Evaluation of a simple model of ethanol drinking to intoxication in C57BL/6J mice.
paper
Cited
Public
Unavailable
- Authors
- Rhodes, Justin S; Best, Karyn; Belknap, John K; Finn, Deborah A; Crabbe, John C
- Year
- 2005
- Journal
- Physiology & behavior
- PMID
- 15642607
- DOI
- 10.1016/j.physbeh.2004.10.007
Because of intrinsic differences between humans and mice, no single mouse model can represent all features of a complex human trait such as alcoholism. It is therefore necessary to develop partial models. One important feature is drinking to the point where blood ethanol concentration (BEC) reaches levels that have measurable affects on physiology and/or behavior (>1.0 mg ethanol/ml blood). Most models currently in use examine relative oral self-administration from a bottle containing alcohol versus one containing water (two-bottle preference drinking), or oral operant self-administration. In these procedures, it is not clear when or if the animals drink to pharmacologically significant levels because the drinking is episodic and often occurs over a 24-h period. The aim of this study was to identify the optimal parameters and evaluate the reliability of a very simple procedure, taking advantage of a mouse genotype (C57BL/6J) that is known to drink large quantities of ethanol. We exchanged for the water bottle a solution containing ethanol in tap water for a limited period, early in the dark cycle, in the home cage. Mice regularly drank sufficient ethanol to achieve BEC>1.0 mg ethanol/ml blood. The concentration of ethanol offered (10%, 20% or 30%) did not affect consumption in g ethanol/kg body weight. The highest average BEC ( approximately 1.6 mg/ml) occurred when the water-to-ethanol switch occurred 3 h into the dark cycle, and when the ethanol was offered for 4 rather than 2 h. Ethanol consumption was consistent within individual mice, and reliably predicted BEC after the period of ethanol access. C57BL/6J mice from three sources provided equivalent data, while DBA/2J mice drank much less than C57BL/6J in this test. We discuss advantages of the model for high-throughput screening assays where the goal is to find other genotypes of mice that drink excessively, or to screen drugs for their efficacy in blocking excessive drinking.
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| Chemogenetic manipulation of astrocytic signaling in the basolateral amygdala reduces binge-like alcohol consumption in male mice. | Nwachukwu KN et al. | β | 2021 | β |
| Compulsive alcohol consumption is regulated by dorsal striatum fast-spiking interneurons. | Patton MS et al. | β | 2021 | β |
| Contribution of GlyR Ξ±3 Subunits to the Sensitivity and Effect of Ethanol in the Nucleus Accumbens. | San Martin LS et al. | β | 2021 | β |
| Effect of caffeine on alcohol drinking in mice. | Haun HL et al. | β | 2021 | β |
| Effects of a Peripherally Restricted Hybrid Inhibitor of CB1 Receptors and iNOS on Alcohol Drinking Behavior and Alcohol-Induced Endotoxemia. | Santos-Molina L et al. | β | 2021 | β |
| Effects of chemogenetic manipulation of the nucleus accumbens core in male C57BL/6J mice. | Townsley KG et al. | β | 2021 | β |
| Effects of High-Fat Diet and Maternal Binge-Like Alcohol Consumption and Their Influence on Cocaine Response in Female Mice Offspring. | Duart-Castells L et al. | β | 2021 | β |
| Enhancement of alcohol aversion by the nicotinic acetylcholine receptor drug sazetidine-A. | Touchette JC et al. | β | 2021 | β |
| Ethanol-Related Behaviors in Mouse Lines Selectively Bred for Drinking to Intoxication. | Jensen BE et al. | β | 2021 | β |
| Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder. | Gutridge AM et al. | β | 2021 | β |
