A genome scan of neuroticism in nicotine dependent smokers.
paper
Cited
Public
Unavailable
- Authors
- Neale, Benjamin M; Sullivan, Patrick F; Kendler, Kenneth S
- Year
- 2005
- Journal
- American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- PMID
- 15389754
- DOI
- 10.1002/ajmg.b.30095
Neuroticism is a personality factor that has consistently been demonstrated to be associated with anxiety, depression, and other "internalizing" disorders. We analyzed a genome scan for neuroticism on a sample of 129 sib-pair families (113 with a single sibling pair, 18 with multiple sibling pairs) containing a total of 201 possible sibling pairs, ascertained for concordance on nicotine dependence. Using Merlin-Regress, we replicated peaks for neuroticism described by prior studies, on chromosomes 1 and 11 with LOD scores of 2.52 and 1.97 (P-value of 0.003 and 0.0108) respectively, and have some evidence for a novel finding on chromosome 12 with a LOD of 2.85 (P-value of 0.0014).
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Emotional dysregulation, alexithymia and neuroticism: a systematic review on the genetic basis of a subset of psychological traits. | Castellini G et al. | — | 2023 | → |
| Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps. | Ramos A et al. | — | 2023 | → |
| Cigarette smoking and personality: interrogating causality using Mendelian randomisation. | Sallis HM et al. | — | 2019 | → |
| Uncovering the Genetic Architecture of Major Depression. | McIntosh AM et al. | — | 2019 | → |
| Cigarette smoking and personality: Investigating causality using Mendelian randomization | Sallis HM et al. | — | 2018 | — |
| Risk factors influencing smoking behavior: a Turkish twin study. | Oncel SY et al. | — | 2014 | → |
| Homozygosity mapping of depressive disorder in a large family from Pakistan: significant linkage on chromosome 6 and 9. | Ayub M et al. | — | 2013 | → |
| A genome-wide linkage study of individuals with high scores on NEO personality traits. | Amin N et al. | — | 2012 | → |
| Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. | Vinkhuyzen AA et al. | — | 2012 | → |
| Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes. | Webb BT et al. | — | 2012 | → |
| Meta-analysis of genome-wide association studies for personality. | de Moor MH et al. | — | 2012 | → |
| Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. | Le-Niculescu H et al. | — | 2011 | → |
| Dissecting the genetic architecture of human personality. | Munafò MR et al. | — | 2011 | → |
| A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality. | Verweij KJ et al. | — | 2010 | → |
| A genome-wide association study of neuroticism in a population-based sample. | Calboli FC et al. | — | 2010 | → |
| A genome-wide screen for depression in two independent Dutch populations. | Schol-Gelok S et al. | — | 2010 | → |
| Genome-wide association scan for five major dimensions of personality. | Terracciano A et al. | — | 2010 | → |
| The genetic and environmental relationship between major depression and the five-factor model of personality. | Kendler KS et al. | — | 2010 | → |
| Linkage and association studies of anxiety disorders. | Hamilton SP | — | 2009 | → |
| Suggestive linkage on chromosome 2, 8, and 17 for lifetime major depression. | Middeldorp CM et al. | — | 2009 | → |
| The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity. | Distel MA et al. | — | 2009 | → |
| The impact of personality characteristics on the clinical expression in neurodegenerative disorders--a review. | von Gunten A et al. | — | 2009 | → |
| A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: psychoticism, extraversion, neuroticism, and lie. | Gillespie NA et al. | — | 2008 | → |
| A whole genome association study of neuroticism using DNA pooling. | Shifman S et al. | — | 2008 | → |
| Experiential and genetic contributions to depressive- and anxiety-like disorders: clinical and experimental studies. | Anisman H et al. | — | 2008 | → |
| Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. | Boomsma DI et al. | — | 2008 | → |
| Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. | Wray NR et al. | — | 2008 | → |
| Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. | Fullerton JM et al. | — | 2008 | → |
| Molecular genetics of anxiety in mice and men. | Hovatta I et al. | — | 2008 | → |
| Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. | Le-Niculescu H et al. | — | 2008 | → |
| Toward a neurogenetic theory of neuroticism. | Canli T | — | 2008 | → |
| What is the genetic relationship between anxiety and depression? | Hettema JM | — | 2008 | → |
| A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence. | Kuo PH et al. | — | 2007 | → |
| Genetics of recurrent early-onset major depression (GenRED): final genome scan report. | Holmans P et al. | — | 2007 | → |
| Identifying the genetic determinants of emotionality in humans; insights from rodents. | Willis-Owen SA et al. | — | 2007 | → |
| Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. | Fanous AH et al. | — | 2007 | → |
| New approaches to the genetic analysis of neuroticism and anxiety. | Fullerton J | — | 2006 | → |
| The genetics of depression: a review. | Levinson DF | — | 2006 | → |
| The influence of genetics on nicotine dependence and the role of pharmacogenetics in treating the smoking habit. | Chatkin JM | — | 2006 | → |
| The molecular genetic architecture of human personality: beyond self-report questionnaires. | Ebstein RP | — | 2006 | → |
| Dissecting the genetic etiology of major depressive disorder using linkage analysis. | Camp NJ et al. | — | 2005 | → |
| Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. | Camp NJ et al. | — | 2005 | → |
| The genetics of depression and related traits. | Huezo-Diaz P et al. | — | 2005 | → |