Gene-environment interactions in depression research: genetic polymorphisms and life-stress polyprocedures.
paper
Cited
Public
Unavailable
- Authors
- Monroe, Scott M; Reid, Mark W
- Year
- 2008
- Journal
- Psychological science
- PMID
- 19000200
- DOI
- 10.1111/j.1467-9280.2008.02181.x
Recent studies on life stress, depression, and polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) are characterized by powerful genetic techniques, but are also characterized by unconventional and inconsistent approaches to assessing life stress. The present review addresses this problem by critically evaluating this rapidly growing literature with regard to the concepts and procedures employed to assess life stress and the research designs used to test causal associations. The existing body of evidence is seriously compromised by the predominance of ad hoc approaches for measuring life stress and by a lack of attention to key issues concerning research design. Principles and procedures for more refined and rigorous stress measurement are outlined. Improved guidelines are needed to direct future research on interactive effects of life stress and genes in psychopathology, pathophysiological processes, and disease.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Polygene by environment interactions predicting depressive outcomes. | Grillo AR | — | 2025 | → |
| Differential interactions between gene expressions and stressors across the lifespan in major depressive disorder. | Wang R et al. | — | 2024 | → |
| Life stress influences the relationship between sex hormone fluctuation and affective symptoms in peripubertal female adolescents. | Andersen E et al. | — | 2024 | → |
| Association of polygenic scores for depression and neuroticism with perceived stress in daily life during a long-lasting stress period. | Peter HL et al. | — | 2023 | → |
| A neural model of vulnerability and resilience to stress-related disorders linked to differential susceptibility. | Homberg JR et al. | — | 2022 | → |
| Relationship between family history of alcohol problems and different clusters of depressive symptoms. | Castaldelli-Maia JM et al. | — | 2022 | → |
| A year in the social life of a teenager: Within-person fluctuations in stress, phone communication, and anxiety and depression. | Rodman AM et al. | — | 2021 | → |
| Genetic markers of the stress generation model: A systematic review. | Bahji A et al. | — | 2021 | → |
| A narrative review of suicide and suicidal behavior in medical students. | Watson C et al. | — | 2020 | → |
| Childhood trauma, HPA axis activity and antidepressant response in patients with depression. | Nikkheslat N et al. | — | 2020 | → |
| Children's Attention to Mother and Adolescent Stress Moderate the Attachment-Depressive Symptoms Link. | Bosmans G et al. | — | 2020 | → |
| Recent Stressful Life Events (SLE) and Adolescent Mental Health: Initial Validation of the LEIA, a New Checklist for SLE Assessment According to Their Severity, Interpersonal, and Dependent Nature. | Moya-Higueras J et al. | — | 2020 | → |
| Characteristics of severe life events, attachment style, and depression - Using a new online approach. | Bifulco A et al. | — | 2019 | → |
| Dynamic associations between stressful life events and adolescent internalizing psychopathology in a multiwave longitudinal study. | Jenness JL et al. | — | 2019 | → |
| Felbamate produces antidepressant-like actions in the chronic unpredictable mild stress and chronic social defeat stress models of depression. | Li X et al. | — | 2019 | → |
| Large Sample Sizes Cannot Compensate for Mismeasured Environments in Gene-by-Environment Research. | Vrshek-Schallhorn S et al. | — | 2019 | → |
| Resting state coupling between the amygdala and ventromedial prefrontal cortex is related to household income in childhood and indexes future psychological vulnerability to stress. | Hanson JL et al. | — | 2019 | → |
| Serotonergic multilocus genetic variation moderates the association between major interpersonal stress and adolescent depressive symptoms: Replication and candidate environment specification. | Starr LR et al. | — | 2019 | → |
| The influence of genetic factors on personality and coping with stress among healthy late reproductive age women. | Jurczak A et al. | — | 2019 | → |
