Genome-wide association studies: potential next steps on a genetic journey.
paper
Cited
Public
Unavailable
- Authors
- McCarthy, Mark I; Hirschhorn, Joel N
- Year
- 2008
- Journal
- Human molecular genetics
- PMID
- 18852205
- DOI
- 10.1093/hmg/ddn289
- PMCID
- PMC2782356
Genome-wide association studies have successfully identified numerous loci at which common variants influence disease risk or quantitative traits. Despite these successes, the variants identified by these studies have generally explained only a small fraction of the heritable component of disease risk, and have not pinpointed with certainty the causal variant(s) at the associated loci. Furthermore, the mechanisms of action by which associated loci influence disease or quantitative phenotypes are often unclear, because we do not know through which gene(s) the associated variants exert their effects or because these gene(s) are of unknown function or have no clear connection to known disease biology. Thus, the initial set of genome-wide association studies serve as a starting point for future genetic and functional studies. We outline possible next steps that may help accelerate progress from genetic studies to the biological knowledge that can guide the development of predictive, preventive, or therapeutic measures.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Feasibility of SNP Genotyping Using Dried Blood Spot Samples Collected in an Epidemiological Study and Its Integration With Genetic Risk Analysis for Endometriosis. | Kitahara Y et al. | β | 2025 | β |
| Genetics of Keratoconus: A Comprehensive Review. | Barcelo-Canton RH et al. | β | 2025 | β |
| Genome-wide identification of DNA methylation marks associated with resistance to Streptococcus agalactiae in the GIFT strain of Nile Tilapia (Oreochromis niloticus) | Qiao TF et al. | β | 2025 | β |
| Identity-By-Descent Mapping Using Multi-Individual IBD With Genome-Wide Multiple Testing Adjustment. | Cai R et al. | β | 2025 | β |
| Reveal genomic insights into cotton domestication and improvement using gene level functional haplotype-based GWAS. | Qi G et al. | β | 2025 | β |
| Ethnic and region-specific genetic risk variants of stroke and its comorbid conditions can define the variations in the burden of stroke and its phenotypic traits. | Sukumaran R et al. | β | 2024 | β |
| Massively parallel screen uncovers many rare 3' UTR variants regulating mRNA abundance of cancer driver genes. | Fu T et al. | β | 2024 | β |
| Natural polymorphisms in ZMET2 encoding a DNA methyltransferase modulate the number of husk layers in maize. | Wang Z et al. | β | 2024 | β |
| Stress-induced epigenetic effects driven by maternal lactation in dairy cattle: a comethylation network approach. | LΓ³pez-Catalina A et al. | β | 2024 | β |
| CandiHap: a haplotype analysis toolkit for natural variation study. | Li X et al. | β | 2023 | β |
| Gene-Folic Acid Interactions and Risk of Conotruncal Heart Defects: Results from the National Birth Defects Prevention Study. | Webber DM et al. | β | 2023 | β |
| Multiple Germline Events Contribute to CancerΒ Development in Patients with Li-Fraumeni Syndrome. | Subasri V et al. | β | 2023 | β |
| Association Between SNPs in 1q32.2 and NSCLβΒ±β<i>P</i> in Han Chinese Population. | Yin B et al. | β | 2022 | β |
| Epigenome-wide association study of incident type 2 diabetes: a meta-analysis of five prospective European cohorts. | Fraszczyk E et al. | β | 2022 | β |
| Powerful and robust inference of complex phenotypes' causal genes with dependent expression quantitative loci by a median-based Mendelian randomization. | Jiang L et al. | β | 2022 | β |
| The missing heritability in type 1 diabetes. | Pang H et al. | β | 2022 | β |
| Three legs of the missing heritability problem. | Matthews LJ et al. | β | 2022 | β |
| Genome editing to define the function of risk loci and variants in rheumatic disease. | Baglaenko Y et al. | β | 2021 | β |
