Familial pathways to early-onset suicidal behavior: familial and individual antecedents of suicidal behavior.
paper
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- Authors
- Melhem, Nadine M; Brent, David A; Ziegler, Melissa; Iyengar, Satish; Kolko, David; Oquendo, Maria; Birmaher, Boris; Burke, Ainsley; Zelazny, Jamie; Stanley, Barbara; Mann, J John
- Year
- 2007
- Journal
- The American journal of psychiatry
- PMID
- 17728421
- DOI
- 10.1176/appi.ajp.2007.06091522
- PMCID
- PMC3804909
OBJECTIVE: The authors sought to identify clinical predictors of new-onset suicidal behavior in children of parents with a history of mood disorder and suicidal behavior. METHOD: In a prospective study of offspring of parents with mood disorders, 365 offspring (average age, 20 years) of 203 parents were followed for up to 6 years. Offspring with incident suicide attempts or emergency referrals for suicidal ideation or behavior ("incident events") were compared with offspring without such events on demographic and clinical characteristics. Multivariate analyses were conducted to examine predictors of incident events and predictors of time to incident event. RESULTS: Offspring of probands who had made suicide attempts, compared with offspring of parents with mood disorders who had not made attempts, had a higher rate of incident suicide attempts (4.1% versus 0.6%, relative risk=6.5) as well as overall suicidal events (8.3% versus 1.9%, relative risk=4.4). Mood disorder and self-reported impulsive aggression in offspring and a history of sexual abuse and self-reported depression in parents predicted earlier time to, and greater hazard of, an incident suicidal event. CONCLUSIONS: In offspring of parents with mood disorders, precursors of early-onset suicidal behavior include mood disorder and impulsive aggression as well as parental history of suicide attempt, sexual abuse, and self-reported depression. These results suggest that efforts to prevent the familial transmission of early-onset suicidal behavior by targeting these domains could reduce the morbidity of suicidal behavior in high-risk youths.
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| Title | Year | PMID |
|---|---|---|
| Parent and child psychopathology and suicide attempts among children of parents with alcohol use disorder. | 2014 | 24716789 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Age matters: a narrative review and machine learning analysis on shared and separate multidimensional risk domains for early and late onset suicidal behavior. | Galfalvy H et al. | — | 2026 | → |
| Annual Research Review: Self-harm in young people. | Ougrin D et al. | — | 2026 | → |
| Generational effects in self-reported age of onset for youth suicidal ideation, self-harm and attempted suicide: A retrospective analysis using data from the Australian National Study of Mental Health and Wellbeing, 2020-2022. | Witt K et al. | — | 2026 | → |
| Proximal Risk of Suicide-Related Behavior in Black Youth With a Parental History of Mood Disorder. | Zelazny J et al. | — | 2026 | → |
| Characterizing facilitators of and barriers to suicide prevention program development and use: An exploratory study. | Hartman CL et al. | — | 2025 | → |
| Characterizing suicidal thoughts and behaviours in individuals presenting to a psychiatric emergency department: a protocol for a multimethod approach for suicide prevention research. | Baharikhoob P et al. | — | 2025 | → |
| Comprehensive view of suicide: A neuro-immune-endocrine approach. | Ponce-Regalado MD et al. | — | 2025 | → |
| Exploring the Lived Experiences of Iranian Adolescents Exhibiting Suicidal Behavior and Ideation. | Arbabi K et al. | — | 2025 | → |
| Multimodal Machine Learning Prediction of 12-Month Suicide Attempts in Bipolar Disorder. | Pigoni A et al. | — | 2025 | → |
| The lifetime prevalence and associated factors of suicidal ideation and suicide attempts among high school adolescents in Ethiopia: a systematic review and meta-analysis. | Tekeba B et al. | — | 2025 | → |
| Is Late-Onset Suicidal Behavior a Distinct Subtype? | Szanto K et al. | — | 2024 | → |
