The association between cannabis use and mood disorders: A longitudinal study.
paper
Cited
Public
Unavailable
- Authors
- Feingold, Daniel; Weiser, Mark; Rehm, Jürgen; Lev-Ran, Shaul
- Year
- 2015
- Journal
- Journal of affective disorders
- PMID
- 25451420
- DOI
- 10.1016/j.jad.2014.10.006
BACKGROUND: The association between cannabis use and mood disorders is well documented, yet evidence regarding causality is conflicting. This study explored the association between cannabis use, major depressive disorder (MDD) and bipolar disorder (BPD) in a 3-year prospective study. METHODS: Data was drawn from waves 1 and 2 of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). MDD and BPD were controlled at baseline and defined as meeting full criteria in the 12 months prior to the follow-up. Initiation of cannabis use was defined as any cannabis used by former lifetime abstainers in the time period between baseline and follow-up. RESULTS: Cannabis use was not significantly associated with increased incidence of MDD (Adjusted Odds Ratio (AOR) for daily use=0.58(0.22-1.51)). Weekly to almost daily cannabis use was associated with increased incidence of BPD ((AOR for weekly to daily use=2.47(1.03-5.92)); daily use was not (AOR=0.52(0.17-1.55)). Baseline MDD was associated with initiation of cannabis use (AOR=1.72(1.1-2.69)). A crude association between baseline BPD and incidence of cannabis use was not maintained in adjusted models (AOR=0.61(0.36-1.04)). LIMITATIONS: Lack of information regarding frequency of cannabis use at follow-up and limitations regarding generalization of the results. CONCLUSIONS: Our findings do not support a longitudinal association between cannabis use and incidence of MDD. Results regarding the association between cannabis use and incidence of BPD are conflicting and require further investigation. Baseline MDD, but not BPD, may be associated with future initiation of cannabis use. This may have implications for clinical, social and legislative aspects of cannabis use.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The intersectionality of cannabis use and depression symptoms on functional brain topology in adults. | Liu C et al. | — | 2026 | → |
| Cannabis and Cannabinoids in Mood and Anxiety Disorders: Impact on Illness Onset and Course, and Assessment of Therapeutic Potential. | Botsford SL et al. | — | 2025 | → |
| Cannabis and psychopathology: 2024 Snapshot of a meandering journey. | Mahintamani T et al. | — | 2025 | → |
| Cannabis Use is Related to Anhedonia in Adolescents With Diverse Mood and Anxiety Symptoms. | Nguyen TNB et al. | — | 2025 | → |
| Correlates of cannabis use and cannabis use disorder among adolescents with major depressive disorder and bipolar disorder in the National Comorbidity Survey-Adolescent Supplement (NCS-A). | Sultan AA et al. | — | 2025 | → |
| Effects of persistent cannabis use on depression, psychosis, and suicidality following cannabis-induced psychosis: A longitudinal study. | Ricci V et al. | — | 2025 | → |
| Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort. | Steeger CM et al. | — | 2025 | → |
| Heavy and Chronic Cannabis Addiction does not Impact Motor Function: A BOLD-fMRI Study. | Boujraf S et al. | — | 2025 | → |
| The association between cannabis and depression: an updated Systematic Review and Meta-analysis. | Churchill V et al. | — | 2025 | → |
| Associations of cannabis use, tobacco use, and incident anxiety, mood, and psychotic disorders: a systematic review and meta-analysis. | Burke C et al. | — | 2024 | → |
| Cannabis use and mood disorders: a systematic review. | Sorkhou M et al. | — | 2024 | → |
| Changes in Cannabis Use Patterns in Psychiatric Populations Pre- and Post-Legalization of Recreational Cannabis Use in Canada: A Repeated Cross-Sectional Survey. | Sorkhou M et al. | — | 2024 | → |
| Early exposure to cannabis and bipolar disorder incidence: Findings from a 22-year birth cohort study in Brazil. | Jorge ACR et al. | — | 2024 | → |
| Effect of recreational cannabis use on bone mineral density: a systematic review. | Magno LAV et al. | — | 2024 | → |
| Investigating Cannabis-Use Among Students Attending High Schools Within the Cherokee Nation Reservation 2017 and 2019. | Campbell JE et al. | — | 2024 | → |
| Substance Use and Mental Health among Canadian Social Workers. | Kiepek N et al. | — | 2024 | → |
