Mapping multiple sclerosis susceptibility to the HLA-DR locus in African Americans.
paper
Cited
Public
Unavailable
- Authors
- Oksenberg, Jorge R; Barcellos, Lisa F; Cree, Bruce A C; Baranzini, Sergio E; Bugawan, Teodorica L; Khan, Omar; Lincoln, Robin R; Swerdlin, Amy; Mignot, Emmanuel; Lin, Ling; Goodin, Douglas; Erlich, Henry A; Schmidt, Silke; Thomson, Glenys; Reich, David E; Pericak-Vance, Margaret A; Haines, Jonathan L; Hauser, Stephen L
- Year
- 2004
- Journal
- American journal of human genetics
- PMID
- 14669136
- DOI
- 10.1086/380997
- PMCID
- PMC1181903
An underlying complex genetic susceptibility exists in multiple sclerosis (MS), and an association with the HLA-DRB1*1501-DQB1*0602 haplotype has been repeatedly demonstrated in high-risk (northern European) populations. It is unknown whether the effect is explained by the HLA-DRB1 or the HLA-DQB1 gene within the susceptibility haplotype, which are in strong linkage disequilibrium (LD). African populations are characterized by greater haplotypic diversity and distinct patterns of LD compared with northern Europeans. To better localize the HLA gene responsible for MS susceptibility, case-control and family-based association studies were performed for DRB1 and DQB1 loci in a large and well-characterized African American data set. A selective association with HLA-DRB1*15 was revealed, indicating a primary role for the DRB1 locus in MS independent of DQB1*0602. This finding is unlikely to be solely explained by admixture, since a substantial proportion of the susceptibility chromosomes from African American patients with MS displayed haplotypes consistent with an African origin.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure. | 2005 | 16451699 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Genetic Determinants of Multiple Sclerosis Susceptibility in People From Diverse Ancestral Backgrounds. | Jacobs BM et al. | β | 2026 | β |
| Genetic determinants of Multiple Sclerosis susceptibility in diverse ancestral backgrounds | Jacobs BM et al. | β | 2025 | β |
| HLA-transgenic mouse models to study autoimmune central nervous system diseases. | Pressley KR et al. | β | 2024 | β |
| MHConstructor: a high-throughput, haplotype-informed solution to the MHC assembly challenge. | Wade KJ et al. | β | 2024 | β |
| Modifiable risk factors for multiple sclerosis have consistent directions of effect across diverse ethnic backgrounds: a nested case-control study in an English population-based cohort. | Jacobs BM et al. | β | 2024 | β |
| Multiple Sclerosis in Black and Hispanic Populations: Serving the Underserved. | Williams MJ et al. | β | 2024 | β |
| MHC2AffyPred: A machine-learning approach to estimate affinity of MHC class II peptides based on structural interaction fingerprints. | Jani SP et al. | β | 2023 | β |
| Origins and immunopathogenesis of autoimmune central nervous system disorders. | Ramanathan S et al. | β | 2023 | β |
| Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing. | Kalomoiri M et al. | β | 2023 | β |
| Ancestral risk modification for multiple sclerosis susceptibility detected across the Major Histocompatibility Complex in a multi-ethnic population. | Beecham AH et al. | β | 2022 | β |
| High-resolution HLA class II sequencing of Swedish multiple sclerosis patients. | Akel O et al. | β | 2022 | β |
| Role of the gut microbiome in multiple sclerosis: From etiology to therapeutics. | Shahi SK et al. | β | 2022 | β |
| Towards a global view of multiple sclerosis genetics. | Jacobs BM et al. | β | 2022 | β |
| Association of HLA-DR2-Related Haplotype (HLA-DRB5*01-DRB1*1501-DQB1*0602) in Patients with Multiple Sclerosis in Khuzestan Province. | Delfan N et al. | β | 2021 | β |
| Class II HLA (DRB1, & DQB1) alleles and IL7R (rs6897932) variants and the risk for Multiple Sclerosis in Kerala, India. | Vinoy N et al. | β | 2021 | β |
