Endocannabinoid system and alcohol addiction: pharmacological studies.
paper
Cited
Public
Unavailable
- Authors
- Colombo, Giancarlo; Serra, Salvatore; Vacca, Giovanni; Carai, Mauro A M; Gessa, Gian Luigi
- Year
- 2005
- Journal
- Pharmacology, biochemistry, and behavior
- PMID
- 15939463
- DOI
- 10.1016/j.pbb.2005.01.022
The present paper describes the results of recent pharmacological studies implicating the cannabinoid CB1 receptor in the neural circuitry regulating alcohol consumption and motivation to consume alcohol. Cannabinoid CB1 receptor agonists have been found to specifically stimulate alcohol intake and alcohol's motivational properties in rats. Conversely, the cannabinoid CB1 receptor antagonist, SR 141716, has been reported to specifically suppress acquisition and maintenance of alcohol drinking behavior, relapse-like drinking and alcohol's motivational properties in rats. More recent data indicate that opioid receptor antagonists a) blocked the stimulatory effect of cannabinoids on alcohol intake, and b) synergistically potentiated the suppressing effect of SR 141716 on alcohol intake and alcohol's motivational properties. Consistently, SR 141716 blocked the stimulatory effect of morphine on alcohol intake. These results suggest a) the existence of a functional link between the cannabinoid and opioid receptor systems in the control of alcohol intake and motivation to consume alcohol, and b) that novel and potentially effective therapeutic strategies for alcoholism may come from the combination of cannabinoid and opioid receptor antagonists.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol and cannabis use for pain management: Translational findings of relative risks, benefits, and interactions. | Lee S et al. | β | 2025 | β |
| The neural and psychophysiological effects of cannabidiol in youth with alcohol use disorder: A randomized controlled clinical trial. | Kirkland AE et al. | β | 2025 | β |
| Alcohol and Cannabinoids - From the Editors. | Metrik J et al. | β | 2022 | β |
| Patterns of Cannabis and Alcohol Co-Use: Substitution Versus Complementary Effects. | Gunn RL et al. | β | 2022 | β |
| Role of Cannabinoid CB2 Receptor in Alcohol Use Disorders: From Animal to Human Studies. | GarcΓa-GutiΓ©rrez MS et al. | β | 2022 | β |
| CB1 receptor neutral antagonist treatment epigenetically increases neuropeptide Y expression and decreases alcohol drinking. | Dulman RS et al. | β | 2021 | β |
| Endocannabinoid signaling in the lateral habenula regulates pain and alcohol consumption. | Fu R et al. | β | 2021 | β |
| Neural Substrates and Circuits of Drug Addiction. | Feltenstein MW et al. | β | 2021 | β |
| Reductions in alcohol use following medical cannabis initiation: results from a large cross-sectional survey of medical cannabis patients in Canada. | Lucas P et al. | β | 2020 | β |
| The therapeutic potential of second and third generation CB<sub>1</sub>R antagonists. | Cinar R et al. | β | 2020 | β |
| Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum. | Rivera P et al. | β | 2019 | β |
| Targeting Peripheral CB<sub>1</sub> Receptors Reduces Ethanol Intake via a Gut-Brain Axis. | Godlewski G et al. | β | 2019 | β |
| Cannabinoid-1 receptor neutral antagonist reduces binge-like alcohol consumption and alcohol-induced accumbal dopaminergic signaling. | Balla A et al. | β | 2018 | β |
| Pharmacological regulation of cannabinoid CB2 receptor modulates the reinforcing and motivational actions of ethanol. | Navarrete F et al. | β | 2018 | β |
| Cannabis use during treatment for alcohol use disorders predicts alcohol treatment outcomes. | Subbaraman MS et al. | β | 2017 | β |
| Co-use of Alcohol and Cannabis: A Review. | Yurasek AM et al. | β | 2017 | β |
| Suppressing effect of COR659 on alcohol, sucrose, and chocolate self-administration in rats: involvement of the GABA<sub>B</sub> and cannabinoid CB<sub>1</sub> receptors. | Maccioni P et al. | β | 2017 | β |
| Involvement of Endocannabinoids in Alcohol "Binge" Drinking: Studies of Mice with Human Fatty Acid Amide Hydrolase Genetic Variation and After CB1 Receptor Antagonists. | Zhou Y et al. | β | 2016 | β |
| Approach to the pharmacological management of chronic pain in patients with an alcohol use disorder. | Murphy L et al. | β | 2015 | β |
| Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol. | Hanlon EC et al. | β | 2015 | β |
| Interactions between ethanol and the endocannabinoid system atΒ GABAergic synapses on basolateral amygdala principal neurons. | Talani G et al. | β | 2015 | β |
| Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. | Rivera P et al. | β | 2015 | β |
| Synthetic cannabinoids: the dangers of spicing it up. | Salani DA et al. | β | 2015 | β |
| Enhanced endocannabinoid-mediated modulation of rostromedial tegmental nucleus drive onto dopamine neurons in Sardinian alcohol-preferring rats. | Melis M et al. | β | 2014 | β |
| Functional interaction and cross-tolerance between ethanol and Ξ9-THC: possible modulation by mouse cerebellar adenosinergic A1/GABAergic-A receptors. | Dar MS | β | 2014 | β |
| Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice. | Luque-Rojas MJ et al. | β | 2013 | β |
| Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography. | Hirvonen J et al. | β | 2013 | β |
| Systems level neuroplasticity in drug addiction. | Feltenstein MW et al. | β | 2013 | β |
| Association of genetic polymorphisms of glutamate decarboxylase 2 and the dopamine D2 receptor with obesity in Taiwanese subjects. | Chen KC et al. | β | 2012 | β |
| Interactions between the cannabinoid and dopaminergic systems: evidence from animal studies. | El Khoury MA et al. | β | 2012 | β |
| Neurochemical and neurostructural plasticity in alcoholism. | Gass JT et al. | β | 2012 | β |
| Neuropeptide modulation of central amygdala neuroplasticity is a key mediator of alcohol dependence. | Gilpin NW et al. | β | 2012 | β |
| The genetic basis of the endocannabinoid system and drug addiction in humans. | LΓ³pez-Moreno JA et al. | β | 2012 | β |
| The genetics of substance dependence. | Wang JC et al. | β | 2012 | β |
| ACSL6 is associated with the number of cigarettes smoked and its expression is altered by chronic nicotine exposure. | Chen J et al. | β | 2011 | β |
| Activation of Ο-receptors induces binge-like drinking in Sardinian alcohol-preferring rats. | Sabino V et al. | β | 2011 | β |
| Association Study of Two Cannabinoid Receptor Genes, CNR1 and CNR2, with Methamphetamine Dependence. | Okahisa Y et al. | β | 2011 | β |
| CB1 receptors regulate alcohol-seeking behavior and alcohol self-administration of alcohol-preferring (P) rats. | Getachew B et al. | β | 2011 | β |
| Neurobiology of overeating and obesity: the role of melanocortins and beyond. | Pandit R et al. | β | 2011 | β |
| SLV330, a cannabinoid CB(1) receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats. | de Bruin NM et al. | β | 2011 | β |
| Converging action of alcohol consumption and cannabinoid receptor activation on adult hippocampal neurogenesis. | AlΓ©n F et al. | β | 2010 | β |
| Emerging drugs to treat alcoholism. | Soyka M et al. | β | 2010 | β |
| The endocannabinoid system tonically regulates inhibitory transmission and depresses the effect of ethanol in central amygdala. | Roberto M et al. | β | 2010 | β |
| Agonism of the endocannabinoid system modulates binge-like alcohol intake in male C57BL/6J mice: involvement of the posterior ventral tegmental area. | Linsenbardt DN et al. | β | 2009 | β |
| Alcoholism: a systems approach from molecular physiology to addictive behavior. | Spanagel R | β | 2009 | β |
| Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol. | Blednov YA et al. | β | 2009 | β |
| Effects of a short-term exposure to alcohol in rats on FAAH enzyme and CB1 receptor in different brain areas. | Rubio M et al. | β | 2009 | β |
| Electrophysiological properties of dopamine neurons in the ventral tegmental area of Sardinian alcohol-preferring rats. | Melis M et al. | β | 2009 | β |
| Pharmacotherapy of addictive disorders. | Ross S et al. | β | 2009 | β |
| Understanding and treating alcohol craving and dependence: recent pharmacological and neuroendocrinological findings. | Leggio L | β | 2009 | β |
| Cannabinoid receptor 1 gene association with nicotine dependence. | Chen X et al. | β | 2008 | β |
| CB1 receptor blockade reduces the anxiogenic-like response and ameliorates the neurochemical imbalances associated with alcohol withdrawal in rats. | Rubio M et al. | β | 2008 | β |