| Vitamin B-6 and depressive symptomatology, over time, in older Latino adults. | Arévalo SP et al. | — | 2019 | → |
| A systematic review and secondary data analysis of the interactions between the serotonin transporter 5-HTTLPR polymorphism and environmental and psychological factors in eating disorders. | Rozenblat V et al. | — | 2017 | → |
| Chronic psychosocial stressors in adulthood: Studies in mice, rats and tree shrews. | Pryce CR et al. | — | 2017 | → |
| Letter to the Editor: Bias in the measurement of bias. Letter regarding 'Citation bias and selective focus on positive findings in the literature on the serotonin transporter gene (5-HTTLPR), life stress and depression'. | Vrshek-Schallhorn S et al. | — | 2017 | → |
| Culture as a mediator of gene-environment interaction: Cultural consonance, childhood adversity, a 2A serotonin receptor polymorphism, and depression in urban Brazil. | Dressler WW et al. | — | 2016 | → |
| Depression, Stressful Life Events, and the Impact of Variation in the Serotonin Transporter: Findings from the National Longitudinal Study of Adolescent to Adult Health (Add Health). | Haberstick BC et al. | — | 2016 | → |
| Differential sensitivity to the environment: contribution of cognitive biases and genes to psychological wellbeing. | Fox E et al. | — | 2016 | → |
| Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older. | Arpawong TE et al. | — | 2016 | → |
| In search of the HPA axis activity in unipolar depression patients with childhood trauma: Combined cortisol awakening response and dexamethasone suppression test. | Lu S et al. | — | 2016 | → |
| Serotonin promoter polymorphism (5-HTTLPR) predicts biased attention for emotion stimuli: Preliminary evidence of moderation by the social environment. | Pearson R et al. | — | 2016 | → |
| Stressful life events moderate the relationship between genes and biased attention to emotional faces in youth. | Jenness JL et al. | — | 2016 | → |
| Additive genetic risk from five serotonin system polymorphisms interacts with interpersonal stress to predict depression. | Vrshek-Schallhorn S et al. | — | 2015 | → |
| Candidate gene-environment interaction research: reflections and recommendations. | Dick DM et al. | — | 2015 | → |
| Depression from childhood into late adolescence: Influence of gender, development, genetic susceptibility, and peer stress. | Hankin BL et al. | — | 2015 | → |
| Dysfunctional Attitudes and Affective Responses to Daily Stressors: Separating Cognitive, Genetic, and Clinical Influences on Stress Reactivity. | Conway CC et al. | — | 2015 | → |
| Lower structural integrity of the uncinate fasciculus is associated with a history of child maltreatment and future psychological vulnerability to stress. | Hanson JL et al. | — | 2015 | → |
| Measuring adolescents' exposure to victimization: The Environmental Risk (E-Risk) Longitudinal Twin Study. | Fisher HL et al. | — | 2015 | → |
| Reply to: the liptak-stouffer test for meta-analyses. | Byrd AL et al. | — | 2015 | → |
| The Dopamine D2 Receptor Polymorphism (DRD2 TaqIA) Interacts with Maternal Parenting in Predicting Early Adolescent Depressive Symptoms: Evidence of Differential Susceptibility and Age Differences. | Zhang W et al. | — | 2015 | → |
| The interaction between stress and genetic factors in the etiopathogenesis of depression. | McGuffin P et al. | — | 2015 | → |
| Bias in a protocol for a meta-analysis of 5-HTTLPR, stress, and depression. | Moffitt TE et al. | — | 2014 | → |
| Depression and psychological trauma: an overview integrating current research and specific evidence of studies in the treatment of depression in public mental health services in chile. | Vitriol V et al. | — | 2014 | → |
| Enhancing the gene-environment interaction framework through a quasi-experimental research design: evidence from differential responses to September 11. | Fletcher JM | — | 2014 | → |
| Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search. | Uher R | — | 2014 | → |
| Gene-environment interactions in severe mental illness. | Uher R | — | 2014 | → |
| Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis. | Hosang GM et al. | — | 2014 | → |
| Life events and suicidal ideation and behavior: a systematic review. | Liu RT et al. | — | 2014 | → |
