Gene expression profiling in the brains of human cocaine abusers.
- Authors
- Bannon, Michael; Kapatos, Gregory; Albertson, Dawn
- Year
- 2005
- Journal
- Addiction biology
- PMID
- 15849025
- DOI
- 10.1080/13556210412331308921
- PMCID
- PMC2215307
Chronic cocaine abuse induces long-term neurochemical, structural and behavioural changes thought to result from altered gene expression within the nucleus accumbens and other brain regions playing a critical role in addiction. Recent methodological advances now allow the profiling of gene expression in human postmortem brain. In this article, we review studies in which we have used Affymetrix oligonucleotide microarrays to identify transcripts that are differentially expressed in the nucleus accumbens of cocaine abusers in comparison to well-matched control subjects. Of the approximately 39,000 gene transcripts interrogated, the expression of only a fraction of 1% is significantly modified in cocaine abusers. Found within this list are equivalent incidences of increased and decreased transcript abundance, including known gene transcripts clustered into several functional categories. A striking exception is a group of myelin-related genes, consisting of multiple transcripts representing myelin basic protein (MBP), proteolipid protein (PLP) and myelin-associated oligodendrocyte basic protein (MOBP), which as a group are substantially decreased in cocaine abusers compared to controls. These data, suggesting a possible dysregulation of myelin in cocaine abusers, are discussed in the context of myelin-related changes in other human brain disorders. Finally, the effects of cocaine abuse on the profile of gene expression in some other brain regions critical for addiction (the prefrontal cortex and ventral midbrain) are briefly reviewed.
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In this knowledge base
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| The genetic epidemiology of substance use disorder: A review. | 2017 | 28938182 |
| Gene expression in the addicted brain. | 2014 | 25172478 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Molecular genetics of cocaine use disorders in humans. | FernΓ ndez-Castillo N et al. | β | 2022 | β |
| Cocaine-induced neural adaptations in the lateral hypothalamic melanin-concentrating hormone neurons and the role in regulating rapid eye movement sleep after withdrawal. | Wang Y et al. | β | 2021 | β |
| Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice. | Mukherjee D et al. | β | 2021 | β |
| Epigenetics of addiction. | Cadet JL et al. | β | 2021 | β |
| Multidimensional Intersection of Nicotine, Gene Expression, and Behavior. | Sherafat Y et al. | β | 2021 | β |
| White matter deficits in cocaine use disorder: convergent evidence from in vivo diffusion tensor imaging and ex vivo proteomic analysis. | Tondo LP et al. | β | 2021 | β |
| Cocaine Administration and Its Abstinence Conditions Modulate Neuroglia. | GawliΕska K et al. | β | 2020 | β |
| <i>Egr2</i> induction in <i>Drd1</i><sup>+</sup> ensembles of the ventrolateral striatum supports the development of cocaine reward | Mukherjee D et al. | β | 2020 | β |
| Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol. | Park HM et al. | β | 2019 | β |
| A New Insight into the Role of CART in Cocaine Reward: Involvement of CaMKII and Inhibitory G-Protein Coupled Receptor Signaling. | Yu C et al. | β | 2017 | β |
| The genetic epidemiology of substance use disorder: A review. | Prom-Wormley EC et al. | β | 2017 | β |
| Transcriptomic profiling of the ventral tegmental area and nucleus accumbens in rhesus macaques following long-term cocaine self-administration. | Vallender EJ et al. | β | 2017 | β |
| Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure. | Vassoler FM et al. | β | 2017 | β |
| HIV and Cocaine Impact Glial Metabolism: Energy Sensor AMP-activated protein kinase Role in Mitochondrial Biogenesis and Epigenetic Remodeling. | Samikkannu T et al. | β | 2016 | β |
| A New Outlook on Mental Illnesses: Glial Involvement Beyond the Glue. | Elsayed M et al. | β | 2015 | β |
| Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine. | Sutton LP et al. | β | 2015 | β |
| Investigating the potential influence of cause of death and cocaine levels on the differential expression of genes associated with cocaine abuse. | Bannon MJ et al. | β | 2015 | β |
| CART in the brain of vertebrates: circuits, functions and evolution. | Subhedar NK et al. | β | 2014 | β |
| Chronic cocaine administration causes extensive white matter damage in brain: diffusion tensor imaging and immunohistochemistry studies. | Narayana PA et al. | β | 2014 | β |
| Cocaine-and-Amphetamine Regulated Transcript (CART) peptide attenuates dopamine- and cocaine-mediated locomotor activity in both male and female rats: lack of sex differences. | Job MO et al. | β | 2014 | β |
| Gene expression in the addicted brain. | Zhou Z et al. | β | 2014 | β |
| Glial modulators as potential treatments of psychostimulant abuse. | Beardsley PM et al. | β | 2014 | β |
| Regionally-specific alterations in myelin proteins in nonhuman primate white matter following prolonged cocaine self-administration. | Smith HR et al. | β | 2014 | β |
| Changes in microRNA expression profile in hippocampus during the acquisition and extinction of cocaine-induced conditioned place preference in rats. | Chen CL et al. | β | 2013 | β |
| The inhibition of cocaine-induced locomotor activity by CART 55-102 is lost after repeated cocaine administration. | Job MO et al. | β | 2013 | β |
| Global Approaches to the Role of miRNAs in Drug-Induced Changes in Gene Expression. | Eipper-Mains JE et al. | β | 2012 | β |
| Intra-accumbal administration of shRNAs against CART peptides cause increases in body weight and cocaine-induced locomotor activity in rats. | Job MO et al. | β | 2012 | β |
| Rapamycin attenuates the expression of cocaine-induced place preference and behavioral sensitization. | Bailey J et al. | β | 2012 | β |
| White matter microstructure in opiate addiction. | Bora E et al. | β | 2012 | β |
| Mass spectrometry screening reveals peptides modulated differentially in the medial prefrontal cortex of rats with disparate initial sensitivity to cocaine. | Romanova EV et al. | β | 2010 | β |
| Characterizing intercellular signaling peptides in drug addiction. | Romanova EV et al. | β | 2009 | β |
| Diffusion tensor imaging in cocaine dependence: regional effects of cocaine on corpus callosum and effect of cocaine administration route. | Ma L et al. | β | 2009 | β |
| Expression of transcripts for myelin related genes in postmortem brain from cocaine abusers. | Kristiansen LV et al. | β | 2009 | β |
| The Role of Glial Cells in Drug Abuse. | Miguel-Hidalgo JJ | β | 2009 | β |
| Correlating human and animal studies of cocaine abuse and gene expression. | Lull ME et al. | β | 2008 | β |
| Neuropeptidomics of the supraoptic rat nucleus. | Bora A et al. | β | 2008 | β |
| Parsing the Addiction Phenomenon: Self-Administration Procedures Modeling Enhanced Motivation for Drug and Escalation of Drug Intake. | Oleson EB et al. | β | 2008 | β |
| How to make a rat addicted to cocaine. | Roberts DC et al. | β | 2007 | β |
| Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. | Le-Niculescu H et al. | β | 2007 | β |
| Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. | Albertson DN et al. | β | 2006 | β |
| Widespread axonal damage in the brain of drug abusers as evidenced by accumulation of beta-amyloid precursor protein (beta-APP): an immunohistochemical investigation. | BΓΌttner A et al. | β | 2006 | β |