Under the influence of genetics: how transdisciplinarity leads us to rethink social pathways to illness.
- Authors
- Pescosolido, Bernice A; Perry, Brea L; Long, J Scott; Martin, Jack K; Nurnberger, John I; Hesselbrock, Victor
- Year
- 2008
- Journal
- AJS; American journal of sociology
- PMID
- 19569404
- DOI
- 10.1086/592209
- PMCID
- PMC4443492
This article describes both sociological and genetic theories of illness causation and derives propositions expected under each and under a transdisciplinary theoretical frame. The authors draw propositions from three theories -- fundamental causes, social stress processes, and social safety net theories -- and tailor hypotheses to the case of alcohol dependence. Analyses of a later wave of the Collaborative Study on the Genetics of Alcoholism reveal a complex interplay of the GABRA2 gene with social structural factors to produce cases meeting DSM/ICD diagnoses. Only modest evidence suggests that genetic influence works through social conditions and experiences. Further, women are largely unaffected in their risk for alcohol dependence by allele status at this candidate gene; family support attenuates genetic influence; and childhood deprivation exacerbates genetic predispositions. These findings highlight the essential intradisciplinary tension in the role of proximal and distal influences in social processes and point to the promise of focusing directly on dynamic, networked sequences that produce different pathways to health and illness.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. | 2013 | 23974430 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Comparing Observed and Unobserved Components of Childhood: Evidence From Finnish Register Data on Midlife Mortality From Siblings and Their Parents. | Kröger H et al. | — | 2018 | → |
| Plastic and immobile: Unequal intergenerational mobility by genetic sensitivity score within sibling pairs. | Rauscher E | — | 2017 | → |
| Social Context, Biology, and the Definition of Disorder. | Horwitz AV | — | 2017 | → |
| Gene worlds. | Timmermans S et al. | — | 2016 | → |
| Opportunities and challenges of big data for the social sciences: The case of genomic data. | Liu H et al. | — | 2016 | → |
| The biosocial: sociological themes and issues. | Meloni M et al. | — | 2016 | → |
| Disadvantaged family background and depression among young adults in the United States: the roles of chronic stress and self-esteem. | Mossakowski KN | — | 2015 | → |
| Gene by Social-Environment Interaction for Youth Delinquency and Violence: Thirty-Nine Aggression-related Genes. | Liu H et al. | — | 2015 | → |
| Lifetime Socioeconomic Status, Historical Context, and Genetic Inheritance in Shaping Body Mass in Middle and Late Adulthood. | Liu H et al. | — | 2015 | → |
| Sibling genes as environment: Sibling dopamine genotypes and adolescent health support frequency dependent selection. | Rauscher E et al. | — | 2015 | → |
| A new synthesis. | Forest PG | — | 2014 | → |
| Consensus paper of the WFSBP task force on biological markers: biological markers for alcoholism. | Hashimoto E et al. | — | 2013 | → |
| Contextualizing Disparities: The Case for Comparative Research on Social Inequalities in Health. | Olafsdottir S et al. | — | 2013 | → |
| Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. | Perry BL et al. | — | 2013 | → |
| Genetic interactions with prenatal social environment: effects on academic and behavioral outcomes. | Conley D et al. | — | 2013 | → |
| Integrating social science and behavioral genetics: testing the origin of socioeconomic disparities in depression using a genetically informed design. | Mezuk B et al. | — | 2013 | → |
| Job Authority and Breast Cancer. | Pudrovska T | — | 2013 | → |
| Conceptual approaches to the study of health disparities. | Diez Roux AV | — | 2012 | → |
| DIFFERENTIAL SUSCEPTIBILITY TO CONTEXT: A PROMISING MODEL OF THE INTERPLAY OF GENES AND THE SOCIAL ENVIRONMENT. | Simons RL et al. | — | 2012 | → |
| Marijuana use development over the course of adolescence among North American Indigenous youth. | Cheadle JE et al. | — | 2012 | → |
| Socioeconomic status and cumulative disadvantage processes across the life course: implications for health outcomes. | Seabrook JA et al. | — | 2012 | → |
| Alcohol use trajectories and problem drinking over the course of adolescence: a study of north american indigenous youth and their caretakers. | Cheadle JE et al. | — | 2011 | → |
| Gene-environment correlations in the stress-depression relationship. | Schnittker J | — | 2010 | → |
| Genotype-environment interaction and sociology: contributions and complexities. | Seabrook JA et al. | — | 2010 | → |
| Incorporating children's lives into a life course perspective on stress and mental health. | Avison WR | — | 2010 | → |