| Female mice are more prone to develop an addictive-like phenotype for sugar consumption. | Wei S et al. | β | 2021 | β |
| Genes identified in rodent studies of alcohol intake are enriched for heritability of human substance use. | Huggett SB et al. | β | 2021 | β |
| Genetic differences in ethanol consumption: effects on iron, copper, and zinc regulation in mouse hippocampus. | Jones BC et al. | β | 2021 | β |
| Hnrnph1 is a novel regulator of alcohol reward. | Fultz EK et al. | β | 2021 | β |
| Housing Condition Differentially Impacts Escalation of Alcohol Intake, Relapse-Like Drinking, Anxiety-Like Behavior, and Stress History Effects by Sex. | Moench KM et al. | β | 2021 | β |
| Kappa opioid receptor and dynorphin signaling in the central amygdala regulates alcohol intake. | Bloodgood DW et al. | β | 2021 | β |
| Lateral hypothalamus-projecting noradrenergic locus coeruleus pathway modulates binge-like ethanol drinking in male and female TH-ires-cre mice. | Burnham NW et al. | β | 2021 | β |
| Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood. | Beecher K et al. | β | 2021 | β |
| MPEP Lowers Binge Drinking in Male and Female C57BL/6 Mice: Relationship with mGlu5/Homer2/Erk2 Signaling. | Huang G et al. | β | 2021 | β |
| On the Use of Heterogeneous Stock Mice to Map Transcriptomes Associated With Excessive Ethanol Consumption. | Hitzemann R et al. | β | 2021 | β |
| Recent Perspectives on Sex Differences in Compulsion-Like and Binge Alcohol Drinking. | Radke AK et al. | β | 2021 | β |
| Repeated binge ethanol drinking enhances electrical activity of central amygdala corticotropin releasing factor neurons in vivo. | Aroni S et al. | β | 2021 | β |
| Repetitive binge-like consumption based on the Drinking-in-the-Dark model alters the microglial population in the mouse hippocampus. | Nelson JC et al. | β | 2021 | β |
| Shortening time for access to alcohol drives up front-loading behavior, bringing consumption in male rats to the level of females. | Flores-Bonilla A et al. | β | 2021 | β |
| Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice. | Dao NC et al. | β | 2021 | β |
| Studying Sex Differences in Rodent Models of Addictive Behavior. | Radke AK et al. | β | 2021 | β |
| Sucrose Consumption Alters Serotonin/Glutamate Co-localisation Within the Prefrontal Cortex and Hippocampus of Mice. | Beecher K et al. | β | 2021 | β |
| The impact of Drinking in the Dark (DID) procedural manipulations on ethanol intake in High Drinking in the Dark (HDID) mice. | Savarese AM et al. | β | 2021 | β |
| The Influence of Moderate Physical Activity on Brain Monoaminergic Responses to Binge-Patterned Alcohol Ingestion in Female Mice. | Buhr TJ et al. | β | 2021 | β |
| The paraventricular thalamus provides a polysynaptic brake on limbic CRF neurons to sex-dependently blunt binge alcohol drinking and avoidance behavior in mice. | Levine OB et al. | β | 2021 | β |
| The serotonin 2C receptor agonist lorcaserin, alone and in combination with the opioid receptor antagonist naltrexone, attenuates binge-like ethanol drinking. | Tabbara RI et al. | β | 2021 | β |
| Time elapsed between choices in a probabilistic task correlates with repeating the same decision. | JabΕoΕska J et al. | β | 2021 | β |
| Voluntary binge-patterned alcohol drinking and sex-specific influences on monoamine-related neurochemical signatures in the mouse gut and brain. | Bauer EE et al. | β | 2021 | β |
| Adolescent low-dose ethanol drinking in the dark increases ethanol intake later in life in C57BL/6J, but not DBA/2J mice. | Wolstenholme JT et al. | β | 2020 | β |
| A history of ethanol drinking increases locomotor stimulation and blunts enhancement of dendritic dopamine transmission by methamphetamine. | Tschumi CW et al. | β | 2020 | β |