| Preschool-Onset Major Depressive Disorder as a Strong Predictor of Suicidal Ideation and Behaviors Into Preadolescence. | Hennefield L et al. | — | 2024 | → |
| The familial transmission of suicide and non-suicidal self-injury in different income levels in town. | Yu M et al. | — | 2024 | → |
| Cognitive and neuropsychiatric endophenotypes in amyotrophic lateral sclerosis. | Costello E et al. | — | 2023 | → |
| Impact of Parental Mental Health and Help-Seeking on Adolescents' Suicidal Ideations and Help-Seeking Behaviors. | Han J et al. | — | 2023 | → |
| Mapping the genetic architecture of suicide attempt and suicide death using polygenic risk scores for clinically-related psychiatric disorders and traits. | Otsuka I et al. | — | 2023 | → |
| Neurocognitive and clinical characteristics of elementary school-aged children with a history of suicidal thoughts and behaviors. | Chen Q et al. | — | 2023 | → |
| Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review. | Nguyen TML et al. | — | 2023 | → |
| Brain 5-HT1A Receptor PET Binding, Cortisol Responses to Stress, and the Familial Transmission of Suicidal Behavior. | Melhem NM et al. | — | 2022 | → |
| Opioid use as a proximal risk factor for suicidal behavior in young adults. | Marengo L et al. | — | 2022 | → |
| Sibling alcohol use disorder is associated with increased risk for suicide attempt. | Stephenson ME et al. | — | 2022 | → |
| Characteristics and Precipitating Circumstances of Suicide Among Children Aged 5 to 11 Years in the United States, 2013-2017. | Ruch DA et al. | — | 2021 | → |
| Clinical risk factors, emotional reactivity/regulation and suicidal ideation in elementary school-aged children. | Sheftall AH et al. | — | 2021 | → |
| Global DNA methylation in suicidal ideation and suicide attempt in schizophrenia. | Bani-Fatemi A et al. | — | 2021 | → |
| Parental Factors Related to Adolescent Girls' Suicide Attempts: A Cross-Sectional Study from 2015 to 2018. | Lee YJ et al. | — | 2021 | → |
| Risk factors for pre-adolescent onset suicidal behavior in a high-risk sample of youth. | Zelazny J et al. | — | 2021 | → |
| A Theory-Based Longitudinal Investigation Examining Predictors of Self-Harm in Adolescents With and Without Bereavement Experiences. | Del Carpio L et al. | — | 2020 | → |
| Differential Impact of Child Sexual Abuse and Family History of Suicidal Behavior in High-Risk Suicidal Patients. | Grendas LN et al. | — | 2020 | → |
| Emotion Regulation in Elementary School-Aged Children with a Maternal History of Suicidal Behavior: A Pilot Study. | Sheftall AH et al. | — | 2020 | → |
| Family Members' Perspectives on Family and Social Support Available to Suicidal Patients, and Health Systems' Interactions and Responses to Suicide Cases in Alberta: Protocol for a Quantitative Research Study. | Abou El-Magd RM et al. | — | 2020 | → |
| Psychosocial risk factors and outcomes associated with suicide attempts in childhood: A retrospective study. | Itzhaky L et al. | — | 2020 | → |
| Relative deprivation and suicide risk in South Korea. | Pak TY et al. | — | 2020 | → |
| Re-testing reported significant SNPs related to suicide in a historical high -risk isolated population from north east India. | Gupta G et al. | — | 2020 | → |
| Suicide, Self-Harm, & Traumatic Stress Exposure: A Trauma-Informed Approach to the Evaluation and Management of Suicide Risk. | Asarnow JR et al. | — | 2020 | → |
| The intergenerational transmission of suicidal behavior: an offspring of siblings study. | O'Reilly LM et al. | — | 2020 | → |
| Exposure to maternal depressive symptoms in childhood and suicide-related thoughts and attempts in Canadian youth: test of effect-modifying factors. | Goodday SM et al. | — | 2019 | → |
| Familial and social transmission of suicidal behavior in older adults. | Kenneally LB et al. | — | 2019 | → |
| Family Members' Perspectives of Health Care System Interactions With Suicidal Patients and Responses to Suicides: Protocol for a Qualitative Research Study. | Bryksa E et al. | — | 2019 | → |
| Fathers' alcohol use and suicidal behaviour in offspring during youth and young adulthood. | Landberg J et al. | — | 2019 | → |