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | Preuss UW et al. | — | 2023 | → |
| Cannabis use and its relationship with bipolar disorder: A systematic review and meta-analysis. | Maggu G et al. | — | 2023 | → |
| Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder. | Jefsen OH et al. | — | 2023 | → |
| Cannabis use in repeated representative cross-sectional studies on Italian adults after the COVID-19 pandemic. | Amerio A et al. | — | 2023 | → |
| Directional associations between cannabis use and depression from late adolescence to young adulthood: the role of adverse childhood experiences. | Davis JP et al. | — | 2023 | → |
| Ecological Momentary Assessment of Cannabis Use and Affect Among Adolescents Following Psychiatric Discharge. | Brick LA et al. | — | 2023 | → |
| Endocannabinoid System and Exogenous Cannabinoids in Depression and Anxiety: A Review. | Hasbi A et al. | — | 2023 | → |
| Predictors of Cannabis Use Among Canadian University Students. | Llewelyn-Williams J et al. | — | 2023 | → |
| Should gastroenterologists prescribe cannabis? The highs, the lows and the unknowns. | Samuel S et al. | — | 2023 | → |
| Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use. | Johnstad PG | — | 2023 | → |
| Associations between cannabis use, cannabis use disorder, and mood disorders: longitudinal, genetic, and neurocognitive evidence. | Kuhns L et al. | — | 2022 | → |
| Autism and associated disorders: cannabis as a potential therapy. | Babayeva M et al. | — | 2022 | → |
| Childhood polyvictimization and marijuana use trajectories. | Plummer Lee C et al. | — | 2022 | → |
| Clinical Value of Inflammatory and Neurotrophic Biomarkers in Bipolar Disorder: A Systematic Review and Meta-Analysis. | Vega-Núñez A et al. | — | 2022 | → |
| Comorbidity and Coaggregation of Major Depressive Disorder and Bipolar Disorder and Cannabis Use Disorder in a Controlled Family Study. | Quick CR et al. | — | 2022 | → |
| Examining the Use of Antidepressants for Adolescents with Depression/Anxiety Who Regularly Use Cannabis: A Narrative Review. | Hen-Shoval D et al. | — | 2022 | → |
| Gender Differences in Dual Diagnoses Associated with Cannabis Use: A Review. | Prieto-Arenas L et al. | — | 2022 | → |
| Is early exposure to cannabis associated with bipolar disorder? Results from a Finnish birth cohort study. | Denissoff A et al. | — | 2022 | → |
| Modulation of Endocannabinoid System Components in Depression: Pre-Clinical and Clinical Evidence. | Bright U et al. | — | 2022 | → |
| Moral injury and cannabis use disorder among Israeli combat veterans: The role of depression and perceived social support. | Ashwal-Malka A et al. | — | 2022 | → |
| Perceived racial and social class discrimination and cannabis involvement among Black youth and young adults. | Ahuja M et al. | — | 2022 | → |
| Predicting Self-Medication with Cannabis in Young Adults with Hazardous Cannabis Use. | Wallis D et al. | — | 2022 | → |
| Review of systemic and syndromic complications of cannabis use: A review. | Shah J et al. | — | 2022 | → |
| Risks and Benefits of Cannabis and Cannabinoids in Psychiatry. | Hill KP et al. | — | 2022 | → |
| Shifting the Paradigm on Cannabis Safety. | Bannigan P et al. | — | 2022 | → |
| Sociodemographic and clinical correlates of cannabis dependence among Israeli combat veterans. | Asper A et al. | — | 2022 | → |
| Bipolar disorder and cannabis use: A bidirectional two-sample Mendelian randomization study. | Jefsen OH et al. | — | 2021 | → |
| Cannabis and Depression. | Feingold D et al. | — | 2021 | → |
| Cannabis Associated Mental Health Effects: A Review. | Kancherla N et al. | — | 2021 | → |
| Environmental Risk Factors for Schizophrenia and Bipolar Disorder and Their Relationship to Genetic Risk: Current Knowledge and Future Directions. | Robinson N et al. | — | 2021 | → |
| Environmental Risk Factors in Bipolar Disorder and Psychotic Depression: A Systematic Review and Meta-Analysis of Prospective Studies. | Rodriguez V et al. | — | 2021 | → |
| From an Alternative Medicine to a New Treatment for Refractory Epilepsies: Can Cannabidiol Follow the Same Path to Treat Neuropsychiatric Disorders? | Bitencourt RM et al. | — | 2021 | → |
| Looking into a Deluded Brain through a Neuroimaging Lens. | Arjmand S et al. | — | 2021 | → |