| Genetic susceptibility to multiple sclerosis in African Americans. | Goodin DS et al. | β | 2021 | β |
| HLA-DQA1*04:01 is related to a higher multiple sclerosis lesion load on T2/Flair MRI sequences. | Noro F et al. | β | 2021 | β |
| Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans. | Boullerne AI et al. | β | 2021 | β |
| MHC Haplotyping of SARS-CoV-2 Patients: HLA Subtypes Are Not Associated with the Presence and Severity of COVID-19 in the Israeli Population. | Ben Shachar S et al. | β | 2021 | β |
| African Americans experience disproportionate neurodegenerative changes in the medulla and upper cervical spinal cord in early multiple sclerosis. | Moog TM et al. | β | 2020 | β |
| An Intergenic rs9275596 Polymorphism on Chr. 6p21 Is Associated with Multiple Sclerosis in Latvians. | Paramonova N et al. | β | 2020 | β |
| Human Leukocyte Antigen Genotype as a Marker of Multiple Sclerosis Prognosis. | Lysandropoulos AP et al. | β | 2020 | β |
| Immune-mediated genesis of multiple sclerosis. | Cavallo S | β | 2020 | β |
| Integrative systems and functional analyses reveal a role of dopaminergic signaling in myelin pathogenesis. | Ding S et al. | β | 2020 | β |
| Involvement of Genetic Factors in Multiple Sclerosis. | FerrΓ¨ L et al. | β | 2020 | β |
| MHCII3D-Robust Structure Based Prediction of MHC II Binding Peptides. | Laimer J et al. | β | 2020 | β |
| Multiple Sclerosis: Lipids, Lymphocytes, and Vitamin D. | Hayes CE et al. | β | 2020 | β |
| Some Common SNPs of the T-Cell Homeostasis-Related Genes Are Associated with Multiple Sclerosis, but Not with the Clinical Manifestations of the Disease, in the Polish Population. | ChorΔ ΕΌy M et al. | β | 2020 | β |
| Admixture mapping reveals evidence of differential multiple sclerosis risk by genetic ancestry. | Chi C et al. | β | 2019 | β |
| Association Between IL7R Promoter Polymorphisms and Multiple Sclerosis in Turkish Population. | Simsek H et al. | β | 2019 | β |
| Biomarkers in Multiple Sclerosis. | Paul A et al. | β | 2019 | β |
| Clinical Characteristics of Multiple Sclerosis in African-Americans. | Cipriani VP et al. | β | 2019 | β |
| Familial multiple sclerosis in a Brazilian sample: Is HLA-DR15 involved in susceptibility to the disease? | da Silva Bernardes M et al. | β | 2019 | β |
| High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis. | Mack SJ et al. | β | 2019 | β |
| The Contribution of Major Histocompatibility Complex Class II Genes to an Association with Autoimmune Diseases. | Zakharova MY et al. | β | 2019 | β |
| Association of human leukocyte antigen-DRB haplotype in multiple sclerosis population of Khuzestan, Iran. | Delfan N et al. | β | 2018 | β |
| Brain and retinal atrophy in African-Americans versus Caucasian-Americans with multiple sclerosis: a longitudinal study. | Caldito NG et al. | β | 2018 | β |
| DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. | Kular L et al. | β | 2018 | β |
| Ethnic Considerations and Multiple Sclerosis Disease Variability in the United States. | Rivas-RodrΓguez E et al. | β | 2018 | β |
| Genetic Association in the HLA Region. | Moutsianas L et al. | β | 2018 | β |
| Genomic Analyses of Human European Diversity at the Southwestern Edge: Isolation, African Influence and Disease Associations in the Canary Islands. | Guillen-Guio B et al. | β | 2018 | β |
| Identification of a two-SNP PLA2R1 Haplotype and HLA-DRB1 Alleles as Primary Risk Associations in Idiopathic Membranous Nephropathy. | Latt KZ et al. | β | 2018 | β |
| Salivary biomarkers for the diagnosis andΒ monitoring of neurological diseases. | Farah R et al. | β | 2018 | β |
| Tests of fit of historically-informed models of African American Admixture. | Gross JM | β | 2018 | β |
