The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor.
paper
Cited
Public
Unavailable
- Authors
- Cordes, S P; Barsh, G S
- Year
- 1994
- Journal
- Cell
- PMID
- 8001130
- DOI
- 10.1016/0092-8674(94)90033-7
The mouse kreisler (kr) mutation causes segmentation abnormalities in the caudal hindbrain and defective inner ear development. Based on an inversion discovered in the original kr allele, we selected a candidate cDNA highly expressed in the developing caudal hindbrain. This cDNA encodes a basic domain-leucine zipper (bZIP) transcription factor and was confirmed to represent the kr gene by analysis of a second kr allele, generated by chemical mutagenesis, in which a serine is substituted for an asparagine residue conserved in the DNA-binding domain of all known bZIP family members. The identity, expression, and mutant phenotype of kr indicate an early role in axial patterning and provide insights into the molecular and embryologic mechanisms that govern hindbrain and otic development.
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| Transcription factors for lens development assessed in vivo. | Kondoh H | β | 1999 | β |
| A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo. | Motohashi H et al. | β | 1998 | β |
| A detailed physical and transcriptional map of the region of chromosome 20 that is deleted in myeloproliferative disorders and refinement of the common deleted region. | Bench AJ et al. | β | 1998 | β |
| All-trans-retinoic acid upregulates the expression of COUP-TFI in early-somite mouse embryos cultured in vitro. | Clotman F et al. | β | 1998 | β |
| An Oak Ridge legacy: the specific locus test and its role in mouse mutagenesis. | Davis AP et al. | β | 1998 | β |
| A role for Groucho tetramerization in transcriptional repression. | Chen G et al. | β | 1998 | β |
| c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation. | Hedge SP et al. | β | 1998 | β |
| Development and maintenance of ear innervation and function: lessons from mutations in mouse and man. | Fritzsch B et al. | β | 1998 | β |
| Early expression of Osteopontin in the chick is restricted to rhombomeres 5 and 6 and to a subpopulation of neural crest cells that arise from these segments. | Thayer JM et al. | β | 1998 | β |
| Equivalence in the genetic control of hindbrain segmentation in fish and mouse. | Moens CB et al. | β | 1998 | β |
| Evolution of the vestibulo-ocular system. | Fritzsch B | β | 1998 | β |
| Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes. | Fernandez AS et al. | β | 1998 | β |
| Functional genomics in the mouse: phenotype-based mutagenesis screens. | Schimenti J et al. | β | 1998 | β |
| How to build a vertebrate hindbrain. Lessons from genetics. | Schneider-Maunoury S et al. | β | 1998 | β |
| Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. | Gavalas A et al. | β | 1998 | β |
| Hoxa1 and Krox-20 synergize to control the development of rhombomere 3. | Helmbacher F et al. | β | 1998 | β |
| Interaction of the CNC-bZIP factor TCF11/LCR-F1/Nrf1 with MafG: binding-site selection and regulation of transcription. | Johnsen O et al. | β | 1998 | β |
| Rat maf-related factors: the specificities of DNA binding and heterodimer formation. | Matsushima-Hibiya Y et al. | β | 1998 | β |
| Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. | Xiang M et al. | β | 1998 | β |
| Segmental expression of the EphA4 (Sek-1) receptor tyrosine kinase in the hindbrain is under direct transcriptional control of Krox-20. | Theil T et al. | β | 1998 | β |
| The development of the vertebrate inner ear. | Torres M et al. | β | 1998 | β |
| The mutagenic activity of ethylnitrosourea at low doses in spermatogonia of the mouse as assessed by the specific-locus test. | Favor J | β | 1998 | β |
| The winged helix transcription factor Fkh10 is required for normal development of the inner ear. | Hulander M et al. | β | 1998 | β |
| Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo. | Herbrand H et al. | β | 1998 | β |
| A role for the roof plate and its resident TGFbeta-related proteins in neuronal patterning in the dorsal spinal cord. | Liem KF et al. | β | 1997 | β |
| Genetics of neural development in zebrafish. | Schier AF | β | 1997 | β |
| Heterogeneous expression of multiple putative patterning genes by single cells from the chick hindbrain. | Kato K et al. | β | 1997 | β |
| Human bZIP transcription factor gene NRL: structure, genomic sequence, and fine linkage mapping at 14q11.2 and negative mutation analysis in patients with retinal degeneration. | Farjo Q et al. | β | 1997 | β |
| Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. | Blank V et al. | β | 1997 | β |
| Mice with a targeted disruption of the neurotrophin receptor trkB lose their gustatory ganglion cells early but do develop taste buds. | Fritzsch B et al. | β | 1997 | β |
| Organization and development of facial motor neurons in the kreisler mutant mouse. | McKay IJ et al. | β | 1997 | β |