| Maternal DNA Methylation During Pregnancy: a Review. | Das J et al. | β | 2021 | β |
| Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus. | Soliai MM et al. | β | 2021 | β |
| Non-coding SingleΒ Nucleotide Variants of Renin and the (Pro)renin Receptor are Associated with Polygenic Diseases in a Bangladeshi Population. | Akther J et al. | β | 2021 | β |
| Perspectives on Drug Repurposing. | Schcolnik-Cabrera A et al. | β | 2021 | β |
| Brain mRNA Expression Associated with Cortical Volume Alterations in Autism Spectrum Disorder. | Xie Y et al. | β | 2020 | β |
| Computational analysis of functional single nucleotide polymorphisms associated with SLC26A4 gene. | Hasnain MJU et al. | β | 2020 | β |
| Loss-of-function tolerance of enhancers in the human genome. | Xu D et al. | β | 2020 | β |
| Clinical Implications of Single Nucleotide Polymorphisms in Diagnosis of Asthma and its Subtypes. | Park JS et al. | β | 2019 | β |
| Early in life effects and heredity: reconciling neo-Darwinism with neo-Lamarckism under the banner of the inclusive evolutionary synthesis. | Danchin Γ et al. | β | 2019 | β |
| Multi-omics integrative analysis identified SNP-methylation-mRNA: Interaction in peripheral blood mononuclear cells. | Lu YH et al. | β | 2019 | β |
| Potentially functional genetic variants in the TNF/TNFR signaling pathway genes predict survival of patients with non-small cell lung cancer in the PLCO cancer screening trial. | Guo Y et al. | β | 2019 | β |
| A Critical Review of Methods and Results in the Search for Genetic Contributors to Alcohol Sensitivity. | Schuckit MA | β | 2018 | β |
| A genome wide SNP genotyping study in the Tunisian population: specific reporting on a subset of common breast cancer risk loci. | Hamdi Y et al. | β | 2018 | β |
| A regulatory mutant on TRIM26 conferring the risk of nasopharyngeal carcinoma by inducing low immune response. | Lyu XM et al. | β | 2018 | β |
| Association Analysis Identifies New Risk Loci for Coal Workers' Pneumoconiosis in Han Chinese Men. | Wang T et al. | β | 2018 | β |
| A two-stage hidden Markov model design for biomarker detection, with application to microbiome research. | Zhou YH et al. | β | 2018 | β |
| Community-wide scan identifies fish species associated with coral reef services across the Indo-Pacific. | Maire E et al. | β | 2018 | β |
| Generalization and fine mapping of red blood cell trait genetic associations to multi-ethnic populations: The PAGE Study. | Jo Hodonsky C et al. | β | 2018 | β |
| Genetic variants in two pathways influence serum urate levels and gout risk: a systematic pathway analysis. | Dong Z et al. | β | 2018 | β |
| Genome-wide association study of primary open-angle glaucoma in continental and admixed African populations. | Bonnemaijer PWM et al. | β | 2018 | β |
| MS <i>AHI1</i> genetic risk promotes IFNΞ³<sup>+</sup> CD4<sup>+</sup> T cells. | Kaskow BJ et al. | β | 2018 | β |
| Neurological and neuropsychological effects of low and moderate prenatal alcohol exposure. | Comasco E et al. | β | 2018 | β |
| Novel insights into the genetic basis of buffalo reproductive performance. | Li J et al. | β | 2018 | β |
| A Model of Compound Heterozygous, Loss-of-Function Alleles Is Broadly Consistent with Observations from Complex-Disease GWAS Datasets. | Sanjak JS et al. | β | 2017 | β |
| A new paramutation-like example at the Delta gene of Drosophila. | Capovilla M et al. | β | 2017 | β |
| Application of Single-Nucleotide Polymorphism-Related Risk Estimates in Identification of Increased Genetic Susceptibility to Cardiovascular Diseases: A Literature Review. | Fiatal S et al. | β | 2017 | β |
| Dimensionality and Genetic Correlates of Problem Behavior in Low-Income African American Adolescents. | Latendresse SJ et al. | β | 2017 | β |
| Endurance Exercise Ability in the Horse: A Trait with Complex Polygenic Determinism. | Ricard A et al. | β | 2017 | β |
