SLO-1 potassium channels control quantal content of neurotransmitter release at the C. elegans neuromuscular junction.
paper
Cited
Public
Unavailable
- Authors
- Wang, Z W; Saifee, O; Nonet, M L; Salkoff, L
- Year
- 2001
- Journal
- Neuron
- PMID
- 11738032
- DOI
- 10.1016/s0896-6273(01)00522-0
Six mutants of SLO-1, a large-conductance, Ca(2+)-activated K(+) channel of C. elegans, were obtained in a genetic screen for regulators of neurotransmitter release. Mutants were isolated by their ability to suppress lethargy of an unc-64 syntaxin mutant that restricts neurotransmitter release. We measured evoked postsynaptic currents at the neuromuscular junction in both wild-type and mutants and observed that the removal of SLO-1 greatly increased quantal content primarily by increasing duration of release. The selective isolation of slo-1 as the only ion channel mutant derived from a whole genomic screen to detect regulators of neurotransmitter release suggests that SLO-1 plays an important, if not unique, role in regulating neurotransmitter release.
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