Impulsive choice as a predictor of acquisition of IV cocaine self- administration and reinstatement of cocaine-seeking behavior in male and female rats.
paper
Cited
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- Authors
- Perry, Jennifer L; Nelson, Sarah E; Carroll, Marilyn E
- Year
- 2008
- Journal
- Experimental and clinical psychopharmacology
- PMID
- 18489020
- DOI
- 10.1037/1064-1297.16.2.165
Drug abuse and impulsive choice are related in humans. In female rats, impulsive choice predicted the rate of acquisition of IV cocaine self-administration. The objectives of the present experiments were to: (a) compare impulsive choice in males and females, (b) extend previous research on impulsive choice and acquisition of cocaine self-administration to males, and (c) compare males and females during maintenance, extinction, and reinstatement of cocaine-seeking behavior. Male and female rats were trained on an adjusting delay task in which a response on one of two levers yielded one food pellet immediately, and a response on the other resulted in three pellets after an adjusting delay that decreased after responses on the immediate lever and increased after responses on the delay lever. A mean adjusted delay (MAD) was used as the quantitative measure of impulsivity. In Experiment 1, MADs were analyzed for sex differences. In Experiment 2, acquisition of cocaine self-administration was examined in rats selected for high (HiI; MADs < or =9 seconds) or low (LoI; MADs > or =13 seconds) impulsivity. In Experiment 3, HiI and LoI groups were compared on maintenance and extinction of cocaine self-administration and cocaine-primed reinstatement of drug-seeking behavior. There were no sex differences in impulsive choice; however, HiI male and female rats acquired cocaine self-administration faster than their LoI counterparts. LoI females responded more on a cocaine-associated lever during maintenance and extinction than HiI females, but HiI females showed greater reinstatement of cocaine-seeking behavior than all other groups at the highest dose tested (15 mg/kg). Thus, individual differences in impulsive choice were associated with differences in cocaine-seeking behavior. Impulsive choice and sex may be additive vulnerability factors in certain phases of drug abuse.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
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| Repeated footshock stress enhances cocaine self-administration in male and female rats: Role of the cannabinoid receptor 1. | Gaulden AD et al. | — | 2025 | → |
| Using sign tracking to experimentally increase self-control in rats. | Mahmoudi S et al. | — | 2024 | → |
| Are There Prevalent Sex Differences in Psychostimulant Use Disorder? A Focus on the Potential Therapeutic Efficacy of Atypical Dopamine Uptake Inhibitors. | Hersey M et al. | — | 2023 | → |
| Cognitive mechanisms underlying decision making involving risk of explicit punishment in male and female rats. | Truckenbrod LM et al. | — | 2023 | → |
| Divergent risky decision-making and impulsivity behaviors in Lewis rat substrains with low genetic difference. | Gabriel DBK et al. | — | 2023 | → |
| Motor impulsivity but not risk-related impulsive choice is associated to drug intake and drug-primed relapse. | Arrondeau C et al. | — | 2023 | → |
| Sex differences in addiction-relevant behavioral outcomes in rodents following early life stress. | Rincón-Cortés M | — | 2023 | → |
| Adolescent reinforcement-learning trajectories predict cocaine-taking behaviors in adult male and female rats. | Villiamma P et al. | — | 2022 | → |
| Behavioral phenotypes revealed during reversal learning are linked with novel genetic loci in diversity outbred mice. | Bagley JR et al. | — | 2022 | → |
| Effects of immediate-reinforcement training on delay discounting behavior in rats. | Fox AE | — | 2022 | → |
| Examining the effects of psychoactive drugs on complex behavioral processes in laboratory animals. | Kangas BD | — | 2022 | → |
| Interactions between impulsivity and MDPV self-administration in rats. | Abbott MS et al. | — | 2022 | → |
| Reinforcement learning detuned in addiction: integrative and translational approaches. | Groman SM et al. | — | 2022 | → |
| Reversal Learning Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice | Bagley JR et al. | — | 2022 | — |
| Bidirectional causality between addiction and cognitive deficits. | Melugin PR et al. | — | 2021 | → |
| Effects of a high-fat diet on impulsive choice in rats. | Garman TS et al. | — | 2021 | → |