| Epigenetics in the Primary Biliary Cholangitis and Primary Sclerosing Cholangitis. | Cheung AC et al. | β | 2017 | β |
| Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. | Monsell SE et al. | β | 2017 | β |
| Genome-Wide Analysis Studies and Chronic Kidney Disease. | Piras D et al. | β | 2017 | β |
| Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cells. | Lin X et al. | β | 2017 | β |
| Identification of novel OCT4 genetic variant associated with the risk of chronic hepatitis B in a Korean population. | Shin JG et al. | β | 2017 | β |
| Integrated rare variant-based risk gene prioritization in disease case-control sequencing studies. | Lin JR et al. | β | 2017 | β |
| Integrative multi-omics analysis revealed SNP-lncRNA-mRNA (SLM) networks in human peripheral blood mononuclear cells. | Xia W et al. | β | 2017 | β |
| Lumbosacral stenosis in Labrador retriever military working dogs - an exomic exploratory study. | Mukherjee M et al. | β | 2017 | β |
| The systematic analysis of coding and long non-coding RNAs in the sub-chronic and chronic stages of spinal cord injury. | Duran RC et al. | β | 2017 | β |
| A BAYESIAN GRAPHICAL MODEL FOR GENOME-WIDE ASSOCIATION STUDIES (GWAS). | Briollais L et al. | β | 2016 | β |
| A Photoreceptor Contributes to the Natural Variation of Diapause Induction in Daphnia magna. | Roulin AC et al. | β | 2016 | β |
| Candidate genes involved in the susceptibility of primary open angle glaucoma. | Kumar S et al. | β | 2016 | β |
| Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets. | Vinayagam A et al. | β | 2016 | β |
| Dissecting quantitative trait variation in the resequencing era: complementarity of bi-parental, multi-parental and association panels. | Pascual L et al. | β | 2016 | β |
| Genes associated with diabetes: potential for novel therapeutic targets? | Hara K et al. | β | 2016 | β |
| Inference of domain-disease associations from domain-protein, protein-disease and disease-disease relationships. | Zhang W et al. | β | 2016 | β |
| Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero. | Rotroff DM et al. | β | 2016 | β |
| Pathway analysis of expression-related SNPs on genome-wide association study of basal cell carcinoma. | Li X et al. | β | 2016 | β |
| Proteome-wide association studies identify biochemical modules associated with a wing-size phenotype in Drosophila melanogaster. | Okada H et al. | β | 2016 | β |
| Beyond the usual suspects: a multidimensional genetic exploration of infant attachment disorganization and security. | Pappa I et al. | β | 2015 | β |
| Canonical genetic signatures of the adult human brain. | Hawrylycz M et al. | β | 2015 | β |
| Concept and design of a genome-wide association genotyping array tailored for transplantation-specific studies. | Li YR et al. | β | 2015 | β |
| Constitutional epimutation as a mechanism for cancer causality and heritability? | Hitchins MP | β | 2015 | β |
| Dissection of a Complex Disease Susceptibility Region Using a Bayesian Stochastic Search Approach to Fine Mapping. | Wallace C et al. | β | 2015 | β |
| DNA methylation in psychosis: insights into etiology and treatment. | Castellani CA et al. | β | 2015 | β |
| Enlight: web-based integration of GWAS results with biological annotations. | Guo Y et al. | β | 2015 | β |
| Fast eQTL Analysis for Twin Studies. | Yin Z et al. | β | 2015 | β |
| From genome-wide to candidate gene: an investigation of variation at the major histocompatibility complex in common bottlenose dolphins exposed to harmful algal blooms. | Cammen KM et al. | β | 2015 | β |
| Genetics in child and adolescent psychiatry: methodological advances and conceptual issues. | Hohmann S et al. | β | 2015 | β |
| Gene variants associated with age at menopause are also associated with polycystic ovary syndrome, gonadotrophins and ovarian volume. | Saxena R et al. | β | 2015 | β |
