Genetic variation in human NPY expression affects stress response and emotion.
paper
Cited
Public
Unavailable
- Authors
- Zhou, Zhifeng; Zhu, Guanshan; Hariri, Ahmad R; Enoch, Mary-Anne; Scott, David; Sinha, Rajita; Virkkunen, Matti; Mash, Deborah C; Lipsky, Robert H; Hu, Xian-Zhang; Hodgkinson, Colin A; Xu, Ke; Buzas, Beata; Yuan, Qiaoping; Shen, Pei-Hong; Ferrell, Robert E; Manuck, Stephen B; Brown, Sarah M; Hauger, Richard L; Stohler, Christian S; Zubieta, Jon-Kar; Goldman, David
- Year
- 2008
- Journal
- Nature
- PMID
- 18385673
- DOI
- 10.1038/nature06858
- PMCID
- PMC2715959
Understanding inter-individual differences in stress response requires the explanation of genetic influences at multiple phenotypic levels, including complex behaviours and the metabolic responses of brain regions to emotional stimuli. Neuropeptide Y (NPY) is anxiolytic and its release is induced by stress. NPY is abundantly expressed in regions of the limbic system that are implicated in arousal and in the assignment of emotional valences to stimuli and memories. Here we show that haplotype-driven NPY expression predicts brain responses to emotional and stress challenges and also inversely correlates with trait anxiety. NPY haplotypes predicted levels of NPY messenger RNA in post-mortem brain and lymphoblasts, and levels of plasma NPY. Lower haplotype-driven NPY expression predicted higher emotion-induced activation of the amygdala, as well as diminished resiliency as assessed by pain/stress-induced activations of endogenous opioid neurotransmission in various brain regions. A single nucleotide polymorphism (SNP rs16147) located in the promoter region alters NPY expression in vitro and seems to account for more than half of the variation in expression in vivo. These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic markers of stress, resilience and success at an elite military selection course. | Petrovick M et al. | β | 2026 | β |
| Modulating neuropeptide Y pathways to combat nicotine addiction through emerging evidence and future directions. | Khidkikar S et al. | β | 2026 | β |
| Revisited case for intranasal neuropeptide Y based therapeutics: From preclinical to clinical. | Sabban EL et al. | β | 2026 | β |
| Subcellular interactions of neuropeptide Y and corticotropin-releasing factor in the central nucleus of the amygdala in the mouse. | Yerraguntla H et al. | β | 2026 | β |
| Autonomic Nervous System in Bone Remodeling: From Mechanisms to Novel Therapies in Orthopedic Diseases. | Xia R et al. | β | 2025 | β |
| Genetic Predictors of Psychosomatic Symptoms in Individuals with Metabolic Syndrome: Insights from a Cross-Sectional Study in Kazakhstan. | Nemetova D et al. | β | 2025 | β |
| Genetic Predisposition and Genetic Resilience Factors in Stress-Related Disorders During the Developmental Age: A Narrative Review. | Raffagnato A et al. | β | 2025 | β |
| Modulation by NPY/NPF-like receptor underlies experience-dependent, sexually dimorphic learning. | Peedikayil-Kurien S et al. | β | 2025 | β |
| Modulation of temporoammonic-CA1 synapses by neuropeptide Y is through Y1 receptors in mice. | Cortes MA et al. | β | 2025 | β |
| Molecular Links Between Metabolism and Mental Health: Integrative Pathways from GDF15-Mediated Stress Signaling to Brain Energy Homeostasis. | Seo M et al. | β | 2025 | β |
| Molecular Mechanisms of Depression: The Interplay Between Genes and Receptors. | Oatu A et al. | β | 2025 | β |
| Neurological Mechanisms Exploration and Therapeutic Targets in Segmental Vitiligo Accompanied by White Hair. | Fu S et al. | β | 2025 | β |
| Neuropeptidergic systems in psychiatric disorders. | Hodzic S et al. | β | 2025 | β |
| Post-bariatric surgery quality-of-life decline: analysis of the gut-brain axis. | Jiao Y et al. | β | 2025 | β |
| Sweroside Modulates Oxidative Stress and Neuroplasticity-Related Gene Expression in Scopolamine-Treated Zebrafish. | Brinza I et al. | β | 2025 | β |
| The autonomic nervous system and bone health in chronic kidney disease. | Zoccali C et al. | β | 2025 | β |
| Modulation of Temporoammonic-CA1 Synapses by Neuropeptide Y is Through Y1 Receptors | Cortes MA et al. | β | 2024 | β |
| Neuropeptide Y and Pain: Insights from Brain Research. | Nelson TS et al. | β | 2024 | β |
| Neuropeptide Y gene variants and Agreeableness: interaction effect with the birth cohort and the serotonin transporter promoter polymorphism. | Kiive E et al. | β | 2024 | β |
| Pain-related single nucleotide polymorphisms: association with lumbar spinal stenosis patient experience and non-surgical treatment outcomes. | Ernst S et al. | β | 2024 | β |
| Stress and substance use disorders: risk, relapse, and treatment outcomes. | Sinha R | β | 2024 | β |
| The missing hallmark of health: psychosocial adaptation. | LΓ³pez-OtΓn C et al. | β | 2024 | β |
| The role of resilience in the relationship between stress and alcohol. | Schwandt ML et al. | β | 2024 | β |
| Cross talk about the role of Neuropeptide Y in CNS disorders and diseases. | Bale R et al. | β | 2023 | β |
| Design of Novel Imidazopyrazine Derivative against Breast Cancer <i>via</i> Targeted NPY1R Antagonist. | Niranjan V et al. | β | 2023 | β |
| Potential benefits of intranasal neuropeptide Y include sustained extinction of fear memory. | Sabban EL et al. | β | 2023 | β |
| The effects of Korean Red Ginseng on stress-related neurotransmitters and gene expression: A randomized, double-blind, placebo-controlled trial. | Yoon J et al. | β | 2023 | β |