| Life events trajectories, allostatic load, and the moderating role of age at arrival from Puerto Rico to the US mainland. | Arévalo SP et al. | — | 2014 | → |
| Life stress and family history for depression: the moderating role of past depressive episodes. | Monroe SM et al. | — | 2014 | → |
| Oxytocin receptor gene polymorphism, perceived social support, and psychological symptoms in maltreated adolescents. | Hostinar CE et al. | — | 2014 | → |
| Parent relationship quality buffers against the effect of peer stressors on depressive symptoms from middle childhood to adolescence. | Hazel NA et al. | — | 2014 | → |
| Refining the Candidate Environment: Interpersonal Stress, the Serotonin Transporter Polymorphism, and Gene-Environment Interactions in Major Depression. | Vrshek-Schallhorn S et al. | — | 2014 | → |
| Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study. | Starr LR et al. | — | 2014 | → |
| Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype and stressful life events interact to predict preschool-onset depression: a replication and developmental extension. | Bogdan R et al. | — | 2014 | → |
| The role of the monoamine oxidase A gene in moderating the response to adversity and associated antisocial behavior: a review. | Buades-Rotger M et al. | — | 2014 | → |
| Transmission of parental neuroticism to offspring's depression: the mediating role of rumination. | Sachs-Ericsson N et al. | — | 2014 | → |
| Vulnerability-specific stress generation: an examination of depressogenic cognitive vulnerability across multiple domains. | Liu RT et al. | — | 2014 | → |
| Adverse life events and emotional and behavioural problems in adolescence: the role of coping and emotion regulation. | Flouri E et al. | — | 2013 | → |
| A neurogenetics approach to understanding individual differences in brain, behavior, and risk for psychopathology. | Bogdan R et al. | — | 2013 | → |
| MAOA genotype, social exclusion and aggression: an experimental test of a gene-environment interaction. | Gallardo-Pujol D et al. | — | 2013 | → |
| Principles underlying the use of multiple informants' reports. | De Los Reyes A et al. | — | 2013 | → |
| Psychometric properties of the List of Threatening Experiences--LTE and its association with psychosocial factors and mental disorders according to different scoring methods. | Motrico E et al. | — | 2013 | → |
| White-matter density abnormalities in depressive patients with and without childhood neglect: a voxel-based morphometry (VBM) analysis. | Peng H et al. | — | 2013 | → |
| 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence. | Owens M et al. | — | 2012 | → |
| Coaction of stress and serotonin transporter genotype in predicting aggression at the transition to adulthood. | Conway CC et al. | — | 2012 | → |
| Does Personality Moderate Reaction and Adaptation to Major Life Events? Evidence from the British Household Panel Survey. | Yap SC et al. | — | 2012 | → |
| Does ragging play a role in medical student depression - cause or effect? | Castaldelli-Maia JM et al. | — | 2012 | → |
| DRD4 polymorphism moderates the effect of alcohol consumption on social bonding. | Creswell KG et al. | — | 2012 | → |
| Gene expression patterns in the hippocampus and amygdala of endogenous depression and chronic stress models. | Andrus BM et al. | — | 2012 | → |
| Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females. | Vaske J et al. | — | 2012 | → |
| Moderating role of the MAOA genotype in antisocial behaviour. | Fergusson DM et al. | — | 2012 | → |
| Neural mechanisms underlying 5-HTTLPR-related sensitivity to acute stress. | Drabant EM et al. | — | 2012 | → |
| Serotonin transporter gene as a predictor of stress generation in depression. | Starr LR et al. | — | 2012 | → |
| Stress-sensitive neurosignalling in depression: an integrated network biology approach to candidate gene selection for genetic association analysis. | van Eekelen JA et al. | — | 2012 | → |
| Adversity, Emotional Arousal, and Problem Behaviour in Adolescence: The Role of Non-Verbal Cognitive Ability as a Resilience Promoting Factor. | Flouri E et al. | — | 2011 | → |
| Annual Research Review: Developmental considerations of gene by environment interactions. | Lenroot RK et al. | — | 2011 | → |