| Genome-wide association study in an admixed case series reveals IL12A as a new candidate in BehΓ§et disease. | Kappen JH et al. | β | 2015 | β |
| Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort. | Hong KW et al. | β | 2015 | β |
| Genomewide investigation of adaptation to harmful algal blooms in common bottlenose dolphins (TursiopsΒ truncatus). | Cammen KM et al. | β | 2015 | β |
| In-silico analysis of inflammatory bowel disease (IBD) GWAS loci to novel connections. | Mesbah-Uddin M et al. | β | 2015 | β |
| Kuwaiti population subgroup of nomadic Bedouin ancestry-Whole genome sequence and analysis. | John SE et al. | β | 2015 | β |
| The genome as pharmacopeia: association of genetic dose with phenotypic response. | Wadhawan S et al. | β | 2015 | β |
| The promise of biomarkers in diagnosing major depression in primary care: the present and future. | Redei EE et al. | β | 2015 | β |
| The role of rare variants in systolic blood pressure: analysis of ExomeChip data in HyperGEN African Americans. | Sung YJ et al. | β | 2015 | β |
| A formal perturbation equation between genotype and phenotype determines the Evolutionary Action of protein-coding variations on fitness. | Katsonis P et al. | β | 2014 | β |
| A genome-wide identification of chromosomal regions determining nitrogen use efficiency components in wheat (Triticum aestivum L.). | Cormier F et al. | β | 2014 | β |
| An empirical comparison of meta-analysis and mega-analysis of individual participant data for identifying gene-environment interactions. | Sung YJ et al. | β | 2014 | β |
| A powerful association test of multiple genetic variants using a random-effects model. | Cheng KF et al. | β | 2014 | β |
| Approach to clinical and genetic characterization of statin-induced myopathy. | Feng Q | β | 2014 | β |
| A robust method for genome-wide association meta-analysis with the application to circulating insulin-like growth factor I concentrations. | Wang T et al. | β | 2014 | β |
| Comparison of two methods for analysis of gene-environment interactions in longitudinal family data: the Framingham heart study. | Sung YJ et al. | β | 2014 | β |
| Effects of GWAS-associated genetic variants on lncRNAs within IBD and T1D candidate loci. | Mirza AH et al. | β | 2014 | β |
| Exonic variants associated with development of aspirin exacerbated respiratory diseases. | Shin SW et al. | β | 2014 | β |
| Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants. | van der Valk RJ et al. | β | 2014 | β |
| Genetics of lipid traits: Genome-wide approaches yield new biology and clues to causality in coronary artery disease. | Khetarpal SA et al. | β | 2014 | β |
| Genetics of polycystic ovary syndrome. | Welt CK et al. | β | 2014 | β |
| GWAS in a box: statistical and visual analytics of structured associations via GenAMap. | Xing EP et al. | β | 2014 | β |
| Homoeologous duplicated regions are involved in quantitative resistance of Brassica napus to stem canker. | Fopa Fomeju B et al. | β | 2014 | β |
| Metabolomics of Ramadan fasting: an opportunity for the controlled study of physiological responses to food intake. | Mathew S et al. | β | 2014 | β |
| Methods for collapsing multiple rare variants in whole-genome sequence data. | Sung YJ et al. | β | 2014 | β |
| Pharmacogenetics at 50: genomic personalization comes of age. | Urban TJ et al. | β | 2014 | β |
| Predicting gene ontology annotations of orphan GWAS genes using protein-protein interactions. | Kuppuswamy U et al. | β | 2014 | β |
| Proteasome inhibition in skeletal muscle cells unmasks metabolic derangements in type 2 diabetes. | Al-Khalili L et al. | β | 2014 | β |
| Quantitative genetics in the study of virus-induced disease. | Ferris MT et al. | β | 2014 | β |
| Rare and low-frequency variants in human common diseases and other complex traits. | Lettre G | β | 2014 | β |
