leadership Role Occupancy. | De Neve JE et al. | β | 2013 | β |
| Brain nitric oxide metabolites in rats preselected for nicotine preference and intake. | Keser A et al. | β | 2013 | β |
| Butyrylcholinesterase genotype and gender influence Alzheimer's disease phenotype. | Lane RM et al. | β | 2013 | β |
| CC4, a dimer of cytisine, is a selective partial agonist at Ξ±4Ξ²2/Ξ±6Ξ²2 nAChR with improved selectivity for tobacco smoking cessation. | Sala M et al. | β | 2013 | β |
| Cholinergic modulation of hippocampal network function. | Teles-Grilo Ruivo LM et al. | β | 2013 | β |
| Cholinergic receptors: functional role of nicotinic ACh receptors in brain circuits and disease. | Yakel JL | β | 2013 | β |
| Choline transporter hemizygosity results in diminished basal extracellular dopamine levels in nucleus accumbens and blunts dopamine elevations following cocaine or nicotine. | Dong Y et al. | β | 2013 | β |
| Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry. | Wang JC et al. | β | 2013 | β |
| Co-activation of VTA DA and GABA neurons mediates nicotine reinforcement. | Tolu S et al. | β | 2013 | β |
| Derivatives of dibenzothiophene for positron emission tomography imaging of Ξ±7-nicotinic acetylcholine receptors. | Gao Y et al. | β | 2013 | β |
| Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. | Yi B et al. | β | 2013 | β |
| Effects of chronic sazetidine-A, a selective Ξ±4Ξ²2 neuronal nicotinic acetylcholine receptors desensitizing agent on pharmacologically-induced impaired attention in rats. | Rezvani AH et al. | β | 2013 | β |
| Effects of maternally exposed coloring food additives on receptor expressions related to learning and memory in rats. | Ceyhan BM et al. | β | 2013 | β |
| Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia. | Young JW et al. | β | 2013 | β |
| Free energy, precision and learning: the role of cholinergic neuromodulation. | Moran RJ et al. | β | 2013 | β |
| Gating of long-term potentiation by nicotinic acetylcholine receptors at the cerebellum input stage. | Prestori F et al. | β | 2013 | β |
| High density of nicotinic receptors in the cingulo-insular network. | Picard F et al. | β | 2013 | β |
| How cigarette smoking may increase the risk of anxiety symptoms and anxiety disorders: a critical review of biological pathways. | Moylan S et al. | β | 2013 | β |
| Impact of sustained exposure to Ξ²-amyloid on calcium homeostasis and neuronal integrity in model nerve cell system expressing Ξ±4Ξ²2 nicotinic acetylcholine receptors. | Arora K et al. | β | 2013 | β |
| Impacts of chronic low-level nicotine exposure on Caenorhabditis elegans reproduction: identification of novel gene targets. | Smith MA et al. | β | 2013 | β |
| Importance of the nicotinic acetylcholine receptor system in the prefrontal cortex. | Wallace TL et al. | β | 2013 | β |
| Interactions between mecamylamine and alcohol in Long-Evans rats: flash-evoked potentials, body temperature, behavior, and blood alcohol concentration. | Hetzler BE et al. | β | 2013 | β |
| Interactions between the neuromodulatory systems and the amygdala: exploratory survey using the Allen Mouse Brain Atlas. | Zaldivar A et al. | β | 2013 | β |
| Involvement of dorsal hippocampal and medial septal nicotinic receptors in cross state-dependent memory between WIN55, 212-2 and nicotine or ethanol in mice. | Alijanpour S et al. | β | 2013 | β |
| Involvement of the Ξ±7-nicotinic acetylcholine receptors in the anti-inflammatory action of the thymulin-related peptide (PAT). | Safieh-Garabedian B et al. | β | 2013 | β |
| Kynurenic acid, by targeting Ξ±7 nicotinic acetylcholine receptors, modulates extracellular GABA levels in the rat striatum in vivo. | Beggiato S et al. | β | 2013 | β |
| Lidocaine effects on acetylcholine-elicited currents from mouse superior cervical ganglion neurons. | Alberola-Die A et al. | β | 2013 | β |
| Long term alterations in synaptic physiology, expression of Ξ²2 nicotinic receptors and ERK1/2 signaling in the hippocampus of rats with prenatal nicotine exposure. | Parameshwaran K et al. | β | 2013 | β |
| Molecular Neurobiology of Depression: PET Findings on the Elusive Correlation with Symptom Severity. | Smith DF et al. | β | 2013 | β |
