Electrophysiological evidence of enhanced performance monitoring in recently abstinent alcoholic men.

paper Cited Public

Authors: Padilla, Mayra L; Colrain, Ian M; Sullivan, Edith V; Mayer, Benjamin Z; Turlington, Sharon R; Hoffman, Lindsay R; Wagstaff, Amanda E; Pfefferbaum, Adolf
Year: 2011
Journal: Psychopharmacology
PMID: 20941595
DOI: 10.1007/s00213-010-2018-1
PMCID: PMC3015191

Fig. 1

Task description. Outline of the sequence of events for the four different experimental conditions: high stimulus conflict and high response conflict (HsHr), high stimulus conflict and low response conflict (HsLr), low stimulus conflict and high response conflict (LsHr), low stimulus conflict and low response conflict (LsLr)

Fig. 2

a RTs for correct trials by conditions. Data represent mean values and error bars represent standard errors for each condition. b RTs for correct and error trials. Data represent mean values and error bars represent standard errors for overall correct and error trials

Fig. 3

N2 amplitudes. Peak N2 values from electrode FCZ are plotted for the four condition types for correct responses. Error bars index standard error for each condition. Alcoholics produced similar amplitude N2 potentials to control group. This implies that similar stimulus processing occurred in both groups

Fig. 4

N2 waveforms. Stimulus-locked N2 waveforms at electrode FCZ for correct response are plotted for the four conditions (HsHr, HsLr, LsHr, LsLr) in dark blue (solid line) for controls and in red (dashed line) for alcoholics. No group differences were found

Fig. 5

a CRN amplitudes by condition. CRN mean amplitudes from electrode FCZ and their respective error bars, which index standard error values, are displayed for the four condition types for correct responses. Alcoholics generated significantly larger negative amplitudes than the controls suggesting that they engaged enhanced performance monitoring processes during all correct trial types. b CRN and ERN amplitudes. Mean CRN and ERN amplitudes from electrode FCZ are displayed with their corresponding standard error bars. CRN represents the mean amplitude across all correct trial types and the ERN represents the mean amplitude for all incorrect responses. Alcoholics generated significantly larger negative amplitude potentials for both correct and incorrect trials compared to the controls

Fig. 6

a CRN waveforms. Response-locked CRN waveforms at electrode FCZ for correct responses are plotted for the four condition types (HsHr, HsLr, LsHr, LsLr) in dark blue (solid line) for controls and in red (dashed line) for alcoholics. Alcoholics produced larger CRN potentials for all trial types than control subjects. Note that the peak values represented in this figure do not correspond to the values reported in Fig. 5a as those are the average amplitude over a 100 ms time window. b CRN and ERN waveforms. Response-locked correct (left panel) and incorrect (right panel) waveforms are plotted at electrode FCZ in dark blue (solid line) for controls and in red (dashed line) for alcoholics. Waveforms were derived by averaging across all four trial types. Alcoholics compared to the controls produced significantly larger CRN amplitudes for all correct responses and larger ERN amplitudes to all incorrect responses. Note that the peak values represented in this figure do not correspond to the values reported in Fig. 5b as those are the average amplitude over a 100 ms time window

#	Section	Preview
40	Discussion	To the extent that greater amplitude of these electrophysiological markers of performance monitoring…

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