Psychophysiological responses to drug-associated stimuli in chronic heavy cannabis use.
paper
Cited
Public
Unavailable
- Authors
- WΓΆlfling, Klaus; Flor, Herta; GrΓΌsser, Sabine M
- Year
- 2008
- Journal
- The European journal of neuroscience
- PMID
- 18333968
- DOI
- 10.1111/j.1460-9568.2008.06051.x
Due to learning processes originally neutral stimuli become drug-associated and can activate an implicit drug memory, which leads to a conditioned arousing 'drug-seeking' state. This condition is accompanied by specific psychophysiological responses. The goal of the present study was the analysis of changes in cortical and peripheral reactivity to cannabis as well as alcohol-associated pictures compared with emotionally significant drug-unrelated and neutral pictures in long-term heavy cannabis users. Participants were 15 chronic heavy cannabis users and 15 healthy controls. Verbal reports as well as event-related potentials of the electroencephalogram and skin conductance responses were assessed in a cue-reactivity paradigm to determine the psychophysiological effects caused by drug-related visual stimulus material. The evaluation of self-reported craving and emotional processing showed that cannabis stimuli were perceived as more arousing and pleasant and elicited significantly more cannabis craving in cannabis users than in healthy controls. Cannabis users also demonstrated higher cannabis stimulus-induced arousal, as indicated by significantly increased skin conductance and a larger late positivity of the visual event-related brain potential. These findings support the assumption that drug-associated stimuli acquire increased incentive salience in addiction history and induce conditioned physiological patterns, which lead to craving and potentially to drug intake. The potency of visual drug-associated cues to capture attention and to activate drug-specific memory traces and accompanying physiological symptoms embedded in a cycle of abstinence and relapse--even in a 'so-called' soft drug--was assessed for the first time.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Artificial Intelligence Approximates Human Affect Ratings of Cannabis Images | Borodovsky JT et al. | β | 2025 | β |
| Decoding the neural correlates of social cognition and emotion recognition in cannabis users: A systematic review of neuroimaging studies. | Romein C et al. | β | 2025 | β |
| Decomposing the late positive potential to cannabis cues in regular cannabis users: A temporal-spatial principal component analysis. | Preston TJ et al. | β | 2024 | β |
| Associations of the P300 Event-Related Potentials and Self-Reported Craving in Substance Use Disorders: A Systematic Review. | Epp T et al. | β | 2023 | β |
| Impact of a computerized distress intolerance intervention on electrocortical reactivity to cannabis and threat cues: A randomized controlled trial. | Macatee RJ et al. | β | 2022 | β |
| Neuronal and Astrocytic Morphological Alterations Driven by Prolonged Exposure with Ξ9-Tetrahydrocannabinol but Not Cannabidiol. | Landucci E et al. | β | 2022 | β |
| Development and validation of a cannabis cue stimulus set. | Macatee RJ et al. | β | 2021 | β |
| SmoCuDa: A Validated Smoking Cue Database to Reliably Induce Craving in Tobacco Use Disorder. | Manoliu A et al. | β | 2021 | β |
| Heart Rate Variability, Cue-Evoked Ventromedial Prefrontal Cortical Response, and Problem Alcohol Use in Adult Drinkers. | Wang W et al. | β | 2020 | β |
| Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers. | Wang W et al. | β | 2019 | β |
| Distress intolerance moderation of motivated attention to cannabis and negative stimuli after induced stress among cannabis users: an ERP study. | Macatee RJ et al. | β | 2019 | β |
| Drug-related Virtual Reality Cue Reactivity is Associated with Gamma Activity in Reward and Executive Control Circuit in Methamphetamine UseΒ Disorders. | Tan H et al. | β | 2019 | β |
| Investigating a novel fMRI cannabis cue reactivity task in youth. | Karoly HC et al. | β | 2019 | β |
| Testing the role of the posterior cingulate cortex in processing salient stimuli in cannabis users: an rTMS study. | Prashad S et al. | β | 2019 | β |
| Early onset cigarette smokers exhibit greater P300 reactivity to smoking-related stimuli and report greater craving. | Mashhoon Y et al. | β | 2018 | β |
| Food product health warnings promote dietary self-control through reductions in neural signals indexing food cue reactivity. | Rosenblatt DH et al. | β | 2018 | β |
| The effects of cannabis use on salience attribution: a systematic review. | Wijayendran SB et al. | β | 2018 | β |
| Beyond Cue Reactivity: Non-Drug-Related Motivationally Relevant Stimuli Are Necessary to Understand Reactivity to Drug-Related Cues. | Versace F et al. | β | 2017 | β |
| Subanesthetic ketamine decreases the incentive-motivational value of reward-related cues. | Fitzpatrick CJ et al. | β | 2017 | β |
| Craving cannabis: a meta-analysis of self-report and psychophysiological cue-reactivity studies. | Norberg MM et al. | β | 2016 | β |
| Cue-elicited increases in incentive salience for marijuana: Craving, demand, and attentional bias. | Metrik J et al. | β | 2016 | β |
| Electrophysiology for addiction medicine: From methodology to conceptualization of reward deficits. | Stewart JL et al. | β | 2016 | β |
| Genome-wide Association Study of Cannabis Dependence Severity, Novel Risk Variants, and Shared Genetic Risks. | Sherva R et al. | β | 2016 | β |