| Genome-wide association studies identify polygenic effects for completed suicide in the Japanese population. | Otsuka I et al. | — | 2019 | → |
| Recent advances in understanding and managing self-harm in adolescents | Clarke S et al. | — | 2019 | — |
| Recent advances in understanding and managing self-harm in adolescents. | Clarke S et al. | — | 2019 | → |
| Severity and Variability of Depression Symptoms Predicting Suicide Attempt in High-Risk Individuals. | Melhem NM et al. | — | 2019 | → |
| Suicidal behaviors and irritability in children and adolescents: a systematic review of the nature and mechanisms of the association. | Benarous X et al. | — | 2019 | → |
| Suicidal subtypes, stress responsivity and impulsive aggression. | Stanley B et al. | — | 2019 | → |
| Suicidal thoughts and attempts in First Nations communities: links to parental Indian residential school attendance across development. | Bombay A et al. | — | 2019 | → |
| The role of substance use, smoking, and inflammation in risk for suicidal behavior. | Chang HB et al. | — | 2019 | → |
| Cultural Stigma Manifested in Official Suicide Death in South Korea. | Im JS et al. | — | 2018 | → |
| [Suicidal tendencies in adolescence : Dysfunctional familiar communication as risk factor]. | Radde S et al. | — | 2018 | → |
| Systematic Literature Review of Attempted Suicide and Offspring. | Lunde I et al. | — | 2018 | → |
| The influence of family factors on time to suicidal ideation onsets during the adolescent developmental period. | Oppenheimer CW et al. | — | 2018 | → |
| Animal models to improve our understanding and treatment of suicidal behavior. | Gould TD et al. | — | 2017 | → |
| Assessment of Whole-Exome Sequence Data in Attempted Suicide within a Bipolar Disorder Cohort. | Monson ET et al. | — | 2017 | → |
| Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters. | Melhem NM et al. | — | 2017 | → |
| Multiple tissue methylation analysis of HTR2A exon I in suicidal behavior. | Bani-Fatemi A et al. | — | 2017 | → |
| Positive and negative life events and reasons for living modulate suicidal ideation in a sample of patients with history of suicide attempts. | Laglaoui Bakhiyi C et al. | — | 2017 | → |
| Runs of homozygosity, copy number variation, and risk for depression and suicidal behavior in an Arab Bedouin kindred. | Melhem NM et al. | — | 2017 | → |
| The Life Span Model of Suicide and Its Neurobiological Foundation. | Ludwig B et al. | — | 2017 | → |
| Blunted HPA Axis Activity in Suicide Attempters Compared to those at High Risk for Suicidal Behavior. | Melhem NM et al. | — | 2016 | → |
| Differences between female suicidal patients with family history of suicide attempt and family history of completed suicide. | Rodante D et al. | — | 2016 | → |
| Effect of Socioeconomic Status on the Linkage Between Suicidal Ideation and Suicide Attempts. | Kim JL et al. | — | 2016 | → |
| GWAS analysis of suicide attempt in schizophrenia: Main genetic effect and interaction with early life trauma. | Bani-Fatemi A et al. | — | 2016 | → |
| Suicide and suicidal behaviour. | Turecki G et al. | — | 2016 | → |
| Familial pathways to early-onset suicide attempt: a 5.6-year prospective study. | Brent DA et al. | — | 2015 | → |
| How Illegal Drug Use, Alcohol Use, Tobacco Use, and Depressive Symptoms Affect Adolescent Suicidal Ideation: A Secondary Analysis of the 2011 Youth Risk Behavior Survey. | Gart R et al. | — | 2015 | → |
| MATERNAL EXPERIENCE OF ABUSE IN CHILDHOOD AND DEPRESSIVE SYMPTOMS IN ADOLESCENT AND ADULT OFFSPRING: A 21-YEAR LONGITUDINAL STUDY. | Roberts AL et al. | — | 2015 | → |
| Pathways to offspring suicidal behavior may begin with maternal suicide attempt. | Brent DA et al. | — | 2015 | → |
| Self-injurious implicit attitudes among adolescent suicide attempters versus those engaged in nonsuicidal self-injury. | Dickstein DP et al. | — | 2015 | → |
| Aggressiveness across development and suicidal behavior in depressed patients. | Carballo JJ et al. | — | 2014 | → |
| Association between parental psychopathology and suicidal behavior among adult offspring: results from the cross-sectional South African Stress and Health survey. | Atwoli L et al. | — | 2014 | → |
