Gilles de la Tourette's syndrome and obsessive-compulsive disorder. Evidence supporting a genetic relationship.
paper
Cited
Public
Unavailable
- Authors
- Pauls, D L; Towbin, K E; Leckman, J F; Zahner, G E; Cohen, D J
- Year
- 1986
- Journal
- Archives of general psychiatry
- PMID
- 3465280
- DOI
- 10.1001/archpsyc.1986.01800120066013
Previous studies have suggested that obsessive-compulsive symptoms frequently occur among patients with Gilles de la Tourette's syndrome (TS). To examine the relationship between TS and obsessive-compulsive disorder (OCD), data from all first-degree relatives of TS probands were obtained with a semistructured interview designed to collect information on the presence of TS, other tic disorders, and neuropsychiatric illnesses during the lifetime of the individual. The rate of OCD among first-degree relatives was significantly increased over estimates from the general population and a control sample of adoptive relatives. The rates of TS, OCD, and chronic multiple tics (CMT) were virtually the same in families of probands with OCD (TS +/- OCD) when compared with families of probands without OCD (TS - OCD). Finally, the frequency of OCD without TS or CMT among first-degree relatives was significantly elevated in families of both TS + OCD and TS - OCD probands, suggesting that some forms of OCD may represent an alternative expression of the factors responsible for TS and/or CMT.
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