| The immunogenetics of neurological disease. | Misra MK et al. | β | 2018 | β |
| Unravelling the Roles of Susceptibility Loci for Autoimmune Diseases in the Post-GWAS Era. | Ye J et al. | β | 2018 | β |
| A Sensitive Method for Detecting Peptide-specific CD4<sup>+</sup> T Cell Responses in Peripheral Blood from Patients with Myasthenia Gravis. | Sharma S et al. | β | 2017 | β |
| Clinical effectiveness and cost-effectiveness of beta-interferon and glatiramer acetate for treating multiple sclerosis: systematic review and economic evaluation. | Melendez-Torres GJ et al. | β | 2017 | β |
| Epstein-Barr virus, cytomegalovirus, and multiple sclerosis susceptibility: A multiethnic study. | Langer-Gould A et al. | β | 2017 | β |
| HLA genotype as a marker of multiple sclerosis prognosis: A pilot study. | Lysandropoulos AP et al. | β | 2017 | β |
| HLA haplotypes in primary sclerosing cholangitis patients of admixed and non-European ancestry. | Henriksen EKK et al. | β | 2017 | β |
| Human leucocyte antigen (HLA) class I and II typing in Belgian multiple sclerosis patients. | Lysandropoulos AP et al. | β | 2017 | β |
| Multiple Sclerosis and EIF2B5: A Paradox or a Missing Link. | Zahoor I et al. | β | 2017 | β |
| Multiple sclerosis in Kashmir: Where we stand. | Zahoor I et al. | β | 2017 | β |
| Genetic predictors of relapse rate in pediatric MS. | Graves JS et al. | β | 2016 | β |
| High-density Association Mapping and Interaction Analysis of PLA2R1 and HLA Regions with Idiopathic Membranous Nephropathy in Japanese. | Thiri M et al. | β | 2016 | β |
| HLA associations in South Asian multiple sclerosis. | Pandit L et al. | β | 2016 | β |
| Multiple sclerosis-like diagnosis as a complication of previously treated malaria in an iron and vitamin D deficient Nigerian patient. | van Rensburg SJ et al. | β | 2016 | β |
| The killer immunoglobulin-like receptor KIR3DL1 in combination with HLA-Bw4 is protective against multiple sclerosis in African Americans. | Hollenbach JA et al. | β | 2016 | β |
| Vitamin D receptor biochemical and genetic profiling and HLA-class II genotyping among Lebanese with multiple sclerosis - A pilot study. | Yamout B et al. | β | 2016 | β |
| An ImmunoChip study of multiple sclerosis risk in African Americans. | Isobe N et al. | β | 2015 | β |
| Genetic contribution to multiple sclerosis risk among Ashkenazi Jews. | Khankhanian P et al. | β | 2015 | β |
| Genetic determinants of risk and progression in multiple sclerosis. | Didonna A et al. | β | 2015 | β |
| High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. | Goyette P et al. | β | 2015 | β |
| Sexual dysfunction in patients with multiple sclerosis. | Lew-Starowicz M et al. | β | 2015 | β |
| The CIITA genetic polymorphism rs4774*C in combination with the HLA-DRB1*15:01 allele as a putative susceptibility factor to multiple sclerosis in Brazilian females. | Paradela ER et al. | β | 2015 | β |
| The immunogenetics of multiple sclerosis: A comprehensive review. | Hollenbach JA et al. | β | 2015 | β |
| The Role of HLA in MS Susceptibility and Phenotype. | Greer JM | β | 2015 | β |
| Translational utility of experimental autoimmune encephalomyelitis: recent developments. | Guerreiro-Cacais AO et al. | β | 2015 | β |
| Understanding the Role of the Immune System in the Development of Cancer: New Opportunities for Population-Based Research. | Michaud DS et al. | β | 2015 | β |
| DQB1*06:02-Associated Pathogenic Anti-Myelin Autoimmunity in Multiple Sclerosis-Like Disease: Potential Function of DQB1*06:02 as a Disease-Predisposing Allele. | Kaushansky N et al. | β | 2014 | β |
| HLA-DRB1 15:01 and Epstein-Barr virus in a multiple sclerosis patient with psoriasis, nasopharyngeal and breast cancers. Lessons for possible hidden links for autoimmunity and cancer. | Anagnostouli M et al. | β | 2014 | β |