| Alcohol Binge Drinking and Anxiety-Like Behavior in Socialized Versus Isolated C57BL/6J Mice. | Evans O et al. | β | 2020 | β |
| Antibiotic-induced disruption of commensal microbiome linked to increases in binge-like ethanol consumption behavior. | Reyes REN et al. | β | 2020 | β |
| A prior history of binge-drinking increases sensitivity to the motivational valence of methamphetamine in female C57BL/6J mice. | Sern KR et al. | β | 2020 | β |
| Ceramides affect alcohol consumption and depressive-like and anxiety-like behavior in a brain region- and ceramide species-specific way in male mice. | Zoicas I et al. | β | 2020 | β |
| Chronic Chemogenetic Stimulation of the Nucleus Accumbens Produces Lasting Reductions in Binge Drinking and Ameliorates Alcohol-Related Morphological and Transcriptional Changes. | Pozhidayeva DY et al. | β | 2020 | β |
| Chronic Voluntary Binge Ethanol Consumption Causes Sex-Specific Differences in Microglial Signaling Pathways and Withdrawal-associated Behaviors in Mice. | Rath M et al. | β | 2020 | β |
| Combined Effects of Repetitive Mild Traumatic Brain Injury and Alcohol Drinking on the Neuroinflammatory Cytokine Response and Cognitive Behavioral Outcomes. | Hoffman J et al. | β | 2020 | β |
| Differential patterns of alcohol and nicotine intake: Combined alcohol and nicotine binge consumption behaviors in mice. | DeBaker MC et al. | β | 2020 | β |
| Effects of naltrexone on alcohol, sucrose, and saccharin binge-like drinking in C57BL/6J mice: a study with a multiple bottle choice procedure. | Morales I et al. | β | 2020 | β |
| Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication. | Ozburn AR et al. | β | 2020 | β |
| Ethanol consumption and sedation are altered in mice lacking the glycine receptor Ξ±2 subunit. | San Martin L et al. | β | 2020 | β |
| Further evidence for the involvement of the PPARΞ³ system on alcohol intake and sensitivity in rodents. | Domi E et al. | β | 2020 | β |
| Gender differences in the effects of cannabidiol on ethanol binge drinking in mice. | Viudez-MartΓnez A et al. | β | 2020 | β |
| G protein-biased kratom-alkaloids and synthetic carfentanil-amide opioids as potential treatments for alcohol use disorder. | Gutridge AM et al. | β | 2020 | β |
| Impact of High Fat Diet and Ethanol Consumption on Neurocircuitry Regulating Emotional Processing and Metabolic Function. | Coker CR et al. | β | 2020 | β |
| Increased Responding for Alcohol and Resistance to Aversion in Female Mice. | Sneddon EA et al. | β | 2020 | β |
| Influence of nonsynaptic Ξ±1 glycine receptors on ethanol consumption and place preference. | MuΓ±oz B et al. | β | 2020 | β |
| Kappa opioid receptors in the bed nucleus of the stria terminalis regulate binge-like alcohol consumption in male and female mice. | Haun HL et al. | β | 2020 | β |
| Leveraging Neural Networks in Preclinical Alcohol Research. | Smith LC et al. | β | 2020 | β |
| mTORC1 pathway is involved in the kappa opioid receptor activation-induced increase in excessive alcohol drinking in mice. | Zhou Y et al. | β | 2020 | β |
| MUNC13-1 heterozygosity does not alter voluntary ethanol consumption or sensitivity in mice. | Wooden JI et al. | β | 2020 | β |
| Nucleus accumbens shell Orexin-1 receptors are not needed for single-bottle limited daily access alcohol intake in C57BL/6 mice. | Lei K et al. | β | 2020 | β |
| Social Isolation Stress in Adolescence, but not Adulthood, Produces Hypersocial Behavior in Adult Male and Female C57BL/6J Mice. | Rivera-Irizarry JK et al. | β | 2020 | β |
| Targeting the Glucocorticoid Receptor Reduces Binge-Like Drinking in High Drinking in the Dark (HDID-1) Mice. | Savarese AM et al. | β | 2020 | β |
| Tetracycline derivatives reduce binge alcohol consumption in High Drinking in the Dark mice. | Crabbe JC et al. | β | 2020 | β |