| Unloading-Induced Skeletal Interoception Alters Hypothalamic Signaling to Promote Bone Loss and Fat Metabolism. | Guo Q et al. | β | 2023 | β |
| Amygdala in Action: Functional Connectivity during Approach and Avoidance Behaviors. | LeitΓ£o J et al. | β | 2022 | β |
| Association between neuropeptide Y gene polymorphism and antipsychotics effect. | Zhang Q et al. | β | 2022 | β |
| Exploring the role of neuropeptides in depression and anxiety. | Rana T et al. | β | 2022 | β |
| Gene expression associated with human brain activations in facial expression recognition. | Wang Z et al. | β | 2022 | β |
| Genetic Variants Associated With Resilience in Human and Animal Studies. | Cahill S et al. | β | 2022 | β |
| Neuropeptide System Regulation of Prefrontal Cortex Circuitry: Implications for Neuropsychiatric Disorders. | Casello SM et al. | β | 2022 | β |
| Nutrigenetic variants and response to diet/lifestyle intervention in obese subjects: a pilot study. | Franzago M et al. | β | 2022 | β |
| Predictors of Chronic Fatigue Syndrome and Mood Disturbance After Acute Infection. | Sandler CX et al. | β | 2022 | β |
| Pyrroloquinoline Quinone Regulates Enteric Neurochemical Plasticity of Weaned Rats Challenged With Lipopolysaccharide. | Shi C et al. | β | 2022 | β |
| Sleep and violence perpetration: A review of biological and environmental substrates. | Paiva T et al. | β | 2022 | β |
| The neurobiology of obsessive-compulsive personality disorder: a systematic review. | Marincowitz C et al. | β | 2022 | β |
| The neuropeptide Y single-nucleotide polymorphism <i>rs16147:T</i>><i>C</i> moderates the effect of alcohol dependence on depression in male Chinese Han population. | Wei X et al. | β | 2022 | β |
| Uncovering the Potential Mechanisms of <i>Coptis chinensis</i> Franch. for Serious Mental Illness by Network Pharmacology and Pharmacology-Based Analysis. | Qi Y et al. | β | 2022 | β |
| Unique and joint associations of polygenic risk for major depression and opioid use disorder with endogenous opioid system function. | Love T et al. | β | 2022 | β |
| A balancing act: the role of pro- and anti-stress peptides within the central amygdala in anxiety and alcohol use disorders. | Walker LC | β | 2021 | β |
| Association of Protein and Genetic Biomarkers With Response to Lumbar Epidural Steroid Injections in Subjects With Axial Low Back Pain. | Schaaf S et al. | β | 2021 | β |
| Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study. | Jenz ST et al. | β | 2021 | β |
| Common Factors Underlying Diverse Responses in Alcohol Use Disorder. | Chebolu E et al. | β | 2021 | β |
| Cortical Transcriptomic Alterations in Association With Appetitive Neuropeptides and Body Mass Index in Posttraumatic Stress Disorder. | Stone LA et al. | β | 2021 | β |
| Design, Implementation, and Evaluation of a Distance Learning Framework to Adapt to the Changing Landscape of Anatomy Instruction in Medical Education During COVID-19 Pandemic: A Proof-of-Concept Study. | Naidoo N et al. | β | 2021 | β |
| Hallmarks of Health. | LΓ³pez-OtΓn C et al. | β | 2021 | β |
| Meta-Analysis on the Association of Neuropeptide Y rs16139 Variant With the Risk of Alcoholism. | Chen B et al. | β | 2021 | β |
| Neural Markers of Vulnerability to Anxiety Outcomes after Traumatic Brain Injury. | Popovitz J et al. | β | 2021 | β |
| Neurobiological mechanisms of early life adversity, blunted stress reactivity and risk for addiction. | al'Absi M et al. | β | 2021 | β |
| Neuropeptide Y as a risk factor for cardiorenal disease and cognitive dysfunction in chronic kidney disease: translational opportunities and challenges. | Zoccali C et al. | β | 2021 | β |
| Neuropeptide Y gene variants in obesity, dietary intake, blood pressure, lipid and glucose metabolism: A longitudinal birth cohort study. | Katus U et al. | β | 2021 | β |
| Posttraumatic Stress Disorder and Anxiety-Related Conditions. | Williamson JB et al. | β | 2021 | β |
| Potential gut-brain mechanisms behind adverse mental health outcomes of bariatric surgery. | Brown RM et al. | β | 2021 | β |
| Trait anxiety, a personality risk factor associated with Alzheimer's Disease. | Li S et al. | β | 2021 | β |
| Contribution of NPY Y<sub>5</sub> Receptors to the Reversible Structural Remodeling of Basolateral Amygdala Dendrites in Male Rats Associated with NPY-Mediated Stress Resilience. | Michaelson SD et al. | β | 2020 | β |
| GABAergic System in Stress: Implications of GABAergic Neuron Subpopulations and the Gut-Vagus-Brain Pathway. | Hou X et al. | β | 2020 | β |
| Genetics of resilience: Implications from genome-wide association studies and candidate genes of the stress response system in posttraumatic stress disorder and depression. | Maul S et al. | β | 2020 | β |
| Neuropeptide Y and cannabinoids interaction in the amygdala after exposure to shock and reminders model of PTSD. | Maymon N et al. | β | 2020 | β |
| NPY and Gene Therapy for Epilepsy: How, When,... and Y. | Cattaneo S et al. | β | 2020 | β |
| Offensive Behavior, Striatal Glutamate Metabolites, and Limbic-Hypothalamic-Pituitary-Adrenal Responses to Stress in Chronic Anxiety. | Ullmann E et al. | β | 2020 | β |
| Rabbit Annulus Fibrosus Cells Express Neuropeptide Y, Which Is Influenced by Mechanical and Inflammatory Stress. | Dombrowski ME et al. | β | 2020 | β |
| Sex Differences in the Neuropeptide Y System and Implications for Stress Related Disorders. | Nahvi RJ et al. | β | 2020 | β |