| Multiple sclerosis genetics. | Cree BA | β | 2014 | β |
| No association between identified multiple sclerosis non-MHC risk loci and neuromyelitis optica. | Liu QB et al. | β | 2014 | β |
| Refinement of the MHC risk map in a scandinavian primary sclerosing cholangitis population. | NΓ¦ss S et al. | β | 2014 | β |
| Specific aspects of modern life for people with multiple sclerosis: considerations for the practitioner. | Oreja-Guevara C et al. | β | 2014 | β |
| Update on primary sclerosing cholangitis genetics. | Henriksen EK et al. | β | 2014 | β |
| Biomarkers in Multiple Sclerosis: An Up-to-Date Overview. | Katsavos S et al. | β | 2013 | β |
| Characterization and specification of microsatellite markers in the HLA-DRB1 gene region: a revision to major histocompatibility complex database. | Esfahani MS et al. | β | 2013 | β |
| Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects. | Patsopoulos NA et al. | β | 2013 | β |
| Genetic factors and multiple sclerosis in the Moroccan population: a role for HLA class II. | Ouadghiri S et al. | β | 2013 | β |
| Genetic risk variants in African Americans with multiple sclerosis. | Isobe N et al. | β | 2013 | β |
| Identical twins:one with anti-glomerular basement membrane glomerulonephritis,the other with systemic lupus erythematosus. | Liu X et al. | β | 2013 | β |
| Immune-mediated disease genetics: the shared basis of pathogenesis. | Cotsapas C et al. | β | 2013 | β |
| Structure-based prediction of Major Histocompatibility Complex (MHC) epitopes. | Bordner AJ | β | 2013 | β |
| Balkans syndrome: a potential link between multiple sclerosis and hypervaccination. | Vacchiano G et al. | β | 2012 | β |
| Bridging the gap from genetic association to functional understanding: the next generation of mouse models of multiple sclerosis. | Attfield KE et al. | β | 2012 | β |
| Deep sequencing of the LRRK2 gene in 14,002 individuals reveals evidence of purifying selection and independent origin of the p.Arg1628Pro mutation in Europe. | Rubio JP et al. | β | 2012 | β |
| DQB1*06:02 allele-specific expression varies by allelic dosage, not narcolepsy status. | Weiner Lachmi K et al. | β | 2012 | β |
| DQB1*0602 rather than DRB1*1501 confers susceptibility to multiple sclerosis-like disease induced by proteolipid protein (PLP). | Kaushansky N et al. | β | 2012 | β |
| From genes to characteristics of multiple sclerosis. | Harbo HF et al. | β | 2012 | β |
| Genome-wide homozygosity and multiple sclerosis in Orkney and Shetland Islanders. | McWhirter RE et al. | β | 2012 | β |
| HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia. | Cocco E et al. | β | 2012 | β |
| Human population admixture in Asia. | Xu S | β | 2012 | β |
| Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population. | Maniaol AH et al. | β | 2012 | β |
| Myelin basic protein-specific TCR/HLA-DRB5*01:01 transgenic mice support the etiologic role of DRB5*01:01 in multiple sclerosis. | Quandt JA et al. | β | 2012 | β |
| Neurodegeneration in multiple sclerosis: novel treatment strategies. | Luessi F et al. | β | 2012 | β |
| Pathogenesis of multiple sclerosis via environmental and genetic dysregulation of N-glycosylation. | Grigorian A et al. | β | 2012 | β |
| Progress in multiple sclerosis genetics. | Goris A et al. | β | 2012 | β |
| The genetics of multiple sclerosis: an up-to-date review. | Gourraud PA et al. | β | 2012 | β |
| The influence of the HLA-DRB1 and HLA-DQB1 allele heterogeneity on disease risk and severity in Iranian patients with multiple sclerosis. | Kollaee A et al. | β | 2012 | β |
| Vitamin D receptor binding, chromatin states and association with multiple sclerosis. | Disanto G et al. | β | 2012 | β |
| Analysis of specificity of M2_2_36 marker for genotyping HLA-DRB1: an update to major histocompatibility complex database. | Shaykholeslam M et al. | β | 2011 | β |