| The Behavioral Sequelae of Cannabis Use in Healthy People: A Systematic Review. | Sorkhou M et al. | — | 2021 | → |
| Alcohol Use Disorder Is Differently Associated With Psychotic Symptoms According To Underlying Psychiatric Disorders: A General Population Study. | Pignon B et al. | — | 2020 | → |
| Associations between Psychiatric Disorders and Cannabis-Related Disorders Documented in Electronic Health Records. | Campbell A et al. | — | 2020 | → |
| Cannabis and Cannabinoids in Mood and Anxiety Disorders: Impact on Illness Onset and Course, and Assessment of Therapeutic Potential. | Botsford SL et al. | — | 2020 | → |
| Cannabis Use and Emotional Awareness Difficulties in Adolescents with Co-Occurring Substance Use and Psychiatric Disorders. | Micalizzi L et al. | — | 2020 | → |
| Cannabis Use and the Risk for Psychosis and Affective Disorders. | Sideli L et al. | — | 2020 | → |
| Cannabis Use as a Risk Factor for Depression, Anxiety, and Suicidality: Epidemiological Associations and Implications for Nurses. | Halladay JE et al. | — | 2020 | → |
| Cannabis use, depression and self-harm: phenotypic and genetic relationships. | Hodgson K et al. | — | 2020 | → |
| Cannabis use in early adulthood is prospectively associated with prescriptions of antipsychotics, mood stabilizers, and antidepressants. | Rognli EB et al. | — | 2020 | → |
| Depression level, not pain severity, is associated with smoked medical marijuana dosage among chronic pain patients. | Feingold D et al. | — | 2020 | → |
| Depressive symptoms and cannabis use in a placebo-controlled trial of N-Acetylcysteine for adult cannabis use disorder. | Tomko RL et al. | — | 2020 | → |
| Depressive symptoms moderate cannabis use for young adults in a Text-Delivered randomized clinical trial for cannabis use disorder. | Mason MJ | — | 2020 | → |
| Heavy cannabis use, dependence and the brain: a clinical perspective. | Kroon E et al. | — | 2020 | → |
| Probability and correlates of transition from cannabis use to DSM-5 cannabis use disorder: Results from a large-scale nationally representative study. | Feingold D et al. | — | 2020 | → |
| Reduction and Cessation of Alcohol, Cannabis, and Stimulant Use: Prospective Associations With Changes in Depressive Symptoms Across Two Cohort Studies of Sexual and Gender Minorities. | Dyar C et al. | — | 2020 | → |
| An Examination of Comorbid Psychiatric Disorders in Disordered Gamblers Versus Other Substance-Related Disorders. | Nicholson R et al. | — | 2019 | → |
| An International Society of Bipolar Disorders task force report: Precursors and prodromes of bipolar disorder. | Faedda GL et al. | — | 2019 | → |
| Bipolar disorder and the endocannabinoid system. | Arjmand S et al. | — | 2019 | → |
| Cannabis and mental illness: a review. | Lowe DJE et al. | — | 2019 | → |
| Cannabis use, depression and self-harm: phenotypic and genetic relationships | Hodgson K et al. | — | 2019 | — |
| Effects in rats of adolescent exposure to cannabis smoke or THC on emotional behavior and cognitive function in adulthood. | Bruijnzeel AW et al. | — | 2019 | → |
| Illicit drug use and prescription drug misuse among young adult medical cannabis patients and non-patient users in Los Angeles. | Fedorova EV et al. | — | 2019 | → |
| Medical Cannabis for Older Patients. | Minerbi A et al. | — | 2019 | → |
| Perceived health, medical, and psychiatric conditions in individual and dual-use of marijuana and nonprescription opioids. | Frohe T et al. | — | 2019 | → |
| Trends of major depressive episode among people with cannabis use: Findings from the National Survey on Drug Use and Health 2006-2015. | Carrà G et al. | — | 2019 | → |
| Anxiety, Depression, and Pain Symptoms: Associations With the Course of Marijuana Use and Drug Use Consequences Among Urban Primary Care Patients. | Bertholet N et al. | — | 2018 | → |
| Cannabis and Mood Disorders. | Lucatch AM et al. | — | 2018 | → |
| Cannabis regulatory science: risk-benefit considerations for mental disorders. | Borodovsky JT et al. | — | 2018 | → |
| Clinical and Environmental Risk Factors for Bipolar Disorder: Review of Prospective Studies. | Marangoni C et al. | — | 2018 | → |
| Developmental sensitivity to cannabis use patterns and risk for major depressive disorder in mid-life: findings from 40 years of follow-up. | Schoeler T et al. | — | 2018 | → |