| Systemic administration of ZLc-002 exerts anxiolytic-like effects by dissociation of nNOS from CAPON in adult mice. | Zhu LJ et al. | β | 2020 | β |
| The Role of Nerves in Skeletal Development, Adaptation, and Aging. | Tomlinson RE et al. | β | 2020 | β |
| A precision medicine approach to pharmacological adjuncts to extinction: a call to broaden research. | King G et al. | β | 2019 | β |
| A Stimulus-Response Framework to Investigate the Influence of Continuous Versus Interval Walking Exercise on Select Serum Biomarkers in Knee Osteoarthritis. | Jayabalan P et al. | β | 2019 | β |
| Expression of neuropeptide Y and gonadotropin-releasing hormone gene types in the brain of female Nile tilapia (Oreochromis niloticus) during mouthbrooding and food restriction. | Das K et al. | β | 2019 | β |
| Imaging neuropeptide effects on human brain function. | Lefevre A et al. | β | 2019 | β |
| Neuropeptide Y and religious commitment in healthy young women. | TΓΈnnesen MT et al. | β | 2019 | β |
| Neuropeptide Y and representation of salience in human nucleus accumbens. | Warthen KG et al. | β | 2019 | β |
| Neuropeptide Y Gene Γ Environment Interaction Predicts Resilience and Positive Future Focus. | Gan Y et al. | β | 2019 | β |
| Prefrontal Executive Control Rescues Risk for Anxiety Associated with High Threat and Low Reward Brain Function. | Scult MA et al. | β | 2019 | β |
| Relation of neuropeptide Y gene expression and genotyping with hypertension in chronic kidney disease. | Badr EAE et al. | β | 2019 | β |
| Resilience as a focus of suicide research and prevention. | Sher L | β | 2019 | β |
| The association between prenatal exposure to phthalates and cognition and neurobehavior of children-evidence from birth cohorts. | Zhang Q et al. | β | 2019 | β |
| The Biology of Human Resilience: Opportunities for Enhancing Resilience Across the Life Span. | Feder A et al. | β | 2019 | β |
| Translating Molecular and Neuroendocrine Findings in Posttraumatic Stress Disorder and Resilience to Novel Therapies. | DePierro J et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| A Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder. | Sayed S et al. | β | 2018 | β |
| Biological profiling of plasma neuropeptide Y in relation to posttraumatic stress symptoms in two combat cohorts. | Reijnen A et al. | β | 2018 | β |
| Biological underpinnings of an internalizing pathway to alcohol, cigarette, and marijuana use. | Trucco EM et al. | β | 2018 | β |
| Could a blood test for PTSD and depression be on the horizon? | Aspesi D et al. | β | 2018 | β |
| Effects on gene expression and behavior of untagged short tandem repeats: the case of arginine vasopressin receptor 1a (AVPR1a) and externalizing behaviors. | Landefeld CC et al. | β | 2018 | β |
| Impact of the Autonomic Nervous System on the Skeleton. | Elefteriou F | β | 2018 | β |
| Low resilience to stress is associated with candidate gene expression alterations in the dopaminergic signalling pathway. | Azadmarzabadi E et al. | β | 2018 | β |
| Neuropeptide and Small Transmitter Coexistence: Fundamental Studies and Relevance to Mental Illness. | HΓΆkfelt T et al. | β | 2018 | β |
| Neuropeptide Y, stressful life events and personality trait conscientiousness: Preliminary associations from a Swedish longitudinal study. | Melas PA et al. | β | 2018 | β |
| Neurotransmitter, Peptide, and Steroid Hormone Abnormalities in PTSD: Biological Endophenotypes Relevant to Treatment. | Rasmusson AM et al. | β | 2018 | β |
| Non-invasive genotyping with a massively parallel sequencing panel for the detection of SNPs in HPA-axis genes. | Gutleb DR et al. | β | 2018 | β |
| NPY Induces Stress Resilience via Downregulation of <i>I</i><sub>h</sub> in Principal Neurons of Rat Basolateral Amygdala. | Silveira Villarroel H et al. | β | 2018 | β |
| Potential of Intranasal Neuropeptide Y (NPY) and/or Melanocortin 4 Receptor (MC4R) Antagonists for Preventing or Treating PTSD. | Sabban EL et al. | β | 2018 | β |
| Primary and Secondary Variants of Psychopathy in a Volunteer Sample Are Associated With Different Neurocognitive Mechanisms. | Sethi A et al. | β | 2018 | β |
| Replication in Imaging Genetics: The Case of Threat-Related Amygdala Reactivity. | Avinun R et al. | β | 2018 | β |
| Stress and Addiction: When a Robust Stress Response Indicates Resiliency. | alΚΌAbsi M | β | 2018 | β |
| Stress Response Modulation Underlying the Psychobiology of Resilience. | Averill LA et al. | β | 2018 | β |
| Tulsa 1000: a naturalistic study protocol for multilevel assessment and outcome prediction in a large psychiatric sample. | Victor TA et al. | β | 2018 | β |
| Adapting to Stress: Understanding the Neurobiology of Resilience. | OsΓ³rio C et al. | β | 2017 | β |
| Chronic stress leads to epigenetic dysregulation in the neuropeptide-Y and cannabinoid CB1 receptor genes in the mouse cingulate cortex. | Lomazzo E et al. | β | 2017 | β |
| Comparative Evaluation of Pain, Stress, Neuropeptide Y, ACTH, and Cortisol Levels Between a Conventional Postoperative Care Protocol and a Fast-Track Recovery Program in Patients Undergoing Major Abdominal Surgery. | Kapritsou M et al. | β | 2017 | β |
| Effects of Di-isononyl Phthalate on Neuropeptide Y Expression in Differentiating Human Neuronal Cells. | Rendel F et al. | β | 2017 | β |
| Enhancing the Informativeness and Replicability of Imaging Genomics Studies. | Carter CS et al. | β | 2017 | β |