| Cutting edge issues in primary sclerosing cholangitis. | Bowlus CL | β | 2011 | β |
| Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. | Mkhikian H et al. | β | 2011 | β |
| Genetics of multiple sclerosis. | Hoppenbrouwers IA et al. | β | 2011 | β |
| HLA-DRB1 may be antagonistically regulated by the coordinately evolved promoter and 3'-UTR under stabilizing selection. | Liu B et al. | β | 2011 | β |
| Insights into the changing perspectives of multiple sclerosis in India. | Pandit L | β | 2011 | β |
| Leprosy as a genetic disease. | Alter A et al. | β | 2011 | β |
| Male microchimerism in peripheral blood leukocytes from women with multiple sclerosis. | Bloch EM et al. | β | 2011 | β |
| Multiple sclerosis genetics 2010. | McElroy JP et al. | β | 2011 | β |
| Perspectives on the use of multiple sclerosis risk genes for prediction. | Jafari N et al. | β | 2011 | β |
| Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice. | Luckey D et al. | β | 2011 | β |
| Sex-stratified inheritance of MS: new horizons from studies in MHC region. | Kantarci OH | β | 2011 | β |
| Smoking and multiple sclerosis: a matter of global importance. | Handel AE et al. | β | 2011 | β |
| SNP-based analysis of the HLA locus in Japanese multiple sclerosis patients. | McElroy JP et al. | β | 2011 | β |
| T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. | Wucherpfennig KW et al. | β | 2011 | β |
| Vitamin D in African Americans with multiple sclerosis. | Gelfand JM et al. | β | 2011 | β |
| A major histocompatibility Class I locus contributes to multiple sclerosis susceptibility independently from HLA-DRB1*15:01. | Cree BA et al. | β | 2010 | β |
| A method for simple and accurate identification of the multiple sclerosis associated allele HLA-DRB1*1501 in neuroscience research laboratories. | Cisneros E et al. | β | 2010 | β |
| CIITA variation in the presence of HLA-DRB1*1501 increases risk for multiple sclerosis. | Bronson PG et al. | β | 2010 | β |
| Diagnosis and differential diagnosis of multiple sclerosis. | Cree BA | β | 2010 | β |
| Evidence for CRHR1 in multiple sclerosis using supervised machine learning and meta-analysis in 12,566 individuals. | Briggs FB et al. | β | 2010 | β |
| Genetic and environmental factors and the distribution of multiple sclerosis in Europe. | Handel AE et al. | β | 2010 | β |
| Heterogeneity in multiple sclerosis: scratching the surface of a complex disease. | Disanto G et al. | β | 2010 | β |
| HLA class II alleles and multiple sclerosis in Tunisian patients. | Messadi A et al. | β | 2010 | β |
| HLA-DRB association in neuromyelitis optica is different from that observed in multiple sclerosis. | Brum DG et al. | β | 2010 | β |
| Increased tissue damage and lesion volumes in African Americans with multiple sclerosis. | Weinstock-Guttman B et al. | β | 2010 | β |
| Multiple sclerosis genetics--is the glass half full, or half empty? | Oksenberg JR et al. | β | 2010 | β |
| Multiple sclerosis susceptibility alleles in African Americans. | Johnson BA et al. | β | 2010 | β |
| MultiRTA: a simple yet reliable method for predicting peptide binding affinities for multiple class II MHC allotypes. | Bordner AJ et al. | β | 2010 | β |
| Necrotizing meningoencephalitis of Pug dogs associates with dog leukocyte antigen class II and resembles acute variant forms of multiple sclerosis. | Greer KA et al. | β | 2010 | β |
| Opposing effects of the HLA-DRB1*0301-DQB1*0201 haplotype on the risk for multiple sclerosis in diverse Arab populations in Israel. | Benedek G et al. | β | 2010 | β |
| Pediatric multiple sclerosis. | Mowry EM et al. | β | 2010 | β |
| Primary sclerosing cholangitis in genetically diverse populations listed for liver transplantation: unique clinical and human leukocyte antigen associations. | Bowlus CL et al. | β | 2010 | β |