| Magnitude and duration of cue-induced craving for marijuana in volunteers with cannabis use disorder. | Lundahl LH et al. | β | 2016 | β |
| Measuring wanting and liking from animals to humans: A systematic review. | Pool E et al. | β | 2016 | β |
| Altered reward processing in pathological computer gamers--ERP-results from a semi-natural gaming-design. | Duven EC et al. | β | 2015 | β |
| Effect of oral THC pretreatment on marijuana cue-induced responses in cannabis dependent volunteers. | Lundahl LH et al. | β | 2015 | β |
| Emotional graphic cigarette warning labels reduce the electrophysiological brain response to smoking cues. | Wang AL et al. | β | 2015 | β |
| Ophthalmological assessment of cannabis-induced persisting perception disorder: is there a direct retinal effect? | Zobor D et al. | β | 2015 | β |
| The inhibition of proactive interference among adults with Internet gaming disorder. | Ko CH et al. | β | 2015 | β |
| Validation of the French version of the marijuana craving questionnaire (MCQ) generates a two-factor model. | Chauchard E et al. | β | 2015 | β |
| Can antipsychotic treatment contribute to drug addiction in schizophrenia? | Samaha AN | β | 2014 | β |
| Cannabis cue reactivity and craving among never, infrequent and heavy cannabis users. | Henry EA et al. | β | 2014 | β |
| Cognitive processes associated with compulsive buying behaviours and related EEG coherence. | Lawrence LM et al. | β | 2014 | β |
| Do reward-processing deficits in schizophrenia-spectrum disorders promote cannabis use? An investigation of physiological response to natural rewards and drug cues. | Cassidy CM et al. | β | 2014 | β |
| Electrophysiological evidence of early attentional bias to drug-related pictures in chronic cannabis users. | Asmaro D et al. | β | 2014 | β |
| Event-related potentials in substance use disorders: a narrative review based on articles from 1984 to 2012. | Campanella S et al. | β | 2014 | β |
| Neural responses to subliminally presented cannabis and other emotionally evocative cues in cannabis-dependent individuals. | Wetherill RR et al. | β | 2014 | β |
| Addiction is Not a Natural Kind. | Pober JM | β | 2013 | β |
| A review of human drug self-administration procedures. | Jones JD et al. | β | 2013 | β |
| Molecular mechanisms of cannabinoid addiction. | Fratta W et al. | β | 2013 | β |
| Neural responses associated with cue-reactivity in frequent cannabis users. | Cousijn J et al. | β | 2013 | β |
| Neurocognitive correlates of processing food-related stimuli in a Go/No-go paradigm. | Watson TD et al. | β | 2013 | β |
| Restrictive feeding practices and adiposity are differentially related to P3b cortical responses to food stimuli in children. | Hill C et al. | β | 2013 | β |
| The late positive potential (LPP) in response to varying types of emotional and cigarette stimuli in smokers: a content comparison. | Minnix JA et al. | β | 2013 | β |
| Cannabis cue-elicited craving and the reward neurocircuitry. | Filbey FM et al. | β | 2012 | β |
| Cue-induced craving and physiological reactions in recently and long-abstinent heroin-dependent patients. | Zhao M et al. | β | 2012 | β |
| Effects of a manualized short-term treatment of internet and computer game addiction (STICA): study protocol for a randomized controlled trial. | JΓ€ger S et al. | β | 2012 | β |
| Electrophysiological correlates of associative learning in smokers: a higher-order conditioning experiment. | Littel M et al. | β | 2012 | β |
| Electrophysiological indices of biased cognitive processing of substance-related cues: a meta-analysis. | Littel M et al. | β | 2012 | β |
| Immediate antecedents of marijuana use: an analysis from ecological momentary assessment. | Buckner JD et al. | β | 2012 | β |
| Brain reactivity to emotional, neutral and cigarette-related stimuli in smokers. | Versace F et al. | β | 2011 | β |
| Cue-induced craving for marijuana in cannabis-dependent adults. | Lundahl LH et al. | β | 2011 | β |
| Cue reactivity in cannabis-dependent adolescents. | Nickerson LD et al. | β | 2011 | β |
| Implicit and explicit selective attention to smoking cues in smokers indexed by brain potentials. | Littel M et al. | β | 2011 | β |
| Intentional modulation of the late positive potential in response to smoking cues by cognitive strategies in smokers. | Littel M et al. | β | 2011 | β |
| Reactivity to in vivo marijuana cues among cannabis-dependent adolescents. | Gray KM et al. | β | 2011 | β |
| Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals. | McRae-Clark AL et al. | β | 2011 | β |
| To gamble or not to gamble: at risk for craving and relapse--learned motivated attention in pathological gambling. | WΓΆlfling K et al. | β | 2011 | β |
| Chronic cannabis users show altered neurophysiological functioning on Stroop task conflict resolution. | Battisti RA et al. | β | 2010 | β |
| Chronic use of cannabis and poor neural efficiency in verbal memory ability. | Battisti RA et al. | β | 2010 | β |
| Cigarette cues capture smokers' attention: evidence from event-related potentials. | Versace F et al. | β | 2010 | β |
| Drug- and cue-induced reinstatement of cannabinoid-seeking behaviour in male and female rats: influence of ovarian hormones. | Fattore L et al. | β | 2010 | β |
| Intermediate cannabis dependence phenotypes and the FAAH C385A variant: an exploratory analysis. | Schacht JP et al. | β | 2009 | β |
| Marijuana craving in the brain. | Filbey FM et al. | β | 2009 | β |
| Reliability and validity of a short form of the Marijuana Craving Questionnaire. | Heishman SJ et al. | β | 2009 | β |