Event-related potentials and comorbidity in alcohol-dependent adult males.
- Authors
- Malone, S M; Iacono, W G; McGue, M
- Year
- 2001
- Journal
- Psychophysiology
- PMID
- 11352124
The present study examined event-related potentials (ERPs) elicited by a visual discrimination task in a community sample of adult males with a lifetime diagnosis of alcohol dependence. Study participants were subtyped by the presence of additional comorbid disorders (antisocial personality, depression, and drug abuse or dependence). In all groups of alcohol-dependent subjects, even those without any additional comorbid disorders, P3 amplitude differed from that of a comparison group. Alcohol-dependent subjects with a diagnosis of illicit drug abuse or dependence, especially if they had antisocial personality as well, had the smallest amplitude responses. The amplitude profile of the P3 across the parietal electrodes used as active sites was flattened among alcoholic subjects, with P3 amplitude disproportionately reduced at the midline. Among alcoholic subjects with a lifetime diagnosis of depression, the flattened amplitude profile was due to elevated mean amplitude of the P3 at lateral leads, especially P4, relative to the comparison group. Alterations in ERP responses appear to be a general characteristic of alcoholism in men, although the presence of other comorbid disorders, particularly drug abuse or dependence together with antisocial personality, results in the greatest reductions in P3 amplitude.
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Neuropsychophysiological Measures of Alcohol Dependence: Can We Use EEG in the Clinical Assessment? | Jurado-Barba R et al. | — | 2020 | → |
| Longitudinal stability and predictive utility of the visual P3 response in adults with externalizing psychopathology. | Yoon HH et al. | — | 2015 | → |
| Heritability and molecular-genetic basis of the P3 event-related brain potential: a genome-wide association study. | Malone SM et al. | — | 2014 | → |
| Association between P3 event-related potential amplitude and externalizing disorders: a time-domain and time-frequency investigation of 29-year-old adults. | Yoon HH et al. | — | 2013 | → |
| Effects of a persistent binge drinking pattern of alcohol consumption in young people: a follow-up study using event-related potentials. | López-Caneda E et al. | — | 2013 | → |
| Multifactorial determinants of target and novelty-evoked P300 amplitudes in children of addicted parents. | Euser AS et al. | — | 2013 | → |
| P300 amplitude reduction is associated with early-onset and late-onset pathological substance use in a prospectively studied cohort of 14-year-old adolescents. | Perlman G et al. | — | 2013 | → |
| The P300 event-related brain potential as a neurobiological endophenotype for substance use disorders: a meta-analytic investigation. | Euser AS et al. | — | 2012 | → |
| For distinguished contributions to psychophysiology: William G. Iacono. | Miller GA | — | 2010 | → |
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