Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.
paper
Cited
Public
Unavailable
- Authors
- Oddo, Salvatore; Caccamo, Antonella; Shepherd, Jason D; Murphy, M Paul; Golde, Todd E; Kayed, Rakez; Metherate, Raju; Mattson, Mark P; Akbari, Yama; LaFerla, Frank M
- Year
- 2003
- Journal
- Neuron
- PMID
- 12895417
- DOI
- 10.1016/s0896-6273(03)00434-3
The neuropathological correlates of Alzheimer's disease (AD) include amyloid-beta (Abeta) plaques and neurofibrillary tangles. To study the interaction between Abeta and tau and their effect on synaptic function, we derived a triple-transgenic model (3xTg-AD) harboring PS1(M146V), APP(Swe), and tau(P301L) transgenes. Rather than crossing independent lines, we microinjected two transgenes into single-cell embryos from homozygous PS1(M146V) knockin mice, generating mice with the same genetic background. 3xTg-AD mice progressively develop plaques and tangles. Synaptic dysfunction, including LTP deficits, manifests in an age-related manner, but before plaque and tangle pathology. Deficits in long-term synaptic plasticity correlate with the accumulation of intraneuronal Abeta. These studies suggest a novel pathogenic role for intraneuronal Abeta with regards to synaptic plasticity. The recapitulation of salient features of AD in these mice clarifies the relationships between Abeta, synaptic dysfunction, and tangles and provides a valuable model for evaluating potential AD therapeutics as the impact on both lesions can be assessed.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? | 2018 | 29897633 |
| Transgenic mouse models of Alzheimer's disease. | 2010 | 20101721 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| A compound enhancing lysosomal function reduces tau pathology, microglial reactivity and rescues working memory in 3xTg AD mice. | Mayeri Z et al. | β | 2026 | β |
| A distinct tau oligomer strain defines the molecular and proteomic landscape of rapidly progressive Alzheimer's disease. | Saleem T et al. | β | 2026 | β |
| Alzheimer's Pathology Enhances Excitatory Synaptic Input and Integration in VTA Dopamine Neurons. | Blankenship HE et al. | β | 2026 | β |
| Amyloid neuropathy, tauopathy, decreased cholinergic and dopaminergic neurons, long-term memory and motor deficits, and sleep disturbance in motopsin deficient mice. | Yokoi F et al. | β | 2026 | β |
| Animal Models of Alzheimer's Disease Evaluated with [<sup>11</sup>C]Pittsburg Compound B. | Burgos-Puentes S et al. | β | 2026 | β |
| APP Induces AICD-Mediated Autophagy-Dependent Axon Degeneration. | Luo J et al. | β | 2026 | β |
| A Question of Origins: Non-neuronal Sources of Amyloid-Ξ². | Sasmita AO et al. | β | 2026 | β |
| Association between FDG- and TSPO-PET signals across human and animal studies investigating neurodegenerative conditions: a systematic review. | Machado LS et al. | β | 2026 | β |
| Astrocyte-Specific Nrf2 Expression Transforms Neurotoxic Reactive Astrocytes to Neuroprotective Phenotype in 3xTg-AD Mice. | Guo S et al. | β | 2026 | β |
| AΞ² antibodies target not only amyloid plaques but also distinct brain cells and vessels. | Wen G et al. | β | 2026 | β |
| Comprehensive single-cell transcriptomic atlas of microglia in Alzheimer's disease mouse models. | Liu P et al. | β | 2026 | β |
| Decoding Alzheimer's Disease One Cell Class at a Time. | Darvas M et al. | β | 2026 | β |
| Decoding the mechanisms of amyloid-Ξ² in synaptic toxicity. | ToruΕski P et al. | β | 2026 | β |
| Design, synthesis, and characterization of F-18 sigma-1 receptor radiotracers for Alzheimer disease. | Jiang H et al. | β | 2026 | β |
| Diffusion MRI measures detect brain microstructure changes due to early treatment with neurotrophic peptide mimetic P021 in the 3xTg-AD mouse model of Alzheimer's disease. | Falangola MF et al. | β | 2026 | β |
| Effects of different dietary restriction regimens on cognitive function and pathological markers in Alzheimer's disease mouse models: A systematic review and meta-analysis. | Sun L et al. | β | 2026 | β |
| Efficacy and Safety of Lithium for Behavioral and Cognitive Symptoms in Alzheimer's Disease Dementia: A Systematic Review With Frequentist and Bayesian Meta-Analysis. | Pereira da Silva AM et al. | β | 2026 | β |
| Electrocorticographic, astrocytic and transcriptomic signatures in the triple transgenic mouse model of Alzheimer's disease submitted to stearoyl-CoA desaturase inhibition. | Hector A et al. | β | 2026 | β |
| Enhanced avoidance learning associated with elevated anxiety in the 3xTg-AD mouse model of Alzheimer's disease. | Dos Santos JR et al. | β | 2026 | β |
| Exercise ameliorates microglial activation and cognitive impairment induced by GFAT1 knockdown after traumatic brain injury. | Zai T et al. | β | 2026 | β |
| Experimental and translational models of Alzheimer's disease: From neurodegeneration to novel therapeutic insights. | Khan N et al. | β | 2026 | β |
| Extracellular amyloid-Ξ²<sub>42</sub> oligomers alter endo-lysosomal trafficking of Rab7- and Lamp-1-coated vesicles in cultured neuroblastoma cells. | Mendoza-Franco G et al. | β | 2026 | β |
| Fine motor function deficits in the 5xFAD mouse model of Alzheimer's disease. | Valiantis S et al. | β | 2026 | β |
| Ganglioside sialylation modulates tau internalization and pathology spread. | Li S et al. | β | 2026 | β |
| Gastrodin alleviates mitochondrial energy metabolism dysfunction via activating Ξ²-catenin/c-Myc/MCT2 signaling in Alzheimer's disease models. | Lei HP et al. | β | 2026 | β |
| IL-1Ξ² neutralization ameliorates cognitive deficits and tau pathology in a mouse model of Alzheimer's disease with hyperhomocysteinemia. | Zhao Y et al. | β | 2026 | β |
| Inactive ryanodine receptors sustain lysosomal availability for autophagy by promoting ER-lysosomal contact site formation. | Vervliet T et al. | β | 2026 | β |
| Isoflurane Exposure Influence on Sleep Architecture in a Rat Model of Alzheimer's Disease. | Kreuzer M et al. | β | 2026 | β |
| Lithium-Charged Gold Nanoparticles: A New Powerful Tool for Lithium Delivery and Modulation of Glycogen Synthase Kinase 3 Activity. | Buonerba A et al. | β | 2026 | β |
| Long-term NRF2-driven microglial repopulation mitigates microgliosis, neuronal loss and cognitive deficits in tauopathy. | Viqueira L et al. | β | 2026 | β |
| Long-term thiethylperazine treatment in the Tg4-42 mouse model of Alzheimer's disease mouse: Therapeutic potential vs. adverse effects. | Ruoff LK et al. | β | 2026 | β |
| Low concentrations of amyloid-beta oligomers induce synaptogenesis characteristic for mild cognitive impairment and alter the de novo proteome. | Wu K et al. | β | 2026 | β |
| Medium-chain triglycerides improve cognition and systemic metabolism in mouse models of Alzheimer's disease. | M'Bra PEH et al. | β | 2026 | β |
| Metabolic insights into the 3xTg-AD Alzheimer model mice: Unraveling the hypothalamic-pituitary-thyroid axis and beyond. | SzabΓ³ A et al. | β | 2026 | β |
| Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid-Ξ² and Tau. | Xu YJ et al. | β | 2026 | β |
| Neck Vascular Biomechanical Dysfunction Precedes Brain Biochemical Alterations in a Murine Model of Alzheimer's Disease. | Jones AR et al. | β | 2026 | β |
| Novel drug treatments for schizophrenia. | Coyle JT et al. | β | 2026 | β |
| Photostimulation of locus coeruleus CA1 catecholaminergic terminals reversed Spatial memory impairment in an alzheimer's disease mouse model. | GΓ‘lvez-MΓ‘rquez DK et al. | β | 2026 | β |
| Physical exercise mitigates motor and muscular deficits in the 3xTg-AD model of Alzheimer's disease. | Andrade-Guerrero J et al. | β | 2026 | β |
| Polygonatum Sibiricum polysaccharide ameliorates Alzheimer's disease by alleviating cuproptosis and activating the PI3K/AKT signaling pathway. | Wang S et al. | β | 2026 | β |
| Pretangle tau pathology accrual in the default mode network during the progression of Alzheimer's disease. | Kara B et al. | β | 2026 | β |
| Restoration neurite growth by removing the blockage of endosome trafficking in Alzheimer-like mice. | Zhao H et al. | β | 2026 | β |
| RNA-binding activity of PHGDH drives amyloid-beta production in a human brain organoid model of sporadic Alzheimer's disease. | Chen J et al. | β | 2026 | β |
| Salvianolic acid a inhibits neuroinflammation and ameliorates Alzheimer's disease pathology via the p38 MAPK/NF-ΞΊB pathway based on network pharmacology and experimental validation. | Xiao S et al. | β | 2026 | β |
| Sigma-1 receptor positive allosteric modulator promotes neuronal survival and improves cognitive deficits in AD mice via sigma-1 receptor/ERK pathway. | Wang XY et al. | β | 2026 | β |
| Spinal cord Tau pathology induces tactile deficits and cognitive impairment in Alzheimer's disease via dysregulation of CCK neurons. | Zhou Y et al. | β | 2026 | β |
| Targeting cholinergic cells in a mouse model of Alzheimer's disease: Validating a quadruple transgenic model. | Farkas S et al. | β | 2026 | β |
| The 3xTg-AD Mouse Model of Alzheimer's Disease Exhibits Lifelong Reductions in Circulating Choline Despite Adequate Dietary Intake, With Sex-Specific Neuropathological and Behavioral Phenotypes. | Judd JM et al. | β | 2026 | β |
| Therapeutic nanoliposome vaccine targeting multiple AΞ² and tau epitopes reduces AD-like brain pathologies and rescues cognitive deficits in 3xTg-AD mice. | Dai CL et al. | β | 2026 | β |
| Abnormal calcium activity and CREB phosphorylation are associated with motor memory impairment in presenilin-1 mutant knock-in mice. | Lin Y et al. | β | 2025 | β |
| Acarbose ameliorates Western diet-induced metabolic and cognitive impairments in the 3xTg mouse model of Alzheimer's disease. | Sonsalla MM et al. | β | 2025 | β |
| A Comprehensive Review on Preclinical Alzheimer's Disease Models: Evaluating their Clinical Relevance. | Kushwaha V et al. | β | 2025 | β |
| Adiponectin Receptor Agonist Ameliorates Synaptic Dysfunction in 3xTg Alzheimer's Disease Mouse Model by Activation of AMPK. | Bloemer J et al. | β | 2025 | β |
| Adolescent Alcohol and the Spectrum of Cognitive Dysfunction in Aging. | Deak T et al. | β | 2025 | β |
| Adult hippocampal neurogenesis: New avenues for treatment of brain disorders. | Chen L et al. | β | 2025 | β |
| Advancement in modeling of Alzheimer's disease: a comprehensive review of preclinical screening platforms. | Adak S et al. | β | 2025 | β |
| Alcohol consumption in P301S mice accelerates gait impairments, modifies aggregation of pathological tau and alters microglia within the hippocampus. | Maphis NM et al. | β | 2025 | β |
| Alzheimer's Disease and Frontotemporal Dementia: A Review of Pathophysiology and Therapeutic Approaches. | Kelliny S et al. | β | 2025 | β |
| Alzheimer's disease as an auto-innate immune pathology with potential cell trans-differentiation and enhanced trained immunity in 3xTg-AD mouse model. | Saaoud F et al. | β | 2025 | β |