| Neuronal nicotinic acetylcholine receptors: common molecular substrates of nicotine and alcohol dependence. | Hendrickson LM et al. | β | 2013 | β |
| Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. | Zhong C et al. | β | 2013 | β |
| Nicotine levels after IV nicotine and cigarette smoking in men. | Mello NK et al. | β | 2013 | β |
| Nicotine related brain activity: the influence of smoking history and blood nicotine levels, an exploratory study. | Yamamoto RT et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors contribute to learning-induced metaplasticity in the hippocampus. | Becker B et al. | β | 2013 | β |
| Nicotinic acetylcholine receptors: from basic science to therapeutics. | Hurst R et al. | β | 2013 | β |
| Nicotinic modulation of serotonergic activity in the dorsal raphe nucleus. | Hernandez-Lopez S et al. | β | 2013 | β |
| Nicotinic receptors in addiction pathways. | Leslie FM et al. | β | 2013 | β |
| Physical and virtual screening methods for marine toxins and drug discovery targeting nicotinic acetylcholine receptors. | MolgΓ³ J et al. | β | 2013 | β |
| Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines. | Isaacson MD et al. | β | 2013 | β |
| Potential substrates for nicotine and alcohol interactions: a focus on the mesocorticolimbic dopamine system. | Doyon WM et al. | β | 2013 | β |
| Potential therapeutic uses of mecamylamine and its stereoisomers. | Nickell JR et al. | β | 2013 | β |
| Reducing cannabinoid abuse and preventing relapse by enhancing endogenous brain levels of kynurenic acid. | Justinova Z et al. | β | 2013 | β |
| Regulation of glutamate release by heteromeric nicotinic receptors in layer V of the secondary motor region (Fr2) in the dorsomedial shoulder of prefrontal cortex in mouse. | Aracri P et al. | β | 2013 | β |
| Selective potentiation of (Ξ±4)3(Ξ²2)2 nicotinic acetylcholine receptors augments amplitudes of prefrontal acetylcholine- and nicotine-evoked glutamatergic transients in rats. | Grupe M et al. | β | 2013 | β |
| Species-dependent metabolism of a novel selective Ξ±7 neuronal acetylcholine receptor agonist ABT-107. | Liu H et al. | β | 2013 | β |
| Stoichiometry for activation of neuronal Ξ±7 nicotinic receptors. | Andersen N et al. | β | 2013 | β |
| Structure activity relationship of synaptic and junctional neurotransmission. | Goyal RK et al. | β | 2013 | β |
| Targeting alpha-7 nicotinic neurotransmission in schizophrenia: a novel agonist strategy. | Deutsch SI et al. | β | 2013 | β |
| The potential of nicotinic enhancement of cognitive remediation training in schizophrenia. | Hahn B et al. | β | 2013 | β |
| The shared role of oxidative stress and inflammation in major depressive disorder and nicotine dependence. | Nunes SO et al. | β | 2013 | β |
| Top-down beta rhythms support selective attention via interlaminar interaction: a model. | Lee JH et al. | β | 2013 | β |
| Unraveling the neurobiology of nicotine dependence using genetically engineered mice. | Stoker AK et al. | β | 2013 | β |
| ZY-1, a novel nicotinic analog, promotes proliferation and migration of adult hippocampal neural stem/progenitor cells. | He N et al. | β | 2013 | β |
| Ξ±7-Containing nicotinic acetylcholine receptors on interneurons of the basolateral amygdala and their role in the regulation of the network excitability. | Pidoplichko VI et al. | β | 2013 | β |
| Acetylcholine receptors enable the transport of rapsyn from the Golgi complex to the plasma membrane. | Park JY et al. | β | 2012 | β |
| Alpha7 nicotinic cholinergic neuromodulation may reconcile multiple neurotransmitter hypotheses of schizophrenia. | Bencherif M et al. | β | 2012 | β |
| Amyloid-Ξ² depresses excitatory cholinergic synaptic transmission in Drosophila. | Fang L et al. | β | 2012 | β |
| An interaction between Ξ±7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells. | Nordman JC et al. | β | 2012 | β |
| A novel Ξ±-conotoxin MII-sensitive nicotinic acetylcholine receptor modulates [(3) H]-GABA release in the superficial layers of the mouse superior colliculus. | McClure-Begley TD et al. | β | 2012 | β |
| Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72. | Pandhare A et al. | β | 2012 | β |