| The melanocortin system as a potential target for treating alcohol use disorders: A review of pre-clinical data. | Lerma-Cabrera JM et al. | β | 2020 | β |
| Timing Eclipses Amount: The Critical Importance of Intermittency in Alcohol Exposure Effects. | Spear LP | β | 2020 | β |
| Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice. | Sampedro-Piquero P et al. | β | 2020 | β |
| A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking. | Grifasi IR et al. | β | 2019 | β |
| A cortical-brainstem circuit predicts and governs compulsive alcohol drinking. | Siciliano CA et al. | β | 2019 | β |
| Adolescent but not adult ethanol binge drinking modulates ethanol behavioral effects in mice later in life. | Younis RM et al. | β | 2019 | β |
| Animal models of binge drinking, current challenges to improve face validity. | Jeanblanc J et al. | β | 2019 | β |
| Assessment of Acute Motor Effects and Tolerance Following Self-Administration of Alcohol and Edible β<sup>9</sup> -Tetrahydrocannabinol in Adolescent Male Mice. | Smoker MP et al. | β | 2019 | β |
| Bupropion, Alone and in Combination with Naltrexone, Blunts Binge-Like Ethanol Drinking and Intake Following Chronic Intermittent Access to Ethanol in Male C57BL/6J Mice. | Navarro M et al. | β | 2019 | β |
| Caffeine modulates voluntary alcohol intake in mice depending on the access conditions: Involvement of adenosine receptors and the role of individual differences. | SanMiguel N et al. | β | 2019 | β |
| Changes in brain kynurenine levels <i>via</i> gut microbiota and gut-barrier disruption induced by chronic ethanol exposure in mice. | GimΓ©nez-GΓ³mez P et al. | β | 2019 | β |
| Characterization of the Hippocampal Neuroimmune Response to Binge-Like Ethanol Consumption in the Drinking in the Dark Model. | Grifasi IR et al. | β | 2019 | β |
| Combination of Clinically Utilized Kappa-Opioid Receptor Agonist Nalfurafine With Low-Dose Naltrexone Reduces Excessive Alcohol Drinking in Male and Female Mice. | Zhou Y et al. | β | 2019 | β |
| Complex interactions between the subject factors of biological sex and prior histories of binge-drinking and unpredictable stress influence behavioral sensitivity to alcohol and alcohol intake. | Quadir SG et al. | β | 2019 | β |
| DID it or DIDn't it? Exploration of a failure to replicate binge-like alcohol-drinking in C57BL/6J mice. | Szumlinski KK et al. | β | 2019 | β |
| Dopaminergic-GABAergic interplay and alcohol binge drinking. | Leggio GM et al. | β | 2019 | β |
| Dynorphin-kappa opioid receptor activity in the central amygdala modulates binge-like alcohol drinking in mice. | Anderson RI et al. | β | 2019 | β |
| Ethanol acts on KCNK13 potassium channels in the ventral tegmental area to increase firing rate and modulate binge-like drinking. | You C et al. | β | 2019 | β |
| Ethanol Conditioned Taste Aversion in High Drinking in the Dark Mice. | Crabbe JC et al. | β | 2019 | β |
| Female-specific decreases in alcohol binge-like drinking resulting from GABA<sub>A</sub> receptor delta-subunit knockdown in the VTA. | Darnieder LM et al. | β | 2019 | β |
| GABA<sub>B</sub> receptor positive allosteric modulators with different efficacies affect neuroadaptation to and self-administration of alcohol and cocaine. | de Miguel E et al. | β | 2019 | β |
| Ghrelin: From a gut hormone to a potential therapeutic target for alcohol use disorder. | Farokhnia M et al. | β | 2019 | β |
| Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs. | Bornebusch AB et al. | β | 2019 | β |
| Histone deacetylases inhibitor trichostatin A reverses anxiety-like symptoms and memory impairments induced by maternal binge alcohol drinking in mice. | Montagud-Romero S et al. | β | 2019 | β |