| Refining the association of MHC with multiple sclerosis in African Americans. | McElroy JP et al. | β | 2010 | β |
| The genetic basis of multiple sclerosis: a model for MS susceptibility. | Goodin DS | β | 2010 | β |
| Towards universal structure-based prediction of class II MHC epitopes for diverse allotypes. | Bordner AJ | β | 2010 | β |
| Transgenic mouse models of multiple sclerosis. | Scheikl T et al. | β | 2010 | β |
| Uncovering the genetic architecture of multiple sclerosis. | Esposito F et al. | β | 2010 | β |
| Variation within DNA repair pathway genes and risk of multiple sclerosis. | Briggs FB et al. | β | 2010 | β |
| Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. | Mowry EM et al. | β | 2010 | β |
| Analysis of HLA DR2&DQ6 (DRB1*1501, DQA1*0102, DQB1*0602) haplotypes in Iranian patients with multiple sclerosis. | Ghabaee M et al. | β | 2009 | β |
| Association between protective and deleterious HLA alleles with multiple sclerosis in Central East Sardinia. | Pastorino R et al. | β | 2009 | β |
| Association of susceptibility to multiple sclerosis in Southern Han Chinese with HLA-DRB1, -DPB1 alleles and DRB1-DPB1 haplotypes: distinct from other populations. | Wu XM et al. | β | 2009 | β |
| Does intra-individual major histocompatibility complex diversity keep a golden mean? | Woelfing B et al. | β | 2009 | β |
| Epistasis among HLA-DRB1, HLA-DQA1, and HLA-DQB1 loci determines multiple sclerosis susceptibility. | Lincoln MR et al. | β | 2009 | β |
| From genes to function: the next challenge to understanding multiple sclerosis. | Fugger L et al. | β | 2009 | β |
| Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis. | Baranzini SE et al. | β | 2009 | β |
| Genotype-Phenotype correlations in multiple sclerosis: HLA genes influence disease severity inferred by 1HMR spectroscopy and MRI measures. | Okuda DT et al. | β | 2009 | β |
| HLA class II alleles in patients with multiple sclerosis in the Biscay province (Basque Country, Spain). | FernΓ‘ndez O et al. | β | 2009 | β |
| HLA-DQ8 (DQB1*0302)-restricted Th17 cells exacerbate experimental autoimmune encephalomyelitis in HLA-DR3-transgenic mice. | Mangalam A et al. | β | 2009 | β |
| Immunogenetics of drug-induced skin blistering disorders. Part II: synthesis. | Bowman C et al. | β | 2009 | β |
| Modification of Multiple Sclerosis Phenotypes by African Ancestry at HLA. | Cree BA et al. | β | 2009 | β |
| Multiple sclerosis and the major histocompatibility complex. | Ramagopalan SV et al. | β | 2009 | β |
| Multiple sclerosis risk: interaction between human leukocyte antigen and the environment in Sardinian population. | Cocco E et al. | β | 2009 | β |
| Pediatric multiple sclerosis. | Waubant E et al. | β | 2009 | β |
| Structural chromosomal variations in neurological diseases. | Kalman B et al. | β | 2009 | β |
| T cell-mediated autoimmune disease due to low-affinity crossreactivity to common microbial peptides. | Harkiolaki M et al. | β | 2009 | β |
| The genetic aspects of multiple sclerosis. | Sawcer S | β | 2009 | β |
| Type 1 diabetes mellitus and multiple sclerosis: common etiological features. | Handel AE et al. | β | 2009 | β |
| Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. | Ramagopalan SV et al. | β | 2009 | β |
| Admixture mapping of white cell count: genetic locus responsible for lower white blood cell count in the Health ABC and Jackson Heart studies. | Nalls MA et al. | β | 2008 | β |
| A genome-wide analysis of admixture in Uyghurs and a high-density admixture map for disease-gene discovery. | Xu S et al. | β | 2008 | β |
| Analysis of genomic admixture in Uyghur and its implication in mapping strategy. | Xu S et al. | β | 2008 | β |
