Chronic intracerebroventricular neuropeptide-Y administration to normal rats mimics hormonal and metabolic changes of obesity.
paper
Cited
Public
Unavailable
- Authors
- Zarjevski, N; Cusin, I; Vettor, R; Rohner-Jeanrenaud, F; Jeanrenaud, B
- Year
- 1993
- Journal
- Endocrinology
- PMID
- 8404618
- DOI
- 10.1210/endo.133.4.8404618
Chronic intracerebroventricular (icv) administration of neuropeptide-Y (NPY; 10 micrograms/day) was performed in normal female rats to investigate its hormonal and metabolic consequences. Intracerebroventricular NPY produced hyperphagia, increased basal insulinemia, as well as liver and adipose tissue lipogenic activity. It also increased basal morning corticosteronemia. When NPY-induced hyperphagia was prevented by pair-feeding, the icv NPY treatment resulted in the same increases in basal insulinemia and corticosteronemia, and liver and white adipose tissue lipogenesis was still higher than that in respective controls. Under the ad libitum and pair-feeding conditions, icv NPY stimulated glucose uptake as well as total lipoprotein lipase activity in white adipose tissue; it resulted in an increase total activity of hepatic and white adipose tissue acetyl coenzyme-A-carboxylase. As all hormonal and metabolic changes elicited by icv NPY remained present (at the same or to a lesser extent depending upon the parameter considered) when hyperphagia was prevented by pair-feeding, it was, thus, shown that icv NPY per se induces peripheral hormonal and metabolic alterations via efferent routes, which remain to be determined. The effects of icv NPY reported in this study are similar to the defects observed in the early phase of genetic obesity in rodents, the hypothalamus of which has increased NPY levels. NPY could, thus, be of relevance in the occurrence of genetically induced obesity.
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| Title | Year | PMID |
|---|---|---|
| Neuropeptide Y receptor genes are associated with alcohol dependence, alcohol withdrawal phenotypes, and cocaine dependence. | 2008 | 18828811 |
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| Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. | Daniels AJ et al. | — | 2002 | → |
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| Chronic administration of neuropeptide Y into the lateral ventricle of C57BL/6J male mice produces an obesity syndrome including hyperphagia, hyperleptinemia, insulin resistance, and hypogonadism. | Raposinho PD et al. | — | 2001 | → |
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| Chronic blockade of the melanocortin 4 receptor subtype leads to obesity independently of neuropeptide Y action, with no adverse effects on the gonadotropic and somatotropic axes. | Raposinho PD et al. | — | 2000 | → |
| Effects of blockers of carbohydrate and lipid metabolism on expression of mRNA of some hypothalamic neuropeptides. | Sergeev VG et al. | — | 2000 | → |
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| Zinc elevates neuropeptide Y levels in rat pheochromocytoma cells by a mechanism independent of L-channel mediated inhibition of release. | Schwartz PJ et al. | — | 2000 | → |
| Chronic intracerebroventricular administration of orexin-A to rats increases food intake in daytime, but has no effect on body weight. | Yamanaka A et al. | — | 1999 | → |
| Conservation of expression of neuropeptide Y5 receptor between human and rat hypothalamus and limbic regions suggests an integral role in central neuroendocrine control. | Nichol KA et al. | — | 1999 | → |
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| Evidence that the inhibition of luteinizing hormone secretion exerted by central administration of neuropeptide Y (NPY) in the rat is predominantly mediated by the NPY-Y5 receptor subtype. | Raposinho PD et al. | — | 1999 | → |
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| Regulation of neuropeptide Y release by neuropeptide Y receptor ligands and calcium channel antagonists in hypothalamic slices. | King PJ et al. | — | 1999 | → |
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| Brain administration of OB protein (leptin) inhibits neuropeptide-Y-induced feeding in ob/ob mice. | Smith FJ et al. | — | 1998 | → |
| Effect of uteroplacental insufficiency upon brain neuropeptide Y and corticotropin-releasing factor gene expression and concentrations. | Rajakumar PA et al. | — | 1998 | → |
| Hypothalamic neuropeptide Y and galanin in overweight rats fed a cafeteria diet. | Pedrazzi P et al. | — | 1998 | → |
| Immunohistochemical localization of leptin receptor in the rat brain. | Shioda S et al. | — | 1998 | → |
| Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor. | Xu B et al. | — | 1998 | → |
| Intraventricular injection of neuropeptide Y antisera curbs weight gain and feeding, and increases the display of sexual behaviors in obese Zucker female rats. | Marín-Bivens CL et al. | — | 1998 | → |
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| Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. | Wieland HA et al. | — | 1998 | → |
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| Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes. | Schwartz MW et al. | — | 1997 | → |
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| Increased receptor sensitivity to neuropeptide Y in the hypothalamus may underlie transient hyperphagia and body weight gain. | Kalra PS et al. | — | 1997 | → |
| Leptin, corticotropin-releasing hormone (CRH), and neuropeptide Y (NPY)in free-ranging pregnant bats. | Widmaier EP et al. | — | 1997 | → |
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