| Impact of Genetic Variation on Stress-Related Ethanol Consumption. | Mulligan MK et al. | β | 2019 | β |
| Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice. | Crowley NA et al. | β | 2019 | β |
| Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation. | Cantacorps L et al. | β | 2019 | β |
| Medial prefrontal cortex neuropeptide Y modulates binge-like ethanol consumption in C57BL/6J mice. | Robinson SL et al. | β | 2019 | β |
| Modulation of serotonin and noradrenaline in the BLA by pindolol reduces long-term ethanol intake. | Patkar OL et al. | β | 2019 | β |
| Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice. | Huynh N et al. | β | 2019 | β |
| Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement. | Morel C et al. | β | 2019 | β |
| NOP Receptor Antagonists Decrease Alcohol Drinking in the Dark in C57BL/6J Mice. | Brunori G et al. | β | 2019 | β |
| Nuclear transcriptional changes in hypothalamus of Pomc enhancer knockout mice after excessive alcohol drinking. | Zhou Y et al. | β | 2019 | β |
| Pindolol Rescues Anxiety-Like Behavior and Neurogenic Maladaptations of Long-Term Binge Alcohol Intake in Mice. | Patkar OL et al. | β | 2019 | β |
| Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder? | Tunstall BJ et al. | β | 2019 | β |
| Scn4b regulates the hypnotic effects of ethanol and other sedative drugs. | Blednov YA et al. | β | 2019 | β |
| Self-administration of edible Ξ<sup>9</sup>-tetrahydrocannabinol and associated behavioral effects in mice. | Smoker MP et al. | β | 2019 | β |
| Sex Differences in Aversion-Resistant Ethanol Intake in Mice. | Fulenwider HD et al. | β | 2019 | β |
| Sex Differences in Binge-Like and Aversion-Resistant Alcohol Drinking in C57BL/6J Mice. | Sneddon EA et al. | β | 2019 | β |
| Sex differences in the effect of bupropion and naltrexone combination on alcohol drinking in mice. | Zhou Y et al. | β | 2019 | β |
| Targeting Peripheral CB<sub>1</sub> Receptors Reduces Ethanol Intake via a Gut-Brain Axis. | Godlewski G et al. | β | 2019 | β |
| The Ξ±3Ξ²4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice. | Miller CN et al. | β | 2019 | β |
| Understanding Addiction Using Animal Models. | Kuhn BN et al. | β | 2019 | β |
| Voluntary elevated ethanol consumption in adolescent Sprague-Dawley rats: Procedural contributors and age-specificity. | HosovΓ‘ D et al. | β | 2019 | β |
| 5-HT1A receptor-dependent modulation of emotional and neurogenic deficits elicited by prolonged consumption of alcohol. | Belmer A et al. | β | 2018 | β |
| Adolescent social stress increases anxiety-like behavior and ethanol consumption in adult male and female C57BL/6J mice. | Caruso MJ et al. | β | 2018 | β |
| A single episode of binge alcohol drinking causes sleep disturbance, disrupts sleep homeostasis, and down-regulates equilibrative nucleoside transporter 1. | Sharma R et al. | β | 2018 | β |
| Assessment of ventral tegmental area-projecting GABAergic neurons from the bed nucleus of the stria terminalis in modulating binge-like ethanol intake. | Companion MA et al. | β | 2018 | β |
| Behavioral Characterization of Ξ²-Arrestin 1 Knockout Mice in Anxiety-Like and Alcohol Behaviors. | Robins MT et al. | β | 2018 | β |
| Behavioral Evaluation of Seeking and Preference of Alcohol in Mice Subjected to Stress. | Canseco-Alba A et al. | β | 2018 | β |
| Caffeine Delays Light-entrained Activity and Potentiates Circadian Photic Phase-resetting in Mice. | Ruby CL et al. | β | 2018 | β |
| Cannabinoid-1 receptor neutral antagonist reduces binge-like alcohol consumption and alcohol-induced accumbal dopaminergic signaling. | Balla A et al. | β | 2018 | β |
| Central Administration of Cyclosporine A Decreases Ethanol Drinking. | Ronan PJ et al. | β | 2018 | β |
