Cannabinoid receptors in the human brain: a detailed anatomical and quantitative autoradiographic study in the fetal, neonatal and adult human brain.
paper
Cited
Public
Unavailable
- Authors
- Glass, M; Dragunow, M; Faull, R L
- Year
- 1997
- Journal
- Neuroscience
- PMID
- 9472392
- DOI
- 10.1016/s0306-4522(96)00428-9
The anatomical distribution and density of cannabinoid receptors in the human brain was studied in one fetal (33 weeks gestation), two neonatal (aged three to six months) and eight adult (aged 21-81 years) human cases using quantitative receptor autoradiography following in vitro labelling of sections with the synthetic cannabinoid agonist [3H]CP55,940. Cannabinoid receptors were distributed in a heterogeneous fashion throughout the adult human brain and spinal cord. The allocortex contained very high concentrations of cannabinoid receptor binding sites in the dentate gyrus, Ammons's horn and subiculum of the hippocampal formation; high concentrations of receptors were also present in the entorhinal cortex and amygdaloid complex. Cannabinoid receptor binding sites were also present throughout all regions of the neocortex, where they showed a marked variation in density between the primary, secondary and associational cortical regions: the greatest densities of receptors were present in the associational cortical regions of the frontal and limbic lobes, with moderate densities in the secondary sensory and motor cortical regions, and with the lowest densities of receptors in the primary sensory and motor cortical regions. Relatively high concentrations of cannabinoid receptors were consistently seen in cortical regions of the left (dominant) hemisphere, known to be associated with verbal language functions. In all of the cortical regions, the pattern and density of receptor labelling followed the neocortical laminar organization, with the greatest density of receptors localized in two discrete bands--a clearly delineated narrow superficial band which coincided with lamina I and a deeper broader, conspicuous band of labelling which corresponded to laminae V and VI. Labelling in the intervening cortical laminae (II-IV) showed lower densities, with a well delineated narrow band of label in the middle of laminae IV in the associational cortical regions. The thalamus showed a distinctive heterogeneous distribution of cannabinoid receptors, with the highest concentration of receptors localized in the mediodorsal nucleus, anterior nuclear complex, and in the midline and intralaminar complex of nuclei, i.e. in thalamic nuclei which have connectional affiliations with the associational cortical areas. The basal ganglia showed a distinctive heterogeneous pattern of receptor binding, with the very highest concentrations in the globus pallidus internus, moderate concentrations in the globus pallidus externus and ventral pallidum, and moderately low levels of binding throughout the striatal complex. In the midbrain, some of the highest levels of cannabinoid receptor binding sites in the human brain were present in the substantia nigra pars reticulata, with very low levels of labelling in all other midbrain areas. The highest densities of cannabinoid receptor binding in the hindbrain were localized in the molecular layer of the cerebellar cortex and the dorsal motor nucleus of the vagus, with moderate densities of receptors in the nucleus of the solitary tract. The spinal cord showed very low levels of receptor binding. Studies on the distribution of cannabinoid receptors in the fetal and neonatal human brain showed similar patterns of receptor distribution to that observed in the adult human brain, except that the density of receptor binding was generally markedly higher, especially in the basal ganglia and substantia nigra. The pattern of cannabinoid receptor labelling in the striatum showed a striking patchy pattern of organization which was especially conspicuous in the fetal brain. These results show that cannabinoid receptor binding sites in the human brain are localized mainly in: forebrain areas associated with higher cognitive functions; forebrain, midbrain and hindbrain areas associated with the control of movement; and in hindbrain areas associated with the control of motor and sensory functions of the autonomic nervous system. (AB