| Reducing impulsive choice VII: effects of duration of delay-exposure training. | Renda CR et al. | — | 2021 | → |
| Spontaneously Hypertensive Rat substrains show differences in model traits for addiction risk and cocaine self-administration: Implications for a novel rat reduced complexity cross. | Kantak KM et al. | — | 2021 | → |
| Unlocking the reinforcement-learning circuits of the orbitofrontal cortex. | Groman SM et al. | — | 2021 | → |
| A time-based intervention to treat impulsivity in male and female rats. | Panfil K et al. | — | 2020 | → |
| Distinct relationships between risky decision making and cocaine self-administration under short- and long-access conditions. | Orsini CA et al. | — | 2020 | → |
| Effects of the GluN2B antagonist, Ro 25-6981, on extinction consolidation following adolescent- or adult-onset methamphetamine self-administration in male and female rats. | Westbrook SR et al. | — | 2020 | → |
| High trait impulsivity potentiates the effects of chronic pain on impulsive behavior. | Cunha AM et al. | — | 2020 | → |
| Impaired decision making following escalation of cocaine self-administration predicts vulnerability to relapse in rats. | Cocker PJ et al. | — | 2020 | → |
| Sex differences in impulsivity in adult rats are mediated by organizational actions of neonatal gonadal hormones and not by hormones acting at puberty or in adulthood. | Darling JS et al. | — | 2020 | → |
| Testicular hormones mediate robust sex differences in impulsive choice in rats. | Hernandez CM et al. | — | 2020 | → |
| The role of impulsivity as predisposing behavioural trait in different aspects of alcohol self-administration in rats. | Pattij T et al. | — | 2020 | → |
| Alternation in dopamine D<sub>2</sub>-like and metabotropic glutamate type 5 receptor density caused by differing housing conditions during abstinence from cocaine self-administration in rats. | Frankowska M et al. | — | 2019 | → |
| Changing Delay Discounting and Impulsive Choice: Implications for Addictions, Prevention, and Human Health. | Rung JM et al. | — | 2019 | → |
| Interventions aimed at changing impulsive choice in rats: Effects of immediate and relatively long delay to reward training. | Fox AE et al. | — | 2019 | → |
| Kappa opioid receptors mediate yohimbine-induced increases in impulsivity in the 5-choice serial reaction time task. | Funk D et al. | — | 2019 | → |
| The neurobiology of impulsivity and substance use disorders: implications for treatment. | Kozak K et al. | — | 2019 | → |
| Dissecting drug effects in preclinical models of impulsive choice: emphasis on glutamatergic compounds. | Yates JR | — | 2018 | → |
| Durability and generalizability of time-based intervention effects on impulsive choice in rats. | Bailey C et al. | — | 2018 | → |
| Effects of GluN2B-selective antagonists on delay and probability discounting in male rats: Modulation by delay/probability presentation order. | Yates JR et al. | — | 2018 | → |
| Impulsive choice and pre-exposure to delays: iv. effects of delay- and immediacy-exposure training relative to maturational changes in impulsivity. | Renee Renda C et al. | — | 2018 | → |
| Impulsive choice does not predict binge-like eating in rats. | Moore CF et al. | — | 2018 | → |
| Individual decision-making in the causal pathway to addiction: contributions and limitations of rodent models. | Ahmed SH | — | 2018 | → |
| Sex Differences in Context-Driven Reinstatement of Methamphetamine Seeking is Associated with Distinct Neuroadaptations in the Dentate Gyrus. | Takashima Y et al. | — | 2018 | → |
| Shaping vulnerability to addiction - the contribution of behavior, neural circuits and molecular mechanisms. | Egervari G et al. | — | 2018 | → |
| Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability. | Miller ML et al. | — | 2018 | → |
| Working memory and salivary brain-derived neurotrophic factor as developmental predictors of cocaine seeking in male and female rats. | Jordan CJ et al. | — | 2018 | → |
| Cocaine administration dose-dependently increases sexual desire and decreases condom use likelihood: The role of delay and probability discounting in connecting cocaine with HIV. | Johnson MW et al. | — | 2017 | → |
| Contribution of Impulsivity and Serotonin Receptor Neuroadaptations to the Development of an MDMA ('Ecstasy') Substance Use Disorder. | Schenk S et al. | — | 2017 | → |
| RETRACTED ARTICLE: A Clock mutation enhances light-phase responsiveness to cocaine in locomotor activity and self-administration with impulsive-like responding in mice. | Meng H et al. | — | 2017 | → |