| Alzheimer's Disease-Associated Amyloid-Ξ² Precursor Protein Prevents Aging Stress-Induced Mitophagy and Fumarate Depletion to Improve Antitumor Immunity. | Kassir MF et al. | β | 2025 | β |
| Ambroxol confers neuroprotection against scopolamine-induced Alzheimer's-like pathology by modulating oxidative stress, neuroinflammation, and cognitive deficits via Nrf-2/JNK/GSK-3Ξ² signaling pathways. | Ahmad W et al. | β | 2025 | β |
| A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus. | Ash AM et al. | β | 2025 | β |
| Amyloid precursor protein and presenilin-1 knock-in immunodeficient mice exhibit intraneuronal AΞ² pathology, microgliosis, and extensive neuronal loss. | Yeapuri P et al. | β | 2025 | β |
| Androgens Regulate Tau Phosphorylation Through Phosphatidylinositol 3-Kinase-Protein Kinase B-Glycogen Synthase Kinase 3Ξ² Signaling. | Yao M et al. | β | 2025 | β |
| Animal Models for the Study of Neurological Diseases and Their Link to Sleep. | Rubio C et al. | β | 2025 | β |
| Anle138b binds predominantly to the central cavity in lipidic AΞ²ββ fibrils and modulates fibril formation. | Han M et al. | β | 2025 | β |
| An orally administered quinolinium molecule mitigates neuropathology of Alzheimer's disease through modulation of mitochondrial dysfunction and neuroinflammation. | He J et al. | β | 2025 | β |
| Antibiotic-Induced Gut Dysbiosis Modulates Alzheimer's Disease-Associated Gene Expression and Protein Aggregation in 3xTg-AD Mice via the Gut-Brain Axis. | Tettevi EJ et al. | β | 2025 | β |
| An update on mammalian and non-mammalian animal models for biomarker development in neurodegenerative disorders. | Mishra R et al. | β | 2025 | β |
| APP Ξ²-CTF triggers cell-autonomous synaptic toxicity independent of AΞ². | Luo M et al. | β | 2025 | β |
| Asparagine endopeptidase (AEP) inhibitor formulation via zein-based nanoparticle improves the therapeutic efficacy toward Alzheimer's disease. | Meng X et al. | β | 2025 | β |
| AΞ²-driven nuclear pore complex dysfunction alters activation of necroptosis proteins in a mouse model of Alzheimer's disease. | Bansal VA et al. | β | 2025 | β |
| Beyond the brain: early autonomic dysfunction in Alzheimer's disease. | Nanclares C et al. | β | 2025 | β |
| Beyond Transgenic Mice: Emerging Models and Translational Strategies in Alzheimer's Disease. | Alexandra Lopes P et al. | β | 2025 | β |
| Blockade of A<sub>2A</sub>R improved brain perfusion and cognitive function in a mouse model of Alzheimer's disease. | Udo MSB et al. | β | 2025 | β |
| Bone marrow-derived myeloid cells drive neuroinflammation in Alzheimer's disease: Insights from the FAD<sup>4T</sup> mouse model. | Pang Y et al. | β | 2025 | β |
| Buyang Huanwu Decoction Modulates the Gut Microbiota-C/EBPΞ²/AEP Axis to Ameliorate Cognitive Impairment in Alzheimer's Disease Mice. | Liang J et al. | β | 2025 | β |
| CD103<sup>-</sup>CD8<sup>+</sup> T cells promote neurotoxic inflammation in Alzheimer's disease via granzyme K-PAR-1 signaling. | Terrabuio E et al. | β | 2025 | β |
| Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars. | Kshirsagar S et al. | β | 2025 | β |
| Cerebrovascular alterations in a mouse model of late-onset Alzheimer's disease. | Crouzet C et al. | β | 2025 | β |
| Circadian Clocks, Daily Stress, and Neurodegenerative Disease. | Nyamugenda E et al. | β | 2025 | β |
| CNEURO-201, an Anti-amyloidogenic Agent and Ο1-Receptor Agonist, Improves Cognition in the <i>3xTg</i> Mouse Model of Alzheimer's Disease by Multiple Actions in the Pathology. | MartΓnez-Orozco H et al. | β | 2025 | β |
| CNS muscarinic receptors and muscarinic receptor agonists in Alzheimer disease treatment. | Fisher A et al. | β | 2025 | β |
| Cognitive improvement via cortical cannabinoid receptors and choline-containing lipids. | Moreno-RodrΓguez M et al. | β | 2025 | β |
| Comparative Investigation of the Retinal Phenotype of Three Mouse Models of Alzheimer's Disease With Optical Coherence Tomography. | Ladurner G et al. | β | 2025 | β |
| Cornuside alleviates cognitive impairments induced by AΞ²<sub>1-42</sub> through attenuating NLRP3-mediated neurotoxicity by promoting mitophagy. | Zhou F et al. | β | 2025 | β |
| Cortical Bone Loss and Fragility in a 2-Month Triple Transgenic Mouse Model of Alzheimer's Disease. | Storlino G et al. | β | 2025 | β |
| Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer's disease-associated proteopathology. | Xie L et al. | β | 2025 | β |
| Dietary salt, vascular dysfunction, and cognitive impairment. | Faraco G | β | 2025 | β |
| Diffusion MRI in 2-Month-Old Mouse Brain Predicts Alzheimer's Pathology Genotype. | Falangola MF et al. | β | 2025 | β |
| Discovery of FO-4-15, a novel 1,2,4-oxadiazole derivative, ameliorates cognitive impairments in 3ΓTg mice by activating the mGluR1/CaMKIIΞ± pathway. | Luo ZH et al. | β | 2025 | β |
| Disorganized hippocampal excitatory and inhibitory connectivity in a mouse model of Alzheimer's disease. | Ito T et al. | β | 2025 | β |
| Disruption of hnRNP A2-mediated RNA dynamics by amyloid-Ξ² drives MBP increase in Alzheimer's disease. | Gaminde-Blasco A et al. | β | 2025 | β |
| Early involvement of D-serine in Ξ²-amyloid-dependent pathophysiology. | Billard JM et al. | β | 2025 | β |
| Early Oral Administration of D-Chiro-Inositol Reverses Hippocampal Insulin and Glutamate Signaling Deficits in the 3ΓTg Humanized Mouse Model of Alzheimer's Disease. | Pacheco-SΓ‘nchez B et al. | β | 2025 | β |
| Electrophysiological insights into Alzheimer's disease: A review of human and animal studies. | Calvin-Dunn KN et al. | β | 2025 | β |
| Epitranscriptomic dysregulation in neurodegenerative diseases and its implications for disease pathology and mechanisms. | Shafik AM et al. | β | 2025 | β |
| Erebosis of Neurons May Exist in the Brain with Alzheimer's Disease. | Li J et al. | β | 2025 | β |
| Evaluation of altered cell-cell communication between glia and neurons in the hippocampus of 3xTg-AD mice at two time points. | Soelter TM et al. | β | 2025 | β |
| Executive dysfunction is associated with altered hippocampal-prefrontal functional connectivity in 3xTg Alzheimer's model mice. | Cunliffe G et al. | β | 2025 | β |
| Experimental modeling for tauopathies: An isogenic panel of humanized MAPT knock-in mice. | Morito T et al. | β | 2025 | β |
| Exploring the Interconnections of Genetic, Lifestyle, and Epigenetic Influences on Brain Aging: A Comprehensive Review. | Mehrabadi S et al. | β | 2025 | β |
| Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer's disease. | Babygirija R et al. | β | 2025 | β |
| Female 3xTg-AD mice demonstrate hyperexcitability phenotype of Alzheimer's disease in structure-function and function-behavior relationships. | Wang ηεζ‘ Z et al. | β | 2025 | β |
| Focused ultrasound-induced blood-brain barrier opening promotes glioprotective phenotypes in ACSA-II+ murine astrocytes. | Noel RL et al. | β | 2025 | β |
| From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae. | Ferreira-Junior JR et al. | β | 2025 | β |
| Gene-dose-dependent reduction of Fshr expression improves spatial memory deficits in Alzheimer's mice. | Korkmaz F et al. | β | 2025 | β |
| Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia: New Insights from Single-Cell and Spatial Transcriptomics. | Chiu Y et al. | β | 2025 | β |
| Genotype and microbiome shape immunity in a sex-specific manner in mouse models of Alzheimer's disease. | Bostick JW et al. | β | 2025 | β |
| Glial cells are involved in day-night protein dysregulation in the hippocampus of a mouse model of Alzheimer's disease. | Badina AM et al. | β | 2025 | β |
| Gonadal hormones contribute to sex differences in behavior, pathology and epigenetic modifications in the 3ΓTg-AD mouse model of Alzheimer's disease. | Song W et al. | β | 2025 | β |
| Hampered AMPK-ULK1 cascade in Alzheimer's disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin. | Mary A et al. | β | 2025 | β |
| Harnessing team science in dementia research: Insights from the Alzheimer's disease research group in South Carolina. | Akter S et al. | β | 2025 | β |
| Highly efficient prime editors for mammalian genome editing based on porcine retrovirus reverse transcriptase. | Liu W et al. | β | 2025 | β |
| HSP110 is a modulator of amyloid beta (AΞ²) aggregation and proteotoxicity. | Montresor S et al. | β | 2025 | β |
| Human and Mouse Alzheimer's Seeds Differentially Affect Amyloid Deposition and Microglia-Dependent Plaque Response in Aged Mice. | Andreo-Lopez J et al. | β | 2025 | β |
| Human and mouse proteomics reveals the shared pathways in Alzheimer's disease and delayed protein turnover in the amyloidome. | Yarbro JM et al. | β | 2025 | β |
| Human tau promotes Warburg effect-like glycolytic metabolism under acute hyperglycemia conditions. | Yao J et al. | β | 2025 | β |
| Hyperphosphorylated Tau Induces Cortical Hypoexcitability in Transgenic Mouse Models: A Meta-Analysis. | GarcΓa-Carlos CA et al. | β | 2025 | β |
| Inhibition of PDE4B ameliorates cognitive defects in the model of alcoholic dementia in 3xTg-AD mice via PDE4B/cAMP/PKA signaling. | Sun R et al. | β | 2025 | β |
| Inhibition of the GSK3Ξ²/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability. | Baumgartner TJ et al. | β | 2025 | β |
| Integrating neuroinflammation biomarkers into the ATN(X) framework: Advances in Alzheimer's pathogenesis, diagnosis, and insights from non-human primate models. | Jin Z et al. | β | 2025 | β |
| Interactions with tau's microtubule-binding repeats modulate amyloid-Ξ² aggregation and toxicity. | Kim M et al. | β | 2025 | β |
| In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds. | Watamura N et al. | β | 2025 | β |
| In Vivo Seeding of Amyloid-Ξ² Protein and Implications in Modeling Alzheimer's Disease Pathology. | Liu Q et al. | β | 2025 | β |
| IRF1 ameliorates synaptic dysfunction through the modulation of O-GlcNAcylation on GluN1 subunit of NMDAR. | Fan X et al. | β | 2025 | β |
| Ketone body metabolism and the NLRP3 inflammasome in Alzheimer's disease. | Shippy DC et al. | β | 2025 | β |
| Knowing the enemy: strategic targeting of complement to treat Alzheimer disease. | Tenner AJ et al. | β | 2025 | β |
| Limitations and Applications of Rodent Models in Tauopathy and Synucleinopathy Research. | Szegvari E et al. | β | 2025 | β |
| Lithium deficiency and the onset of Alzheimer's disease. | Aron L et al. | β | 2025 | β |
| Longitudinal Evaluation of the Detection Potential of Serum Oligoelements Cu, Se and Zn for the Diagnosis of Alzheimer's Disease in the 3xTg-AD Animal Model. | Dias OFM et al. | β | 2025 | β |
| Loss of lysosomal acid lipase contributes to Alzheimer's disease pathology and cognitive decline. | Barnett AM et al. | β | 2025 | β |