| Increased severity of suicidal behavior in impulsive aggressive patients exposed to familial adversities. | Lopez-Castroman J et al. | — | 2014 | → |
| Low plasma eicosapentaenoic acid levels are associated with elevated trait aggression and impulsivity in major depressive disorder with a history of comorbid substance use disorder. | Beier AM et al. | — | 2014 | → |
| Neuropsychological deficits in past suicide attempters with varying levels of depression severity. | Keilp JG et al. | — | 2014 | → |
| Parental suicide attempt and offspring self-harm and suicidal thoughts: Results from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort. | Geulayov G et al. | — | 2014 | → |
| Parent and child psychopathology and suicide attempts among children of parents with alcohol use disorder. | Conner KR et al. | — | 2014 | → |
| Psychological models of suicide. | Barzilay S et al. | — | 2014 | → |
| Reconsidering the link between impulsivity and suicidal behavior. | Anestis MD et al. | — | 2014 | → |
| Rising youth suicide and the changing cultural context in South Korea. | Park BC et al. | — | 2014 | → |
| Suicidal behaviors in adolescents with ADHD: associations with depressive and other comorbidity, parent-child conflict, trauma exposure, and impairment. | Daviss WB et al. | — | 2014 | → |
| Adolescents exposed to suicidal behavior of others: prevalence of self-harm and associated psychological, lifestyle, and life event factors. | McMahon EM et al. | — | 2013 | → |
| Affective temperament, history of suicide attempt and family history of suicide in general practice patients. | Rihmer Z et al. | — | 2013 | → |
| Differentiating Army suicide attempters from psychologically treated and untreated soldiers: a demographic, psychological and stress-reaction characterization. | Yacobi A et al. | — | 2013 | → |
| Familial transmission of parental mood disorders: unipolar and bipolar disorders in offspring. | Oquendo MA et al. | — | 2013 | → |
| Gender-specific factors of suicide ideation among adolescents in the Republic of Korea: a nationally representative population-based study. | Park S | — | 2013 | → |
| Intimate partner violence and incident depressive symptoms and suicide attempts: a systematic review of longitudinal studies. | Devries KM et al. | — | 2013 | → |
| Lithium, but not valproate, reduces impulsive choice in the delay-discounting task in mice. | Halcomb ME et al. | — | 2013 | → |
| Prevalence and risk factors for first onset of suicidal behaviors in the Netherlands Mental Health Survey and Incidence Study-2. | Ten Have M et al. | — | 2013 | → |
| Prospective predictors of adolescent suicidality: 6-month post-hospitalization follow-up. | Yen S et al. | — | 2013 | → |
| Serotonergic genes and suicide: a systematic review. | Antypa N et al. | — | 2013 | → |
| The serotonergic system in mood disorders and suicidal behaviour. | Mann JJ | — | 2013 | → |
| A genome-wide association study of attempted suicide. | Willour VL et al. | — | 2012 | → |
| Age of first suicide attempt in men and women: an admixture analysis. | Blasco-Fontecilla H et al. | — | 2012 | → |
| A life-course study on effects of parental markers of morbidity and mortality on offspring's suicide attempt. | Mittendorfer-Rutz E et al. | — | 2012 | → |
| A longitudinal study of nonsuicidal self-injury in offspring at high risk for mood disorder. | Cox LJ et al. | — | 2012 | → |
| Association study of serotonin pathway genes in attempted suicide. | Judy JT et al. | — | 2012 | → |
| Can we really prevent suicide? | Schwartz-Lifshitz M et al. | — | 2012 | → |
| Endophenotypes as a measure of suicidality. | Chistiakov DA et al. | — | 2012 | → |
| Familial and individual correlates of nonsuicidal self-injury in the offspring of mood-disordered parents. | Cox LJ et al. | — | 2012 | → |
| Number of childhood abuse perpetrators and the occurrence of depressive episodes in adulthood. | Liu RT et al. | — | 2012 | → |
| Protective factors and suicidality in members of Arab kindred. | Hamdan S et al. | — | 2012 | → |
| The association of parental fatal and non-fatal suicidal behaviour with offspring suicidal behaviour and depression: a systematic review and meta-analysis. | Geulayov G et al. | — | 2012 | → |
