The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update.
paper
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- Authors
- Uher, R; McGuffin, P
- Year
- 2010
- Journal
- Molecular psychiatry
- PMID
- 20029411
- DOI
- 10.1038/mp.2009.123
An updated review of 34 human observational studies indicates that the length polymorphism of the serotonin transporter gene moderates the effect of environmental adversity in the development of depression. This finding depends on the use of contextual or objective methods to assess environmental adversity and is attenuated when self-report instruments are used. Inconsistent findings in male adolescents suggest a developmental stage and sex-specific protective mechanism. These systematic relationships between method and results should be followed up to specify causal mechanisms leading to depression.
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| An interaction between a neuropeptide Y gene polymorphism and early adversity modulates endocrine stress responses. | Witt SH et al. | — | 2011 | → |
| Behavioral and molecular genetics of dissociation: the role of the serotonin transporter gene promoter polymorphism (5-HTTLPR). | Pieper S et al. | — | 2011 | → |
| Building conditions, 5-HTTLPR genotype, and depressive symptoms in adolescent males and females. | Uddin M et al. | — | 2011 | → |
| Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders. | Wilkinson PO et al. | — | 2011 | → |
| Childhood adversity interacts separately with 5-HTTLPR and BDNF to predict lifetime depression diagnosis. | Carver CS et al. | — | 2011 | → |
| Chronic family stress interacts with 5-HTTLPR to predict prospective depressive symptoms among youth. | Jenness JL et al. | — | 2011 | → |
| Cognitive appraisal and life stress moderate the effects of the 5-HTTLPR polymorphism on amygdala reactivity. | Lemogne C et al. | — | 2011 | → |
| Common abnormalities and disorder-specific compensation during implicit regulation of emotional processing in generalized anxiety and major depressive disorders. | Etkin A et al. | — | 2011 | → |
| Developmental perspectives on vulnerability to nonsuicidal self-injury in youth. | Barrocas AL et al. | — | 2011 | → |
| Differential susceptibility to the environment: an evolutionary--neurodevelopmental theory. | Ellis BJ et al. | — | 2011 | → |
| Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament. | Holmboe K et al. | — | 2011 | → |
| Droplets of black bile? Development of vulnerability and resilience to depression in young age. | Harro J et al. | — | 2011 | → |
| Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study. | Coplan JD et al. | — | 2011 | → |
| Effects of acute psychosocial stress exposure on endocrine and affective reactivity in college students differing in the 5-HTTLPR genotype and trait neuroticism. | Verschoor E et al. | — | 2011 | → |
| Epigenetic modification of the BDNF locus by early-life enrichment: towards a molecular correlate of resilience? | Pittenger C | — | 2011 | → |
| Four potential criteria for deciding when to use antidepressants or psychotherapy for unipolar depression: a literature review. | Sharpley CF et al. | — | 2011 | → |
| Gene-environment interaction in anorexia nervosa: relevance of non-shared environment and the serotonin transporter gene. | Karwautz AF et al. | — | 2011 | → |
| Gene-environment interaction in the etiology of mathematical ability using SNP sets. | Docherty SJ et al. | — | 2011 | → |
| Gene-environment interactions: early life stress and risk for depressive and anxiety disorders. | Nugent NR et al. | — | 2011 | → |
| Gene-environment interactions in panic disorder and CO₂ sensitivity: Effects of events occurring early in life. | Spatola CA et al. | — | 2011 | → |
| Genetics in psychiatry: are the promises met? | Bondy B | — | 2011 | → |
| Interaction between serotonin transporter gene variants and life events predicts response to antidepressants in the GENDEP project. | Keers R et al. | — | 2011 | → |
| Interaction of 5-HTTLPR and idiographic stressors predicts prospective depressive symptoms specifically among youth in a multiwave design. | Hankin BL et al. | — | 2011 | → |
| Interaction of early environment, gender and genes of monoamine neurotransmission in the aetiology of depression in a large population-based Finnish birth cohort. | Nyman ES et al. | — | 2011 | → |
| Interaction of serotonin transporter gene-linked polymorphic region and stressful life events predicts cortisol stress response. | Mueller A et al. | — | 2011 | → |
| Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study. | Fergusson DM et al. | — | 2011 | → |
| Pathobiological targets of depression. | Chopra K et al. | — | 2011 | → |
| Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study. | Székely E et al. | — | 2011 | → |
| Research review: gene-environment interaction research in youth depression - a systematic review with recommendations for future research. | Dunn EC et al. | — | 2011 | → |
