Cannabis Use is an Independent Risk Factor for Manic Episode: A Report from 380,265 Bipolar Inpatients.
- Authors
- Patel, Rikinkumar S; Cheema, Zainab; Singla, Ashima; Cornejo, Miglia; Verma, Geetika
- Year
- 2022
- Journal
- Substance use & misuse
- PMID
- 34895014
- DOI
- 10.1080/10826084.2021.2012690
OBJECTIVES: To evaluate the odds for bipolar disorder (BP) mania and depression-related hospitalization due to cannabis use disorders (CUD). METHODS: We conducted a cross-sectional study using the national inpatient sample (NIS), and included adult BP hospitalizations sub-grouped by manic (N = 209,785) versus depressive episodes (N = 170480). A logistic regression model was used to evaluate adjusted odds ratio (aOR) of association between CUD and BP-mania-related hospitalizations and was adjusted for demographics confounders, psychiatric comorbidities and other substance use disorders (SUD). RESULTS: Comorbidities were less prevalent in BP mania compared to BP depression: anxiety disorders (22.7% vs. 35.3%), PTSD (8.7% vs. 14.3%), and personality disorders (15.4% vs. 20.5%). Among SUD, methamphetamine (aOR 1.27, 95%CI 1.22 - 1.32) and CUD (aOR 1.53, 95%CI 1.50 - 1.56) had increased odds for hospitalization for BP mania. CONCLUSION: CUD increases the odds for hospitalization for BP manic episode by 53%. Due to the rising prevalence of cannabis use among patients with BP it is important to provide substance use counseling/psychoeducation and discourage cannabis use among youth to prevent long-term adverse consequences.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | 2023 | 37626487 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The highs and lows: Cannabis use and positive valence bipolar mood and emotion processes in emerging adults. | Rosa L et al. | — | 2026 | → |
| Cannabis use and mood disorders: a systematic review. | Sorkhou M et al. | — | 2024 | → |
| Herbal Cannabis and Depression: A Review of Findings Published over the Last Three Years. | Haller J | — | 2024 | → |
| A Prospective Comparison of Bipolar I and II Subjects with and without Comorbid Cannabis Use Disorders from the COGA Dataset. | Preuss UW et al. | — | 2023 | → |
| Tobacco and Cannabis Use During and After Pregnancy in California. | Azenkot T et al. | — | 2023 | → |
| Unhealthy behaviors associated with mental health disorders: a systematic comparative review of diet quality, sedentary behavior, and cannabis and tobacco use. | Johnstad PG | — | 2023 | → |