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| Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence. | Coppola M et al. | β | 2013 | β |
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| Recent progress in understanding the pathophysiology of post-traumatic stress disorder: implications for targeted pharmacological treatment. | Bailey CR et al. | β | 2013 | β |
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| Sphingosine lysolipids in the CNS: endogenous cannabinoid antagonists or a parallel pain modulatory system? | Selley DE et al. | β | 2013 | β |
| Striatal GABAergic and cortical glutamatergic neurons mediate contrasting effects of cannabinoids on cortical network synchrony. | Sales-Carbonell C et al. | β | 2013 | β |
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| The endocannabinoid system, cannabinoids, and pain. | Fine PG et al. | β | 2013 | β |
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| A novel touch-sensitive apparatus for behavioral studies in unrestrained squirrel monkeys. | Kangas BD et al. | β | 2012 | β |
| Cannabinoid-1 receptors in the mouse ventral pallidum are targeted to axonal profiles expressing functionally opposed opioid peptides and contacting N-acylphosphatidylethanolamine-hydrolyzing phospholipase D terminals. | Pickel VM et al. | β | 2012 | β |
| Cannabinoid modulation of the dopaminergic circuitry: implications for limbic and striatal output. | Fitzgerald ML et al. | β | 2012 | β |
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| Dose-related modulation of event-related potentials to novel and target stimuli by intravenous ΞβΉ-THC in humans. | D'Souza DC et al. | β | 2012 | β |
| Drugs of abuse and increased risk of psychosis development. | Gururajan A et al. | β | 2012 | β |
| Examining the effects of former cannabis use on cerebellum-dependent eyeblink conditioning in humans. | Steinmetz AB et al. | β | 2012 | β |
| Expression pattern of the cannabinoid receptor genes in the frontal cortex ofΒ mood disorder patients and mice selectively bred for high and low fear. | Choi K et al. | β | 2012 | β |
| Genetic dissection of the role of cannabinoid type-1 receptors in the emotional consequences of repeated social stress in mice. | Dubreucq S et al. | β | 2012 | β |
| Inhibition of forebrain ΞΌ-opioid receptor signaling by low concentrations of rimonabant does not require cannabinoid receptors and directly involves ΞΌ-opioid receptors. | ZΓ‘dor F et al. | β | 2012 | β |
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| Mechanisms underlying the link between cannabis use and prospective memory. | Cuttler C et al. | β | 2012 | β |
| Neuroanatomical substrates involved in cannabinoid modulation of defensive responses. | Moreira FA et al. | β | 2012 | β |
| Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study. | Cheetham A et al. | β | 2012 | β |
| Positron emission tomography shows elevated cannabinoid CB1 receptor binding in men with alcohol dependence. | Neumeister A et al. | β | 2012 | β |
| Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers. | Hirvonen J et al. | β | 2012 | β |
| Substance Abuse, Hepatitis C, and Aging in HIV: Common Cofactors that Contribute to Neurobehavioral Disturbances. | Schuster RM et al. | β | 2012 | β |
| The decrease of dopamine Dβ/Dβ receptor densities in the putamen and nucleus caudatus goes parallel with maintained levels of CBβ cannabinoid receptors in Parkinson's disease: a preliminary autoradiographic study with the selective dopamine Dβ/Dβ antagonist [Β³H]raclopride and the novel CBβ inverse agonist [ΒΉΒ²β΅I]SD7015. | Farkas S et al. | β | 2012 | β |
| The effect of chronic cannabinoids on broadband EEG neural oscillations in humans. | Skosnik PD et al. | β | 2012 | β |
| Acute effects of delta-9-tetrahydrocannabinol on performance monitoring in healthy volunteers. | Spronk D et al. | β | 2011 | β |
| Brain cannabinoid CBβ receptors modulate cocaine's actions in mice. | Xi ZX et al. | β | 2011 | β |
| Cannabinoids: potential targets for bladder dysfunction. | Ruggieri MR | β | 2011 | β |