| Medium-chain triglycerides and ketogenic diet prevent alterations of the gut microbiome in transgenic Alzheimer's disease mice. | M'Bra PEH et al. | β | 2025 | β |
| Microbial Composition, Disease Trajectory and Genetic Background in a Slow Onset Model of Frontotemporal Lobar Degeneration. | Daude N et al. | β | 2025 | β |
| Microglial Drivers of Alzheimer's Disease Pathology: AnΒ Evolution of Diverse Participating States. | Kuhn MK et al. | β | 2025 | β |
| Mid-life exposure to chronic stress accelerates cerebrovascular dysfunction and upregulates oxidative stress in Alzheimer's disease mice. | Prabhu SS et al. | β | 2025 | β |
| Modeling Alzheimer's Disease: A Review of Gene-Modified and Induced Animal Models, Complex Cell Culture Models, and Computational Modeling. | Timofeeva AM et al. | β | 2025 | β |
| Molecular pathogenesis of Alzheimer's disease onset in a mouse model: effects of cannabidiol treatment. | Bishara MA et al. | β | 2025 | β |
| Monitoring Acidification Preceding AΞ² Deposition in Alzheimer's Disease. | Zhu G et al. | β | 2025 | β |
| Mouse models of Anti-AΞ² immunotherapies. | Pikus P et al. | β | 2025 | β |
| Multi-Target Inhibitor of ZJQ- 3βF Against AChE/BACE1/GSK3Ξ² Targets Improves the Cognitive Impairment of APP/PS1/Tau Triple-Transgenic Mouse Models of Alzheimer's Disease. | Wang N et al. | β | 2025 | β |
| Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition. | Saternos HC et al. | β | 2025 | β |
| N6-methyladenosine RNA modification regulates microglial phagocytosis in the APP/PS1 mouse model of Alzheimer's disease. | Qu X et al. | β | 2025 | β |
| Nanobody Therapeutics in Alzheimer's Disease: From Molecular Mechanisms to Translational Approaches. | Godugu D et al. | β | 2025 | β |
| Nanomedicine: A New Frontier in Alzheimer's Disease Drug Targeting. | Pathak K et al. | β | 2025 | β |
| Neurodegenerative Diseases: Pathogenesis and Preclinical Models for Translational Drug Discovery. | Fusaro L et al. | β | 2025 | β |
| Neuroglia in neurodegeneration: Alzheimer, Parkinson, and Huntington disease. | Lim D et al. | β | 2025 | β |
| Neuroinflammatory chemokine networks in transgenic models of Alzheimer's disease: A comparative multi-compartmental analysis. | Sun Y et al. | β | 2025 | β |
| Neuroinflammatory mechanisms linking high-fat diets to Alzheimer's disease vulnerability: Beyond the amyloid hypothesis. | Mackey-Alfonso SE et al. | β | 2025 | β |
| Neuron-Astrocyte Interactions in Aging and Alzheimer's Disease: Dysregulation of Amyloid Precursor Protein. | JΓ‘uregui GV et al. | β | 2025 | β |
| Neuroprotective Effects of Dehydroepiandrosterone Sulphate Against AΞ² Toxicity and Accumulation in Cellular and Animal Model of Alzheimer's Disease. | Vuic B et al. | β | 2025 | β |
| Neurotrophic factor-Ξ±1/carboxypeptidase E regulates critical protein networks to rescue neurodegeneration, defective synaptogenesis and impaired autophagy in Alzheimer's disease mice. | Xiao L et al. | β | 2025 | β |
| New progress on the role and mechanism of tau protein in Alzheimer's disease and depression. | Wang Y et al. | β | 2025 | β |
| Organelle perturbation in Alzheimer's disease: do intracellular amyloid-Γ and the fragmented Golgi mediate early intracellular neurotoxicity? | Fourriere L et al. | β | 2025 | β |
| Ovariectomy attenuates phenotypes related to Alzheimer's disease in a preclinical mouse model and in C57BL/6 J mice. | Fujii K et al. | β | 2025 | β |
| Oxidative Stress in HIV-Associated Neurodegeneration: Mechanisms of Pathogenesis and Therapeutic Targets. | Gagliardi S et al. | β | 2025 | β |
| Perimenopausal state oestradiol to progesterone imbalance drives Alzheimer's risk via ERRΞ± dysregulation and energy dyshomeostasis. | Sun JK et al. | β | 2025 | β |
| Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology. | Vegas-Gomez L et al. | β | 2025 | β |
| Photobiomodulation therapy increases neural stem cell pool in aged 3xTg-AD mice. | Johnson KJ et al. | β | 2025 | β |
| PI(3)P coordinates SNX17- and SNX27-dependent protein recycling for long-term synaptic plasticity. | Rivero-RΓos P et al. | β | 2025 | β |
| Potential Benefits of Quercetin through P2X7 Modulation against Neuroinflammation in Alzheimer's Disease. | Bianchini MC et al. | β | 2025 | β |
| Preclinical insights into gamma-tACS: foundations for clinical translation in neurodegenerative diseases. | SΓ‘nchez-Garrido Campos G et al. | β | 2025 | β |
| Proteomic and non-proteomic changes of presynaptic proteins in animal models of Alzheimer's disease: A meta-analysis 2015-2023. | Anschuetz A et al. | β | 2025 | β |
| Proteomic landscape of Alzheimer's disease: emerging technologies, advances and insights (2021 - 2025). | Yarbro JM et al. | β | 2025 | β |
| Proteomic Profiling Reveals Mitochondrial Dysregulation in Rapidly Progressive Alzheimer's: Role of DLDH in Amyloid Beta Aggregation. | Zafar S et al. | β | 2025 | β |
| Qifuyin alleviates anxiety and depression in 3ΓTg-AD mice by modulating neuroendocrine function. | Yu T et al. | β | 2025 | β |
| Rebalancing Immune Interactions within the Brain-Spleen Axis Mitigates Neuroinflammation in an Aging Mouse Model of Alzheimer's Disease. | Cantone AF et al. | β | 2025 | β |
| Reduction of Neuroinflammation as a Common Mechanism of Action of Anorexigenic and Orexigenic Peptide Analogues in the Triple Transgenic Mouse Model of AlzheimerΒ΄s Disease. | Mengr A et al. | β | 2025 | β |
| Regulation of non-emotional memory through Ξ±<sub>1</sub>-adrenergic receptors activation: A short review. | de Barros EC | β | 2025 | β |
| Research models to study lewy body dementia. | Boschen SL et al. | β | 2025 | β |
| Retinal degeneration driven by brain-derived neurotrophic factor deficiency in microglia and T-lymphocytes. | Reinehr S et al. | β | 2025 | β |
| Rewired m6A of promoter antisense RNAs in Alzheimer's disease regulates neuronal genes in 3D nucleome. | Hu B et al. | β | 2025 | β |
| Rhynchophylline alleviates cognitive deficits in multiple transgenic mouse models of Alzheimer's disease via modulating neuropathology and gut microbiota. | Zhong M et al. | β | 2025 | β |
| Robust Increase in IQCK Protein Expression in Mouse Models of Alzheimer's Disease and iPSC-Derived Neurons. | Akkaoui J et al. | β | 2025 | β |
| Rodent models of Alzheimer's disease: Critical analysis of current hypotheses and pathways for future research. | Singhaarachchi PH et al. | β | 2025 | β |
| Ryanodex Reduces Persistent Hippocampal Effects of Single Mild Traumatic Brain Injury in Rats. | Berlet R et al. | β | 2025 | β |
| Schisandra total lignans ameliorate neuronal ferroptosis in 3xTg-AD mice via regulating NADK/NADPH/GSH pathway. | Wu Y et al. | β | 2025 | β |
| SENP6 Maintains Mitochondrial Homeostasis by Regulating Mitochondrial Protein Import Through deSUMOylation of TOM40. | Hu L et al. | β | 2025 | β |
| Sleep fragmentation impairs cognitive function and exacerbates Alzheimer's disease-related pathology in a mouse model by disrupting mitochondrial biogenesis. | Liu S et al. | β | 2025 | β |
| Splenomegaly, Spleen Amyloidosis and Neutrophil Infiltration are Present in 3xTg-AD, but not Tg-SwDI Mice. | Acero G et al. | β | 2025 | β |
| Spontaneous mammalian models for Alzheimer's disease and dementia. | Ford M et al. | β | 2025 | β |
| Structures and functions of the MICOS: Pathogenesis and therapeutic implications in Alzheimer's disease. | Wang Z et al. | β | 2025 | β |
| Sub-Immunosuppressive Tacrolimus Ameliorates Amyloid-Beta and Tau Pathology in 3xTg-AD Mice. | Silva J et al. | β | 2025 | β |
| Targeting mitophagy in neurodegenerative diseases. | Antico O et al. | β | 2025 | β |
| Targeting Neural Oscillations for Cognitive Enhancement in Alzheimer's Disease. | Palacino F et al. | β | 2025 | β |
| The Impact of Biological Sex And High-Fat High-Fructose Diet on Brain Dysfunction in an Animal Model of Sepsis. | Vieira A et al. | β | 2025 | β |
| The Multifaceted Role of Neuroprotectin D1: Physiological, Pathophysiological, and Pharmacological Insights in Neurodegenerative Diseases. | Zia B et al. | β | 2025 | β |
| The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease. | Antonioni A et al. | β | 2025 | β |
| The pathophysiology of mixed Alzheimer's disease and vascular dementia. | Sarhan M et al. | β | 2025 | β |
| Therapeutic promise of Ξ±-hederin in Alzheimer's disease: Insights into inflammation, oxidative stress, and apoptosis modulation. | Chettupalli AK et al. | β | 2025 | β |
| The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer's disease. | Sha X et al. | β | 2025 | β |
| Triple-Target Inhibition of Cholinesterase, Amyloid Aggregation, and GSK3Ξ² to Ameliorate Cognitive Deficits and Neuropathology in the Triple-Transgenic Mouse Model of Alzheimer's Disease. | He J et al. | β | 2025 | β |
| Troriluzole rescues glutamatergic deficits, amyloid and tau pathology, and synaptic and memory impairments in 3xTg-AD mice. | Pfitzer J et al. | β | 2025 | β |
| TSPO contributes to neuropathology and cognitive deficits in Alzheimer's disease. | CeyzΓ©riat K et al. | β | 2025 | β |
| Twenty years of therapeutic development in tauopathy mouse models: a scoping review. | Langness VF et al. | β | 2025 | β |
| UHPLC-Q Exactive-Orbitrap-MS and network pharmacology analyses to investigate the mechanism by which Danggui-Shaoyao-San affects 27-OHC-induced cell damage in SH-SY5Y/C6 coculture. | Huang Y et al. | β | 2025 | β |
| Understanding Tau pathology: Insights from animal models. | Zhang H et al. | β | 2025 | β |
| Water-directed pinning is key to tau prion formation. | Vigers MP et al. | β | 2025 | β |
| A Combination of Heavy Metals and Intracellular Pathway Modulators Induces Alzheimer Disease-like Pathologies in Organotypic Brain Slices. | Korde DS et al. | β | 2024 | β |
| Advancing Alzheimer's Disease Modelling by Developing a Refined Biomimetic Brain Microenvironment for Facilitating High-Throughput Screening of Pharmacological Treatment Strategies. | Mohd Murshid N et al. | β | 2024 | β |
| Age- and sex-associated alterations in hypothalamic mitochondrial bioenergetics and inflammatory-associated signaling in the 3xTg mouse model of Alzheimer's disease. | Adlimoghaddam A et al. | β | 2024 | β |
| Age-associated temporal decline in butyrate-producing bacteria plays a key pathogenic role in the onset and progression of neuropathology and memory deficits in 3ΓTg-AD mice. | Chilton PM et al. | β | 2024 | β |
| Age-dependent impact of streptozotocin on metabolic endpoints and Alzheimer's disease pathologies in 3xTg-AD mice. | Canet G et al. | β | 2024 | β |
| Age, sex and Alzheimer's disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer's patients. | Barber AJ et al. | β | 2024 | β |
| Akt-activated GSK3Ξ² inhibitory peptide effectively blocks tau hyperphosphorylation. | Lee E et al. | β | 2024 | β |
