Dose-related effect of alcohol on mismatch negativity and reaction time performance.
- Authors
- Jääskeläinen, I P; Pekkonen, E; Alho, K; Sinclair, J D; Sillanaukee, P; Näätänen, R
- Year
- 1995
- Journal
- Alcohol (Fayetteville, N.Y.)
- PMID
- 8590608
- DOI
- 10.1016/0741-8329(95)00009-7
In a recent study, the mismatch negativity (MMN) component of auditory event-related potential, elicited by occasional frequency changes in a repetitive tone, was strongly attenuated by a low dosage of alcohol. We investigated the phenomenon in nine subjects with two different dosages of ethanol (0.35 and 0.55 g/kg), and with two magnitudes of frequency changes (5% and 10%), in a single-blind, placebo-controlled paradigm. Ethanol had no observable effect on the N1 and P2 deflections, nor on the reaction time to frequency changes measured in a separate session. However, the MMN was attenuated after administration of the larger dosage of alcohol, suggesting impaired preconscious processing of stimulus features outside the scope of attention. The results support the view according to which the automatic functions of human information processing are more sensitive than the controlled functions to the detrimental effects of alcohol. The fact that the MMN suppression was stronger when stimulus deviation was smaller indicates that at relatively low blood alcohol concentrations the detection of small deviations is especially hampered.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol and Neural Dynamics: A Meta-analysis of Acute Alcohol Effects on Event-Related Brain Potentials. | Fairbairn CE et al. | — | 2021 | → |
| Using Mismatch Negativity to Investigate the Pathophysiology of Substance Use Disorders and Comorbid Psychosis. | Ramlakhan JU et al. | — | 2018 | → |
| Alcohol use in bipolar disorder: A neurobiological model to help predict susceptibility, select treatments and attenuate cortical insult. | Chitty KM et al. | — | 2015 | → |
| The N-methyl-D-aspartate receptor as a neurobiological intersection between bipolar disorder and alcohol use: a longitudinal mismatch negativity study. | Chitty KM et al. | — | 2015 | → |
| Different effects of alcohol on automatic detection of colour, location and time change: a mismatch negativity study. | He J et al. | — | 2014 | → |
| Risky alcohol use predicts temporal mismatch negativity impairments in young people with bipolar disorder. | Chitty KM et al. | — | 2014 | → |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | — | 2014 | → |
| Effects of alcohol on auditory pre-attentive processing of four sound features: evidence from mismatch negativity. | He J et al. | — | 2013 | → |
| Speed isn't everything: complex processing speed measures mask individual differences and developmental changes in executive control. | Cepeda NJ et al. | — | 2013 | → |
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| Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability, and interstimulus/interdeviant interval. | Javitt DC et al. | — | 1998 | → |
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| Mismatch negativity subcomponents and ethyl alcohol. | Jääskeläinen IP et al. | — | 1996 | → |