| Chaperoning Ξ±7 neuronal nicotinic acetylcholine receptors. | VallΓ©s AS et al. | β | 2012 | β |
| Cholinergic coordination of presynaptic and postsynaptic activity induces timing-dependent hippocampal synaptic plasticity. | Gu Z et al. | β | 2012 | β |
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| Presynaptic targeting of alpha4beta 2 nicotinic acetylcholine receptors is regulated by neurexin-1beta. | Cheng SB et al. | β | 2009 | β |
| Primary sensory neuronal expression of SLURP-1, an endogenous nicotinic acetylcholine receptor ligand. | Moriwaki Y et al. | β | 2009 | β |
| Proteomic analysis of an alpha7 nicotinic acetylcholine receptor interactome. | Paulo JA et al. | β | 2009 | β |
| Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. | Wang JC et al. | β | 2009 | β |
| Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes. | Sydserff S et al. | β | 2009 | β |
| Structural and functional diversity of native brain neuronal nicotinic receptors. | Gotti C et al. | β | 2009 | β |
| Structural basis for alpha-conotoxin potency and selectivity. | Turner M et al. | β | 2009 | β |
| Synaptic plasticity within midbrain dopamine centers contributes to nicotine addiction. | Placzek AN et al. | β | 2009 | β |
| Synthesis of H-bonding probes of alpha7 nAChR agonist selectivity. | Wang J et al. | β | 2009 | β |
| Targeting reward-relevant nicotinic receptors in the discovery of novel pharmacotherapeutic agents to treat tobacco dependence. | Dwoskin LP et al. | β | 2009 | β |
| TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia. | Hauser TA et al. | β | 2009 | β |
| The dynamic effects of nicotine on the developing brain. | Dwyer JB et al. | β | 2009 | β |
| The impact of cigarette smoking on stimulant addiction. | Weinberger AH et al. | β | 2009 | β |
| The novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked [(3)H]norepinephrine overflow from rat hippocampal slices. | Smith AM et al. | β | 2009 | β |
| [11C]CHIBA-1001 as a novel PET ligand for alpha7 nicotinic receptors in the brain: a PET study in conscious monkeys. | Hashimoto K et al. | β | 2008 | β |
| 3'-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for alpha4beta2 versus alpha3beta4 nAChRs. | Abdrakhmanova GR et al. | β | 2008 | β |
| [3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain. | Anderson DJ et al. | β | 2008 | β |
| Acetylcholine receptors in dementia and mild cognitive impairment. | Sabri O et al. | β | 2008 | β |
| Adenomatous polyposis coli plays a key role, in vivo, in coordinating assembly of the neuronal nicotinic postsynaptic complex. | Rosenberg MM et al. | β | 2008 | β |
| Allosteric modulation of alpha 7 nicotinic receptors selectively depolarizes hippocampal interneurons, enhancing spontaneous GABAergic transmission. | Arnaiz-Cot JJ et al. | β | 2008 | β |
| Allosteric modulators of the alpha7 nicotinic acetylcholine receptor. | Faghih R et al. | β | 2008 | β |
| Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. | Shao XM et al. | β | 2008 | β |
| Amino acid residues that confer high selectivity of the alpha6 nicotinic acetylcholine receptor subunit to alpha-conotoxin MII[S4A,E11A,L15A]. | Azam L et al. | β | 2008 | β |
| A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence. | Grucza RA et al. | β | 2008 | β |
| Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. | Lee J et al. | β | 2008 | β |
| Behavioral sequence analysis reveals a novel role for beta2* nicotinic receptors in exploration. | Maubourguet N et al. | β | 2008 | β |
| Brain regions mediating alpha3beta4 nicotinic antagonist effects of 18-MC on methamphetamine and sucrose self-administration. | Glick SD et al. | β | 2008 | β |
| Cholinergic mediation of attention: contributions of phasic and tonic increases in prefrontal cholinergic activity. | Parikh V et al. | β | 2008 | β |
| Chronic nicotine alters nicotinic receptor-induced presynaptic Ca2+ responses in isolated nerve terminals. | Dougherty JJ et al. | β | 2008 | β |
| Crystal structures of Lymnaea stagnalis AChBP in complex with neonicotinoid insecticides imidacloprid and clothianidin. | Ihara M et al. | β | 2008 | β |
| Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons. | RΓ³zsa B et al. | β | 2008 | β |