| Alcohol Use Disorder and Dementia: A Review. | Zahr NM | β | 2024 | β |
| Altered firing output of VIP interneurons and early dysfunctions in CA1 hippocampal circuits in the 3xTg mouse model of Alzheimer's disease. | Michaud F et al. | β | 2024 | β |
| Altered neuronal group 1 metabotropic glutamate receptor- and endoplasmic reticulum-mediated Ca<sup>2+</sup> signaling in two rodent models of Alzheimer's disease. | Kaar A et al. | β | 2024 | β |
| Aluminum chloride and D-galactose induced a zebrafish model of Alzheimer's disease with cognitive deficits and aging. | Luo L et al. | β | 2024 | β |
| Alzheimer's Disease as a Membrane Dysfunction Tauopathy? New Insights into the Amyloid Cascade Hypothesis. | Olejar T et al. | β | 2024 | β |
| Alzheimer's Disease: Cellular and Pharmacological Aspects. | Aranda-Abreu GE et al. | β | 2024 | β |
| Alzheimer's Disease from Modeling to Mechanism Research. | Sun X et al. | β | 2024 | β |
| Amino Acid Transporters Proteins Involved in the Glutamate-Glutamine Cycle and Their Alterations in Murine Models of Alzheimer's Disease. | VΓ‘zquez-DurΓ‘n DL et al. | β | 2024 | β |
| A modified deep learning method for Alzheimer's disease detection based on the facial submicroscopic features in mice. | Shen G et al. | β | 2024 | β |
| An emerging role for the gut microbiome in tauopathy. | Zhu Y et al. | β | 2024 | β |
| Animal models of Alzheimer's disease: Current strategies and new directions. | Wang Q et al. | β | 2024 | β |
| Another Use for a Proven Drug: Experimental Evidence for the Potential of Artemisinin and Its Derivatives to Treat Alzheimer's Disease. | Kiss E et al. | β | 2024 | β |
| A pentavalent peptide vaccine elicits AΞ² and tau antibodies with prophylactic activity in an Alzheimer's disease mouse model. | Song Y et al. | β | 2024 | β |
| Astrocyte S100Ξ² expression and selective differentiation to GFAP and GS in the entorhinal cortex during ageing in the 3xTg-Alzheimer's disease mouse model. | RodrΓguez JJ et al. | β | 2024 | β |
| Astrocytic centrin-2 expression in entorhinal cortex correlates with Alzheimer's disease severity. | Degl'Innocenti E et al. | β | 2024 | β |
| Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice. | Romero-Molina C et al. | β | 2024 | β |
| Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease. | Marshall JPS et al. | β | 2024 | β |
| Can exercise benefits be harnessed with drugs? A new way to combat neurodegenerative diseases by boosting neurogenesis. | Zhao R | β | 2024 | β |
| Cellular prion protein acts as mediator of amyloid beta uptake by caveolin-1 causing cellular dysfunctions in vitro and in vivo. | da Silva Correia A et al. | β | 2024 | β |
| Central inhibition of stearoyl-CoA desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer's disease mouse model. | Hamilton LK et al. | β | 2024 | β |
| Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum. | Kebschull JM et al. | β | 2024 | β |
| Cerebrovascular Dysfunction in Alzheimer's Disease and Transgenic Rodent Models. | Fang X et al. | β | 2024 | β |
| Cerebrovascular miRNAs Track Early Development of Alzheimer's Disease and Target Molecular Markers of Angiogenesis and Blood Flow Regulation. | Chum PP et al. | β | 2024 | β |
| Characterization of gut microbiota dynamics in an Alzheimer's disease mouse model through clade-specific marker-based analysis of shotgun metagenomic data. | Favero F et al. | β | 2024 | β |
| Chemical Probes Review: Choosing the Right Path Towards Pharmacological Targets in Drug Discovery, Challenges and Future Perspectives. | Ahuja A et al. | β | 2024 | β |
| Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice. | Zhang N et al. | β | 2024 | β |
| Chronic inflammation with microglia senescence at basal forebrain: impact on cholinergic deficit in Alzheimer's brain haemodynamics. | Liu D et al. | β | 2024 | β |
| Clathrin mediated endocytosis in Alzheimer's disease: cell type specific involvement in amyloid beta pathology. | Jaye S et al. | β | 2024 | β |
| Cognitive trajectories in longitudinally trained 3xTg-AD mice. | Duggan MR et al. | β | 2024 | β |
| Combining supervised and unsupervised analyses to quantify behavioral phenotypes and validate therapeutic efficacy in a triple transgenic mouse model of Alzheimer's disease. | Del Rosario Hernandez T et al. | β | 2024 | β |
| Consequences of Amyloid-Ξ² Deficiency for the Liver. | Buniatian GH et al. | β | 2024 | β |
| Dementia exacerbates periodontal bone loss in females. | Yamada C et al. | β | 2024 | β |
| Differential impact of eicosapentaenoic acid and docosahexaenoic acid in an animal model of Alzheimer's disease. | Oye Mintsa Mi-Mba MF et al. | β | 2024 | β |
| Differential involvement of central and peripheral catecholamines between Alzheimer's disease and vascular dementia. | Hong XY et al. | β | 2024 | β |
| Disease Modifying Monoclonal Antibodies and Symptomatic Pharmacological Treatment for Alzheimer's Disease. | Qi X et al. | β | 2024 | β |
| Disentangling tau: One protein, many therapeutic approaches. | Lane-Donovan C et al. | β | 2024 | β |
| Disruption of sphingomyelin synthase 2 gene alleviates cognitive impairment in a mouse model of Alzheimer's disease. | Uchiumi O et al. | β | 2024 | β |
| Early hippocampal hyperexcitability and synaptic reorganization in mouse models of amyloidosis. | Ray A et al. | β | 2024 | β |
| Early-Onset Hearing Loss in Mouse Models of Alzheimer's Disease and Increased DNA Damage in the Cochlea. | Park JH et al. | β | 2024 | β |
| Early oxidative stress and DNA damage in AΞ²-burdened hippocampal neurons in an Alzheimer's-like transgenic rat model. | Foret MK et al. | β | 2024 | β |
| Early PSA-NCAM reduction in the dentate gyrus and impaired plasticity in the AlzheimerΒ΄s disease 3xTg-mice model. | RodrΓguez JJ et al. | β | 2024 | β |
| Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer's Disease: A Systematic Review and Meta-analysis of Preclinical Studies. | Cai J et al. | β | 2024 | β |
| Effect of recurrent severe insulin-induced hypoglycemia on the cognitive function and brain oxidative status in the rats. | Nikpendar M et al. | β | 2024 | β |
| Effects and mechanisms of APP and its cleavage product AΞ² in the comorbidity of sarcopenia and Alzheimer's disease. | Wu J et al. | β | 2024 | β |
| Emerging role of Metformin in Alzheimer's disease: A translational view. | RΓos JA et al. | β | 2024 | β |
| Endoplasmic reticulum stress and its role in various neurodegenerative diseases. | Singh R et al. | β | 2024 | β |
| Enhanced hippocampal TIAM2S expression alleviates cognitive deficits in Alzheimer's disease model mice. | Sung KC et al. | β | 2024 | β |
| Enhanced prefrontal nicotinic signaling as evidence of active compensation in Alzheimer's disease models. | Power SK et al. | β | 2024 | β |
| Esketamine induces tripartite motif-containing protein 24 to improve cognitive dysfunction in Alzheimer's disease. | Tu Y et al. | β | 2024 | β |
| Exploring Dimethylsulfoniopropionate as a potential treatment for Alzheimer's disease: A study using the 3 Γ Tg-AD mouse model. | Sun F et al. | β | 2024 | β |
| Exploring the role of mitochondrial uncoupling protein 4 in brain metabolism: implications for Alzheimer's disease. | Crivelli SM et al. | β | 2024 | β |
| Food Finding Test without Deprivation: A Sensorial Paradigm Sensitive to Sex, Genotype, and Isolation Shows Signatures of Derangements in Old Mice with Alzheimer's Disease Pathology and Normal Aging. | MarΓn-Pardo D et al. | β | 2024 | β |
| GeneβDoseβDependent Reduction Fshr Expression Improves Spatial Memory Deficits in Alzheimerβs Mice | Frolinger T et al. | β | 2024 | β |
| Genetic deletion of astrocytic calcineurin B1 prevents cognitive impairment and neuropathology development in acute and chronic mouse models of Alzheimer's disease. | Tapella L et al. | β | 2024 | β |
| Glomerular Hypertrophy and Splenic Red Pulp Degeneration Concurrent with Oxidative Stress in 3xTg-AD Mice Model for Alzheimer's Disease and Its Exacerbation with Sex and Social Isolation. | Fraile-Ramos J et al. | β | 2024 | β |
| Higher Neuronal Facilitation and Potentiation with APOE4 Suppressed by Angiotensin II. | Scheinman SB et al. | β | 2024 | β |
| High-Fat Diets in Animal Models of Alzheimer's Disease: How Can Eating Too Much Fat Increase Alzheimer's Disease Risk? | Valentin-Escalera J et al. | β | 2024 | β |
| Hippocampal hyperphosphorylated tau-induced deficiency is rescued by L-type calcium channel blockade. | Crossley CA et al. | β | 2024 | β |
| Human stem cell transplantation models of Alzheimer's disease. | Ifediora N et al. | β | 2024 | β |
| Increased Cerebral Level of P2X7R in a Tauopathy Mouse Model by PET Using [<sup>18</sup>F]GSK1482160. | Kong Y et al. | β | 2024 | β |
| Induced pluripotent stem cell models as a tool to investigate and test fluid biomarkers in Alzheimer's disease and frontotemporal dementia. | McInvale JJ et al. | β | 2024 | β |
| Inhibition of the mitochondrial pyruvate carrier in astrocytes reduces amyloid and tau accumulation in the 3xTgAD mouse model of Alzheimer's disease. | CeyzΓ©riat K et al. | β | 2024 | β |
| Insights on the Use of Transgenic Mice Models in Alzheimer's Disease Research. | PΓ‘dua MS et al. | β | 2024 | β |
| Integrative analysis of microRNA-mediated mitochondrial dysfunction in hippocampal neural progenitor cell death in relation with Alzheimer's disease. | Han AR et al. | β | 2024 | β |
| Integrative multi-omic analysis reveals conserved cell-projection deficits in human Down syndrome brains. | Rastogi M et al. | β | 2024 | β |
| Investigating metabolic dysregulation in serum of triple transgenic Alzheimer's disease male mice: implications for pathogenesis and potential biomarkers. | Zhuang H et al. | β | 2024 | β |
| Ketogenic diet and BHB rescue the fall of long-term potentiation in an Alzheimer's mouse model and stimulates synaptic plasticity pathway enzymes. | Di Lucente J et al. | β | 2024 | β |
| Lithium Ions as Modulators of Complex Biological Processes: The Conundrum of Multiple Targets, Responsiveness and Non-Responsiveness, and the Potential to Prevent or Correct Dysregulation of Systems during Aging and in Disease. | Hart DA | β | 2024 | β |
| Lost in translation: Inconvenient truths on the utility of mouse models in Alzheimer's disease research. | Granzotto A et al. | β | 2024 | β |
| LRRC25 expression during physiological aging and in mouse models of Alzheimer's disease and iPSC-derived neurons. | Devadoss D et al. | β | 2024 | β |
| Mean KΓ€rger Model Water Exchange Rate in Brain. | Jensen JH et al. | β | 2024 | β |
| Memantine: Updating a rare success story in pro-cognitive therapeutics. | Karimi Tari P et al. | β | 2024 | β |
| Mitochondrial Dysfunction: A Key Player in Brain Aging and Diseases. | Bartman S et al. | β | 2024 | β |