| DSM-5 cannabis use disorder in the National Epidemiologic Survey on Alcohol and Related Conditions-III: Gender-specific profiles. | Kerridge BT et al. | — | 2018 | → |
| Epidemiology and risk factors for bipolar disorder. | Rowland TA et al. | — | 2018 | → |
| Health conditions and motivations for marijuana use among young adult medical marijuana patients and non-patient marijuana users. | Lankenau SE et al. | — | 2018 | → |
| Medical and non-medical marijuana use in depression: Longitudinal associations with suicidal ideation, everyday functioning, and psychiatry service utilization. | Bahorik AL et al. | — | 2018 | → |
| Self-medication with alcohol or drugs for mood and anxiety disorders: A narrative review of the epidemiological literature. | Turner S et al. | — | 2018 | → |
| The association between adolescent cannabis use and anxiety: A parallel process analysis. | Duperrouzel J et al. | — | 2018 | → |
| The association between severity of depression and prescription opioid misuse among chronic pain patients with and without anxiety: A cross-sectional study. | Feingold D et al. | — | 2018 | → |
| A review of Indian research on co-occurring cannabis use disorders& psychiatric disorders. | Singh S et al. | — | 2017 | → |
| Cannabis and Depression: A Twin Model Approach to Co-morbidity. | Smolkina M et al. | — | 2017 | → |
| Cannabis and development of dual diagnoses: A literature review. | Hanna RC et al. | — | 2017 | → |
| Cannabis use and the course and outcome of major depressive disorder: A population based longitudinal study. | Feingold D et al. | — | 2017 | → |
| Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana. | Feingold D et al. | — | 2017 | → |
| Is cannabis treatment for anxiety, mood, and related disorders ready for prime time? | Turna J et al. | — | 2017 | → |
| Longitudinal Studies on the Etiology of Cannabis Use Disorder: A Review. | Courtney KE et al. | — | 2017 | → |
| Medical Cannabinoids in Children and Adolescents: A Systematic Review. | Wong SS et al. | — | 2017 | → |
| Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness. | Schuster RM et al. | — | 2017 | → |
| The clinical implications of legalizing marijuana: Are physician and non-physician providers prepared? | Brooks E et al. | — | 2017 | → |
| The Devil Is in the Details! On Regulating Cannabis Use in Canada Based on Public Health Criteria Comment on "Legalizing and Regulating Marijuana in Canada: Review of Potential Economic, Social, and Health Impacts". | Rehm J et al. | — | 2017 | → |
| Animal Models of Maternal Immune Activation in Depression Research. | Ronovsky M et al. | — | 2016 | → |
| Cannabis use, depression and anxiety: A 3-year prospective population-based study. | Danielsson AK et al. | — | 2016 | → |
| Demographic and clinical characteristics associated with comorbid cannabis use disorders (CUDs) in hospitalized patients with bipolar I disorder. | Weinstock LM et al. | — | 2016 | → |
| Do bipolar subjects' responses to personality questionnaires lack reliability? Evidence from the PsyCoLaus study. | Dupuis M et al. | — | 2016 | → |
| Onset of opportunity to use cannabis and progression from opportunity to dependence: Are influences consistent across transitions? | Hines LA et al. | — | 2016 | → |
| REDUCTIONS IN CANNABIS USE ARE ASSOCIATED WITH MOOD IMPROVEMENT IN FEMALE EMERGING ADULTS. | Moitra E et al. | — | 2016 | → |
| The association between cannabis use and anxiety disorders: Results from a population-based representative sample. | Feingold D et al. | — | 2016 | → |
| The association between cannabis use and suicidality among men and women: A population-based longitudinal study. | Shalit N et al. | — | 2016 | → |
| The role of environmental exposures as risk factors for bipolar disorder: A systematic review of longitudinal studies. | Marangoni C et al. | — | 2016 | → |
| Traditional marijuana, high-potency cannabis and synthetic cannabinoids: increasing risk for psychosis. | Murray RM et al. | — | 2016 | → |
| Cannabis use and mental health-related quality of life among individuals with depressive disorders. | Aspis I et al. | — | 2015 | → |
| Gene-environment interaction in major depression: focus on experience-dependent biological systems. | Lopizzo N et al. | — | 2015 | → |