| Different oxidative profile and nicotinic receptor interaction of amphetamine and 3,4-methylenedioxy-methamphetamine. | Chipana C et al. | β | 2008 | β |
| Effects of galantamine on measures of attention: results from 2 clinical trials in Alzheimer disease patients with comparisons to donepezil. | Galvin JE et al. | β | 2008 | β |
| Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes. | Butt C et al. | β | 2008 | β |
| Epibatidine application in vitro blocks retinal waves without silencing all retinal ganglion cell action potentials in developing retina of the mouse and ferret. | Sun C et al. | β | 2008 | β |
| Four excitatory postsynaptic ionotropic receptors coactivated at the motoneuron-Renshaw cell synapse. | Lamotte d'Incamps B et al. | β | 2008 | β |
| Glutamatergic contributions to nicotinic acetylcholine receptor agonist-evoked cholinergic transients in the prefrontal cortex. | Parikh V et al. | β | 2008 | β |
| High affinity binding of epibatidine to serotonin type 3 receptors. | Drisdel RC et al. | β | 2008 | β |
| Influence of neuronal nicotinic receptors over nicotine addiction and withdrawal. | De Biasi M et al. | β | 2008 | β |
| In vivo measurement of nicotinic acetylcholine receptors with [18F]norchloro-fluoro-homoepibatidine. | Brust P et al. | β | 2008 | β |
| Long-term nicotine treatment differentially regulates striatal alpha6alpha4beta2* and alpha6(nonalpha4)beta2* nAChR expression and function. | Perez XA et al. | β | 2008 | β |
| Maternal tobacco smoking, nicotine replacement and neurobehavioural development. | Pauly JR et al. | β | 2008 | β |
| Mitochondrial reactive oxygen species inactivate neuronal nicotinic acetylcholine receptors and induce long-term depression of fast nicotinic synaptic transmission. | Campanucci VA et al. | β | 2008 | β |
| Nicotine and brain development. | Dwyer JB et al. | β | 2008 | β |
| Nicotine and ethanol interact during adolescence: effects on the central cholinergic systems. | Ribeiro-Carvalho A et al. | β | 2008 | β |
| Nicotine and Parkinson's disease: implications for therapy. | Quik M et al. | β | 2008 | β |
| NMDA receptor blockade augmented nicotine-evoked dopamine release from rat prefrontal cortex slices. | Rodvelt KR et al. | β | 2008 | β |
| Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia. | Severance EG et al. | β | 2008 | β |
| Oscillatory bands, neuronal synchrony and hippocampal function: implications of the effects of prenatal choline supplementation for sleep-dependent memory consolidation. | Cheng RK et al. | β | 2008 | β |
| Pharmacological characterization of (S)-(2)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine HCl (SIB-1508Y, Altinicline), a novel nicotinic acetylcholine receptor agonist. | Rao TS et al. | β | 2008 | β |
| Positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor: ligand interactions with distinct binding sites and evidence for a prominent role of the M2-M3 segment. | Bertrand D et al. | β | 2008 | β |
| Presynaptic nicotinic receptors: a dynamic and diverse cholinergic filter of striatal dopamine neurotransmission. | Exley R et al. | β | 2008 | β |
| Pudendal motoneurons of the rat located in separated spinal nuclei possess nicotinic acetylcholine receptors having distinct pharmacological profiles. | Ogier R et al. | β | 2008 | β |
| Recurrent inhibitory network among striatal cholinergic interneurons. | Sullivan MA et al. | β | 2008 | β |
| RIC-3: a nicotinic acetylcholine receptor chaperone. | Millar NS | β | 2008 | β |
| Role of the glutamatergic system in nicotine dependence : implications for the discovery and development of new pharmacological smoking cessation therapies. | Liechti ME et al. | β | 2008 | β |
| Structural answers and persistent questions about how nicotinic receptors work. | Wells GB | β | 2008 | β |
| The endocannabinoid system: a new molecular target for the treatment of tobacco addiction. | Scherma M et al. | β | 2008 | β |
| The marine phycotoxin gymnodimine targets muscular and neuronal nicotinic acetylcholine receptor subtypes with high affinity. | Kharrat R et al. | β | 2008 | β |
| The neuronal nicotinic acetylcholine receptors alpha 4* and alpha 6* differentially modulate dopamine release in mouse striatal slices. | Meyer EL et al. | β | 2008 | β |