| Modeling sporadic Alzheimer's disease in mice by combining Apolipoprotein E4 risk gene with environmental risk factors. | Ganesan K et al. | β | 2024 | β |
| Modifying reaction time tasks parameters in the automated IntelliCage identifies heightened impulsivity and impaired attention in the 3xTg-AD model of Alzheimer's disease. | Judd JM et al. | β | 2024 | β |
| Modulation of hippocampal protein expression by a brain penetrant biologic TNF-Ξ± inhibitor in the 3xTg Alzheimer's disease mice. | Jagadeesan N et al. | β | 2024 | β |
| Myricetin ameliorates cognitive impairment in 3ΓTg Alzheimer's disease mice by regulating oxidative stress and tau hyperphosphorylation. | Wang L et al. | β | 2024 | β |
| Navigating Alzheimer's Disease Mouse Models: Age-Related Pathology and Cognitive Deficits. | De Plano LM et al. | β | 2024 | β |
| Neural stem cells promote neuroplasticity: a promising therapeutic strategy for the treatment of Alzheimer's disease. | Chang J et al. | β | 2024 | β |
| Neurobiological mechanisms of electroconvulsive therapy for depression: Insights into hippocampal volumetric increases from clinical and preclinical studies. | Abe Y et al. | β | 2024 | β |
| Neuroprotective effects of cerebroprotein hydrolysate and its combination with antioxidants against oxidative stress-induced HT22 cell death. | Yang EJ et al. | β | 2024 | β |
| Neurotoxic Microglial Activation via IFNΞ³-Induced Nrf2 Reduction Exacerbating Alzheimer's Disease. | Kang YJ et al. | β | 2024 | β |
| NRF2 Deficiency Promotes Ferroptosis of Astrocytes Mediated by Oxidative Stress in Alzheimer's Disease. | Tang Z et al. | β | 2024 | β |
| OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives. | SΓ‘nchez-Puebla L et al. | β | 2024 | β |
| Oligodendrocyte Dysfunction in Tauopathy: A Less Explored Area in Tau-Mediated Neurodegeneration. | Majumder M et al. | β | 2024 | β |
| Oligomeric amyloid-Ξ² targeted contrast agent for MRI evaluation of Alzheimer's disease mouse models. | Park JW et al. | β | 2024 | β |
| Optogenetic and chemogenetic approaches for modeling neurological disorders in vivo. | Krut' VG et al. | β | 2024 | β |
| Paradoxical attenuation of early amyloid-induced cognitive impairment and synaptic plasticity in an aged APP/Tau bigenic rat model. | Emmerson JT et al. | β | 2024 | β |
| Pathophysiologic abnormalities in transgenic mice carrying the Alzheimer disease PSEN1 Ξ440 mutation. | Fuller PE et al. | β | 2024 | β |
| Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade. | Li L et al. | β | 2024 | β |
| Performance of SOBA-AD blood test in discriminating Alzheimer's disease patients from cognitively unimpaired controls in two independent cohorts. | Chen A et al. | β | 2024 | β |
| Pharmacological enhancement of cholinergic neurotransmission alleviates neuroinflammation and improves functional outcomes in a triple transgenic mouse model of Alzheimer's disease. | MunafΓ² A et al. | β | 2024 | β |
| Pharmacological inhibition of PLK2 kinase activity mitigates cognitive decline but aggravates APP pathology in a sex-dependent manner in APP/PS1 mouse model of Alzheimer's disease. | MartΓnez-Drudis L et al. | β | 2024 | β |
| Physcion Mitigates LPS-Induced Neuroinflammation, Oxidative Stress, and Memory Impairments via TLR-4/NF-ΠΊB Signaling in Adult Mice. | Ahmad S et al. | β | 2024 | β |
| Prodromic Inflammatory-Oxidative Stress in Peritoneal Leukocytes of Triple-Transgenic Mice for Alzheimer's Disease. | CepriΓ‘n N et al. | β | 2024 | β |
| Profiling the neuroimmune cascade in 3xTg-AD mice exposed to successive mild traumatic brain injuries. | Pybus AF et al. | β | 2024 | β |
| Protein arginine methyltransferase 4 modulates nitric oxide synthase uncoupling and cerebral blood flow in Alzheimer's disease. | Clemons GA et al. | β | 2024 | β |
| Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer's disease. | Babygirija R et al. | β | 2024 | β |
| Relationship Between Reactive Astrocytes, by [<sup>18</sup>F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer's Disease. | Kong Y et al. | β | 2024 | β |
| Rodent Models of Alzheimer's Disease: Past Misconceptions and Future Prospects. | Collins HM et al. | β | 2024 | β |
| RyR2-dependent modulation of neuronal hyperactivity: A potential therapeutic target for treating Alzheimer's disease. | Yao J et al. | β | 2024 | β |
| Selective Orexin 2 Receptor Blockade Alleviates Cognitive Impairments and the Pathological Progression of Alzheimer's Disease in 3xTg-AD Mice. | Hu XH et al. | β | 2024 | β |
| Senescence Targeting Methods Impact Alzheimer's Disease Features in 3xTg Mice. | Ng PY et al. | β | 2024 | β |
| Sex and Gender Differences in Alzheimer's Disease: Genetic, Hormonal, and Inflammation Impacts. | Kolahchi Z et al. | β | 2024 | β |
| Shaping the future of preclinical development of successful disease-modifying drugs against Alzheimer's disease: a systematic review of tau propagation models. | Basheer N et al. | β | 2024 | β |
| Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications. | Facchin S et al. | β | 2024 | β |
| Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a mouse model of Alzheimer's disease. | Mackey-Alfonso SE et al. | β | 2024 | β |
| SIK1 Downregulates Synaptic AMPA Receptors and Contributes to Cognitive Defects in Alzheimer's Disease. | Hou Q et al. | β | 2024 | β |
| Slowing Alzheimer's disease progression through probiotic supplementation. | Medeiros D et al. | β | 2024 | β |
| Spatiotemporal development of the neuronal accumulation of amyloid precursor protein and the amyloid plaque formation in the brain of 3xTg-AD mice. | Ono M et al. | β | 2024 | β |
| SSK1-Loaded Neurotransmitter-Derived Nanoparticles for Alzheimer's Disease Therapy via Clearance of Senescent Cells. | Ji W et al. | β | 2024 | β |
| Stable ubiquitin conjugation for biological interrogation of ubiquitinated tau repeat domain. | Viola G et al. | β | 2024 | β |
| Systemic Treatment with siRNA Targeting Gamma-Secretase Activating Protein Inhibits Amyloid-Ξ² Accumulation in Alzheimer's Disease. | Kim S et al. | β | 2024 | β |
| Targeting Iron Responsive Elements (IREs) of APP mRNA into Novel Therapeutics to Control the Translation of Amyloid-Ξ² Precursor Protein in Alzheimer's Disease. | Khan MA | β | 2024 | β |
| Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss. | Lei HY et al. | β | 2024 | β |
| Tau induces inflammasome activation and microgliosis through acetylating NLRP3. | Zhang L et al. | β | 2024 | β |
| Tau Protein and Tauopathies: Exploring Tau Protein-Protein and Microtubule Interactions, Cross-Interactions and Therapeutic Strategies. | Di Lorenzo D | β | 2024 | β |
| The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer's disease. | Vaillant-Beuchot L et al. | β | 2024 | β |
| The changes of peripheral blood hub genes in 24-week-old APP/PS1/Tau triple transgenic mouse model based on weighted gene co-expression network analysis. | Liu H et al. | β | 2024 | β |
| The duality of amyloid-Ξ²: its role in normal and Alzheimer's disease states. | Azargoonjahromi A | β | 2024 | β |
| The microtubule-dynamin binding inhibitor peptide PHDP5 rescues spatial learning and memory deficits in Alzheimer's disease model mice. | Chang CJ et al. | β | 2024 | β |
| Therapeutic Effects of AΞ²-Specific Regulatory T Cells in Alzheimer's Disease: A Study in 5xFAD Mice. | Park SY et al. | β | 2024 | β |
| Therapeutic Targets in Innate Immunity to Tackle Alzheimer's Disease. | Serradas ML et al. | β | 2024 | β |
| The relationship between intraoperative hypothermia and postoperative delirium: The PNDRFAP study. | Wang J et al. | β | 2024 | β |
| Thermoneutral temperature exposure enhances slow-wave sleep with a correlated improvement in amyloid pathology in a triple-transgenic mouse model of Alzheimer's disease. | Wang J et al. | β | 2024 | β |
| The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms. | Yu Y et al. | β | 2024 | β |
| The role of PI3K signaling pathway in Alzheimer's disease. | Pan J et al. | β | 2024 | β |
| The role of the FKBP51-Hsp90 complex in Alzheimer's disease: An emerging new drug target. | Jeanne X et al. | β | 2024 | β |
| The synergistic effect of curcumin and mitoquinol mesylate on cognitive impairment and the neuropathology of Alzheimer's disease. | Xie Y et al. | β | 2024 | β |
| Thy1-ApoE4/C/EBPΞ² double transgenic mice act as a sporadic model with Alzheimer's disease. | Qian Z et al. | β | 2024 | β |
| Top 100 most-cited articles on tau protein: a bibliometric analysis and evidence mapping. | Chen Z et al. | β | 2024 | β |
| Transgenic amyloid precursor protein mouse models of amyloidosis. Incomplete models for Alzheimer's disease but effective predictors of anti-amyloid therapies. | Morgan DG et al. | β | 2024 | β |
| Unveiling biomarker detection in Alzheimer's disease: a computational approach to microarray analysis. | Khan NS et al. | β | 2024 | β |
| Updates in Alzheimer's disease: from basic research to diagnosis and therapies. | Liu E et al. | β | 2024 | β |
| Updates on mouse models of Alzheimer's disease. | Zhong MZ et al. | β | 2024 | β |
| Use and Reuse of Animal Behavioral, Molecular, and Biochemical Data in Alzheimer's Disease Research: Focus on 3Rs and Saving People's Tax Dollars. | Islam MA et al. | β | 2024 | β |
| Use of Ordered Beta Regression Unveils Cognitive Flexibility Index and Longitudinal Cognitive Training Signatures in Normal and Alzheimer's Disease Pathological Aging. | Alveal-Mellado D et al. | β | 2024 | β |
| Voluntary wheel running decreases amyloidogenic pathway and rescues cognition and mitochondrial energy metabolism in middle-aged female 3xTg-AD mouse model of Alzheimer's disease. | Dos Santos JR et al. | β | 2024 | β |
| VTA dopamine neurons are hyperexcitable in 3xTg-AD mice due to casein kinase 2-dependent SK channel dysfunction. | Blankenship HE et al. | β | 2024 | β |
| What <i>N</i> Is N-ough for MRI-Based Animal Neuroimaging? | Grandjean J et al. | β | 2024 | β |
| Ξ²-Amyloids and Immune Responses Associated with Alzheimer's Disease. | Kolobova E et al. | β | 2024 | β |
| Aberrant Expression of GABA-Related Genes in the Hippocampus of 3xTg-AD Model Mice from the Early to End Stages of Alzheimer's Disease. | Mori H et al. | β | 2023 | β |
| Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease. | Li YD et al. | β | 2023 | β |
| ADAM10- and Ξ³-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease. | Liu S et al. | β | 2023 | β |
| Adeno-associated virus (AAV) 9-mediated gene delivery of Nurr1 and Foxa2 ameliorates symptoms and pathologies of Alzheimer disease model mice by suppressing neuro-inflammation and glial pathology. | Yang Y et al. | β | 2023 | β |
| Administration of recombinant FOXN1 protein attenuates Alzheimer's pathology in mice. | Zhao J et al. | β | 2023 | β |
| Advance in Neurotoxicity Research from Development to Aging. | Cutuli D et al. | β | 2023 | β |
