Using brain organoids to understand Zika virus-induced microcephaly.
paper
Cited
Public
Unavailable
- Authors
- Qian, Xuyu; Nguyen, Ha Nam; Jacob, Fadi; Song, Hongjun; Ming, Guo-Li
- Year
- 2017
- Journal
- Development (Cambridge, England)
- PMID
- 28292840
- DOI
- 10.1242/dev.140707
- PMCID
- PMC5358105
Technologies to differentiate human pluripotent stem cells into three-dimensional organized structures that resemble organs are pushing the frontiers of human disease modeling and drug development. In response to the global health emergency posed by the Zika virus (ZIKV) outbreak, brain organoids engineered to mimic the developing human fetal brain have been employed to model ZIKV-induced microcephaly. Here, we discuss the advantages of brain organoids over other model systems to study development and highlight recent advances in understanding ZIKV pathophysiology and its underlying pathogenesis mechanisms. We further discuss perspectives on overcoming limitations of current organoid systems for their future use in ZIKV research.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | 2019 | 30087005 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Harnessing induced pluripotent stem cells and organoids for disease modeling and precision medicine. | Lee CJ et al. | β | 2026 | β |
| Mapping the Evolution of Brain Organoid Research: A Decade of Progress and Future Perspectives (2015-2025). | Yin T et al. | β | 2026 | β |
| Oropouche virus infects human neural progenitor cells and alters the growth of brain organoids. | Albert A et al. | β | 2026 | β |
| Adopting organoid technology for Co-infections: Innovative solutions for infectious diseases and cancer therapy. | Alaeq RA et al. | β | 2025 | β |
| Advances in the Development and Application of Human Organoids: Techniques, Applications, and Future Perspectives. | Zhu Z et al. | β | 2025 | β |
| Biomaterial-assisted organoid technology for disease modeling and drug screening. | Shao Y et al. | β | 2025 | β |
| Comparison of human cerebral organoids infected with wild-type Zika versus attenuated DN-2 virus strains uncovers differences in host immune responses. | Choo YY et al. | β | 2025 | β |
| Natural bioactive compounds form herbal medicine in Alzheimer's disease: from the perspective of GSK-3Ξ². | Wang M et al. | β | 2025 | β |
| Organoids: physiologically relevant <i>ex vivo</i> models for viral disease research. | Wang Y et al. | β | 2025 | β |
| The need for a global effort to attend to human neural organoid and assembloid research. | PaΘca SP et al. | β | 2025 | β |
| 3D Spheroid and Organoid Models to Study Neuroinfection of RNA Viruses. | Dos Reis VP et al. | β | 2024 | β |
| An Overview of Zika Virus and Zika Virus Induced Neuropathies. | Wahaab A et al. | β | 2024 | β |
| A prospects tool in virus research: Analyzing the applications of organoids in virus studies. | Shen Q et al. | β | 2024 | β |
| Brain organoids: A revolutionary tool for modeling neurological disorders and development of therapeutics. | Acharya P et al. | β | 2024 | β |
| Global Literature Analysis of Organoid and Organ-on-Chip Research. | Shoji JY et al. | β | 2024 | β |
| Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations. | Park SB et al. | β | 2024 | β |
| Microfabricated dynamic brain organoid cocultures to assess the effects of surface geometry on assembloid formation. | Cassel de Camps C et al. | β | 2024 | β |
| Neuroinflammation generated by HIV-infected microglia promotes dysfunction and death of neurons in human brain organoids. | Kong W et al. | β | 2024 | β |
| Organoids as preclinical models of human disease: progress and applications. | Chen B et al. | β | 2024 | β |
| Parechovirus infection in human brain organoids: host innate inflammatory response and not neuro-infectivity correlates to neurologic disease. | Capendale PE et al. | β | 2024 | β |
| Probing the molecular and cellular pathological mechanisms of schizophrenia using human induced pluripotent stem cell models. | Sebastian R et al. | β | 2024 | β |
| Progress and potential of brain organoids in epilepsy research. | Brown R et al. | β | 2024 | β |
| The Promise and Potential of Brain Organoids. | Smirnova L et al. | β | 2024 | β |
| Unravelling the genetic basis of Schizophrenia. | Casey C et al. | β | 2024 | β |
| Zika Virus Neuropathogenesis-Research and Understanding. | Metzler AD et al. | β | 2024 | β |