| Genetics of generalized anxiety disorder and related traits. | Gottschalk MG et al. | β | 2017 | β |
| Genetic studies of alcohol dependence in the context of the addiction cycle. | Reilly MT et al. | β | 2017 | β |
| Individual differences in human eye movements: An oculomotor signature? | Bargary G et al. | β | 2017 | β |
| Neuropeptide Y in Alcohol Addiction and Affective Disorders. | Thorsell A et al. | β | 2017 | β |
| Neuropeptide Y, resilience, and PTSD therapeutics. | Kautz M et al. | β | 2017 | β |
| Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. | Statello R et al. | β | 2017 | β |
| Transcriptomic analysis of gene expression in mice treated with troxerutin. | Wang Y et al. | β | 2017 | β |
| An association between neuropeptide Y levels and leukocyte subsets in stress-exacerbated asthmatic mice. | Lu Y et al. | β | 2016 | β |
| Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-Containing Neuropeptide. | Yang CY et al. | β | 2016 | β |
| Association of Neuropeptide-Y (NPY) and Interleukin-1beta (IL1B), Genotype-Phenotype Correlation and Plasma Lipids with Type-II Diabetes. | Patel R et al. | β | 2016 | β |
| Association of neuropeptide Y promoter polymorphism (rs16147) with perceived stress and cardiac vagal outflow in humans. | Chang HA et al. | β | 2016 | β |
| Dopamine Rebound-Excitation Theory: Putting Brakes on PTSD. | Lee JC et al. | β | 2016 | β |
| Dysfunctional stress responses in chronic pain. | Woda A et al. | β | 2016 | β |
| Existing and Future Drugs for the Treatment of the Dark Side of Addiction. | Koob GF et al. | β | 2016 | β |
| FKBP5 genotype interacts with early life trauma to predict heavy drinking in college students. | Lieberman R et al. | β | 2016 | β |
| Genetic Correlates of Individual Differences in Sleep Behavior of Free-Living Great Tits (Parus major). | Stuber EF et al. | β | 2016 | β |
| Genetic influences on the neural and physiological bases of acute threat: A research domain criteria (RDoC) perspective. | Sumner JA et al. | β | 2016 | β |
| Genome-wide significant loci for addiction and anxiety. | Hodgson K et al. | β | 2016 | β |
| Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis. | Borrow AP et al. | β | 2016 | β |
| Neuropeptide Y: A stressful review. | Reichmann F et al. | β | 2016 | β |
| Neuropeptide Y Impairs Retrieval of Extinguished Fear and Modulates Excitability of Neurons in the Infralimbic Prefrontal Cortex. | Vollmer LL et al. | β | 2016 | β |
| Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): A translational update. | Schmeltzer SN et al. | β | 2016 | β |
| Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder. | Sabban EL et al. | β | 2016 | β |
| Research Lumbar Punctures among African Americans and Caucasians: Perception Predicts Experience. | Howell JC et al. | β | 2016 | β |
| Short photoperiod condition increases susceptibility to stress in adolescent male rats. | Xu LZ et al. | β | 2016 | β |
| Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation. | Lach G et al. | β | 2016 | β |
| The abundance of cis-acting loci leading to differential allele expression in F1 mice and their relationship to loci harboring genes affecting complex traits. | Yeo S et al. | β | 2016 | β |
| The role of Neuropeptide Y in fear conditioning and extinction. | Tasan RO et al. | β | 2016 | β |
| Translational approach for gene therapy in epilepsy: Model system and unilateral overexpression of neuropeptide Y and Y2 receptors. | Ledri LN et al. | β | 2016 | β |
| Association of neuropeptide Y gene rs16147 polymorphism with metabolic syndrome in patients with documented coronary artery disease. | Parizadeh SA et al. | β | 2015 | β |
| Comprehensive evaluation of the neuropeptide-Y gene variants in the risk of obesity: a case-control study and meta-analysis. | Zain SM et al. | β | 2015 | β |
| DPP4-deficient congenic rats display blunted stress, improved fear extinction and increased central NPY. | Canneva F et al. | β | 2015 | β |
| History of chronic stress modifies acute stress-evoked fear memory and acoustic startle in male rats. | Schmeltzer SN et al. | β | 2015 | β |
| Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codon. | Tikkanen R et al. | β | 2015 | β |
| Neuropeptide Y genotype, central obesity, and abdominal fat distribution: the POUNDS LOST trial. | Lin X et al. | β | 2015 | β |
| Posttraumatic stress disorder. | Jorge RE | β | 2015 | β |
| Targeting the Neuropeptide Y System in Stress-related Psychiatric Disorders. | Enman NM et al. | β | 2015 | β |
| The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour. | Farzi A et al. | β | 2015 | β |
| The Neuromodulation of the Intestinal Immune System and Its Relevance in Inflammatory Bowel Disease. | Di Giovangiulio M et al. | β | 2015 | β |
| The shared neuroanatomy and neurobiology of comorbid chronic pain and PTSD: therapeutic implications. | Scioli-Salter ER et al. | β | 2015 | β |
| Transcriptional regulation of glutamic acid decarboxylase in the male mouse amygdala by dietary phyto-oestrogens. | Sandhu KV et al. | β | 2015 | β |
| A review of factors influencing the stress response in Australian marsupials. | Hing S et al. | β | 2014 | β |
| Association of age at onset in Huntington disease with functional promoter variations in NPY and NPY2R. | Kloster E et al. | β | 2014 | β |
| Association of neuropeptide Y (NPY), interleukin-1B (IL1B) genetic variants and correlation of IL1B transcript levels with vitiligo susceptibility. | Laddha NC et al. | β | 2014 | β |