| Reading and language disorders: the importance of both quantity and quality. | Newbury DF et al. | β | 2014 | β |
| The ENIGMA Consortium: large-scale collaborative analyses of neuroimaging and genetic data. | Thompson PM et al. | β | 2014 | β |
| Whole-exome imputation of sequence variants identified two novel alleles associated with adult body height in African Americans. | Du M et al. | β | 2014 | β |
| A silent exonic SNP in kdm3a affects nucleic acids structure but does not regulate experimental autoimmune encephalomyelitis. | Gillett A et al. | β | 2013 | β |
| Blood-derived DNA methylation markers of cancer risk. | Marsit C et al. | β | 2013 | β |
| Cohort Profile: the international childhood cardiovascular cohort (i3C) consortium. | Dwyer T et al. | β | 2013 | β |
| Evaluating genome-wide association study-identified breast cancer risk variants in African-American women. | Long J et al. | β | 2013 | β |
| Evaluation of allele frequency estimation using pooled sequencing data simulation. | Guo Y et al. | β | 2013 | β |
| Fine Mapping and Identification of BMI Loci in African Americans. | Gong J et al. | β | 2013 | β |
| First genome-wide association study on anxiety-related behaviours in childhood. | Trzaskowski M et al. | β | 2013 | β |
| GUESS-ing polygenic associations with multiple phenotypes using a GPU-based evolutionary stochastic search algorithm. | Bottolo L et al. | β | 2013 | β |
| Identification of grouped rare and common variants via penalized logistic regression. | Ayers KL et al. | β | 2013 | β |
| Low-density lipoprotein receptor mutations generate synthetic genome-wide associations. | Oosterveer DM et al. | β | 2013 | β |
| Massively parallel sequencing: the new frontier of hematologic genomics. | Johnsen JM et al. | β | 2013 | β |
| Mendelian forms of structural cardiovascular disease. | MacRae CA | β | 2013 | β |
| Properties and modeling of GWAS when complex disease risk is due to non-complementing, deleterious mutations in genes of large effect. | Thornton KR et al. | β | 2013 | β |
| Rab38 modulates proteinuria in model of hypertension-associated renal disease. | Rangel-Filho A et al. | β | 2013 | β |
| Replication of genome wide association identified candidate genes confirm the role of common and rare variants in PAX7 and VAX1 in the etiology of nonsyndromic CL(P). | Butali A et al. | β | 2013 | β |
| Response to "A closer look at FBXO41 as a Parkinson's disease risk factor". | Liang H et al. | β | 2013 | β |
| The genomics revolution: will canine atopic dermatitis be predictable and preventable? | Nuttall T | β | 2013 | β |
| The Role of Genes in the Insomnia Phenotype. | Gehrman PR et al. | β | 2013 | β |
| Treatment factors rather than genetic variation determine metabolic syndrome in childhood cancer survivors. | van Waas M et al. | β | 2013 | β |
| A latent variable partial least squares path modeling approach to regional association and polygenic effect with applications to a human obesity study. | Xue F et al. | β | 2012 | β |
| A novel variational Bayes multiple locus Z-statistic for genome-wide association studies with Bayesian model averaging. | Logsdon BA et al. | β | 2012 | β |
| Beyond the fourth wave of genome-wide obesity association studies. | Sandholt CH et al. | β | 2012 | β |
| Cis-acting polymorphisms affect complex traits through modifications of microRNA regulation pathways. | Arnold M et al. | β | 2012 | β |
| Correlation of rare coding variants in the gene encoding human glucokinase regulatory protein with phenotypic, cellular, and kinetic outcomes. | Rees MG et al. | β | 2012 | β |
| Extensive natural variation for cellular hydrogen peroxide release is genetically controlled. | Attar H et al. | β | 2012 | β |
| Fine-mapping and initial characterization of QT interval loci in African Americans. | Avery CL et al. | β | 2012 | β |
| Gene by neuroticism interaction and cognitive function among older adults. | Dar-Nimrod I et al. | β | 2012 | β |
| Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach. | Fardo DW et al. | β | 2012 | β |
| Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. | Fan Q et al. | β | 2012 | β |
| Human genetic individuality. | Olson MV | β | 2012 | β |
| Human genomic disease variants: a neutral evolutionary explanation. | Dudley JT et al. | β | 2012 | β |
| Identification of QTL for UV-protective eye area pigmentation in cattle by progeny phenotyping and genome-wide association analysis. | Pausch H et al. | β | 2012 | β |
| Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome. | Gao C et al. | β | 2012 | β |
| Individualized risk for statin-induced myopathy: current knowledge, emerging challenges and potential solutions. | Feng Q et al. | β | 2012 | β |
| Personalized medicine: caught between hope, hype and the real world. | Dammann M et al. | β | 2012 | β |
| Predicting signatures of "synthetic associations" and "natural associations" from empirical patterns of human genetic variation. | Chang D et al. | β | 2012 | β |
| Rare variants in TMEM132D in a case-control sample for panic disorder. | Quast C et al. | β | 2012 | β |
| The impact of imputation on meta-analysis of genome-wide association studies. | Li J et al. | β | 2012 | β |
| The value of twins in epigenetic epidemiology. | Bell JT et al. | β | 2012 | β |
| Type 2 Diabetes Genetics: Beyond GWAS. | Sanghera DK et al. | β | 2012 | β |
| Untargeted metabolome quantitative trait locus mapping associates variation in urine glycerate to mutant glycerate kinase. | Cazier JB et al. | β | 2012 | β |
| A twin approach to unraveling epigenetics. | Bell JT et al. | β | 2011 | β |
| Comprehensive analysis of the genes responsible for neuroacanthocytosis in mood disorder and schizophrenia. | Shimo H et al. | β | 2011 | β |
| Dark matter: are mice the solution to missing heritability? | Parker CC et al. | β | 2011 | β |
| Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study. | InterAct Consortium et al. | β | 2011 | β |
| Diagnostic testing for vaccinomics: is the regulatory approval framework adequate? A comparison of Canada, the United States, and Europe. | Joly Y et al. | β | 2011 | β |
| Discovering how environmental exposures alter genes could lead to new treatments for chronic illnesses. | Olden K et al. | β | 2011 | β |
| Evidence for age as a modifier of genetic associations for lipid levels. | Dumitrescu L et al. | β | 2011 | β |
| Expanding the range of ZNF804A variants conferring risk of psychosis. | Steinberg S et al. | β | 2011 | β |
| Genes involved in vasoconstriction and vasodilation system affect salt-sensitive hypertension. | Citterio L et al. | β | 2011 | β |
| Genetic analysis of complex traits via Bayesian variable selection: the utility of a mixture of uniform priors. | KnΓΌrr T et al. | β | 2011 | β |
| Genetic association studies: hypertension and beyond. | Wang C | β | 2011 | β |
| Genome-wide association studies of chronic kidney disease: what have we learned? | O'Seaghdha CM et al. | β | 2011 | β |
| Genome-wide association studies: results from the first few years and potential implications for clinical medicine. | Hirschhorn JN et al. | β | 2011 | β |
| Genotype-environment interactions and their translational implications. | Baye TM et al. | β | 2011 | β |
| ICSNPathway: identify candidate causal SNPs and pathways from genome-wide association study by one analytical framework. | Zhang K et al. | β | 2011 | β |
| Implementing ReliefF filters to extract meaningful features from genetic lifetime datasets. | Beretta L et al. | β | 2011 | β |
| Ionising radiation and genetic risks. XVI. A genome-based framework for risk estimation in the light of recent advances in genome research. | Sankaranarayanan K et al. | β | 2011 | β |
| MixupMapper: correcting sample mix-ups in genome-wide datasets increases power to detect small genetic effects. | Westra HJ et al. | β | 2011 | β |