| Activated <i>KRAS</i> reprograms neural progenitor cells to glioma stem cellβlike phenotype. | Qin Z et al. | β | 2023 | β |
| Animal Model Alternatives in Filovirus and Bornavirus Research. | Widerspick L et al. | β | 2023 | β |
| Bibliometric analysis of cerebral organoids and diseases in the last 10 years. | Luo BY et al. | β | 2023 | β |
| Brain organoids and organoid intelligence from ethical, legal, and social points of view. | Hartung T et al. | β | 2023 | β |
| Emerging Landscape of Preclinical Models for Studying COVID-19 Neurologic Diseases. | Li J et al. | β | 2023 | β |
| Give Them Vasculature and Immune Cells: How to Fill the Gap of Organoids. | Yip S et al. | β | 2023 | β |
| Glioblastoma modeling with 3D organoids: progress and challenges. | Wang X et al. | β | 2023 | β |
| HCMV Infection Reduces Nidogen-1 Expression, Contributing to Impaired Neural Rosette Development in Brain Organoids. | Ijezie EC et al. | β | 2023 | β |
| How do scientists model humanness? A qualitative study of human organoids in biomedical research. | Hinterberger A et al. | β | 2023 | β |
| Human Brain Organoids: Why There Can Be Moral Concerns If They Grow Up in the Lab and Are Transplanted or Destroyed. | Lavazza A et al. | β | 2023 | β |
| Modelling host- <i>Trypanosoma brucei gambiense</i> interactions <i>in vitro</i> using human induced pluripotent stem cell-derived cortical brain organoids. | Chandrasegaran P et al. | β | 2023 | β |
| Noncoding RNA of Zika Virus Affects Interplay between Wnt-Signaling and Pro-Apoptotic Pathways in the Developing Brain Tissue. | Slonchak A et al. | β | 2023 | β |
| Pathophysiology and mechanisms of hearing impairment related to neonatal infection diseases. | Capra D et al. | β | 2023 | β |
| Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons. | Liu W et al. | β | 2023 | β |
| The Antiviral Potential of AdipoRon, an Adiponectin Receptor Agonist, Reveals the Ability of Zika Virus to Deregulate Adiponectin Receptor Expression. | El Safadi D et al. | β | 2023 | β |
| The technology, opportunities, and challenges of Synthetic Biological Intelligence. | Kagan BJ et al. | β | 2023 | β |
| Three-Dimensional Human Brain Organoids to Model HIV-1 Neuropathogenesis. | Dos Reis RS et al. | β | 2023 | β |
| Toward the next generation of vascularized human neural organoids. | Li M et al. | β | 2023 | β |
| Zika virus infection of retinal cells and the developing mouse eye induces host responses that contrasts to the brain and dengue virus infection. | Cowell E et al. | β | 2023 | β |
| A Comprehensive Update of Cerebral Organoids between Applications and Challenges. | Li X et al. | β | 2022 | β |
| Advances in Understanding Neuropathogenesis of Rift Valley Fever Virus. | Connors KA et al. | β | 2022 | β |
| Applications of Brain Organoids for Infectious Diseases. | Fan W et al. | β | 2022 | β |
| First report of canine morbillivirus infection of adipose tissue-derived stem cells from dogs with distemper. | Altamirano-Samaniego F et al. | β | 2022 | β |
| Human Organoids as a Promising Platform for Fighting COVID-19. | Chen D et al. | β | 2022 | β |
| Human organoids in basic research and clinical applications. | Tang XY et al. | β | 2022 | β |
| Media portrayal of ethical and social issues in brain organoid research. | Presley A et al. | β | 2022 | β |
| Modeling human neurodevelopmental diseases with brain organoids. | Lu X et al. | β | 2022 | β |
| Modeling Human Organ Development and Diseases With Fetal Tissue-Derived Organoids. | Liang J et al. | β | 2022 | β |
| Organoid Technologies for SARS-CoV-2 Research. | Sutton K et al. | β | 2022 | β |
| Organoid technology and applications in lung diseases: Models, mechanism research and therapy opportunities. | Chen J et al. | β | 2022 | β |
| Organotypic and Microphysiological Human Tissue Models for Drug Discovery and Development-Current State-of-the-Art and Future Perspectives. | Youhanna S et al. | β | 2022 | β |
| SARS-CoV-2 pathogenesis. | Lamers MM et al. | β | 2022 | β |
| Stem cell-based region-specific brain organoids: Novel models to understand neurodevelopmental defects. | Shafique S | β | 2022 | β |
| The Many Moral Matters of Organoid Models: A systematic review of reasons. | Barnhart AJ et al. | β | 2022 | β |
| Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved. | Komarasamy TV et al. | β | 2022 | β |