| Association of the catechol-O-methyltransferase val158met polymorphism and anxiety-related traits: a meta-analysis. | Lee LO et al. | β | 2014 | β |
| Associations between serum biomarkers and pain and pain-related function in older adults with low back pain: a pilot study. | Sowa GA et al. | β | 2014 | β |
| Cerebrospinal fluid neuropeptide Y in combat veterans with and without posttraumatic stress disorder. | Sah R et al. | β | 2014 | β |
| Conditional inactivation of neuropeptide Y Y1 receptors unravels the role of Y1 and Y5 receptors coexpressing neurons in anxiety. | Longo A et al. | β | 2014 | β |
| Disentangling the molecular genetic basis of personality: from monoamines to neuropeptides. | Montag C et al. | β | 2014 | β |
| Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study. | Rothbaum BO et al. | β | 2014 | β |
| Emerging novel roles of neuropeptide Y in the retina: from neuromodulation to neuroprotection. | Santos-Carvalho A et al. | β | 2014 | β |
| Framing ethnic variations in alcohol outcomes from biological pathways to neighborhood context. | Chartier KG et al. | β | 2014 | β |
| From non-pharmacological treatments for post-traumatic stress disorder to novel therapeutic targets. | Hendriksen H et al. | β | 2014 | β |
| Genetic approaches to understanding post-traumatic stress disorder. | Almli LM et al. | β | 2014 | β |
| Genetic, psychosocial, and demographic factors associated with social disinhibition in Mexican-origin youth. | Archer NP et al. | β | 2014 | β |
| Genome-wide exploration identifies sex-specific genetic effects of alleles upstream NPY to increase the risk of severe periodontitis in men. | Freitag-Wolf S et al. | β | 2014 | β |
| Genomics of impulsivity: integrating genes and neuroscience. | Goldman D | β | 2014 | β |
| Interaction of neuropeptide Y genotype and childhood emotional maltreatment on brain activity during emotional processing. | Opmeer EM et al. | β | 2014 | β |
| Lack of an association between a functional polymorphism in the neuropeptide Y gene promoter and the presence of coronary artery disease in an Iranian population. | Parizadeh SA et al. | β | 2014 | β |
| Low neuropeptide Y in cerebrospinal fluid in bipolar patients is associated with previous and prospective suicide attempts. | Sandberg JV et al. | β | 2014 | β |
| Making sense of deep sequencing. | Goldman D et al. | β | 2014 | β |
| Neuropeptides and the microbiota-gut-brain axis. | Holzer P et al. | β | 2014 | β |
| Neuropeptide y attenuates stress-induced bone loss through suppression of noradrenaline circuits. | Baldock PA et al. | β | 2014 | β |
| Neuropeptide Y receptor gene expression in the primate amygdala predicts anxious temperament and brain metabolism. | Roseboom PH et al. | β | 2014 | β |
| NPY2-receptor variation modulates iconic memory processes. | Arning L et al. | β | 2014 | β |
| Peptide YY, neuropeptide Y and corticotrophin-releasing factor modulate gastrointestinal motility and food intake during acute stress. | Forbes SC et al. | β | 2014 | β |
| Stress and alcohol interactions: animal studies and clinical significance. | Spanagel R et al. | β | 2014 | β |
| Sympathetic activation in resistant hypertension: theory and therapy. | Oliva RV et al. | β | 2014 | β |
| Testosterone rapidly increases neural reactivity to threat in healthy men: a novel two-step pharmacological challenge paradigm. | Goetz SM et al. | β | 2014 | β |
| The missing heritability of behavior: the search continues. | Goldman D | β | 2014 | β |
| Understanding the pharmacogenetics of selective serotonin reuptake inhibitors. | Fabbri C et al. | β | 2014 | β |
| Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression. | Melas PA et al. | β | 2013 | β |
| Association of a functional polymorphism in neuropeptide Y with antipsychotic-induced weight gain in schizophrenia patients. | Tiwari AK et al. | β | 2013 | β |
| Changes in genetic and environmental influences on trait anxiety Δfrom middle adolescence to early adulthood. | Garcia SE et al. | β | 2013 | β |
| Characterization of cerebrospinal fluid (CSF) and plasma NPY levels in normal volunteers over a 24-h timeframe. | Baker DG et al. | β | 2013 | β |
| Comparative distribution of central neuropeptide Y (NPY) in the prairie (Microtus ochrogaster) and meadow (M. pennsylvanicus) vole. | Hostetler CM et al. | β | 2013 | β |
| Effect of experimental stress in 2 different pain conditions affecting the facial muscles. | Woda A et al. | β | 2013 | β |
| Emerging neuropeptide targets in inflammation: NPY and VIP. | Chandrasekharan B et al. | β | 2013 | β |
| Exaggerated neurobiological sensitivity to threat as a mechanism linking anxiety with increased risk for diseases of aging. | O'Donovan A et al. | β | 2013 | β |
| Functional polymorphism in the neuropeptide Y gene promoter (rs16147) is associated with serum leptin levels and waist-hip ratio in women. | Mutschler J et al. | β | 2013 | β |
| Impact of sleep quality on amygdala reactivity, negative affect, and perceived stress. | Prather AA et al. | β | 2013 | β |
| Individual multi-locus heterozygosity is associated with lower morning plasma cortisol concentrations. | Zgaga L et al. | β | 2013 | β |
| Influence of variants in the NPY gene on obesity and metabolic syndrome features in Spanish children. | Olza J et al. | β | 2013 | β |
| Loss of metabotropic glutamate receptor 2 escalates alcohol consumption. | Zhou Z et al. | β | 2013 | β |