| CRF modulation of central monoaminergic function: Implications for sex differences in alcohol drinking and anxiety. | Pleil KE et al. | β | 2018 | β |
| Cross-Species Alterations in Synaptic Dopamine Regulation After Chronic Alcohol Exposure. | Siciliano CA et al. | β | 2018 | β |
| Effects of Nicotine on Alcohol Drinking in Female Mice Selectively Bred for High or Low Alcohol Preference. | Weera MM et al. | β | 2018 | β |
| Emerging role for the medial prefrontal cortex in alcohol-seeking behaviors. | Klenowski PM | β | 2018 | β |
| Environmental Enrichment During Adolescence Acts as a Protective and Therapeutic Tool for Ethanol Binge-Drinking, Anxiety-Like, Novelty Seeking and Compulsive-Like Behaviors in C57BL/6J Mice During Adulthood. | RodrΓguez-Ortega E et al. | β | 2018 | β |
| Environmental Enrichment Modulates Drug Addiction and Binge-Like Consumption of Highly Rewarding Substances: A Role for Anxiety and Compulsivity Brain Systems? | RodrΓguez-Ortega E et al. | β | 2018 | β |
| Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes. | Huang D et al. | β | 2018 | β |
| Gender-Specific Effects of Selection for Drinking in the Dark on the Network Roles of Coding and Noncoding RNAs. | Iancu OD et al. | β | 2018 | β |
| Genetic Contribution to Initial and Progressive Alcohol Intake Among Recombinant Inbred Strains of Mice. | Mulligan MK et al. | β | 2018 | β |
| Hippocampal neurogenesis in the C57BL/6J mice at early adulthood following prenatal alcohol exposure. | Olateju OI et al. | β | 2018 | β |
| Increased ethanol drinking in "humanized" mice expressing the mu opioid receptor A118G polymorphism are mediated through sex-specific mechanisms. | Henderson-Redmond AN et al. | β | 2018 | β |
| Increasing kynurenine brain levels reduces ethanol consumption in mice by inhibiting dopamine release in nucleus accumbens. | GimΓ©nez-GΓ³mez P et al. | β | 2018 | β |
| Investigational drugs for alcohol use disorders: a review of preclinical data. | Ch'Ng SS et al. | β | 2018 | β |
| Involvement of Activated Brain Stress Responsive Systems in Excessive and "Relapse" Alcohol Drinking in Rodent Models: Implications for Therapeutics. | Zhou Y et al. | β | 2018 | β |
| Knockout of alpha 5 nicotinic acetylcholine receptors subunit alters ethanol-mediated behavioral effects and reward in mice. | Dawson A et al. | β | 2018 | β |
| Maternal care-related differences in males and females rats' sensitivity to ethanol and the associations between the GABAergic system and steroids in males. | Popoola DO et al. | β | 2018 | β |
| Maternal separation increases alcohol-drinking behaviour and reduces endocannabinoid levels in the mouse striatum and prefrontal cortex. | Portero-Tresserra M et al. | β | 2018 | β |
| mGlu5-dependent modulation of anxiety during early withdrawal from binge-drinking in adult and adolescent male mice. | Lee KM et al. | β | 2018 | β |
| mGlu5 Receptor Blockade Within the Nucleus Accumbens Shell Reduces Behavioral Indices of Alcohol Withdrawal-Induced Anxiety in Mice. | Lee KM et al. | β | 2018 | β |
| Murine sperm capacitation, oocyte penetration and decondensation following moderate alcohol intake. | SΓ‘nchez MC et al. | β | 2018 | β |
| Neuromodulatory Treatments for Alcohol Use Disorder: A Review. | Salib AN et al. | β | 2018 | β |
| On the relationships in rhesus macaques between chronic ethanol consumption and the brain transcriptome. | Iancu OD et al. | β | 2018 | β |
| Ovarian Hormones Contribute to High Levels of Binge-Like Drinking by Female Mice. | Satta R et al. | β | 2018 | β |
| Oxytocin and Rodent Models of Addiction. | Leong KC et al. | β | 2018 | β |
| Pharmacogenetic Manipulation of the Nucleus Accumbens Alters Binge-Like Alcohol Drinking in Mice. | Purohit K et al. | β | 2018 | β |