| Risk-preferring rats make worse decisions and show increased incubation of craving after cocaine self-administration. | Ferland JN et al. | — | 2017 | → |
| Sex differences in animal models of decision making. | Orsini CA et al. | — | 2017 | → |
| Cocaine self-administration and reinstatement in female rats selectively bred for high and low voluntary running. | Smethells JR et al. | — | 2016 | → |
| Effect of daily morphine administration and its discontinuation on delay discounting of food in rhesus monkeys. | Maguire DR et al. | — | 2016 | → |
| Impulsive choice and pre-exposure to delays: III. Four-month test-retest outcomes in male wistar rats. | Renda CR et al. | — | 2016 | → |
| In search of predictive endophenotypes in addiction: insights from preclinical research. | Belin D et al. | — | 2016 | → |
| The effects of physical activity on impulsive choice: Influence of sensitivity to reinforcement amount and delay. | Strickland JC et al. | — | 2016 | → |
| Translatable and Back-Translatable Measurement of Impulsivity and Compulsivity: Convergent and Divergent Processes. | Voon V et al. | — | 2016 | → |
| Cocaine choice procedures in animals, humans, and treatment-seekers: Can we bridge the divide? | Moeller SJ et al. | — | 2015 | → |
| Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs. | Ozburn AR et al. | — | 2015 | → |
| Delay discounting and the use of mindful attention versus distraction in the treatment of drug addiction: a conceptual review. | Ashe ML et al. | — | 2015 | → |
| Delay discounting of food by rhesus monkeys: Cocaine and food choice in isomorphic and allomorphic situations. | Huskinson SL et al. | — | 2015 | → |
| Discrepant effects of acute cocaine on impulsive choice (delay discounting) in female rats during an increasing- and adjusting-delay procedure. | Smethells JR et al. | — | 2015 | → |
| Dopaminergic function and intertemporal choice. | Joutsa J et al. | — | 2015 | → |
| Early life stress produces compulsive-like, but not impulsive, behavior in females. | Brydges NM et al. | — | 2015 | → |
| Effects of the combination of wheel running and atomoxetine on cue- and cocaine-primed reinstatement in rats selected for high or low impulsivity. | Zlebnik NE et al. | — | 2015 | → |
| Experimental manipulations of delay discounting & related processes: an introduction to the special issue. | Bickel WK et al. | — | 2015 | → |
| Impaired Bayesian learning for cognitive control in cocaine dependence. | Ide JS et al. | — | 2015 | → |
| Importance of sex differences in impulse control and addictions. | Mitchell MR et al. | — | 2015 | → |
| Impulsive choice, alcohol consumption, and pre-exposure to delayed rewards: II. Potential mechanisms. | Stein JS et al. | — | 2015 | → |
| Irrational beliefs, biases and gambling: exploring the role of animal models in elucidating vulnerabilities for the development of pathological gambling. | Cocker PJ et al. | — | 2015 | → |
| Neural processing of reward in adolescent rodents. | Simon NW et al. | — | 2015 | → |
| Sex Differences in Behavioral Dyscontrol: Role in Drug Addiction and Novel Treatments. | Carroll ME et al. | — | 2015 | → |
| Sex Differences in the Reinstatement of Methamphetamine Seeking after Forced Abstinence in Sprague-Dawley Rats. | Ruda-Kucerova J et al. | — | 2015 | → |
| Subchronic administration of atomoxetine causes an enduring reduction in context-induced relapse to cocaine seeking without affecting impulsive decision making. | Broos N et al. | — | 2015 | → |
| Working-memory training: effects on delay discounting in male Long Evans rats. | Renda CR et al. | — | 2015 | → |
| Adolescent risk taking, cocaine self-administration, and striatal dopamine signaling. | Mitchell MR et al. | — | 2014 | → |
| Age and sex differences in reward behavior in adolescent and adult rats. | Hammerslag LR et al. | — | 2014 | → |
| Cocaine-, caffeine-, and stress-evoked cocaine reinstatement in high vs. low impulsive rats: treatment with allopregnanolone. | Regier PS et al. | — | 2014 | → |
| Connecting the pathology of posttraumatic stress and substance use disorders: monoamines and neuropeptides. | Enman NM et al. | — | 2014 | → |
| Individual differences in cocaine addiction: maladaptive behavioural traits. | Homberg JR et al. | — | 2014 | → |
| Intake-dependent effects of cocaine self-administration on impulsive choice in a delay discounting task. | Mitchell MR et al. | — | 2014 | → |