| Primordial respiratory-like rhythm generation in the vertebrate embryo. | Champagnat J et al. | β | 1997 | β |
| Random mutagenesis screen for dominant behavioral mutations in mice. | Nolan PM et al. | β | 1997 | β |
| Spectrum of Bmp5 mutations from germline mutagenesis experiments in mice. | Marker PC et al. | β | 1997 | β |
| The development of vestibulocochlear efferents and cochlear afferents in mice. | Bruce LL et al. | β | 1997 | β |
| The effect of the interval between dose applications on the observed specific-locus mutation rate in the mouse following fractionated treatments of spermatogonia with ethylnitrosourea. | Favor J et al. | β | 1997 | β |
| The expression pattern of the mafB/kr gene in birds and mice reveals that the kreisler phenotype does not represent a null mutant. | Eichmann A et al. | β | 1997 | β |
| The Maf transcription factors: regulators of differentiation. | Blank V et al. | β | 1997 | β |
| The world according to Maf. | Motohashi H et al. | β | 1997 | β |
| Using targeted large deletions and high-efficiency N-ethyl-N-nitrosourea mutagenesis for functional analyses of the mammalian genome. | Justice MJ et al. | β | 1997 | β |
| Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. | Studer M et al. | β | 1996 | β |
| Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site. | Oyake T et al. | β | 1996 | β |
| Complexity of the erythroid transcription factor NF-E2 as revealed by gene targeting of the mouse p18 NF-E2 locus. | Kotkow KJ et al. | β | 1996 | β |
| Differential expression of bone morphogenetic proteins in the developing vestibular and auditory sensory organs. | Oh SH et al. | β | 1996 | β |
| Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. | Granato M et al. | β | 1996 | β |
| Genetics of deafness. | Steel KP et al. | β | 1996 | β |
| Good genes in bad neighbourhoods. | Bedell MA et al. | β | 1996 | β |
| Hoxb-2 transcriptional activation in rhombomeres 3 and 5 requires an evolutionarily conserved cis-acting element in addition to the Krox-20 binding site. | Vesque C et al. | β | 1996 | β |
| Interactions between rhombomeres modulate Krox-20 and follistatin expression in the chick embryo hindbrain. | Graham A et al. | β | 1996 | β |
| MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation. | Sieweke MH et al. | β | 1996 | β |
| Mutations affecting the development of the embryonic zebrafish brain. | Schier AF et al. | β | 1996 | β |
| Paralogous Hox genes: function and regulation. | Maconochie M et al. | β | 1996 | β |
| Patterning the hindbrain. | Guthrie S | β | 1996 | β |
| Patterning the vertebrate neuraxis. | Lumsden A et al. | β | 1996 | β |
| Regionalized expression of Nkx5-1, Nkx5-2, Pax2 and sek genes during mouse inner ear development. | Rinkwitz-Brandt S et al. | β | 1996 | β |
| Regulation of vertebrate neural cell fate by transcription factors. | Bang AG et al. | β | 1996 | β |
| Reorganization of pontine rhythmogenic neuronal networks in Krox-20 knockout mice. | Jacquin TD et al. | β | 1996 | β |
| Standard atlas of the gross anatomy of the developing inner ear of the chicken. | Bissonnette JP et al. | β | 1996 | β |
| The basic motif-leucine zipper transcription factor Nrl can positively regulate rhodopsin gene expression. | Rehemtulla A et al. | β | 1996 | β |
| The bZIP transcription factor Nrl stimulates rhodopsin promoter activity in primary retinal cell cultures. | Kumar R et al. | β | 1996 | β |
| The role of the laboratory mouse in the human genome project. | Meisler MH | β | 1996 | β |
| valentino: a zebrafish gene required for normal hindbrain segmentation. | Moens CB et al. | β | 1996 | β |
| Dependence of globin gene expression in mouse erythroleukemia cells on the NF-E2 heterodimer. | Kotkow KJ et al. | β | 1995 | β |
| Development of midbrain and anterior hindbrain ocular motoneurons in normal and Wnt-1 knockout mice. | Fritzsch B et al. | β | 1995 | β |
| Extending dimerization interfaces: the bZIP basic region can form a coiled coil. | Krylov D et al. | β | 1995 | β |
| Familial Klippel-Feil syndrome and paracentric inversion inv(8)(q22.2q23.3). | Clarke RA et al. | β | 1995 | β |
| Heterozygosity mapping of partially congenic lines: mapping of a semidominant neurological mutation, Wheels (Whl), on mouse chromosome 4. | Nolan PM et al. | β | 1995 | β |
| Regulation of globin gene expression in erythroid cells. | Orkin SH | β | 1995 | β |
| Rhombomeres and innervation fields. | Fritzsch B | β | 1995 | β |
| Sequence characterization of ENU-induced mutants of glucose phosphate isomerase in mouse. | Pearce SR et al. | β | 1995 | β |
| The new dysmorphology: application of insights from basic developmental biology to the understanding of human birth defects. | Epstein CJ | β | 1995 | β |
| Transcriptional stimulation of the retina-specific QR1 gene upon growth arrest involves a Maf-related protein. | Pouponnot C et al. | β | 1995 | β |