| Molecular signatures of lineage-specific adaptive evolution in a unique sea basin: the example of an anadromous goby Leucopsarion petersii. | Kokita T et al. | β | 2013 | β |
| Neuropeptide Y and posttraumatic stress disorder. | Sah R et al. | β | 2013 | β |
| Nonhuman primate models in the genomic era: a paradigm shift. | Vallender EJ et al. | β | 2013 | β |
| Personality trait predictors of placebo analgesia and neurobiological correlates. | PeciΓ±a M et al. | β | 2013 | β |
| Polymorphic variation as a driver of differential neuropeptide gene expression. | Quinn JP et al. | β | 2013 | β |
| Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior. | Greenman Y et al. | β | 2013 | β |
| Quantitative trait locus for body weight identified on rat chromosome 4 in inbred alcohol-preferring and -nonpreferring rats: potential implications for neuropeptide Y and corticotrophin releasing hormone 2. | Spence JP et al. | β | 2013 | β |
| Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: dissociation between anxiety, locomotion and non-emotional memory behavior. | Lach G et al. | β | 2013 | β |
| Serotonergic innervation and serotonin receptor expression of NPY-producing neurons in the rat lateral and basolateral amygdaloid nuclei. | Bonn M et al. | β | 2013 | β |
| Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats. | Serova LI et al. | β | 2013 | β |
| The neural signatures of distinct psychopathic traits. | CarrΓ© JM et al. | β | 2013 | β |
| Toward an integration of cognitive and genetic models of risk for depression. | Gibb BE et al. | β | 2013 | β |
| Understanding resilience. | Wu G et al. | β | 2013 | β |
| What lies beneath the face of aggression? | CarrΓ© JM et al. | β | 2013 | β |
| Acupuncture at ST36 prevents chronic stress-induced increases in neuropeptide Y in rat. | Eshkevari L et al. | β | 2012 | β |
| Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. | Joeyen-Waldorf J et al. | β | 2012 | β |
| A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress. | Forbes S et al. | β | 2012 | β |
| Association of the leucine-7 to proline-7 variation in the signal sequence of neuropeptide Y with major depression. | Koefoed P et al. | β | 2012 | β |
| Biological studies of post-traumatic stress disorder. | Pitman RK et al. | β | 2012 | β |
| Catechol-O-methyltransferase gene variation: impact on amygdala response to aversive stimuli. | Domschke K et al. | β | 2012 | β |
| Cell-specific expression of calcineurin immunoreactivity within the rat basolateral amygdala complex and colocalization with the neuropeptide Y Y1 receptor. | Leitermann RJ et al. | β | 2012 | β |
| Chronic stress alters neuropeptide Y signaling in the bed nucleus of the stria terminalis in DBA/2J but not C57BL/6J mice. | Pleil KE et al. | β | 2012 | β |
| Common SNPs explain some of the variation in the personality dimensions of neuroticism and extraversion. | Vinkhuyzen AA et al. | β | 2012 | β |
| Corticotropin-releasing hormone downregulates IL-10 production by adaptive forkhead box protein 3-negative regulatory T cells in patients with atopic dermatitis. | Oh SH et al. | β | 2012 | β |
| Genetic modulation of plasma NPY stress response is suppressed in substance abuse: association with clinical outcomes. | Xu K et al. | β | 2012 | β |
| Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome. | Light KC et al. | β | 2012 | β |
| Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking. | Mutschler J et al. | β | 2012 | β |
| Increasing association between a neuropeptide Y promoter polymorphism and body mass index during the course of development. | Hohmann S et al. | β | 2012 | β |
| Interaction between trait anxiety and trait anger predict amygdala reactivity to angry facial expressions in men but not women. | CarrΓ© JM et al. | β | 2012 | β |
| Measures of anxiety, amygdala volumes, and hippocampal scopolamine phMRI response in elderly female rhesus macaques. | Haley GE et al. | β | 2012 | β |
| Meta-analysis of genome-wide association studies for panic disorder in the Japanese population. | Otowa T et al. | β | 2012 | β |
| Molecular evidence for BDNF- and GABA-related dysfunctions in the amygdala of female subjects with major depression. | Guilloux JP et al. | β | 2012 | β |
| Neurobiology of resilience. | Russo SJ et al. | β | 2012 | β |
| Neuropeptide Y: identification of a novel rat mRNA splice-variant that is downregulated in the hippocampus and the prefrontal cortex of a depression-like model. | Melas PA et al. | β | 2012 | β |
| Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model. | Ruohonen ST et al. | β | 2012 | β |
| Neuropeptide Y (NPY): genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses. | Zhang K et al. | β | 2012 | β |
| Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. | Holzer P et al. | β | 2012 | β |
| Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects--the cardiovascular risk in young Finns study. | Jaakkola U et al. | β | 2012 | β |
| Neuropeptide Y promoter polymorphism modifies effects of a weight-loss diet on 2-year changes of blood pressure: the preventing overweight using novel dietary strategies trial. | Zhang X et al. | β | 2012 | β |
| Repeated gastric distension alters food intake and neuroendocrine profiles in rats. | Hargrave SL et al. | β | 2012 | β |
| Sexually selected traits: a fundamental framework for studies on behavioral epigenetics. | JaΕ‘areviΔ E et al. | β | 2012 | β |