| Balancing selection and heterogeneity across the classical human leukocyte antigen loci: a meta-analytic review of 497 population studies. | Solberg OD et al. | β | 2008 | β |
| CCL genes in multiple sclerosis and systemic lupus erythematosus. | Vyshkina T et al. | β | 2008 | β |
| Defining the role of the MHC in autoimmunity: a review and pooled analysis. | Fernando MM et al. | β | 2008 | β |
| Dissection of the multiple sclerosis associated DR2 haplotype. | Etzensperger R et al. | β | 2008 | β |
| Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach. | Rhodes B et al. | β | 2008 | β |
| HLA-associated susceptibility to childhood B-cell precursor ALL: definition and role of HLA-DPB1 supertypes. | Taylor GM et al. | β | 2008 | β |
| HLA-DR2 and white matter lesion distribution in MS. | Sepulcre J et al. | β | 2008 | β |
| Human MHC architecture and evolution: implications for disease association studies. | Traherne JA | β | 2008 | β |
| Marked differences in prevalence of multiple sclerosis between ethnic groups in Oslo, Norway. | Smestad C et al. | β | 2008 | β |
| Multiple sclerosis: an immune or neurodegenerative disorder? | Trapp BD et al. | β | 2008 | β |
| Multiple sclerosis genetics. | McElroy JP et al. | β | 2008 | β |
| Multiple sclerosis in Gypsies from southern Spain: prevalence, mitochondrial DNA haplogroups and HLA class II association. | FernΓ‘ndez O et al. | β | 2008 | β |
| Race, ethnicity and social class and the complex etiologies of asthma. | Drake KA et al. | β | 2008 | β |
| The complex genetics of multiple sclerosis: pitfalls and prospects. | Sawcer S | β | 2008 | β |
| The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. | Oksenberg JR et al. | β | 2008 | β |
| The immunogenetics of multiple sclerosis. | Svejgaard A | β | 2008 | β |
| The Population Reference Sample, POPRES: a resource for population, disease, and pharmacological genetics research. | Nelson MR et al. | β | 2008 | β |
| Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis. | Caillier SJ et al. | β | 2008 | β |
| Analysis of extended HLA haplotypes in multiple sclerosis and narcolepsy families confirms a predisposing effect for the class I region in Tasmanian MS patients. | Rubio JP et al. | β | 2007 | β |
| A second major histocompatibility complex susceptibility locus for multiple sclerosis. | Yeo TW et al. | β | 2007 | β |
| Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. | Brum DG et al. | β | 2007 | β |
| Current concepts of the cellular and molecular pathophysiology of multiple sclerosis. | Greenstein JI | β | 2007 | β |
| DQB1*0301 and DQB1*0601 modulate narcolepsy susceptibility in Koreans. | Hong SC et al. | β | 2007 | β |
| Evaluation of association of SNPs in the TNF alpha gene region with schizophrenia. | Morar B et al. | β | 2007 | β |
| Gene-environment interactions in multiple sclerosis: innate and adaptive immune responses to human endogenous retrovirus and herpesvirus antigens and the lectin complement activation pathway. | Christensen T et al. | β | 2007 | β |
| Genetic analysis of the exon 1 position 49 CD152 dimorphism in multiple sclerosis. | Stuart R et al. | β | 2007 | β |
| HLA-DR15 haplotype and multiple sclerosis: a HuGE review. | Schmidt H et al. | β | 2007 | β |
| Influence of CCR5-Delta32 genotype in Spanish population with multiple sclerosis. | Otaegui D et al. | β | 2007 | β |
| Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami. | Harbo HF et al. | β | 2007 | β |
| Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications. | Niino M et al. | β | 2007 | β |
| The immunological basis for treatment of multiple sclerosis. | HolmΓΈy T et al. | β | 2007 | β |
| The role of HLA-DRB1 alleles on susceptibility and outcome of a Portuguese Multiple Sclerosis population. | Silva AM et al. | β | 2007 | β |