| Endogenous cannabinoids in patients with schizophrenia and substance use disorder during quetiapine therapy. | Potvin S et al. | β | 2008 | β |
| Glutamatergic substrates of drug addiction and alcoholism. | Gass JT et al. | β | 2008 | β |
| Locomotor effects of morphine or alcohol in mice after a repeated treatment with the cannabinoid agonist HU 210. | Hagues G et al. | β | 2008 | β |
| Neuropharmacology of alcohol addiction. | Vengeliene V et al. | β | 2008 | β |
| [Neuropsychopharmacology of delta-9-tetrahydrocannabinol]. | Costentin J | β | 2008 | β |
| Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse. | Alen F et al. | β | 2008 | β |
| The incentive salience of alcohol: translating the effects of genetic variant in CNR1. | Hutchison KE et al. | β | 2008 | β |
| The neurocircuitry of addiction: an overview. | Feltenstein MW et al. | β | 2008 | β |
| Time dependent alterations on tyrosine hydroxylase, opioid and cannabinoid CB1 receptor gene expressions after acute ethanol administration in the rat brain. | Oliva JM et al. | β | 2008 | β |
| Bidirectional alterations of hippocampal cannabinoid 1 receptors and their endogenous ligands in a rat model of alcohol withdrawal and dependence. | Mitrirattanakul S et al. | β | 2007 | β |
| Cannabinoids in health and disease. | Kogan NM et al. | β | 2007 | β |
| Critical enzymes involved in endocannabinoid metabolism. | Basavarajappa BS | β | 2007 | β |
| Endocannabinoid system involvement in brain reward processes related to drug abuse. | Solinas M et al. | β | 2007 | β |
| Gene transcription alterations associated with decrease of ethanol intake induced by naltrexone in the brain of Wistar rats. | Oliva JM et al. | β | 2007 | β |
| Involvement of cannabinoid CB2 receptor in alcohol preference in mice and alcoholism in humans. | Ishiguro H et al. | β | 2007 | β |
| Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation. | Cheer JF et al. | β | 2007 | β |
| Preclinical and clinical pharmacology of alcohol dependence. | Tambour S et al. | β | 2007 | β |
| Repeated exposure to alcoholic beer does not induce long-lasting changes in alcohol self-administration and intake in Sardinian alcohol-preferring and Sardinian non-preferring rats. | OrrΓΉ A et al. | β | 2007 | β |
| Role of endocannabinoids in alcohol consumption and intoxication: studies of mice lacking fatty acid amide hydrolase. | Blednov YA et al. | β | 2007 | β |
| Short-term exposure to alcohol in rats affects brain levels of anandamide, other N-acylethanolamines and 2-arachidonoyl-glycerol. | Rubio M et al. | β | 2007 | β |
| Specific alterations of extracellular endocannabinoid levels in the nucleus accumbens by ethanol, heroin, and cocaine self-administration. | CaillΓ© S et al. | β | 2007 | β |
| Targeted modulators of the endogenous cannabinoid system: future medications to treat addiction disorders and obesity. | Janero DR et al. | β | 2007 | β |
| The cannabinoid CB1 receptor antagonist, rimonabant, as a promising pharmacotherapy for alcohol dependence: preclinical evidence. | Colombo G et al. | β | 2007 | β |
| The CB1 cannabinoid receptor antagonist rimonabant chronically prevents the nicotine-induced relapse to alcohol. | LΓ³pez-Moreno JA et al. | β | 2007 | β |
| The role of the cannabinoid type 1 receptor and down-stream cAMP/DARPP-32 signal in the nucleus accumbens of methamphetamine-sensitized rats. | Chiang YC et al. | β | 2007 | β |
| Cannabinoids, opioids and eating behavior: the molecular face of hedonism? | Cota D et al. | β | 2006 | β |
| Efficacy of rimonabant and other cannabinoid CB1 receptor antagonists in reducing food intake and body weight: preclinical and clinical data. | Carai MA et al. | β | 2006 | β |
| Lack of tolerance to the suppressing effect of rimonabant on chocolate intake in rats. | Gessa GL et al. | β | 2006 | β |
| SR147778, a CB1 cannabinoid receptor antagonist, suppresses ethanol preference in chronically alcoholized Wistar rats. | Lallemand F et al. | β | 2006 | β |
| The endocannabinoid system as an emerging target of pharmacotherapy. | Pacher P et al. | β | 2006 | β |
| Involvement of the endogenous cannabinoid system in the effects of alcohol in the mesolimbic reward circuit: electrophysiological evidence in vivo. | Perra S et al. | β | 2005 | β |