| Next-generation genome-wide association studies: time to focus on phenotype? | MacRae CA et al. | β | 2011 | β |
| On statistical methods for estimating heritability in wild populations. | SillanpÀÀ MJ | β | 2011 | β |
| Overview of techniques to account for confounding due to population stratification and cryptic relatedness in genomic data association analyses. | SillanpÀÀ MJ | β | 2011 | β |
| Single-tissue and cross-tissue heritability of gene expression via identity-by-descent in related or unrelated individuals. | Price AL et al. | β | 2011 | β |
| T2DM: Why Epigenetics? | Fradin D et al. | β | 2011 | β |
| The Next PAGE in understanding complex traits: design for the analysis of Population Architecture Using Genetics and Epidemiology (PAGE) Study. | Matise TC et al. | β | 2011 | β |
| The zebrafish: scalable in vivo modeling for systems biology. | Deo RC et al. | β | 2011 | β |
| Variants in ZNF365 isoform D are associated with Crohn's disease. | Haritunians T et al. | β | 2011 | β |
| What is a functional locus? Understanding the genetic basis of complex phenotypic traits. | Ruiz-NarvΓ‘ez EA | β | 2011 | β |
| A combined genome-wide linkage and association approach to find susceptibility loci for platelet function phenotypes in European American and African American families with coronary artery disease. | Mathias RA et al. | β | 2010 | β |
| A common variant of the latrophilin 3 gene, LPHN3, confers susceptibility to ADHD and predicts effectiveness of stimulant medication. | Arcos-Burgos M et al. | β | 2010 | β |
| Analysis of osteocalcin as a candidate gene for type 2 diabetes (T2D) and intermediate traits in Caucasians and African Americans. | Das SK et al. | β | 2010 | β |
| An approach based on a genome-wide association study reveals candidate loci for narcolepsy. | Shimada M et al. | β | 2010 | β |
| Ancestry informative markers for fine-scale individual assignment to worldwide populations. | Paschou P et al. | β | 2010 | β |
| Association of Fc receptor-like 5 (FCRL5) with Graves' disease is secondary to the effect of FCRL3. | Simmonds MJ et al. | β | 2010 | β |
| Breaking new ground in inflammatory bowel disease genetics: genome-wide association studies and beyond. | Imielinski M et al. | β | 2010 | β |
| Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations. | Takeuchi F et al. | β | 2010 | β |
| Design of association studies with pooled or un-pooled next-generation sequencing data. | Kim SY et al. | β | 2010 | β |
| DRD4 and DAT1 in ADHD: Functional neurobiology to pharmacogenetics. | Turic D et al. | β | 2010 | β |
| Expectations, validity, and reality in pharmacogenetics. | Limdi NA et al. | β | 2010 | β |
| Fine-mapping in African Americans of 8 recently discovered genetic loci for plasma lipids: the Jackson Heart Study. | Keebler ME et al. | β | 2010 | β |
| Fine mapping of the association with obesity at the FTO locus in African-derived populations. | Hassanein MT et al. | β | 2010 | β |
| From GWAS to the clinic: risk factors for intracranial aneurysms. | Ruigrok YM et al. | β | 2010 | β |
| Generation Scotland: Donor DNA Databank; A control DNA resource. | Kerr SM et al. | β | 2010 | β |
| Genetic advances in the study of speech and language disorders. | Newbury DF et al. | β | 2010 | β |
| Genetic bases for glaucoma. | Fuse N | β | 2010 | β |
| Genetic determinants of pubertal timing in the general population. | Gajdos ZK et al. | β | 2010 | β |
| Genetics of allergic disease. | Holloway JW et al. | β | 2010 | β |
| Genetics of psychiatric disorders methods: molecular approaches. | Avramopoulos D | β | 2010 | β |
| Genome-wide association studies in diverse populations. | Rosenberg NA et al. | β | 2010 | β |
| Human variation in alcohol response is influenced by variation in neuronal signaling genes. | Joslyn G et al. | β | 2010 | β |