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| Characterization of a novel and selective CB1 antagonist as a radioligand for receptor occupancy studies. | Yang Y et al. | β | 2011 | β |
| Characterization of NTera2/D1 cells as a model system for the investigation of cannabinoid function in human neurons and astrocytes. | Goodfellow CE et al. | β | 2011 | β |
| Cloning and pharmacological characterization of the dog cannabinoid CBβreceptor. | Ndong C et al. | β | 2011 | β |
| Complementary synaptic distribution of enzymes responsible for synthesis and inactivation of the endocannabinoid 2-arachidonoylglycerol in the human hippocampus. | LudΓ‘nyi A et al. | β | 2011 | β |
| Determination of endocannabinoids in nematodes and human brain tissue by liquid chromatography electrospray ionization tandem mass spectrometry. | Lehtonen M et al. | β | 2011 | β |
| Disruption of frontal ΞΈ coherence by Ξ9-tetrahydrocannabinol is associated with positive psychotic symptoms. | Morrison PD et al. | β | 2011 | β |
| Dysfunctional prefrontal cortical network activity and interactions following cannabinoid receptor activation. | Kucewicz MT et al. | β | 2011 | β |
| Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. | Serrano A et al. | β | 2011 | β |
| Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects. | Marco EM et al. | β | 2011 | β |
| Frontal Assessment Battery (FAB) is a simple tool for detecting executive deficits in chronic cannabis users. | Fontes MA et al. | β | 2011 | β |
| Gender effects on amygdala morphometry in adolescent marijuana users. | McQueeny T et al. | β | 2011 | β |
| Genetics and neuropathology of Huntington's disease. | Reiner A et al. | β | 2011 | β |
| Glycerophospholipids and glycerophospholipid-derived lipid mediators: a complex meshwork in Alzheimer's disease pathology. | Frisardi V et al. | β | 2011 | β |
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| Paranoid schizophrenia is characterized by increased CB1 receptor binding in the dorsolateral prefrontal cortex. | Dalton VS et al. | β | 2011 | β |
| Pharmacological and molecular characterization of a dorsal root ganglion cell line expressing cannabinoid CB(1) and CB(2) receptors. | Fan Y et al. | β | 2011 | β |
| Preliminary evidence for white matter metabolite differences in marijuana-dependent young men using 2D J-resolved magnetic resonance spectroscopic imaging at 4 Tesla. | Silveri MM et al. | β | 2011 | β |
| Residual effects of focal brain ischaemia upon cannabinoid CB(1) receptor density and functionality in female rats. | Rojo ML et al. | β | 2011 | β |
| Review: The neuropathology of drug abuse. | BΓΌttner A | β | 2011 | β |
| Role of cannabinoids in multiple sclerosis. | Zajicek JP et al. | β | 2011 | β |
| Singing under the influence: examining the effects of nutrition and addiction on a learned vocal behavior. | Lovell PV et al. | β | 2011 | β |
| Structural network topology revealed by white matter tractography in cannabis users: a graph theoretical analysis. | Kim DJ et al. | β | 2011 | β |
| A clinical trial assessing the safety and efficacy of taranabant, a CB1R inverse agonist, in obese and overweight patients: a high-dose study. | Aronne LJ et al. | β | 2010 | β |
| Adolescent brain maturation, the endogenous cannabinoid system and the neurobiology of cannabis-induced schizophrenia. | Bossong MG et al. | β | 2010 | β |
| Anandamide prior to sensitization increases cell-mediated immunity in mice. | Ribeiro A et al. | β | 2010 | β |
| Cannabinoid agonist WIN55,212 in vitro inhibits interleukin-6 (IL-6) and monocyte chemo-attractant protein-1 (MCP-1) release by rat pancreatic acini and in vivo induces dual effects on the course of acute pancreatitis. | Petrella C et al. | β | 2010 | β |
| Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? | Smith TH et al. | β | 2010 | β |
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| Cannabinoids and Dementia: A Review of Clinical and Preclinical Data. | Walther S et al. | β | 2010 | β |
| Cannabinoids and experimental models of multiple sclerosis. | Kubajewska I et al. | β | 2010 | β |
| Cannabis dependence: Effects of cannabis consumption on inter-regional cerebral metabolic relationships in an Indian population. | Parkar SR et al. | β | 2010 | β |