| The potential of neuronal nicotinic acetylcholine receptor agonists for treating CNS conditions. | Decker MW et al. | β | 2008 | β |
| Age-dependent changes in the functional expression of two nicotinic receptor subtypes in CA1 stratum radiatum interneurons in the rat hippocampus. | Alkondon M et al. | β | 2007 | β |
| Allosteric modulation of nicotinic acetylcholine receptors. | Bertrand D et al. | β | 2007 | β |
| Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women. | Wojna V et al. | β | 2007 | β |
| Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors. | Kozikowski AP et al. | β | 2007 | β |
| Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. | Terry AV et al. | β | 2007 | β |
| Chronic nicotine cell specifically upregulates functional alpha 4* nicotinic receptors: basis for both tolerance in midbrain and enhanced long-term potentiation in perforant path. | Nashmi R et al. | β | 2007 | β |
| Dendritic Ca2+ signalling due to activation of alpha 7-containing nicotinic acetylcholine receptors in rat hippocampal neurons. | Fayuk D et al. | β | 2007 | β |
| Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD). | Dwoskin LP et al. | β | 2007 | β |
| Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes. | GrΓΈnlien JH et al. | β | 2007 | β |
| Diverse inhibitory actions of quaternary ammonium cholinesterase inhibitors on Torpedo nicotinic ACh receptors transplanted to Xenopus oocytes. | Olivera-Bravo S et al. | β | 2007 | β |
| Effects of chronic neonatal nicotine exposure on nicotinic acetylcholine receptor binding, cell death and morphology in hippocampus and cerebellum. | Huang LZ et al. | β | 2007 | β |
| Exposure to nicotine and sensitization of nicotine-induced behaviors. | Vezina P et al. | β | 2007 | β |
| Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors. | Kobayashi S et al. | β | 2007 | β |
| Flexible synthetic routes to poison-frog alkaloids of the 5,8-disubstituted indolizidine-class I: synthesis of common lactam chiral building blocks and application to the synthesis of (-)-203A, (-)-205A, and (-)-219F. | Toyooka N et al. | β | 2007 | β |
| Heterogeneity and complexity of native brain nicotinic receptors. | Gotti C et al. | β | 2007 | β |
| Is too much inhibition to blame in autosomal dominant nocturnal frontal lobe epilepsy? | Mathews GC | β | 2007 | β |
| Neuronal nicotinic receptors: a perspective on two decades of drug discovery research. | Arneric SP et al. | β | 2007 | β |
| Nicotine neuroprotection against nigrostriatal damage: importance of the animal model. | Quik M et al. | β | 2007 | β |
| Nicotine reduces levodopa-induced dyskinesias in lesioned monkeys. | Quik M et al. | β | 2007 | β |
| Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse. | Solinas M et al. | β | 2007 | β |
| Nicotinic receptor-mediated biphasic effect on neuronal excitability in chick lateral spiriform neurons. | Liu YB et al. | β | 2007 | β |
| Nicotinic receptors as CNS targets for Parkinson's disease. | Quik M et al. | β | 2007 | β |
| Nicotinic receptors as targets for therapeutic discovery. | Lippiello P et al. | β | 2007 | β |
| Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. | Hamurtekin E et al. | β | 2007 | β |
| Potentiation of the nicotinic acetylcholine receptor by aluminum in mammalian neurons. | Hu WP et al. | β | 2007 | β |
| Regulation of synaptic transmission and plasticity by neuronal nicotinic acetylcholine receptors. | McKay BE et al. | β | 2007 | β |
| Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors. | Toyooka N et al. | β | 2007 | β |
| Targeting the alpha9alpha10 nicotinic acetylcholine receptor to treat severe pain. | Vincler M et al. | β | 2007 | β |
| The endocannabinoid anandamide inhibits the function of alpha4beta2 nicotinic acetylcholine receptors. | Spivak CE et al. | β | 2007 | β |
| The role of the hippocampus in mediating emotional responses to nicotine and cannabinoids: a possible neural substrate for functional interactions. | Viveros MP et al. | β | 2007 | β |
| The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum. | Grady SR et al. | β | 2007 | β |
| Translational research in medication development for nicotine dependence. | Lerman C et al. | β | 2007 | β |