Effects of ethanol on temporal recovery of auditory-evoked potentials in individuals at risk for alcoholism.
- Authors
- Cohen, H L; Porjesz, B; Stimus, A T; Begleiter, H
- Year
- 1998
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 9660327
The present investigation examined the effects of placebo (P), low dose (LD), and high dose (HD) ethanol on auditory event-related potential (AEP) recovery functions in a group of males at high risk to develop alcoholism (HR; n = 23, mean = 22.3 years) and a low risk (LR; n = 27, mean = 23.0 years) control group. Condition order was randomized, with one condition (P, LD, or HD) per day and a minimum 1-day interval between conditions. For each subject, both blood alcohol levels (BALs) measured via breathalyzer, and event-related potentials recorded with the entire 10/20 International System, were assessed prior to and at mean intervals of 20, 60, 90, and 130 min after P, LD, or HD administration. A series of binaural auditory stimuli with randomly interposed interstimulus intervals of 0.5, 1.0, and 10.0 sec were used to elicit the N100 and P200 components of the AEP. Between-groups comparisons indicated that ethanol elicited risk group differences in recovery functions not present at baseline. The differences were manifested in the HR group as larger decrements in P200 amplitude during the ascending blood alcohol curve (acute sensitivity) and more rapid returns of both N100 and P200 to baseline levels during the descending blood alcohol curve (acute tolerance). These findings support Newlin and Thomson's (1990) Differentiator Model, suggesting that LR and HR individuals are differentially sensitive to the effects of ethanol.
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In this knowledge base
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| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| High risk groups often have higher levels of alcohol response than low risk: the other side of the coin. | Newlin DB et al. | — | 2010 | → |
| The alcohol clamp: applications, challenges, and new directions--an RSA 2004 symposium summary. | Ramchandani VA et al. | — | 2006 | → |
| Development of acute tolerance during steady-state arterial alcohol concentrations: a study of auditory event-related potentials in rats. | Morzorati SL et al. | — | 2005 | → |
| The utility of neurophysiological markers in the study of alcoholism. | Porjesz B et al. | — | 2005 | → |
| Altered sensitivity to alcohol in the late luteal phase among patients with premenstrual dysphoric disorder. | Nyberg S et al. | — | 2004 | → |
| Auditory adaptation is differentially impaired in familial and sporadic Alzheimer's disease. | Tarkka IM et al. | — | 2002 | → |
| Effects of ethanol on flash-evoked potentials of rats: lack of antagonism by naltrexone. | Hetzler BE et al. | — | 2001 | → |
| What is inherited in the predisposition toward alcoholism? A proposed model. | Begleiter H et al. | — | 1999 | → |