| Role of medial prefrontal and orbitofrontal monoamine transporters and receptors in performance in an adjusting delay discounting procedure. | Yates JR et al. | — | 2014 | → |
| Sex differences in impulsive action and impulsive choice. | Weafer J et al. | — | 2014 | → |
| The behavioral- and neuro-economic process of temporal discounting: A candidate behavioral marker of addiction. | Bickel WK et al. | — | 2014 | → |
| White problem gamblers discount delayed rewards less steeply than their African American and Hispanic counterparts. | Andrade LF et al. | — | 2014 | → |
| A multistep general theory of transition to addiction. | Piazza PV et al. | — | 2013 | → |
| Cocaine self-administration punished by i.v. histamine in rat models of high and low drug abuse vulnerability: effects of saccharin preference, impulsivity, and sex. | Holtz NA et al. | — | 2013 | → |
| Early and prolonged exposure to reward delay: effects on impulsive choice and alcohol self-administration in male rats. | Stein JS et al. | — | 2013 | → |
| Effects of acute and sub-chronic nicotine on impulsive choice in rats in a probabilistic delay-discounting task. | Kelsey JE et al. | — | 2013 | → |
| Escalation of drug self-administration as a hallmark of persistent addiction liability. | Edwards S et al. | — | 2013 | → |
| Individual differences and social influences on the neurobehavioral pharmacology of abused drugs. | Bardo MT et al. | — | 2013 | → |
| Inhibition and impulsivity: behavioral and neural basis of response control. | Bari A et al. | — | 2013 | → |
| Methamphetamine-induced increases in putamen gray matter associate with inhibitory control. | Groman SM et al. | — | 2013 | → |
| Personality and the acute subjective effects of d-amphetamine in humans. | Kirkpatrick MG et al. | — | 2013 | → |
| Prefrontal cortical-striatal dopamine receptor mRNA expression predicts distinct forms of impulsivity. | Simon NW et al. | — | 2013 | → |
| The effects of alcohol problems and smoking on delay discounting in individuals with gambling problems. | Andrade LF et al. | — | 2013 | → |
| The role of impulsivity in relapse vulnerability. | Pattij T et al. | — | 2013 | → |
| Age-related differences in impulsivity among adolescent and adult Sprague-Dawley rats. | Doremus-Fitzwater TL et al. | — | 2012 | → |
| Characterization of a semi-rapid method for assessing delay discounting in rodents. | Foscue EP et al. | — | 2012 | → |
| Cocaine hydrolase encoded in viral vector blocks the reinstatement of cocaine seeking in rats for 6 months. | Anker JJ et al. | — | 2012 | → |
| Cocaine-induced c-Fos expression in rats selectively bred for high or low saccharin intake and in rats selected for high or low impulsivity. | Regier PS et al. | — | 2012 | → |
| Cognitive control and the dopamine D₂-like receptor: a dimensional understanding of addiction. | Groman SM et al. | — | 2012 | → |
| Delay discounting in Lewis and Fischer 344 rats: steady-state and rapid-determination adjusting-amount procedures. | Stein JS et al. | — | 2012 | → |
| High impulsivity in rats predicts amphetamine conditioned place preference. | Yates JR et al. | — | 2012 | → |
| Impulsivity and drugs of abuse: a juice-reinforced operant procedure for determining within-session delay discounting functions in rhesus monkeys. | Maguire DR et al. | — | 2012 | → |
| Interactions between deliberation and delay-discounting in rats. | Papale AE et al. | — | 2012 | → |
| Is premature ejaculation an impulse control disorder? | Ozdemir Ö | — | 2012 | → |
| Sex differences in the effects of social and physical environment on novelty-induced exploratory behavior and cocaine-stimulated locomotor activity in adolescent rats. | Zakharova E et al. | — | 2012 | → |
| Trait impulsive choice predicts resistance to extinction and propensity to relapse to cocaine seeking: a bidirectional investigation. | Broos N et al. | — | 2012 | → |
| Unidirectional relationship between heroin self-administration and impulsive decision-making in rats. | Schippers MC et al. | — | 2012 | → |
| Aberrant learning and memory in addiction. | Torregrossa MM et al. | — | 2011 | → |
| Advances in animal models of drug addiction. | Heidbreder C | — | 2011 | → |
| A multivariate assessment of individual differences in sensation seeking and impulsivity as predictors of amphetamine self-administration and prefrontal dopamine function in rats. | Marusich JA et al. | — | 2011 | → |