| A Functional Pipeline of Genome-Wide Association Data Leads to Midostaurin as a Repurposed Drug for Alzheimer's Disease. | Esteban-Martos A et al. | β | 2023 | β |
| A Gain-of-function Mutation in the Gating Domain of ITPR1 Impairs Motor Movement and Increases Thermal and Mechanical Sensitivity. | Yao J et al. | β | 2023 | β |
| A History of Repeated Alcohol Intoxication Promotes Cognitive Impairment and Gene Expression Signatures of Disease Progression in the 3xTg Mouse Model of Alzheimer's Disease. | Sanna PP et al. | β | 2023 | β |
| Alteration of Cognitive Function in Aging and Alzheimer's Disease Mice Is Related to Dysfunction of the Neuroimmune System. | Jiang WR et al. | β | 2023 | β |
| Alterations of Spatial Memory and Gut Microbiota Composition in Alzheimer's Disease Triple-Transgenic Mice at 3, 6, and 9 Months of Age. | Wei Z et al. | β | 2023 | β |
| Altered circadian behavior and light sensing in mouse models of Alzheimer's disease. | Weigel TK et al. | β | 2023 | β |
| Amyloid Ξ²-based therapy for Alzheimer's disease: challenges, successes and future. | Zhang Y et al. | β | 2023 | β |
| A neurodegeneration checkpoint mediated by REST protects against the onset of Alzheimer's disease. | Aron L et al. | β | 2023 | β |
| An inhibitor with GSK3Ξ² and DYRK1A dual inhibitory properties reduces Tau hyperphosphorylation and ameliorates disease in models of Alzheimer's disease. | Liu X et al. | β | 2023 | β |
| Anti-Amyloid Therapies for Alzheimer's Disease and the Amyloid Cascade Hypothesis. | Fedele E | β | 2023 | β |
| Anxiety and Alzheimer's disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models. | Reyna NC et al. | β | 2023 | β |
| A Perspective on the Link between Mitochondria-Associated Membranes (MAMs) and Lipid Droplets Metabolism in Neurodegenerative Diseases. | Fernandes T et al. | β | 2023 | β |
| Assessment of complementary white matter microstructural changes and grey matter atrophy in a preclinical model of Alzheimer's disease. | Bergamino M et al. | β | 2023 | β |
| Association between CSF biomarkers of Alzheimer's disease and neuropsychiatric symptoms: Mayo Clinic Study of Aging. | Krell-Roesch J et al. | β | 2023 | β |
| A Stable Micellar Formulation of RAD001 for Intracerebroventricular Delivery and the Treatment of Alzheimer's Disease and Other Neurological Disorders. | Gianessi L et al. | β | 2023 | β |
| Asymmetric dysregulation of glutamate dynamics across the synaptic cleft in a mouse model of Alzheimer's disease. | Brymer KJ et al. | β | 2023 | β |
| AΞ²1-6<sub>A2V</sub>(D) peptide, effective on AΞ² aggregation, inhibits tau misfolding and protects the brain after traumatic brain injury. | Diomede L et al. | β | 2023 | β |
| AΞ²-oligomers: A potential therapeutic target for Alzheimer's disease. | Ghosh S et al. | β | 2023 | β |
| Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-ΞΊB pathway in a triple transgenic mouse model. | Xie XM et al. | β | 2023 | β |
| Beyond animal models: revolutionizing neurodegenerative disease modeling using 3D in vitro organoids, microfluidic chips, and bioprinting. | Teli P et al. | β | 2023 | β |
| Bioinformatics analysis and prediction of Alzheimer's disease and alcohol dependence based on Ferroptosis-related genes. | Tian M et al. | β | 2023 | β |
| Brain Hydrophobic Peptides Antagonists of Neurotoxic Amyloid Ξ² Peptide Monomers/Oligomers-Protein Interactions. | Gutierrez-Merino C | β | 2023 | β |
| Brain-neuron targeted nanoparticles for peptide synergy therapy at dual-target of Alzheimer's disease. | Guo Q et al. | β | 2023 | β |
| Casein Kinase 1Ξ΄ Phosphorylates TDP-43 and Suppresses Its Function in Tau mRNA Processing. | Yang M et al. | β | 2023 | β |
| Cerebrovascular insulin receptors are defective in Alzheimer's disease. | Leclerc M et al. | β | 2023 | β |
| CNTN1 Aggravates Neuroinflammation and Triggers Cognitive Deficits in Male Mice by Boosting Crosstalk between Microglia and Astrocytes. | Li SJ et al. | β | 2023 | β |
| Comparative phytochemical studies on the roots of Polygala azizsancarii and P. peshmenii and neuroprotective activities of the two xanthones. | ΓalΔ±Ε Δ° et al. | β | 2023 | β |
| Comparison of Frailty and Chronological Age as Determinants of the Murine Gut Microbiota in an Alzheimer's Disease Mouse Model. | Kapphan LM et al. | β | 2023 | β |
| Comparison of two types of microscopic diffusion anisotropy in mouse brain. | Jensen JH et al. | β | 2023 | β |
| Comparison of Yizhiqingxin formula extraction methods and their pharmacodynamic differences. | Wei W et al. | β | 2023 | β |
| Compensatory remodeling of a septo-hippocampal GABAergic network in the triple transgenic Alzheimer's mouse model. | Wander CM et al. | β | 2023 | β |
| Complement in the Brain: Contributions to Neuroprotection, Neuronal Plasticity, and Neuroinflammation. | Bohlson SS et al. | β | 2023 | β |
| Computationally Designed Small Molecules Disassemble Both Soluble Oligomers and Protofibrils of Amyloid Ξ²-Protein Responsible for Alzheimer's Disease. | Jin Y et al. | β | 2023 | β |
| Critical thinking of Alzheimer's transgenic mouse model: current research and future perspective. | Li X et al. | β | 2023 | β |
| Current State of Modeling Human Psychiatric Disorders Using Zebrafish. | Costa FV et al. | β | 2023 | β |
| Depression-related phenotypes at early stages of AΞ² and tau accumulation in inducible Alzheimer's disease mouse model: Task-oriented and concept-driven interpretations. | Leyder E et al. | β | 2023 | β |
| Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2-<i>b</i>]pyridazines as Glycogen Synthase Kinase-3Ξ² (GSK-3Ξ²) Inhibitors. | Hartz RA et al. | β | 2023 | β |
| Differential roles of regulatory T cells in Alzheimer's disease. | Jafarzadeh A et al. | β | 2023 | β |
| Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. | Hartz RA et al. | β | 2023 | β |
| Does modulation of tau hyperphosphorylation represent a reasonable therapeutic strategy for Alzheimer's disease? From preclinical studies to the clinical trials. | Basheer N et al. | β | 2023 | β |
| Dual role of nitric oxide in Alzheimer's disease. | Azargoonjahromi A | β | 2023 | β |
| Early postnatal defects in neurogenesis in the 3xTg mouse model of Alzheimer's disease. | Liu Y et al. | β | 2023 | β |
| Effects of diverse Types of Toxoplasma gondii on the outcome of Alzheimer's disease in the rat model. | Galeh TM et al. | β | 2023 | β |
| Effects of Voluntary Physical Exercise on the Neurovascular Unit in a Mouse Model of Alzheimer's Disease. | Andrade-Guerrero J et al. | β | 2023 | β |
| Elucidating the inhibitory effects of rationally designed novel hexapeptide against hen egg white lysozyme fibrillation at acidic and physiological pH. | Mitra A et al. | β | 2023 | β |
| Emerging concepts towards a translational framework in Alzheimer's disease. | Cozachenco D et al. | β | 2023 | β |
| Endogenous Amyloid-formed Ca<sup>2+</sup>-permeable Channels in Aged 3xTg AD Mice. | Li S et al. | β | 2023 | β |
| Endolysosomal impairment by binding of amyloid beta or MAPT/Tau to V-ATPase and rescue via the HYAL-CD44 axis in Alzheimer disease. | Kim SH et al. | β | 2023 | β |
| Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer's disease mouse model and proteomics analysis. | Zhou X et al. | β | 2023 | β |
| Evidence of disturbed insulin signaling in animal models of Alzheimer's disease. | Alves SS et al. | β | 2023 | β |
| Experimental approaches for altering the expression of Abeta-degrading enzymes. | Loeffler DA | β | 2023 | β |
| Exposure to environmental airborne particulate matter caused wide-ranged transcriptional changes and accelerated Alzheimer's-related pathology: A mouse study. | Israel LL et al. | β | 2023 | β |
| Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients. | Karakatsani ME et al. | β | 2023 | β |
| Generation and Characterization of the First Murine Model of Alzheimer's Disease with Mutated AΞ²PP Inserted in a BALB/c Background (C.B6/J-APPswe). | Balietti M et al. | β | 2023 | β |
| Genetic predisposition to Alzheimer's disease alters inflammasome activity after traumatic brain injury. | Johnson NH et al. | β | 2023 | β |
| Genome-wide analysis reveals novel regulators of synaptic maintenance in Drosophila. | Sidisky JM et al. | β | 2023 | β |
| Geroprotective interventions in the 3xTg mouse model of Alzheimer's disease. | Sonsalla MM et al. | β | 2023 | β |
| Getting ahead of Alzheimer's disease: early intervention with focused ultrasound. | Noel RL et al. | β | 2023 | β |
| Ginsenoside Rg1 ameliorates Alzheimer's disease pathology via restoring mitophagy. | Wang N et al. | β | 2023 | β |
| Glucagon-like peptide 1 (GLP-1) receptor agonists in experimental Alzheimer's disease models: a systematic review and meta-analysis of preclinical studies. | Kong F et al. | β | 2023 | β |
| Glutamine Supplementation Preserves Glutamatergic Neuronal Activity in the Infralimbic Cortex, Which Delays the Onset of Mild Cognitive Impairment in 3ΓTg-AD Female Mice. | Baek JH et al. | β | 2023 | β |
| Hebbian plasticity: the elusive missing link at the heart of Alzheimer's disease pathogenesis? | Jeans AF | β | 2023 | β |
| HEBP1 - An early trigger for neuronal cell death and circuit dysfunction in Alzheimer's disease. | Chua JJE | β | 2023 | β |
| Hemispheric asymmetries in mental disorders: evidence from rodent studies. | Mundorf A et al. | β | 2023 | β |
| Hepatic Oxi-Inflammation and Neophobia as Potential Liver-Brain Axis Targets for Alzheimer's Disease and Aging, with Strong Sensitivity to Sex, Isolation, and Obesity. | Fraile-Ramos J et al. | β | 2023 | β |
| Hexa-Histidine, a Peptide with Versatile Applications in the Study of Amyloid-Ξ²(1-42) Molecular Mechanisms of Action. | Salazar J et al. | β | 2023 | β |
| Hexosamine biosynthetic pathway and <i>O</i>-GlcNAc cycling of glucose metabolism in brain function and disease. | Kim DY et al. | β | 2023 | β |
| Higher angiotensin-converting enzyme 2 (ACE2) levels in the brain of individuals with Alzheimer's disease. | Reveret L et al. | β | 2023 | β |
| High throughput assay for compounds that boost BDNF expression in neurons. | Liao GY et al. | β | 2023 | β |
| Hippocampal delivery of neurotrophic factor-Ξ±1/carboxypeptidase E gene prevents neurodegeneration, amyloidosis, memory loss in Alzheimer's Disease male mice. | Xiao L et al. | β | 2023 | β |
| Icariin ameliorates memory deficits through regulating brain insulin signaling and glucose transporters in 3ΓTg-AD mice. | Yan F et al. | β | 2023 | β |
| IL-34 exacerbates pathogenic features of Alzheimer's disease and calvaria osteolysis in triple transgenic (3x-Tg) female mice. | Ho A et al. | β | 2023 | β |
| Inceptor as a regulator of brain insulin sensitivity. | Post LA et al. | β | 2023 | β |