| 3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to bioprinting. | de Melo BAG et al. | β | 2021 | β |
| Advances in development and application of human organoids. | Shankaran A et al. | β | 2021 | β |
| Advancing lung organoids for COVID-19 research. | van der Vaart J et al. | β | 2021 | β |
| Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research? | Marrazzo P et al. | β | 2021 | β |
| A simple method to improve the quality and yield of human pluripotent stem cell-derived cerebral organoids. | Choe MS et al. | β | 2021 | β |
| Brain organoid: a 3D technology for investigating cellular composition and interactions in human neurological development and disease models in vitro. | Agboola OS et al. | β | 2021 | β |
| Breakthroughs in microbiology made possible with organoids. | RamΓrez-Flores CJ et al. | β | 2021 | β |
| Cerebral organoids and their potential for studies of brain diseases in domestic animals. | Pain B et al. | β | 2021 | β |
| 'Consciousnessoids': clues and insights from human cerebral organoids for the study of consciousness. | Lavazza A | β | 2021 | β |
| Creation and use of organoids in biomedical research and healthcare: the bioethical and metabioethical issues. | StoeklΓ© HC et al. | β | 2021 | β |
| Cultures and cures: neurodiversity and brain organoids. | Barnhart AJ et al. | β | 2021 | β |
| Early invasion of the bladder wall by solitary bacteria protects UPEC from antibiotics and neutrophil swarms in an organoid model. | Sharma K et al. | β | 2021 | β |
| Engineering organoids. | Hofer M et al. | β | 2021 | β |
| Harness Organoid Models for Virological Studies in Animals: A Cross-Species Perspective. | Sang Y et al. | β | 2021 | β |
| Human Brain Organoids as an <i>In Vitro</i> Model System of Viral Infectious Diseases. | Su X et al. | β | 2021 | β |
| Human Gastrointestinal Organoid Models for Studying Microbial Disease and Cancer. | Chakrabarti J et al. | β | 2021 | β |
| Human organoid systems reveal <i>in vitro</i> correlates of fitness for SARS-CoV-2 B.1.1.7 | Lamers MM et al. | β | 2021 | β |
| Human pluripotent stem cell-derived brain organoids as in vitro models for studying neural disorders and cancer. | Luo J et al. | β | 2021 | β |
| Human stem cell models to study host-virus interactions in the central nervous system. | Harschnitz O et al. | β | 2021 | β |
| Modeling neurological disorders using brain organoids. | Zhang DY et al. | β | 2021 | β |
| Neurotropic Effects of SARS-CoV-2 Modeled by the Human Brain Organoids. | Ramani A et al. | β | 2021 | β |
| Next-Generation Human Cerebral Organoids as Powerful Tools To Advance NeuroHIV Research. | Premeaux TA et al. | β | 2021 | β |
| Opportunities and challenges of glioma organoids. | Xu X et al. | β | 2021 | β |
| Plasma lipidome profiling of newborns with antenatal exposure to Zika virus. | da Costa Faria NR et al. | β | 2021 | β |
| Potential ethical problems with human cerebral organoids: Consciousness and moral status of future brains in a dish. | Lavazza A | β | 2021 | β |
| PPAR Gamma and Viral Infections of the Brain. | Layrolle P et al. | β | 2021 | β |
| The Organoid Platform: Promises and Challenges as Tools in the Fight against COVID-19. | Geurts MH et al. | β | 2021 | β |
| Three-dimensional in vitro tissue culture models of brain organoids. | Gong J et al. | β | 2021 | β |
| Towards organoid culture without Matrigel. | Kozlowski MT et al. | β | 2021 | β |
| Zika Virus and Neuropathogenesis: The Unanswered Question of Which Strain Is More Prone to Causing Microcephaly and Other Neurological Defects. | King EL et al. | β | 2021 | β |
| Zika Virus: A New Therapeutic Candidate for Glioblastoma Treatment. | Francipane MG et al. | β | 2021 | β |
| A fully automated high-throughput workflow for 3D-based chemical screening in human midbrain organoids. | Renner H et al. | β | 2020 | β |
| A Perspective on Organoids for Virology Research. | Sridhar A et al. | β | 2020 | β |
| A Primer on Human Brain Organoids for the Neurosurgeon. | Blue R et al. | β | 2020 | β |
| Asian Zika Virus Isolate Significantly Changes the Transcriptional Profile and Alternative RNA Splicing Events in a Neuroblastoma Cell Line. | Bonenfant G et al. | β | 2020 | β |
| Autism spectrum disorder at the crossroad between genes and environment: contributions, convergences, and interactions in ASD developmental pathophysiology. | Cheroni C et al. | β | 2020 | β |
