Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality.
- Authors
- Su, Jinni; Kuo, Sally I-Chun; Bucholz, Kathleen K; Edenberg, Howard J; Kramer, John R; Schuckit, Marc; Dick, Danielle M
- Year
- 2018
- Journal
- Twin research and human genetics : the official journal of the International Society for Twin Studies
- PMID
- 30027866
- DOI
- 10.1017/thg.2018.36
Genetic predispositions play an important role in the development of internalizing and externalizing behaviors. Understanding the mechanisms through which genetic risk unfolds to influence these developmental outcomes is critical for developing prevention and intervention efforts, capturing key elements of Irv's research agenda and scientific legacy. In this study, we examined the role of parenting and personality in mediating the effect of genetic risk on adolescents' major depressive disorder and conduct disorder symptoms. Longitudinal data were drawn from a sample of 709 European American adolescents and their mothers from the Collaborative Studies on Genetics of Alcoholism. Results from multivariate path analysis indicated that adolescents' depressive symptoms genome-wide polygenic scores (DS_GPS) predicted lower parental knowledge, which in turn was associated with more subsequent major depressive disorder and conduct disorder symptoms. Adolescents' DS_GPS also had indirect effects on these outcomes via personality, with a mediating effect via agreeableness but not via other dimensions of personality. Findings revealed that the pattern of associations was similar across adolescent gender. Our findings emphasize the important role of evocative gene-environment correlation processes and intermediate phenotypes in the pathways of risk from genetic predispositions to complex adolescent outcomes.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
| Filename | Size | Added | |
|---|---|---|---|
| 30027866.pdf | 322770 bytes | 2026-05-15 | View |
No citations found.
No papers in this knowledge base cite this source.
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Should We Really Say Goodbye to the Effects of Nurture on Development? | Koot HM | — | 2024 | → |
| Dimensions of the Hamilton Depression Rating Scale Correlate with Impulsivity and Personality Traits among Youth Patients with Depression. | Rajewska-Rager A et al. | — | 2023 | → |
| Polygenic Effects on Individual Rule Breaking, Peer Rule Breaking, and Alcohol Sips Across Early Adolescence in the ABCD Study. | Elam KK et al. | — | 2023 | → |
| The Collaborative Study on the Genetics of Alcoholism: Overview. | Agrawal A et al. | — | 2023 | → |
| Examining social genetic effects on educational attainment via parental educational attainment, income, and parenting. | Su J et al. | — | 2022 | → |
| Genetic variance in conscientiousness relates to youth psychopathology beyond executive functions. | Shields AN et al. | — | 2022 | → |
| Integrating the study of personality and psychopathology in the context of gene-environment correlations across development. | Perlstein S et al. | — | 2022 | → |
| Systematic Review: Molecular Studies of Common Genetic Variation in Child and Adolescent Psychiatric Disorders. | Akingbuwa WA et al. | — | 2022 | → |
| The Associations of Polygenic Scores for Risky Behaviors and Parenting Behaviors with Adolescent Externalizing Problems. | Ksinan AJ et al. | — | 2022 | → |
| Genetic and environmental contributions to psychopathological symptoms in adulthood: Clarifying the role of individual and parental risk factors. | Kim AR et al. | — | 2020 | → |