| Serotonin receptor 2A gene moderates the effect of childhood maternal nurturance on adulthood social attachment. | Salo J et al. | — | 2011 | → |
| Serotonin transporter gene and childhood trauma--a G × E effect on anxiety sensitivity. | Klauke B et al. | — | 2011 | → |
| Serotonin transporter gene moderates childhood maltreatment's effects on persistent but not single-episode depression: replications and implications for resolving inconsistent results. | Uher R et al. | — | 2011 | → |
| Serotonin transporter gene polymorphism and psychiatric disorders: is there a link? | Margoob MA et al. | — | 2011 | → |
| Serotonin transporter genotype modulates subgenual response to fearful faces using an incidental task. | O'Nions EJ et al. | — | 2011 | → |
| Serotonin transporter polymorphism interacts with childhood adversity to predict aspects of impulsivity. | Carver CS et al. | — | 2011 | → |
| Sleep quality and diurnal preference in a sample of young adults: associations with 5HTTLPR, PER3, and CLOCK 3111. | Barclay NL et al. | — | 2011 | → |
| The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions. | Juhasz G et al. | — | 2011 | → |
| The effects of allostatic load on neural systems subserving motivation, mood regulation, and social affiliation. | Beauchaine TP et al. | — | 2011 | → |
| The genetic blueprint of major depressive disorder: contributions of imaging genetics studies. | Scharinger C et al. | — | 2011 | → |
| The HTR1A and HTR1B receptor genes influence stress-related information processing. | Mekli K et al. | — | 2011 | → |
| The influence of psychiatric screening in healthy populations selection: a new study and meta-analysis of functional 5-HTTLPR and rs25531 polymorphisms and anxiety-related personality traits. | Minelli A et al. | — | 2011 | → |
| The serotonin transporter gene alters sensitivity to attention bias modification: evidence for a plasticity gene. | Fox E et al. | — | 2011 | → |
| The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation. | Karg K et al. | — | 2011 | → |
| The truth about genetic variation in the serotonin transporter gene and response to stress and medication. | McGuffin P et al. | — | 2011 | → |
| Understanding risk for psychopathology through imaging gene-environment interactions. | Hyde LW et al. | — | 2011 | → |
| Update on the 2005 paper: moderation of mental and physical distress by polymorphisms in the 5-HT transporter gene by interacting with social stressors and chronic disease burden. | Grabe HJ et al. | — | 2011 | → |
| Using gene-environment interactions to target personalized treatment in mood disorder. | Klengel T et al. | — | 2011 | → |
| War exposure, 5-HTTLPR genotype and lifetime risk of depression. | Artero S et al. | — | 2011 | → |
| When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience. | Lesch KP | — | 2011 | → |
| Black sheep get the blues: a psychobiological model of social rejection and depression. | Slavich GM et al. | — | 2010 | → |
| Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective. | Wong EH et al. | — | 2010 | → |
| Current developments and controversies: does the serotonin transporter gene-linked polymorphic region (5-HTTLPR) modulate the association between stress and depression? | Wankerl M et al. | — | 2010 | → |
| Early-life stress and neurometabolites of the hippocampus. | Coplan JD et al. | — | 2010 | → |
| Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. | Caspi A et al. | — | 2010 | → |
| Interaction of chronic stress with serotonin transporter and catechol-O-methyltransferase polymorphisms in predicting youth depression. | Conway CC et al. | — | 2010 | → |
| Is there a genetic contribution to cultural differences? Collectivism, individualism and genetic markers of social sensitivity. | Way BM et al. | — | 2010 | → |
| Is there a personalized medicine for mood disorders? | Bartova L et al. | — | 2010 | → |
| Methylation matters: interaction between methylation density and serotonin transporter genotype predicts unresolved loss or trauma. | van IJzendoorn MH et al. | — | 2010 | → |
| Overview of the genetics of major depressive disorder. | Lohoff FW | — | 2010 | → |
| Polymorphisms in BDNF (Val66Met) and 5-HTTLPR, morning cortisol and subsequent depression in at-risk adolescents. | Goodyer IM et al. | — | 2010 | → |
| Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression. | Antypa N et al. | — | 2010 | → |
| Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction. | Wankerl M et al. | — | 2010 | → |
| The serotonin transporter gene length polymorphism (5-HTTLPR) and life events: no evidence for an interaction effect on neuroticism and anxious depressive symptoms. | Middeldorp CM et al. | — | 2010 | → |
| The serotonin transporter promoter polymorphism and childhood positive and negative emotionality. | Hayden EP et al. | — | 2010 | → |