| CEREBRAL ORGANOIDS AS A MODEL FOR GLIOBLASTOMA MULTIFORME. | Silvia N et al. | β | 2020 | β |
| Constitutive activity of a G protein-coupled receptor, DRD1, contributes to human cerebral organoid formation. | Wang Q et al. | β | 2020 | β |
| Defeat Dengue and Zika Viruses With a One-Two Punch of Vaccine and Vector Blockade. | Sun J et al. | β | 2020 | β |
| Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles. | Logan S et al. | β | 2020 | β |
| Generation and biobanking of patient-derived glioblastoma organoids and their application in CAR T cell testing. | Jacob F et al. | β | 2020 | β |
| Human Brain Organoids to Decode Mechanisms of Microcephaly. | Gabriel E et al. | β | 2020 | β |
| Human cerebral organoids and consciousness: a double-edged sword. | Lavazza A | β | 2020 | β |
| Induced Pluripotent Stem Cell (iPSC)-Based Neurodegenerative Disease Models for Phenotype Recapitulation and Drug Screening. | Chang CY et al. | β | 2020 | β |
| JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both <i>In Vitro</i> and <i>In Vivo</i>. | Li Z et al. | β | 2020 | β |
| Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication. | Sahoo BR et al. | β | 2020 | β |
| Methadone interrupts neural growth and function in human cortical organoids. | Yao H et al. | β | 2020 | β |
| Methylene blue is a potent and broad-spectrum inhibitor against Zika virus <i>in vitro</i> and <i>in vivo</i>. | Li Z et al. | β | 2020 | β |
| Organotypic culture assays for murine and human primary and metastatic-site tumors. | Padmanaban V et al. | β | 2020 | β |
| Peli1 signaling blockade attenuates congenital zika syndrome. | Luo H et al. | β | 2020 | β |
| Recent progress in translational engineered in vitro models of the central nervous system. | Nikolakopoulou P et al. | β | 2020 | β |
| Single-cell transcriptomics reveals multiple neuronal cell types in human midbrain-specific organoids. | Smits LM et al. | β | 2020 | β |
| Super resolution microscopy and deep learning identify Zika virus reorganization of the endoplasmic reticulum. | Long RKM et al. | β | 2020 | β |
| Three-dimensional modeling of human neurodegeneration: brain organoids coming of age. | Grenier K et al. | β | 2020 | β |
| Trends in the development of human stem cell-based non-animal drug testing models. | Lee SJ et al. | β | 2020 | β |
| Using brain organoids to study human neurodevelopment, evolution and disease. | Kyrousi C et al. | β | 2020 | β |
| Zika virus can directly infect and damage the auditory and vestibular components of the embryonic chicken inner ear. | Thawani A et al. | β | 2020 | β |
| All Together Now: Modeling the Interaction of Neural With Non-neural Systems Using Organoid Models. | Chukwurah E et al. | β | 2019 | β |
| Applications of Human Brain Organoids to Clinical Problems. | Chen HI et al. | β | 2019 | β |
| Brain organoids: advances, applications and challenges. | Qian X et al. | β | 2019 | β |
| Can We Better Understand How Zika Leads to Microcephaly? A Systematic Review of the Effects of the Zika Virus on Human Brain Organoids. | Sutarjono B | β | 2019 | β |
| Cerebral Cortex Generated from Pluripotent Stem Cells to Model Corticogenesis and Rebuild Cortical Circuits: In Vitro Veritas? | Varrault A et al. | β | 2019 | β |
| Cerebral Organoid Models for Neurotropic Viruses. | Antonucci J et al. | β | 2019 | β |
| Convergence of human cellular models and genetics to study neural stem cell signaling to enhance central nervous system regeneration and repair. | Julian D et al. | β | 2019 | β |
| Exosomes mediate Zika virus transmission through SMPD3 neutral Sphingomyelinase in cortical neurons. | Zhou W et al. | β | 2019 | β |
| Glucocerebrosidase and its relevance to Parkinson disease. | Do J et al. | β | 2019 | β |
| Growth of Zika virus in human reconstituted respiratory, intestinal, vaginal and neural tissues. | Cagno V et al. | β | 2019 | β |
| Host and viral mechanisms of congenital Zika syndrome. | Liang B et al. | β | 2019 | β |
| Human Cytomegalovirus Disruption of Calcium Signaling in Neural Progenitor Cells and Organoids. | Sison SL et al. | β | 2019 | β |
| Modeling Herpes Simplex Virus 1 Infections in Human Central Nervous System Neuronal Cells Using Two- and Three-Dimensional Cultures Derived from Induced Pluripotent Stem Cells. | D'Aiuto L et al. | β | 2019 | β |