| Support for involvement of glutamate decarboxylase 1 and neuropeptide Y in anxiety susceptibility. | Donner J et al. | β | 2012 | β |
| Sympathetic nervous system: role in hypertension and in chronic kidney disease. | Grassi G et al. | β | 2012 | β |
| The genetic basis of addictive disorders. | Ducci F et al. | β | 2012 | β |
| The selective neuropeptide Y Y5 agonist [cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP differently modulates emotional processes and body weight in the rat. | Morales-Medina JC et al. | β | 2012 | β |
| A comparative review of short and long neuropeptide F signaling in invertebrates: Any similarities to vertebrate neuropeptide Y signaling? | NΓ€ssel DR et al. | β | 2011 | β |
| Addiction research centres and the nurturing of creativity: the National Institute on Alcohol Abuse and Alcoholism. | Heilig M et al. | β | 2011 | β |
| Animal models of depression and anxiety: What do they tell us about human condition? | Neumann ID et al. | β | 2011 | β |
| An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses. | Witt SH et al. | β | 2011 | β |
| An update on psychogenic movement disorders. | Ellenstein A et al. | β | 2011 | β |
| Central functions of neuropeptide Y in mood and anxiety disorders. | Wu G et al. | β | 2011 | β |
| Differential Regulation of Neuropeptide Y in the Amygdala and Prefrontal Cortex during Recovery from Chronic Variable Stress. | McGuire JL et al. | β | 2011 | β |
| Emotion processing, major depression, and functional genetic variation of neuropeptide Y. | Mickey BJ et al. | β | 2011 | β |
| Functional polymorphism of the mu-opioid receptor gene (OPRM1) influences reinforcement learning in humans. | Lee MR et al. | β | 2011 | β |
| Genetic factors for functional dyspepsia. | Oshima T et al. | β | 2011 | β |
| Genetics of emotion. | Bevilacqua L et al. | β | 2011 | β |
| Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. | Lesch KP et al. | β | 2011 | β |
| Ghrelin and anorexia nervosa: a psychosomatic perspective. | Ogiso K et al. | β | 2011 | β |
| Meta-analysis and genome-wide interpretation of genetic susceptibility to drug addiction. | Li CY et al. | β | 2011 | β |
| Neuropeptide-S (NPS) receptor genotype modulates basolateral amygdala responsiveness to aversive stimuli. | Dannlowski U et al. | β | 2011 | β |
| Pharmacogenetic approaches to the treatment of alcohol addiction. | Heilig M et al. | β | 2011 | β |
| Polymorphisms in the neuropeptide Y gene and the risk of obesity: findings from two prospective cohorts. | Yeung EH et al. | β | 2011 | β |
| Regulatory functions of limbic Y1 receptors in body weight and anxiety uncovered by conditional knockout and maternal care. | Bertocchi I et al. | β | 2011 | β |
| Sex-dependent control of murine emotional-affective behaviour in health and colitis by peptide YY and neuropeptide Y. | Painsipp E et al. | β | 2011 | β |
| Sex differences in neural responses to stress and alcohol context cues. | Seo D et al. | β | 2011 | β |
| Sex-specific role for adenylyl cyclase type 7 in alcohol dependence. | DesriviΓ¨res S et al. | β | 2011 | β |
| The amygdala: inside and out. | Hariri AR et al. | β | 2011 | β |
| The contribution of imaging genetics to the development of predictive markers for addictions. | Loth E et al. | β | 2011 | β |
| Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. | Rasmusson AM et al. | β | 2010 | β |
| A genetically modulated, intrinsic cingulate circuit supports human nicotine addiction. | Hong LE et al. | β | 2010 | β |
| A genome-wide association study of neuroticism in a population-based sample. | Calboli FC et al. | β | 2010 | β |
| A G-protein-coupled neuropeptide Y-like receptor suppresses behavioral and sensory response to multiple stressful stimuli in Drosophila. | Xu J et al. | β | 2010 | β |
| Amygdalar and hippocampal substrates of anxious temperament differ in their heritability. | Oler JA et al. | β | 2010 | β |
| Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus. | Noe F et al. | β | 2010 | β |
| A possible role of neuropeptide Y in depression and stress. | Morales-Medina JC et al. | β | 2010 | β |
| Association between neuropeptide Y receptor 2 polymorphism and the smoking behavior of elderly Japanese. | Sato N et al. | β | 2010 | β |
| Blood mononuclear cell gene expression signature of postpartum depression. | Segman RH et al. | β | 2010 | β |
| Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. | Thorsell A | β | 2010 | β |
| Delayed stress-induced differences in locomotor and depression-related behaviour in female neuropeptide-Y Y1 receptor knockout mice. | Painsipp E et al. | β | 2010 | β |
| Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge. | Painsipp E et al. | β | 2010 | β |
| Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. | Lindell SG et al. | β | 2010 | β |
| Gene x environment interactions in complex behavior: First, build a telescope. | Goldman D | β | 2010 | β |
| Human NPY promoter variation rs16147:T>C as a moderator of prefrontal NPY gene expression and negative affect. | Sommer WH et al. | β | 2010 | β |
| Human variation in short regions predisposed to deep evolutionary conservation. | Loots GG et al. | β | 2010 | β |
| Imaging genetics of anxiety disorders. | Domschke K et al. | β | 2010 | β |
| Imaging genetics of mood disorders. | Scharinger C et al. | β | 2010 | β |
| Impact of generalized brain arousal on sexual behavior. | Weil ZM et al. | β | 2010 | β |
