Acute and chronic effects of alcohol on preattentive auditory processing as reflected by mismatch negativity.
- Authors
- Ahveninen, J; Escera, C; Polo, M D; Grau, C; Jääskeläinen, I P
- Year
- 2000
- Journal
- Audiology & neuro-otology
- PMID
- 11025330
- DOI
- 10.1159/000013896
Chronic alcoholism, a major worldwide health problem, is associated with a variety of neurocognitive changes in the afflicted individuals. The precise neurophysiological basis of these changes is not yet understood. Mismatch negativity (MMN) is a preattentive event-related potential component indexing cortical auditory memory traces and automatic change detection in the brain that can be used to study the neural basis of cognitive impairments in various neurodegenerative diseases. MMN studies have revealed that even a low dose of acute alcohol significantly impairs automatic change detection and involuntary attention shifting. Recent MMN results on chronic alcoholism in turn suggest that auditory sensory traces decay slightly faster and are substantially more vulnerable to the distracting effect of backward masking in alcoholics than in healthy subjects. Furthermore, chronic alcohol abuse might accelerate the age-related impairment of automatic change detection. There is also evidence that the MMN changes might predict impaired performance in behavioral memory and attention tasks in alcoholics. In MMN studies of detoxified alcoholics, however, many confounding factors have to be taken into account. For instance, postwithdrawal brain hyperexcitability might be associated with a slightly enhanced or accelerated MMN/MMNm (the magnetic equivalent of MMN). In sum, MMN and MMNm provide an objective noninvasive tool for exploring the neurophysiological functional deficits related to both acute alcohol intoxication and chronic alcoholism.
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In this knowledge base
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|---|---|---|
| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Examining the Complex Mismatch Negativity in Early Phase Psychosis Using the Dual Rule Paradigm. | Bissonnette JN et al. | — | 2025 | → |
| The Role of Gamma Oscillations in the Pathophysiology of Substance Use Disorders. | Ramlakhan JU et al. | — | 2020 | → |
| Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis. | Ramlakhan JU et al. | — | 2018 | → |
| Aberrant brain response after auditory deviance in PTSD compared to trauma controls: An EEG study. | Bangel KA et al. | — | 2017 | → |
| Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult. | Chitty KM et al. | — | 2015 | → |
| Effect of boric acid on oxidative stress in rats with fetal alcohol syndrome. | Sogut I et al. | — | 2015 | → |
| The N-methyl-D-aspartate receptor as a neurobiological intersection between bipolar disorder and alcohol use: a longitudinal mismatch negativity study. | Chitty KM et al. | — | 2015 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Effects of alcohol on auditory pre-attentive processing of four sound features: evidence from mismatch negativity. | He J et al. | — | 2013 | → |
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| The mismatch negativity (MMN)--a unique window to disturbed central auditory processing in ageing and different clinical conditions. | Näätänen R et al. | — | 2012 | → |
| Alcohol use and mismatch negativity in young patients with psychotic disorder. | Chitty KM et al. | — | 2011 | → |
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| Mismatch negativity: clinical research and possible applications. | Näätänen R | — | 2003 | → |