| Variation of the myelin oligodendrocyte glycoprotein gene is not primarily associated with multiple sclerosis in the Sardinian population. | Marrosu MG et al. | β | 2007 | β |
| A new era in the genetic analysis of multiple sclerosis. | Sawcer S | β | 2006 | β |
| Association of the truncating splice site mutation in BTNL2 with multiple sclerosis is secondary to HLA-DRB1*15. | Traherne JA et al. | β | 2006 | β |
| Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study. | Barcellos LF et al. | β | 2006 | β |
| Epidemiology and natural history of multiple sclerosis: new insights. | Kantarci O et al. | β | 2006 | β |
| Functional epistasis on a common MHC haplotype associated with multiple sclerosis. | Gregersen JW et al. | β | 2006 | β |
| Genetic analysis of completely sequenced disease-associated MHC haplotypes identifies shuffling of segments in recent human history. | Traherne JA et al. | β | 2006 | β |
| Genetics of autoimmune neuroinflammation. | Olsson T et al. | β | 2006 | β |
| Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. | Barcellos LF et al. | β | 2006 | β |
| Human leucocyte antigen class II polymorphism in Irish patients with multiple sclerosis. | Dunne C et al. | β | 2006 | β |
| MHC class II proteins and disease: a structural perspective. | Jones EY et al. | β | 2006 | β |
| Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. | Brassat D et al. | β | 2006 | β |
| Multiple sclerosis: light at the end of the tunnel. | Sawcer S et al. | β | 2006 | β |
| Phenotype and prognosis in African-Americans with multiple sclerosis: a retrospective chart review. | Naismith RT et al. | β | 2006 | β |
| The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration. | Hauser SL et al. | β | 2006 | β |
| Admixture mapping as a gene discovery approach for complex human traits and diseases. | Nievergelt CM et al. | β | 2005 | β |
| A high-resolution linkage-disequilibrium map of the human major histocompatibility complex and first generation of tag single-nucleotide polymorphisms. | Miretti MM et al. | β | 2005 | β |
| An update on multiple sclerosis. | Hauser SL | β | 2005 | β |
| A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. | Lincoln MR et al. | β | 2005 | β |
| A whole-genome admixture scan finds a candidate locus for multiple sclerosis susceptibility. | Reich D et al. | β | 2005 | β |
| Complex interactions among MHC haplotypes in multiple sclerosis: susceptibility and resistance. | Dyment DA et al. | β | 2005 | β |
| Genetics of multiple sclerosis. | Oksenberg JR et al. | β | 2005 | β |
| Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis. | Fernald GH et al. | β | 2005 | β |
| Multiple sclerosis genetics: leaving no stone unturned. | Oksenberg JR et al. | β | 2005 | β |
| The efficacy of short tandem repeat polymorphisms versus single-nucleotide polymorphisms for resolving population structure. | Kauwe JS et al. | β | 2005 | β |
| The HLA locus and multiple sclerosis in Sicily. | Brassat D et al. | β | 2005 | β |
| The R620W polymorphism of the protein tyrosine phosphatase PTPN22 is not associated with multiple sclerosis. | Begovich AB et al. | β | 2005 | β |
| Clinical characteristics of African Americans vs Caucasian Americans with multiple sclerosis. | Cree BA et al. | β | 2004 | β |
| Gender, age, and season at immunization uniquely influence the genetic control of susceptibility to histopathological lesions and clinical signs of experimental allergic encephalomyelitis: implications for the genetics of multiple sclerosis. | Teuscher C et al. | β | 2004 | β |
| Genes and autoimmune diseases - a complex inheritance. | Mariani SM | β | 2004 | β |
| Linkage and association with the NOS2A locus on chromosome 17q11 in multiple sclerosis. | Barcellos LF et al. | β | 2004 | β |
| Methods for high-density admixture mapping of disease genes. | Patterson N et al. | β | 2004 | β |