| The role of impulsivity in the relationship between anxiety and suicidal ideation. | Schaefer KE et al. | — | 2012 | → |
| Association study of EP1 gene polymorphisms with suicide completers in the Japanese population. | Cui H et al. | — | 2011 | → |
| Childhood exposure to caregiver suicidal behavior and risk for adult suicide attempts: findings from a national survey. | Spiwak R et al. | — | 2011 | → |
| Cognitive-behavioral therapy for adolescent depression and suicidality. | Spirito A et al. | — | 2011 | → |
| Developmental course of impulsivity and capability from age 10 to age 25 as related to trajectory of suicide attempt in a community cohort. | Kasen S et al. | — | 2011 | → |
| Is COPD associated with suicide behavior? | Goodwin RD | — | 2011 | → |
| Parental psychopathology and the risk of suicidal behavior in their offspring: results from the World Mental Health surveys. | Gureje O et al. | — | 2011 | → |
| Risk factors for suicide attempt in an Arab kindred. | Hamdan S et al. | — | 2011 | → |
| Risk for suicidal ideation among the offspring of bipolar parents: results from the Bipolar Offspring Study (BIOS). | Goldstein TR et al. | — | 2011 | → |
| The neuroscience of suicidal behaviors: what can we expect from endophenotype strategies? | Courtet P et al. | — | 2011 | → |
| Achieving adolescent adherence to treatment of major depression. | Staton D | — | 2010 | → |
| Case-control association study of TGOLN2 in attempted suicide. | Mahon PB et al. | — | 2010 | → |
| Pharmacogenomics of suicidal events. | Brent D et al. | — | 2010 | → |
| Suicide attempters' memory traces of exposure to suicidal behavior: a qualitative pilot study. | Ventrice D et al. | — | 2010 | → |
| The association of psychosocial and familial factors with adolescent suicidal ideation: A population-based study. | An H et al. | — | 2010 | → |
| What family studies teach us about suicidal behavior: implications for research, treatment, and prevention. | Brent D | — | 2010 | → |
| Adolescent suicide. | Bursztein C et al. | — | 2009 | → |
| Attitudes toward suicide: the effect of suicide death in the family. | Zhang J et al. | — | 2009 | → |
| Birth order: self-injurious and suicidal behaviour among adolescents. | Kirkcaldy B et al. | — | 2009 | → |
| Candidate endophenotypes for genetic studies of suicidal behavior. | Mann JJ et al. | — | 2009 | → |
| Characteristics of suicide attempters with family history of suicide attempt: a retrospective chart review. | Nakagawa M et al. | — | 2009 | → |
| Comprehending childhood bereavement by parental suicide: a critical review of research on outcomes, grief processes, and interventions. | Hung NC et al. | — | 2009 | → |
| Emotional intelligence is a protective factor for suicidal behavior. | Cha CB et al. | — | 2009 | → |
| Epidemiology of youth suicide and suicidal behavior. | Cash SJ et al. | — | 2009 | → |
| Family history of suicidal behavior predicts impulsive-aggressive behavior levels in psychiatric outpatients. | Diaconu G et al. | — | 2009 | → |
| Family history of suicide: a clinical marker for major depression in primary care practice? | Torzsa P et al. | — | 2009 | → |
| In search of endophenotypes for suicidal behavior. | Brent D | — | 2009 | → |
| Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategies. | Kovacsics CE et al. | — | 2009 | → |
| Personality and attempted suicide. Analysis of anger, aggression and impulsivity. | Giegling I et al. | — | 2009 | → |
| Predicting deliberate self-harm in adolescents: a six month prospective study. | O'Connor RC et al. | — | 2009 | → |
| Self-harm in adolescents: self-report survey in schools in Scotland. | O'Connor RC et al. | — | 2009 | → |
| Building models for the relationship between attitudes toward suicide and suicidal behavior: based on data from general population surveys in Sweden, Norway, and Russia. | Renberg ES et al. | — | 2008 | → |
| Familial transmission of suicidal behavior. | Brent DA et al. | — | 2008 | → |
| Interaction of child and family psychopathology leading to suicidal behavior. | Zalsman G et al. | — | 2008 | → |