| Cannabis use and progressive cortical thickness loss in areas rich in CB1 receptors during the first five years of schizophrenia. | Rais M et al. | β | 2010 | β |
| CB1 and CB2 cannabinoid receptor expression during development and in epileptogenic developmental pathologies. | Zurolo E et al. | β | 2010 | β |
| CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3beta/beta-catenin signaling. | Trazzi S et al. | β | 2010 | β |
| Chronic constriction injury reduces cannabinoid receptor 1 activity in the rostral anterior cingulate cortex of mice. | Hoot MR et al. | β | 2010 | β |
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| Endocannabinoid binding to the cannabinoid receptors: what is known and what remains unknown. | Reggio PH | β | 2010 | β |
| Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex. | Ho WS et al. | β | 2010 | β |
| FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration. | Falenski KW et al. | β | 2010 | β |
| Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands. | Terry GE et al. | β | 2010 | β |
| In vivo pharmacology of endocannabinoids and their metabolic inhibitors: therapeutic implications in Parkinson's disease and abuse liability. | Giuffrida A et al. | β | 2010 | β |
| Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain. | Sanabria-BohΓ³rquez SM et al. | β | 2010 | β |
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| Long-term effects of cannabis on eye movement control in reading. | Huestegge L et al. | β | 2010 | β |
| Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease. | Scotter EL et al. | β | 2010 | β |
| Opposite changes in cannabinoid CB1 and CB2 receptor expression in human gliomas. | De JesΓΊs ML et al. | β | 2010 | β |
| Quantification of cerebral cannabinoid receptors subtype 1 (CB1) in healthy subjects and schizophrenia by the novel PET radioligand [11C]OMAR. | Wong DF et al. | β | 2010 | β |
| Relationship of cannabinoid CB1 receptor and cholecystokinin immunoreactivity in monkey dorsolateral prefrontal cortex. | Eggan SM et al. | β | 2010 | β |
| Selective alterations of the CB1 receptors and the fatty acid amide hydrolase in the ventral striatum of alcoholics and suicides. | Vinod KY et al. | β | 2010 | β |
| SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents. | de Bruin NM et al. | β | 2010 | β |
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| The G1359A-CNR1 gene polymorphism is associated to glioma in Spanish patients. | NΓΊΓ±ez M et al. | β | 2010 | β |
| The influence of recency of use on fMRI response during spatial working memory in adolescent marijuana users. | Schweinsburg AD et al. | β | 2010 | β |
| Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis. | Bortolato M et al. | β | 2010 | β |
| Altered CB receptor-signaling in prefrontal cortex from an animal model of depression is reversed by chronic fluoxetine. | RodrΓguez-Gaztelumendi A et al. | β | 2009 | β |
| Basic neuroanatomy and neuropharmacology of cannabinoids. | Breivogel CS et al. | β | 2009 | β |
| Cannabinoid (CB(1)), GABA(A) and GABA(B) receptor subunit changes in the globus pallidus in Huntington's disease. | Allen KL et al. | β | 2009 | β |
| Chronic treatment and withdrawal of the cannabinoid agonist WIN 55,212-2 modulate the sensitivity of presynaptic receptors involved in the regulation of monoamine syntheses in rat brain. | Moranta D et al. | β | 2009 | β |
| Comorbid mood, psychosis, and marijuana abuse disorders: a theoretical review. | Wilson N et al. | β | 2009 | β |
| Effect of delta9-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans. | Beaumont H et al. | β | 2009 | β |
| Effects of cannabinoids on caffeine contractures in slow and fast skeletal muscle fibers of the frog. | Huerta M et al. | β | 2009 | β |
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| Endocannabinoid system: emerging role from neurodevelopment to neurodegeneration. | Basavarajappa BS et al. | β | 2009 | β |
| Endocannabinoid system in first trimester placenta: low FAAH and high CB1 expression characterize spontaneous miscarriage. | Trabucco E et al. | β | 2009 | β |
| Evaluation of [11C]PipISB and [18F]PipISB in monkey as candidate radioligands for imaging brain cannabinoid type-1 receptors in vivo. | Finnema SJ et al. | β | 2009 | β |
| Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment. | UrigΓΌen L et al. | β | 2009 | β |
| Long-term effects of cannabis on oculomotor function in humans. | Huestegge L et al. | β | 2009 | β |
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| PET imaging studies in rhesus monkey with the cannabinoid-1 (CB1) receptor ligand [11C]CB-119. | Hamill TG et al. | β | 2009 | β |
| Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand. | Terry GE et al. | β | 2009 | β |
| Synthesis and in vitro autoradiographic evaluation of a novel high-affinity radioiodinated ligand for imaging brain cannabinoid subtype-1 receptors. | Donohue SR et al. | β | 2009 | β |
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| The endocannabinoid system as a target for the treatment of cannabis dependence. | Clapper JR et al. | β | 2009 | β |
| The endocannabinoid system is modulated in response to spinal cord injury in rats. | Garcia-Ovejero D et al. | β | 2009 | β |
| Cannabinoids enhance susceptibility of immature brain to ethanol neurotoxicity. | Hansen HH et al. | β | 2008 | β |
| Cannabis and psychiatric disorders: it is not only addiction. | Leweke FM et al. | β | 2008 | β |
| Cerebral glucose metabolism and D2/D3 receptor availability in young adults with cannabis dependence measured with positron emission tomography. | Sevy S et al. | β | 2008 | β |
| Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes. | Dennis I et al. | β | 2008 | β |
| Gender-dependent increases with healthy aging of the human cerebral cannabinoid-type 1 receptor binding using [(18)F]MK-9470 PET. | Van Laere K et al. | β | 2008 | β |
| Immunohistochemical description of the endogenous cannabinoid system in the rat cerebellum and functionally related nuclei. | SuΓ‘rez J et al. | β | 2008 | β |
| Modulation of network oscillatory activity and GABAergic synaptic transmission by CB1 cannabinoid receptors in the rat medial entorhinal cortex. | Morgan NH et al. | β | 2008 | β |
| Reduced cortical cannabinoid 1 receptor messenger RNA and protein expression in schizophrenia. | Eggan SM et al. | β | 2008 | β |
| Role of cannabinoid receptors in the control of gastrointestinal motility and perception. | Fioramonti J et al. | β | 2008 | β |
| Screening for cannabis use in a pediatric sleep clinic. | Verhulst SL et al. | β | 2008 | β |
| Specific detection of CB1 receptors; cannabinoid CB1 receptor antibodies are not all created equal! | Grimsey NL et al. | β | 2008 | β |
| Targeting the endocannabinoid system in Alzheimer's disease. | Koppel J et al. | β | 2008 | β |
| The collection and processing of human brain tissue for research. | Waldvogel HJ et al. | β | 2008 | β |
| The effects of antipsychotics on the density of cannabinoid receptors in the dorsal vagal complex of rats: implications for olanzapine-induced weight gain. | Weston-Green K et al. | β | 2008 | β |
| The influence of marijuana use on neurocognitive functioning in adolescents. | Schweinsburg AD et al. | β | 2008 | β |
| The role of the CB1 receptor in the regulation of sleep. | Murillo-RodrΓguez E | β | 2008 | β |
| [18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor. | Burns HD et al. | β | 2007 | β |
| Acute and non-acute effects of cannabis on brain functioning and neuropsychological performance. | Gonzalez R | β | 2007 | β |
| Acute, chronic and withdrawal effects of the cannabinoid receptor agonist WIN55212-2 on the sequential activation of MAPK/Raf-MEK-ERK signaling in the rat cerebral frontal cortex: short-term regulation by intrinsic and extrinsic pathways. | Moranta D et al. | β | 2007 | β |
| Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients: impact of cannabis use. | Leweke FM et al. | β | 2007 | β |
| An endocannabinoid mechanism in relapse to drug seeking: a review of animal studies and clinical perspectives. | Fattore L et al. | β | 2007 | β |
| Cannabinoid-mediated disinhibition and working memory: dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex. | Carter E et al. | β | 2007 | β |
| Cannabinoid receptor down-regulation in the ventral cochlear nucleus in a salicylate model of tinnitus. | Zheng Y et al. | β | 2007 | β |
| Cannabinoids and pain. | Lever IJ et al. | β | 2007 | β |