| Pharmacological inhibition of Receptor Protein Tyrosine Phosphatase Ξ²/ΞΆ (PTPRZ1) modulates behavioral responses to ethanol. | FernΓ‘ndez-Calle R et al. | β | 2018 | β |
| Prior binge-drinking history promotes the positive affective valence of methamphetamine in mice. | Fultz EK et al. | β | 2018 | β |
| Sex and Ξ²-Endorphin Influence the Effects of Ethanol on Limbic <i>Gabra2</i> Expression in a Mouse Binge Drinking Model. | Rhinehart EM et al. | β | 2018 | β |
| Studying Sex Differences in Animal Models of Addiction: An Emphasis on Alcohol-Related Behaviors. | Hilderbrand ER et al. | β | 2018 | β |
| Suppressing Effect of Baclofen on Multiple Alcohol-Related Behaviors in Laboratory Animals. | Colombo G et al. | β | 2018 | β |
| The influence of adolescent nicotine exposure on ethanol intake and brain gene expression. | Silva CP et al. | β | 2018 | β |
| The nicotinic receptor drug sazetidine-A reduces alcohol consumption in mice without affecting concurrent nicotine consumption. | Touchette JC et al. | β | 2018 | β |
| The nucleus accumbens and alcoholism: a target for deep brain stimulation. | Ho AL et al. | β | 2018 | β |
| The role of the orbitofrontal cortex in alcohol use, abuse, and dependence. | Moorman DE | β | 2018 | β |
| V1b Receptor Antagonist SSR149415 and Naltrexone Synergistically Decrease Excessive Alcohol Drinking in Male and Female Mice. | Zhou Y et al. | β | 2018 | β |
| Varenicline modulates ethanol and saccharin consumption in adolescent male and female C57BL/6J mice. | Kamens HM et al. | β | 2018 | β |
| Alignment of the transcriptome with individual variation in animals selectively bred for High Drinking-In-the-Dark (HDID). | Hitzemann R et al. | β | 2017 | β |
| Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. | Dutton JW et al. | β | 2017 | β |
| Anxiolytic effects of buspirone and MTEP in the Porsolt Forced Swim Test. | Lee KM et al. | β | 2017 | β |
| A Rat Drinking in the Dark Model for Studying Ethanol and Sucrose Consumption. | Holgate JY et al. | β | 2017 | β |
| Binge ethanol drinking during adolescence modifies cocaine responses in mice. | Esteve-Arenys A et al. | β | 2017 | β |
| Blockade of alcohol escalation and "relapse" drinking by pharmacological FAAH inhibition in male and female C57BL/6J mice. | Zhou Y et al. | β | 2017 | β |
| Changes in the Cholinergic, Catecholaminergic, Orexinergic and Serotonergic Structures Forming Part of the Sleep Systems of Adult Mice Exposed to Intrauterine Alcohol. | Olateju OI et al. | β | 2017 | β |
| Circuit and synaptic mechanisms of repeated stress: Perspectives from differing contexts, duration, and development. | Bath KG et al. | β | 2017 | β |
| Different Molecular/Behavioral Endophenotypes in C57BL/6J Mice Predict the Impact of OX<sub>1</sub> Receptor Blockade on Binge-Like Ethanol Intake. | Alcaraz-Iborra M et al. | β | 2017 | β |
| Disruption of blood-brain barrier integrity in postmortem alcoholic brain: preclinical evidence of TLR4 involvement from a binge-like drinking model. | Rubio-Araiz A et al. | β | 2017 | β |
| DNA modifications in models of alcohol use disorders. | Tulisiak CT et al. | β | 2017 | β |
| Dopamine Receptors Differentially Control Binge Alcohol Drinking-Mediated Synaptic Plasticity of the Core Nucleus Accumbens Direct and Indirect Pathways. | Ji X et al. | β | 2017 | β |
| Effect of Shankhpushpi on Alcohol Addiction in Mice. | Heba M et al. | β | 2017 | β |
| Effects of acute alcohol on excitability in the CNS. | Harrison NL et al. | β | 2017 | β |
| Environmental Enrichment Blunts Ethanol Consumption after Restraint Stress in C57BL/6 Mice. | Marianno P et al. | β | 2017 | β |
| Ethanol Consumption in Mice Lacking CD14, TLR2, TLR4, or MyD88. | Blednov YA et al. | β | 2017 | β |