| Baclofen has opposite effects on escalation of cocaine self-administration: increased intake in rats selectively bred for high (HiS) saccharin intake and decreased intake in those selected for low (LoS) saccharin intake. | Holtz NA et al. | — | 2011 | → |
| Contributions of serotonin in addiction vulnerability. | Kirby LG et al. | — | 2011 | → |
| Females are more vulnerable to drug abuse than males: evidence from preclinical studies and the role of ovarian hormones. | Anker JJ et al. | — | 2011 | → |
| Impulsive choice, as measured in a delay discounting paradigm, remains stable after chronic heroin administration. | Harty SC et al. | — | 2011 | → |
| Prefrontal cortex and drug abuse vulnerability: translation to prevention and treatment interventions. | Perry JL et al. | — | 2011 | → |
| Strain differences in the dose-response relationship for morphine self-administration and impulsive choice between Lewis and Fischer 344 rats. | García-Lecumberri C et al. | — | 2011 | → |
| The role of impulsivity in the aetiology of drug dependence: reward sensitivity versus automaticity. | Hogarth L | — | 2011 | → |
| Animal models of substance abuse and addiction: implications for science, animal welfare, and society. | Lynch WJ et al. | — | 2010 | → |
| Are attention lapses related to d-amphetamine liking? | McCloskey M et al. | — | 2010 | → |
| Contributions of the orbitofrontal cortex to impulsive choice: interactions with basal levels of impulsivity, dopamine signalling, and reward-related cues. | Zeeb FD et al. | — | 2010 | → |
| DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. | Paloyelis Y et al. | — | 2010 | → |
| Dopamine D4 receptor (D4R) deletion in mice does not affect operant responding for food or cocaine. | Thanos PK et al. | — | 2010 | → |
| Impulsive choice and response in dopamine agonist-related impulse control behaviors. | Voon V et al. | — | 2010 | → |
| Insight into the relationship between impulsivity and substance abuse from studies using animal models. | Winstanley CA et al. | — | 2010 | → |
| Inter-individual differences in neurobiology as vulnerability factors for affective disorders: implications for psychopharmacology. | Harro J | — | 2010 | → |
| Sex differences and ovarian hormones in animal models of drug dependence. | Carroll ME et al. | — | 2010 | → |
| Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats. | Anker JJ et al. | — | 2010 | → |
| Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in 'waiting' versus 'stopping'. | Robinson ES et al. | — | 2009 | → |
| Differences in impulsivity on a delay-discounting task predict self-administration of a low unit dose of methylphenidate in rats. | Marusich JA et al. | — | 2009 | → |
| Effects of chronic administration of drugs of abuse on impulsive choice (delay discounting) in animal models. | Setlow B et al. | — | 2009 | → |
| Environmental enrichment reduces cocaine seeking and reinstatement induced by cues and stress but not by cocaine. | Chauvet C et al. | — | 2009 | → |
| Impulsivity as a behavioral measure of withdrawal of orally delivered PCP and nondrug rewards in male and female monkeys. | Carroll ME et al. | — | 2009 | → |
| Impulsivity: its genetic, neurochemical and brain substrate determinants and the risks it entails for aberrant motivated behavior and psychopathology. | Duka T et al. | — | 2009 | → |
| Impulsivity predicts the escalation of cocaine self-administration in rats. | Anker JJ et al. | — | 2009 | → |
| Modeling risk factors for nicotine and other drug abuse in the preclinical laboratory. | Carroll ME et al. | — | 2009 | → |
| Performance under a Go/No-go task in rats selected for high and low impulsivity with a delay-discounting procedure. | Anker JJ et al. | — | 2009 | → |
| Positron emission tomography measures of endogenous opioid neurotransmission and impulsiveness traits in humans. | Love TM et al. | — | 2009 | → |
| The effects of chronic cocaine exposure on impulsivity in rats. | Dandy KL et al. | — | 2009 | → |
| Impulsive choice and environmental enrichment: effects of d-amphetamine and methylphenidate. | Perry JL et al. | — | 2008 | → |
| Selective breeding for differential saccharin intake as an animal model of drug abuse. | Carroll ME et al. | — | 2008 | → |
| Steady-state assessment of impulsive choice in Lewis and Fischer 344 rats: between-condition delay manipulations. | Madden GJ et al. | — | 2008 | → |
| The role of impulsive behavior in drug abuse. | Perry JL et al. | — | 2008 | → |
| Higher locomotor response to cocaine in female (vs. male) rats selectively bred for high (HiS) and low (LoS) saccharin intake. | Carroll ME et al. | — | 2007 | → |