| Modelling heme-mediated brain injury associated with cerebral malaria in human brain cortical organoids. | Harbuzariu A et al. | β | 2019 | β |
| Moral Limits of Brain Organoid Research. | Koplin JJ et al. | β | 2019 | β |
| Mouse vs man: Organoid models of brain development & disease. | Marshall JJ et al. | β | 2019 | β |
| "Necessity Is the Mother of Invention" or Inexpensive, Reliable, and Reproducible Protocol for Generating Organoids. | Eremeev AV et al. | β | 2019 | β |
| Neurotropism of Enterovirus D68 Isolates Is Independent of Sialic Acid and Is Not a Recently Acquired Phenotype. | Rosenfeld AB et al. | β | 2019 | β |
| Opportunities and challenges for the use of induced pluripotent stem cells in modelling neurodegenerative disease. | Wu YY et al. | β | 2019 | β |
| Organoid-based chemical approach to dissect the mechanism controlling cellular dynamics. | Lacko LA et al. | β | 2019 | β |
| Pathophysiology and Mechanisms of Zika Virus Infection in the Nervous System. | Christian KM et al. | β | 2019 | β |
| The NIH BRAIN Initiative: Integrating Neuroethics and Neuroscience. | Ramos KM et al. | β | 2019 | β |
| Tumor organoids: From inception to future in cancer research. | Yang L et al. | β | 2019 | β |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | β | 2019 | β |
| Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells. | Ayala-Nunez NV et al. | β | 2019 | β |
| 2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling. | Centeno EGZ et al. | β | 2018 | β |
| Cerebral organoids: ethical issues and consciousness assessment. | Lavazza A et al. | β | 2018 | β |
| Core Concept: Organoids have opened avenues into investigating numerous diseases. But how well do they mimic the real thing? | Shen H | β | 2018 | β |
| Generation of human brain region-specific organoids using a miniaturized spinning bioreactor. | Qian X et al. | β | 2018 | β |
| Human Huntington's Disease iPSC-Derived Cortical Neurons Display Altered Transcriptomics, Morphology, and Maturation. | Mehta SR et al. | β | 2018 | β |
| Human organoid cultures: transformative new tools for human virus studies. | Ramani S et al. | β | 2018 | β |
| Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres. | Abreu CM et al. | β | 2018 | β |
| Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond. | Liu C et al. | β | 2018 | β |
| Modeling Neurological Diseases With Human Brain Organoids. | Wang H | β | 2018 | β |
| Placental Inflammation and Fetal Injury in a Rare Zika Case Associated With Guillain-BarrΓ© Syndrome and Abortion. | Rabelo K et al. | β | 2018 | β |
| Shaping Diversity Into the Brain's Form and Function. | Miterko LN et al. | β | 2018 | β |
| Stem Cells, Genome Editing, and the Path to Translational Medicine. | Soldner F et al. | β | 2018 | β |
| The ethics of experimenting with human brain tissue. | Farahany NA et al. | β | 2018 | β |
| Three-Dimensional Organoids in Cancer Research: The Search for the Holy Grail of Preclinical Cancer Modeling. | Dzobo K et al. | β | 2018 | β |
| Zika virus impairs the development of blood vessels in a mouse model of congenital infection. | Garcez PP et al. | β | 2018 | β |
| Zika virus infected primary microglia impairs NPCs proliferation and differentiation. | Wang J et al. | β | 2018 | β |
| A single mutation in the prM protein of Zika virus contributes to fetal microcephaly. | Yuan L et al. | β | 2017 | β |
| Concise Review: Induced Pluripotent Stem Cell-Based Drug Discovery for Mitochondrial Disease. | Inak G et al. | β | 2017 | β |
| DISC1 Regulates Neurogenesis via Modulating Kinetochore Attachment of Ndel1/Nde1 during Mitosis. | Ye F et al. | β | 2017 | β |
| Ethical issues in human organoid and gastruloid research. | Munsie M et al. | β | 2017 | β |
| How does Zika virus cause microcephaly? | Wen Z et al. | β | 2017 | β |
| Mechanisms of radial glia progenitor cell lineage progression. | Beattie R et al. | β | 2017 | β |
| Organoids: a Special Issue. | Little MH | β | 2017 | β |
| Pluripotent stem cell-derived organoids: using principles of developmental biology to grow human tissues in a dish. | McCauley HA et al. | β | 2017 | β |
| Replication of early and recent Zika virus isolates throughout mouse brain development. | Rosenfeld AB et al. | β | 2017 | β |
| The hope and the hype of organoid research. | Huch M et al. | β | 2017 | β |
| Translational applications of adult stem cell-derived organoids. | Drost J et al. | β | 2017 | β |