| Increased Expression of Autophagy-Related Genes in Alzheimer's Disease-Type 2 Diabetes Mellitus Comorbidity Models in Cells. | Vianello C et al. | β | 2023 | β |
| Increased TSPO expression, pyroglutamate-modified amyloid beta (AΞ²N3(pE)) accumulation and transient clustering of microglia in the thalamus of Tg-SwDI mice. | Rodriguez-Lopez A et al. | β | 2023 | β |
| Investigating the correlation between early vascular alterations and cognitive impairment in Alzheimer's disease in mice with SD-OCT. | Lee JH et al. | β | 2023 | β |
| In vivo synaptic density loss correlates with impaired functional and related structural connectivity in Alzheimer's disease. | Zhang J et al. | β | 2023 | β |
| K<sub>IR</sub> channel regulation of electrical conduction along cerebrovascular endothelium: Enhanced modulation during Alzheimer's disease. | Hakim MA et al. | β | 2023 | β |
| Lithium Provides Broad Therapeutic Benefits in an Alzheimer's Disease Mouse Model. | Wiseman AL et al. | β | 2023 | β |
| Long-term voluntary exercise inhibited AGE/RAGE and microglial activation and reduced the loss of dendritic spines in the hippocampi of APP/PS1 transgenic mice. | Wang YY et al. | β | 2023 | β |
| Maternal High Fat Diet Anticipates the AD-like Phenotype in 3xTg-AD Mice by Epigenetic Dysregulation of AΞ² Metabolism. | Natale F et al. | β | 2023 | β |
| Mitochondrial Ca<sup>2+</sup> signaling and Alzheimer's disease: Too much or too little? | Garcia-Casas P et al. | β | 2023 | β |
| Mitochondria morphometry in 3D datasets obtained from mouse brains with serial block-face scanning electron microscopy. | Jiao W et al. | β | 2023 | β |
| Modulation of L-type calcium channels in Alzheimer's disease: A potential therapeutic target. | Crossley CA et al. | β | 2023 | β |
| Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach. | Strefeler A et al. | β | 2023 | β |
| Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications. | Shahpasand-Kroner H et al. | β | 2023 | β |
| Myelin, aging, and physical exercise. | Graciani AL et al. | β | 2023 | β |
| Nasal administration of anti-CD3 monoclonal antibody ameliorates disease in a mouse model of Alzheimer's disease. | Lopes JR et al. | β | 2023 | β |
| Natural aging and Alzheimer's disease pathology increase susceptibility to focused ultrasound-induced blood-brain barrier opening. | Noel RL et al. | β | 2023 | β |
| Neural Stem Cells in the Treatment of Alzheimer's Disease: Current Status, Challenges, and Future Prospects. | Chen X et al. | β | 2023 | β |
| Neurodegenerative Disease Associated Pathways in the Brains of Triple Transgenic Alzheimer's Model Mice Are Reversed Following Two Weeks of Peripheral Administration of Fasudil. | Killick R et al. | β | 2023 | β |
| Neuronal Transplantation for Alzheimer's Disease and Prospects for Generating Exogenic Neurons as a Source of Cells for Implantation. | Strell P et al. | β | 2023 | β |
| Neuroprotective Effects of a Multi-Herbal Extract on Axonal and Synaptic Disruption <i>in Vitro</i> and Cognitive Impairment <i>in Vivo</i>. | Lin NH et al. | β | 2023 | β |
| Neuroprotective Effects of IVIG against Alzheimer' s Disease via Regulation of Antigen Processing and Presentation by MHC Class I Molecules in 3xTg-AD Mice. | Fei Z et al. | β | 2023 | β |
| Neuroprotective Effects of N-methyl-(2S, 4R)-trans-4-hydroxy-L-proline (NMP) against Amyloid-Ξ²-Induced Alzheimer's Disease Mouse Model. | Ali J et al. | β | 2023 | β |
| Neutrophils as a potential therapeutic target in Alzheimer's disease. | Aries ML et al. | β | 2023 | β |
| Non-conducting functions of potassium channels in cancer and neurological disease. | Sesti F et al. | β | 2023 | β |
| Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease. | Batista A et al. | β | 2023 | β |
| NPLC0393 from Gynostemma pentaphyllum ameliorates Alzheimer's disease-like pathology in mice by targeting protein phosphatase magnesium-dependent 1A phosphatase. | Lv J et al. | β | 2023 | β |
| Oligomerization by co-assembly of Ξ²-amyloid and Ξ±-synuclein. | Kim JR | β | 2023 | β |
| Orexin-A aggravates cognitive deficits in 3xTg-AD mice by exacerbating synaptic plasticity impairment and affecting amyloid Ξ² metabolism. | Li YY et al. | β | 2023 | β |
| Overexpression of UCP4 in astrocytic mitochondria prevents multilevel dysfunctions in a mouse model of Alzheimer's disease. | Rosenberg N et al. | β | 2023 | β |
| Oxidative Stress and Natural Antioxidants: Back and Forth in the Neurological Mechanisms of Alzheimer's Disease. | Mani S et al. | β | 2023 | β |
| Particulate matter exposure and neurodegenerative diseases: A comprehensive update on toxicity and mechanisms. | Lee J et al. | β | 2023 | β |
| PDIA3 Expression Is Altered in the Limbic Brain Regions of Triple-Transgenic Mouse Model of Alzheimer's Disease. | Cassano T et al. | β | 2023 | β |
| Phospholipase D1 Attenuation Therapeutics Promotes Resilience against Synaptotoxicity in 12-Month-Old 3xTg-AD Mouse Model of Progressive Neurodegeneration. | Natarajan C et al. | β | 2023 | β |
| Physiological expression of mutated TAU impaired astrocyte activity and exacerbates Ξ²-amyloid pathology in 5xFAD mice. | Farfara D et al. | β | 2023 | β |
| Pinpointing the locus of GABAergic vulnerability in Alzheimer's disease. | Melgosa-Ecenarro L et al. | β | 2023 | β |
| PKCΞ΅ activator protects hippocampal microvascular disruption and memory defect in 3ΓTg-Alzheimer's disease mice with cerebral microinfarcts. | Wang H et al. | β | 2023 | β |
| Postsynaptic Protein Shank3a Deficiency Synergizes with Alzheimer's Disease Neuropathology to Impair Cognitive Performance in the 3xTg-AD Murine Model. | Landry O et al. | β | 2023 | β |
| Precocious emergence of cognitive and synaptic dysfunction in 3xTg-AD mice exposed prenatally to ethanol. | Tousley AR et al. | β | 2023 | β |
| Predicting Neurodegenerative Disease Using Prepathology Gut Microbiota Composition: a Longitudinal Study in Mice Modeling Alzheimer's Disease Pathologies. | Borsom EM et al. | β | 2023 | β |
| Prenatal alcohol exposure causes persistent microglial activation and age- and sex- specific effects on cognition and metabolic outcomes in an Alzheimer's Disease mouse model. | Walter KR et al. | β | 2023 | β |
| Probing neural circuit mechanisms in Alzheimer's disease using novel technologies. | Grieco SF et al. | β | 2023 | β |
| Progressive Excitability Changes in the Medial Entorhinal Cortex in the 3xTg Mouse Model of Alzheimer's Disease Pathology. | Chen L et al. | β | 2023 | β |
| Progressive sleep disturbance in various transgenic mouse models of Alzheimer's disease. | Drew VJ et al. | β | 2023 | β |
| Prominent and conspicuous astrocyte atrophy in human sporadic and familial Alzheimer's disease. | RodrΓguez JJ et al. | β | 2023 | β |
| Quantification of AMPA receptor subunits and RNA editing-related proteins in the J20 mouse model of Alzheimer's disease by capillary western blotting. | Milham LT et al. | β | 2023 | β |
| Quantitative microglia morphological features correlate with diffusion MRI in 2-month-old 3xTg-AD mice. | Falangola MF et al. | β | 2023 | β |
| Rapamycin and Alzheimer disease: a hypothesis for the effective use of rapamycin for treatment of neurodegenerative disease. | Carosi JM et al. | β | 2023 | β |
| Re-Arranging the Puzzle between the Amyloid-Beta and Tau Pathology: An APP-Centric Approach. | Haut F et al. | β | 2023 | β |
| Reduced Autophagy in Aged Trigeminal Neurons Causes Amyloid Ξ² Diffusion. | Sonoda R et al. | β | 2023 | β |
| Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease. | Marinho D et al. | β | 2023 | β |
| Retinal imaging in animal models: Searching for biomarkers of neurodegeneration. | Batista A et al. | β | 2023 | β |
| Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy. | Anglada-Huguet M et al. | β | 2023 | β |
| Selective orexin 1 receptor antagonist SB-334867 aggravated cognitive dysfunction in 3xTg-AD mice. | Gao WR et al. | β | 2023 | β |
| Senescence-related impairment of autophagy induces toxic intraneuronal amyloid-Ξ² accumulation in a mouse model of amyloid pathology. | Suelves N et al. | β | 2023 | β |
| Serial reversal learning in an olfactory discrimination task in 3xTg-AD mice. | Roddick KM et al. | β | 2023 | β |
| Sex-Dependent Altered Expression of Cannabinoid Signaling in Hippocampal Astrocytes of the Triple Transgenic Mouse Model of Alzheimer's Disease: Implications for Controlling Astroglial Activity. | Pacheco-SΓ‘nchez B et al. | β | 2023 | β |
| Sex differences in hippocampal Ξ²-amyloid accumulation in the triple-transgenic mouse model of Alzheimer's disease and the potential role of local estrogens. | Hu YT et al. | β | 2023 | β |
| Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer's disease. | Robison LS et al. | β | 2023 | β |
| Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer's Disease. | Wang HY et al. | β | 2023 | β |
| Small molecule inhibitor of tau self-association in a mouse model of tauopathy: A preventive study in P301L tau JNPL3 mice. | Davidowitz EJ et al. | β | 2023 | β |
| Spontaneous and familial models of Alzheimer's disease: Challenges and advances in preclinical research. | Ulaganathan S et al. | β | 2023 | β |
| Stealth Liposomes Encapsulating a Potent ACAT1/SOAT1 Inhibitor F12511: Pharmacokinetic, Biodistribution, and Toxicity Studies in Wild-Type Mice and Efficacy Studies in Triple Transgenic Alzheimer's Disease Mice. | De La Torre AL et al. | β | 2023 | β |
| Stimulation of synaptic activity promotes TFEB-mediated clearance of pathological MAPT/Tau in cellular and mouse models of tauopathies. | Akwa Y et al. | β | 2023 | β |
| Strategies for generating mouse model resources of human disease. | Pan J et al. | β | 2023 | β |
| Survival Bias, Non-Lineal Behavioral and Cortico-Limbic Neuropathological Signatures in 3xTg-AD Mice for Alzheimer's Disease from Premorbid to Advanced Stages and Compared to Normal Aging. | Muntsant A et al. | β | 2023 | β |
| Targeting CaN/NFAT in Alzheimer's brain degeneration. | Mackiewicz J et al. | β | 2023 | β |
| Tauopathy and alcohol consumption interact to alter locus coeruleus excitatory transmission and excitability in male and female mice. | Downs AM et al. | β | 2023 | β |
| Tauopathy promotes spinal cord-dependent production of toxic amyloid-beta in transgenic monkeys. | Tu Z et al. | β | 2023 | β |
| TgF344-AD Rat Model of Alzheimer's Disease: Spatial Disorientation and Asymmetry in Hemispheric Neurodegeneration. | Sagalajev B et al. | β | 2023 | β |
| The Biochemistry Behind Cognitive Decline: Biomarkers of Alzheimer's Disease. | Grari O et al. | β | 2023 | β |
| The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease. | Roe SM et al. | β | 2023 | β |
| The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: A calcium dyshomeostasis perspective. | Lim D et al. | β | 2023 | β |
| The Expression of Epac2 and GluA3 in an Alzheimer's Disease Experimental Model and Postmortem Patient Samples. | Zhang T et al. | β | 2023 | β |