| Mindscape: a convergent perspective on life, mind, consciousness and happiness. | Niculescu AB et al. | β | 2010 | β |
| [Neurogenetics of emotional processes. Neuroimaging findings as endophenotypes for depression]. | Dannlowski U et al. | β | 2010 | β |
| Neuropeptide Y (NPY) gene: Impact on emotional processing and treatment response in anxious depression. | Domschke K et al. | β | 2010 | β |
| Neuropeptide Y polymorphisms and ischemic stroke in Chinese population. | Yu JT et al. | β | 2010 | β |
| Neuropeptide Y signaling in the central nucleus of amygdala regulates alcohol-drinking and anxiety-like behaviors of alcohol-preferring rats. | Zhang H et al. | β | 2010 | β |
| NPY moderates the relation between hurricane exposure and generalized anxiety disorder in an epidemiologic sample of hurricane-exposed adults. | Amstadter AB et al. | β | 2010 | β |
| Pain imaging in the emerging era of molecular medicine. | Stohler CS et al. | β | 2010 | β |
| Pathogenic involvement of neuropeptides in anxiety and depression. | Alldredge B | β | 2010 | β |
| Plasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome. | Fletcher MA et al. | β | 2010 | β |
| The 2009 Nobel conference on the role of genetics in promoting suicide prevention and the mental health of the population. | Wasserman D et al. | β | 2010 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Association of the C-399T promoter polymorphism of neuropeptide Y with susceptibility to ischemic stroke. | Kim NS et al. | β | 2009 | β |
| Current status of brain imaging in anxiety disorders. | Damsa C et al. | β | 2009 | β |
| Evidence from knockout mice for distinct implications of neuropeptide-Y Y2 and Y4 receptors in the circadian control of locomotion, exploration, water and food intake. | Edelsbrunner ME et al. | β | 2009 | β |
| Evidence from knockout mice that peptide YY and neuropeptide Y enforce murine locomotion, exploration and ingestive behaviour in a circadian cycle- and gender-dependent manner. | Edelsbrunner ME et al. | β | 2009 | β |
| Expression of the porcine adrenergic receptor beta 2 gene in longissimus dorsi muscle is affected by cis-regulatory DNA variation. | MurΓ‘ni E et al. | β | 2009 | β |
| Fear of harm, a possible phenotype of pediatric bipolar disorder: a dimensional approach to diagnosis for genotyping psychiatric syndromes. | Papolos D et al. | β | 2009 | β |
| Genetic variation in 5HTTLPR is associated with emotional resilience. | Stein MB et al. | β | 2009 | β |
| Is there an association between NPY and neuroticism? | Cotton CH et al. | β | 2009 | β |
| Lack of association between polymorphisms of neuropeptide Y and schizophrenia in Korean population. | Kim HJ et al. | β | 2009 | β |
| Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. | Sah R et al. | β | 2009 | β |
| Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. | Fisher PM et al. | β | 2009 | β |
| Messenger RNA for neuropeptide Y in the arcuate nucleus increases in parallel with plasma adrenocorticotropin during sepsis in the rat. | Carlson DE et al. | β | 2009 | β |
| Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. | Mellios N et al. | β | 2009 | β |
| Neuropeptide Y(1) Receptor NPY1R discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. | Wang L et al. | β | 2009 | β |
| Neuropeptide Y gene polymorphisms confer risk of early-onset atherosclerosis. | Shah SH et al. | β | 2009 | β |
| Neuropeptide Y is expressed by osteocytes and can inhibit osteoblastic activity. | Igwe JC et al. | β | 2009 | β |
| Neuropeptide Y: its multiple effects in the CNS and potential clinical significance. | Benarroch EE | β | 2009 | β |
| Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience. | Krystal JH et al. | β | 2009 | β |
| Phosducin - a candidate gene for stress-dependent hypertension. | Grassi G | β | 2009 | β |
| Positive correlation between the density of neuropeptide y positive neurons in the amygdala and parameters of self-reported anxiety and depression in mesiotemporal lobe epilepsy patients. | Frisch C et al. | β | 2009 | β |
| PreproNPY Pro7 protects against depression despite exposure to environmental risk factors. | SjΓΆholm LK et al. | β | 2009 | β |
| Psychobiology and molecular genetics of resilience. | Feder A et al. | β | 2009 | β |
| Research in anxiety disorders: from the bench to the bedside. | Garner M et al. | β | 2009 | β |
| Strategies for performing genotype-phenotype association studies in nonhuman primates. | Barr CS | β | 2009 | β |
| The intracellular mobility of NPY and a putative mitochondrial form of NPY in neuronal cells. | Kaipio K et al. | β | 2009 | β |
| The novel neuropeptide Y Y5 receptor antagonist Lu AA33810 [N-[[trans-4-[(4,5-dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl]methyl]-methanesulfonamide] exerts anxiolytic- and antidepressant-like effects in rat models of stress sensitivity. | Walker MW et al. | β | 2009 | β |
| The role of non-synonymous NPY gene polymorphism in the nitric oxide production in HUVECs. | Kaipio K et al. | β | 2009 | β |
| Evolutionary signatures of common human cis-regulatory haplotypes. | Ouyang C et al. | β | 2008 | β |
| Neuropeptide Y activates a G-protein-coupled inwardly rectifying potassium current and dampens excitability in the lateral amygdala. | Sosulina L et al. | β | 2008 | β |
| Psychosocial stress and psychosis. A review of the neurobiological mechanisms and the evidence for gene-stress interaction. | van Winkel R et al. | β | 2008 | β |