| Integrated genetic and epigenetic analysis identifies haplotype-specific methylation in the FTO type 2 diabetes and obesity susceptibility locus. | Bell CG et al. | β | 2010 | β |
| Mouse BMD quantitative trait loci show improved concordance with human genome-wide association loci when recalculated on a new, common mouse genetic map. | Ackert-Bicknell CL et al. | β | 2010 | β |
| Rare variants create synthetic genome-wide associations. | Dickson SP et al. | β | 2010 | β |
| Rare variation at the TNFAIP3 locus and susceptibility to rheumatoid arthritis. | Bowes J et al. | β | 2010 | β |
| Replication of past candidate loci for common diseases and phenotypes in 100 genome-wide association studies. | Siontis KC et al. | β | 2010 | β |
| The Gene, Environment Association Studies consortium (GENEVA): maximizing the knowledge obtained from GWAS by collaboration across studies of multiple conditions. | Cornelis MC et al. | β | 2010 | β |
| The genetics of multiple sclerosis: an update 2010. | Hoffjan S et al. | β | 2010 | β |
| The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. | Schumann G et al. | β | 2010 | β |
| The psychiatric GWAS consortium: big science comes to psychiatry. | Sullivan PF | β | 2010 | β |
| Uncovering the roles of rare variants in common disease through whole-genome sequencing. | Cirulli ET et al. | β | 2010 | β |
| Varietas: a functional variation database portal. | Paananen J et al. | β | 2010 | β |
| Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CpG island context. | Christensen BC et al. | β | 2009 | β |
| A risk variant in an miR-125b binding site in BMPR1B is associated with breast cancer pathogenesis. | Saetrom P et al. | β | 2009 | β |
| Association of the thyroid stimulating hormone receptor gene (TSHR) with Graves' disease. | Brand OJ et al. | β | 2009 | β |
| Decanalization and the origin of complex disease. | Gibson G | β | 2009 | β |
| Defining the pathogenicity of DNA sequence variation. | Ho CY et al. | β | 2009 | β |
| Does genomic risk information motivate people to change their behavior? | Henrikson NB et al. | β | 2009 | β |
| Epigenetic inheritance and the missing heritability problem. | Slatkin M | β | 2009 | β |
| Finding the missing heritability of complex diseases. | Manolio TA et al. | β | 2009 | β |
| Genetic overlap between autism, schizophrenia and bipolar disorder. | Carroll LS et al. | β | 2009 | β |
| Genetic variants and normal tissue toxicity after radiotherapy: a systematic review. | Andreassen CN et al. | β | 2009 | β |
| Genome-wide association analysis of canine atopic dermatitis and identification of disease related SNPs. | Wood SH et al. | β | 2009 | β |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | β | 2009 | β |
| Genome-wide association studies: hypothesis-"free" or "engaged"? | Kitsios GD et al. | β | 2009 | β |
| Genome-wide association studies in pharmacogenomics: untapped potential for translation. | Guessous I et al. | β | 2009 | β |
| Genome-wide association study of biochemical traits in Korcula Island, Croatia. | Zemunik T et al. | β | 2009 | β |
| Improving the signal-to-noise ratio in genome-wide association studies. | Martin LJ et al. | β | 2009 | β |
| Next generation disparities in human genomics: concerns and remedies. | Need AC et al. | β | 2009 | β |
| Planning for translational research in genomics. | Hawkins N et al. | β | 2009 | β |
| Polygenic susceptibility to breast cancer: current state-of-the-art. | Ghoussaini M et al. | β | 2009 | β |
| Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. | Hindorff LA et al. | β | 2009 | β |
| Recent progress in the genetics of common obesity. | Loos RJ | β | 2009 | β |
| Sequencing genomes: from individuals to populations. | Mir KU | β | 2009 | β |
| Transgenerational genetic effects on phenotypic variation and disease risk. | Nadeau JH | β | 2009 | β |
| Zebrafish genetic models for arrhythmia. | Milan DJ et al. | β | 2008 | β |