| Ethanol Sensitization during Adolescence or Adulthood Induces Different Patterns of Ethanol Consumption without Affecting Ethanol Metabolism. | Carrara-Nascimento PF et al. | β | 2017 | β |
| Extended Amygdala to Ventral Tegmental Area Corticotropin-Releasing Factor Circuit Controls Binge Ethanol Intake. | Rinker JA et al. | β | 2017 | β |
| Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice. | McMurray KM et al. | β | 2017 | β |
| Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents. | Harris RA et al. | β | 2017 | β |
| Genetic Variability in Adenosine Deaminase-Like Contributes to Variation in Alcohol Preference in Mice. | Lesscher HMB et al. | β | 2017 | β |
| Glutamate plasticity woven through the progression to alcohol use disorder: a multi-circuit perspective. | Hwa L et al. | β | 2017 | β |
| Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice. | Kermanizadeh A et al. | β | 2017 | β |
| High Drinking in the Dark (HDID) mice are sensitive to the effects of some clinically relevant drugs to reduce binge-like drinking. | Crabbe JC et al. | β | 2017 | β |
| Hippocampal encoding of interoceptive context during fear conditioning. | Yoo SW et al. | β | 2017 | β |
| Hypothalamic-specific proopiomelanocortin deficiency reduces alcohol drinking in male and female mice. | Zhou Y et al. | β | 2017 | β |
| Maternal alcohol binge drinking induces persistent neuroinflammation associated with myelin damage and behavioural dysfunctions in offspring mice. | Cantacorps L et al. | β | 2017 | β |
| Mechanistic insights into epigenetic modulation of ethanol consumption. | Ponomarev I et al. | β | 2017 | β |
| Methamphetamine-alcohol interactions in murine models of sequential and simultaneous oral drug-taking. | Fultz EK et al. | β | 2017 | β |
| Midkine in the mouse ventral tegmental area limits ethanol intake and Ccl2 gene expression. | Chen H et al. | β | 2017 | β |
| Modulation of Binge-like Ethanol Consumption by IL-10 Signaling in the Basolateral Amygdala. | Marshall SA et al. | β | 2017 | β |
| Negative Affect and Excessive Alcohol Intake Incubate during Protracted Withdrawal from Binge-Drinking in Adolescent, But Not Adult, Mice. | Lee KM et al. | β | 2017 | β |
| Nicotine Increases Alcohol Intake in Adolescent Male Rats. | LΓ‘rraga A et al. | β | 2017 | β |
| No evidence of a role of the Ξ²4 subunit of the nicotinic acetylcholine receptor in alcohol-related behaviors. | Kamens HM et al. | β | 2017 | β |
| Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques. | Nimitvilai S et al. | β | 2017 | β |
| Oxytocin Reduces Ethanol Self-Administration in Mice. | King CE et al. | β | 2017 | β |
| Pharmacological Inhibition of Brain Fatty Acid Binding Protein Reduces Ethanol Consumption in Mice. | Figueiredo A et al. | β | 2017 | β |
| Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder. | Huynh N et al. | β | 2017 | β |
| Preclinical voluntary drinking models for alcohol abstinence-induced affective disturbances in mice. | Holleran KM et al. | β | 2017 | β |
| Rat animal models for screening medications to treat alcohol use disorders. | Bell RL et al. | β | 2017 | β |
| Social and environmental enrichment has different effects on ethanol and sucrose consumption in mice. | Holgate JY et al. | β | 2017 | β |
| Stress Facilitates the Development of Cognitive Dysfunction After Chronic Ethanol Exposure. | Rodberg EM et al. | β | 2017 | β |
| Synergistic blockade of alcohol escalation drinking in mice by a combination of novel kappa opioid receptor agonist Mesyl Salvinorin B and naltrexone. | Zhou Y et al. | β | 2017 | β |
| The antihypertensive drug pindolol attenuates long-term but not short-term binge-like ethanol consumption in mice. | Patkar OL et al. | β | 2017 | β |
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