| Chronic use of marijuana decreases cannabinoid receptor binding and mRNA expression in the human brain. | Villares J | β | 2007 | β |
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| Effects of prenatal exposure to the CB-1 receptor agonist WIN 55212-2 or CO on the GABAergic neuronal systems of rat cerebellar cortex. | Benagiano V et al. | β | 2007 | β |
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| Endocannabinoids and the gastrointestinal tract: what are the key questions? | Sanger GJ | β | 2007 | β |
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| Inhibition of potassium- and ischemia-evoked [3H] D-aspartate release from isolated bovine retina by cannabinoids. | Opere CA et al. | β | 2006 | β |
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| Targeting dopamine D2 and cannabinoid-1 (CB1) receptors in rat nucleus accumbens. | Pickel VM et al. | β | 2006 | β |
| The emerging role of the endocannabinoid system in endocrine regulation and energy balance. | Pagotto U et al. | β | 2006 | β |
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| Cannabinoids and the immune system: potential for the treatment of inflammatory diseases? | Croxford JL et al. | β | 2005 | β |
| Cannabinoid suppressed bicuculline-induced convulsion without respiratory depression in the brainstem-spinal cord preparation from newborn rats. | Koda S et al. | β | 2005 | β |
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| The cannabinoid receptor agonist WIN 55212-2 inhibits neurogenic inflammations in airway tissues. | Yoshihara S et al. | β | 2005 | β |
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| Immunohistochemical characterisation and localisation of cannabinoid CB1 receptor protein in the rat vestibular nucleus complex and the effects of unilateral vestibular deafferentation. | Ashton JC et al. | β | 2004 | β |
| Influence of age, postmortem delay and freezing storage period on cannabinoid receptor density and functionality in human brain. | Mato S et al. | β | 2004 | β |
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| Repeated, intermittent delta(9)-tetrahydrocannabinol administration to rats impairs acquisition and performance of a test of visuospatial divided attention. | Verrico CD et al. | β | 2004 | β |
| Selective antagonist [3H]SR141716A binding to cannabinoid CB1 receptors is increased in the anterior cingulate cortex in schizophrenia. | Zavitsanou K et al. | β | 2004 | β |
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| The psychotomimetic effects of intravenous delta-9-tetrahydrocannabinol in healthy individuals: implications for psychosis. | D'Souza DC et al. | β | 2004 | β |
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| Cannabinoid1 receptor in the dorsal vagal complex modulates lower oesophageal sphincter relaxation in ferrets. | Partosoedarso ER et al. | β | 2003 | β |
| Cannabinoid CB1 receptor protein expression in the rat hippocampus and entorhinal, perirhinal, postrhinal and temporal cortices: regional variations and age-related changes. | Liu P et al. | β | 2003 | β |
| Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. | Benito C et al. | β | 2003 | β |
| Cannabinoids reduce symptoms of Tourette's syndrome. | MΓΌller-Vahl KR | β | 2003 | β |
| Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats. | Schneider M et al. | β | 2003 | β |
| Effects of levodopa on endocannabinoid levels in rat basal ganglia: implications for the treatment of levodopa-induced dyskinesias. | Ferrer B et al. | β | 2003 | β |
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| Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528: further evidence for cannabinoid CB2 receptor absence in the rat central nervous system. | Griffin G et al. | β | 1999 | β |
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| The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. | Jaggar SI et al. | β | 1998 | β |
| The endogenous cannabinoid anandamide, but not the CB2 ligand palmitoylethanolamide, prevents the viscero-visceral hyper-reflexia associated with inflammation of the rat urinary bladder. | Jaggar SI et al. | β | 1998 | β |
| The functional neuroanatomy of brain cannabinoid receptors. | Breivogel CS et al. | β | 1998 | β |
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