| A translational research framework for enhanced validity of mouse models of psychopathological states in depression. | Pryce CR et al. | — | 2011 | → |
| Chronic family stress interacts with 5-HTTLPR to predict prospective depressive symptoms among youth. | Jenness JL et al. | — | 2011 | → |
| Gene polymorphisms and periodontitis. | Zhang J et al. | — | 2011 | → |
| Helplessness: a systematic translational review of theory and evidence for its relevance to understanding and treating depression. | Pryce CR et al. | — | 2011 | → |
| Influence of the interaction between the serotonin 1A receptor C-1019G polymorphism and negative life stressors on the development of depression. | Kim HK et al. | — | 2011 | → |
| Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design. | Hankin BL et al. | — | 2011 | → |
| Life stressors and 5-HTTLPR interaction in relation to midpregnancy depressive symptoms among African-American women. | Scheid JM et al. | — | 2011 | → |
| MAOA, abuse exposure and antisocial behaviour: 30-year longitudinal study. | Fergusson DM et al. | — | 2011 | → |
| Prenatal stress and risk of behavioral morbidity from age 2 to 14 years: the influence of the number, type, and timing of stressful life events. | Robinson M et al. | — | 2011 | → |
| Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research. | Dunn EC et al. | — | 2011 | → |
| Stressful life events at onset of obsessive-compulsive disorder are associated with a distinct clinical pattern. | Real E et al. | — | 2011 | → |
| The end of the primary outcome measure: a research agenda for constructing its replacement. | De Los Reyes A et al. | — | 2011 | → |
| The origins and current status of behavioral activation treatments for depression. | Dimidjian S et al. | — | 2011 | → |
| Antidepressant effects of estrogens: a basic approximation. | Estrada-Camarena E et al. | — | 2010 | → |
| BDNF genotype moderates the relation between physical activity and depressive symptoms. | Mata J et al. | — | 2010 | → |
| Biosocial Influences on the Family: A Decade Review. | D'Onofrio BM et al. | — | 2010 | → |
| Black sheep get the blues: a psychobiological model of social rejection and depression. | Slavich GM et al. | — | 2010 | → |
| Chronic and acute stress, gender, and serotonin transporter gene-environment interactions predicting depression symptoms in youth. | Hammen C et al. | — | 2010 | → |
| Contemporary Modeling of Gene × Environment Effects in Randomized Multivariate Longitudinal Studies. | McArdle JJ et al. | — | 2010 | → |
| Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. | Caspi A et al. | — | 2010 | → |
| Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. | Fredericks CA et al. | — | 2010 | → |
| Life events in panic disorder-an update on "candidate stressors". | Klauke B et al. | — | 2010 | → |
| New pieces for the stress-depression puzzle. | Pace TW | — | 2010 | → |
| Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. | Goodyer IM et al. | — | 2010 | → |
| Possible involvement of signal transducers and activators of transcription 3 system on depression in the model mice brain. | Mingmalairak S et al. | — | 2010 | → |
| Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources. | Sadeh N et al. | — | 2010 | → |
| Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization. | Sugden K et al. | — | 2010 | → |
| The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. | Uher R et al. | — | 2010 | → |
| The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. | Middeldorp CM et al. | — | 2010 | → |
| The serotonin transporter promoter polymorphism is associated with cortisol response to psychosocial stress. | Way BM et al. | — | 2010 | → |
| Up the Tower of Psychobabel: does lexical anarchy impede research into 'psychological stress'? | Burton RF et al. | — | 2010 | → |
| From age correction to genome-wide association. | Cohen-Woods S et al. | — | 2009 | → |
| Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. | Risch N et al. | — | 2009 | → |
| The role of genetic variation in the causation of mental illness: an evolution-informed framework. | Uher R | — | 2009 | → |
| Vulnerability to depression: what is the role of stress genes in gene x environment interaction? | El Hage W et al. | — | 2009 | → |