| The gut microbiome in Alzheimer's disease: what we know and what remains to be explored. | Chandra S et al. | β | 2023 | β |
| The innate immune response in tauopathies. | Johnson AM et al. | β | 2023 | β |
| The interwoven fibril-like structure of amyloid-beta plaques in mouse brain tissue visualized using super-resolution STED microscopy. | Johansson B et al. | β | 2023 | β |
| The Multifaceted Role of WNT Signaling in Alzheimer's Disease Onset and Age-Related Progression. | Kostes WW et al. | β | 2023 | β |
| The Role of the Transcription Factor Nrf2 in Alzheimer's Disease: Therapeutic Opportunities. | De Plano LM et al. | β | 2023 | β |
| The TgF344-AD rat: behavioral and proteomic changes associated with aging and protein expression in a transgenic rat model of Alzheimer's disease. | Bac B et al. | β | 2023 | β |
| The Triple Alliance: Microbiome, Mitochondria, and Metabolites in the Context of Age-Related Cognitive Decline and Alzheimer's Disease. | Prajapati SK et al. | β | 2023 | β |
| The Ξ·-secretase-derived APP fragment Ξ·CTF is localized in Golgi, endosomes and extracellular vesicles and contributes to AΞ² production. | Afram E et al. | β | 2023 | β |
| Transcriptomic Analyses of Exercise Training in Alzheimer's Disease Cerebral Cortex. | Widjaya MA et al. | β | 2023 | β |
| Transcriptomic Analyses of Neurotoxic Astrocytes Derived from Adult Triple Transgenic Alzheimer's Disease Mice. | Carvalho D et al. | β | 2023 | β |
| Transgenic Mouse Models for the Study of Neurodegenerative Diseases. | MarΓn-Moreno A et al. | β | 2023 | β |
| TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease. | Zhang ZY et al. | β | 2023 | β |
| Under the umbrella of depression and Alzheimer's disease physiopathology: Can cannabinoids be a dual-pleiotropic therapy? | Fonseca C et al. | β | 2023 | β |
| Urolithin A reduces amyloid-beta load and improves cognitive deficits uncorrelated with plaque burden in a mouse model of Alzheimer's disease. | Ballesteros-Γlvarez J et al. | β | 2023 | β |
| Voltage-Gated Na<sup>+</sup> Channels in Alzheimer's Disease: Physiological Roles and Therapeutic Potential. | Baumgartner TJ et al. | β | 2023 | β |
| Abnormal whisker movements in the 3xTg-AD mouse model of Alzheimer's disease. | Simanaviciute U et al. | β | 2022 | β |
| Actin-binding protein filamin-A drives tau aggregation and contributes to progressive supranuclear palsy pathology. | Tsujikawa K et al. | β | 2022 | β |
| Addressing Blood-Brain Barrier Impairment in Alzheimer's Disease. | Sharma C et al. | β | 2022 | β |
| Adiponectin Ameliorates Cognitive Behaviors and in vivo Synaptic Plasticity Impairments in 3xTg-AD Mice. | Yan XD et al. | β | 2022 | β |
| Administration of mucuna beans (Mucuna pruriences (L.) DC. var. utilis) improves cognition and neuropathology of 3βΓβTg-AD mice. | Konishi F et al. | β | 2022 | β |
| Adolescent Binge Alcohol Enhances Early Alzheimer's Disease Pathology in Adulthood Through Proinflammatory Neuroimmune Activation. | Barnett A et al. | β | 2022 | β |
| Adult hippocampal neurogenesis and its impairment in Alzheimer's disease. | Kim TA et al. | β | 2022 | β |
| Age dependence of retinal vascular plexus attenuation in the triple transgenic mouse model of Alzheimer's disease. | Nazari HK et al. | β | 2022 | β |
| Age Related Changes in Muscle Mass and Force Generation in the Triple Transgenic (3xTgAD) Mouse Model of Alzheimer's Disease. | Xu H et al. | β | 2022 | β |
| Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-Ξ² Accumulation and Plaque Deposition in a Transgenic Alzheimer's Disease Mouse Model. | Pontrello CG et al. | β | 2022 | β |
| All roads lead to heterogeneity: The complex involvement of astrocytes and microglia in the pathogenesis of Alzheimer's disease. | St-Pierre MK et al. | β | 2022 | β |
| Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice. | Frame G et al. | β | 2022 | β |
| Alterations of the Sympathoadrenal Axis Related to the Development of Alzheimer's Disease in the 3xTg Mouse Model. | MuΓ±oz-Montero A et al. | β | 2022 | β |
| Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow. | Xie C et al. | β | 2022 | β |
| A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease. | Favero F et al. | β | 2022 | β |
| Amyloid-beta peptide and tau protein crosstalk in Alzheimer's disease. | Roda AR et al. | β | 2022 | β |
| Amyloid Ξ² / PKC-dependent alterations in NMDA receptor composition are detected in early stages of AlzheimerΒ΄s disease. | Ortiz-Sanz C et al. | β | 2022 | β |
| Anesthesia promotes acute expression of genes related to Alzheimer's disease and latent tau aggregation in transgenic mouse models of tauopathy. | Eun JD et al. | β | 2022 | β |
| Animal and Cellular Models of Alzheimer's Disease: Progress, Promise, and Future Approaches. | Trujillo-Estrada L et al. | β | 2022 | β |
| Animal models of Alzheimer's disease: Applications, evaluation, and perspectives. | Chen ZY et al. | β | 2022 | β |
| Animal Models of Cognitive Deficits for Probiotic Treatment. | Kwon OY et al. | β | 2022 | β |
| A novel H129-based anterograde monosynaptic tracer exhibits features of strong labeling intensity, high tracing efficiency, and reduced retrograde labeling. | Yang H et al. | β | 2022 | β |
| Anthocyanin as a therapeutic in Alzheimer's disease: A systematic review of preclinical evidences. | Suresh S et al. | β | 2022 | β |
| A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease. | Zhao P et al. | β | 2022 | β |
| AΞ² Assemblies Promote Amyloidogenic Processing of APP and Intracellular Accumulation of AΞ²42 Through Go/GΞ²Ξ³ Signaling. | Antonino M et al. | β | 2022 | β |
| Blood-brain barrier leakage in Alzheimer's disease: From discovery to clinical relevance. | Nehra G et al. | β | 2022 | β |
| Brain cellular senescence in mouse models of Alzheimer's disease. | Dorigatti AO et al. | β | 2022 | β |
| Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential. | Gao L et al. | β | 2022 | β |
| Brain microstructure abnormalities in the 3xTg-AD mouse - A diffusion MRI and morphology correlation study. | Falangola MF et al. | β | 2022 | β |
| Brain transcriptomes of zebrafish and mouse Alzheimer's disease knock-in models imply early disrupted energy metabolism. | Barthelson K et al. | β | 2022 | β |
| Brain virtual histology with X-ray phase-contrast tomography Part II:3D morphologies of amyloid-<b>Ξ²</b> plaques in Alzheimer's disease models. | Chourrout M et al. | β | 2022 | β |
| Calpain-2 Mediates MBNL2 Degradation and a Developmental RNA Processing Program in Neurodegeneration. | Wang LH et al. | β | 2022 | β |
| C/EBPΞ²/AEP signaling couples atherosclerosis to the pathogenesis of Alzheimer's disease. | Liao J et al. | β | 2022 | β |
| Cerebrovascular microRNA Expression Profile During Early Development of Alzheimer's Disease in a Mouse Model. | Chum PP et al. | β | 2022 | β |
| Characterization of microtubule-associated protein tau isoforms and Alzheimer's disease-like pathology in normal sheep (Ovis aries): relevance to their potential as a model of Alzheimer's disease. | Davies ES et al. | β | 2022 | β |
| Cholinergic Neuron Targeting Nanosystem Delivering Hybrid Peptide for Combinatorial Mitochondrial Therapy in Alzheimer's Disease. | Qian K et al. | β | 2022 | β |
| Chronic-Antibiotics Induced Gut Microbiota Dysbiosis Rescues Memory Impairment and Reduces Ξ²-Amyloid Aggregation in a Preclinical Alzheimer's Disease Model. | Bello-Medina PC et al. | β | 2022 | β |
| Chronic Ethanol Causes Persistent Increases in Alzheimer's Tau Pathology in Female 3xTg-AD Mice: A Potential Role for Lysosomal Impairment. | Tucker AE et al. | β | 2022 | β |
| Chronic Fragmentation of the Daily Sleep-Wake Rhythm Increases Amyloid-beta Levels and Neuroinflammation in the 3xTg-AD Mouse Model of Alzheimer's Disease. | Duncan MJ et al. | β | 2022 | β |
| Combined targeting of pathways regulating synaptic formation and autophagy attenuates Alzheimer's disease pathology in mice. | Bjorkli C et al. | β | 2022 | β |
| Contributions of extracellular-signal regulated kinase 1/2 activity to the memory trace. | Ojea Ramos S et al. | β | 2022 | β |
| Contributions of sex and genotype to exploratory behavior differences in an aged humanized <i>APOE</i> mouse model of late-onset Alzheimer's disease. | McLean JW et al. | β | 2022 | β |
| Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. | Wander CM et al. | β | 2022 | β |
| Crosstalk of Alzheimer's disease-phenotype, HPA axis, splenic oxidative stress and frailty in late-stages of dementia, with special concerns on the effects of social isolation: A translational neuroscience approach. | Muntsant A et al. | β | 2022 | β |
| Cryptotanshinone Attenuates Amyloid-Ξ²<sub>42</sub>-induced Tau Phosphorylation by Regulating PI3K/Akt/GSK3Ξ² Pathway in HT22 Cells. | Lyu D et al. | β | 2022 | β |
| Design and Experimental Evaluation of a Peptide Antagonist against Amyloid Ξ²(1-42) Interactions with Calmodulin and Calbindin-D28k. | Salazar J et al. | β | 2022 | β |
| Development of a system to analyze oral frailty associated with Alzheimer's disease using a mouse model. | Kuramoto E et al. | β | 2022 | β |
| Differences in Immune-Related Genes Underlie Temporal and Regional Pathological Progression in 3xTg-AD Mice. | Fernandes A et al. | β | 2022 | β |
| Discovery of Novel Drug Candidates for Alzheimer's Disease by Molecular Network Modeling. | Zhou J et al. | β | 2022 | β |
| d-Pinitol promotes tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism: A new potential approach for tauopathies? | Medina-Vera D et al. | β | 2022 | β |
| (D-Ser2) oxyntomodulin recovers hippocampal synaptic structure and theta rhythm in Alzheimer's disease transgenic mice. | Yang GZ et al. | β | 2022 | β |
| Early lysosome defects precede neurodegeneration with amyloid-Ξ² and tau aggregation in NHE6-null rat brain. | Lee Y et al. | β | 2022 | β |
| Effect of Selenium Treatment on Central Insulin Sensitivity: A Proteomic Analysis in Ξ²-Amyloid Precursor Protein/Presenilin-1 Transgenic Mice. | Xu X et al. | β | 2022 | β |
| Effects of Chronic Arginase Inhibition with Norvaline on Tau Pathology and Brain Glucose Metabolism in Alzheimer's Disease Mice. | Polis B et al. | β | 2022 | β |
| Effects of DDT on Amyloid Precursor Protein Levels and Amyloid Beta Pathology: Mechanistic Links to Alzheimer's Disease Risk. | Eid A et al. | β | 2022 | β |
| Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease. | Bellanti F et al. | β | 2022 | β |
| Emerging Electroencephalographic Biomarkers to Improve Preclinical to Clinical Translation in Alzheimer's Disease. | Cope ZA et al. | β | 2022 | β |
| Enhanced defense against ferroptosis ameliorates cognitive impairment and reduces neurodegeneration in 5xFAD mice. | Chen L et al. | β | 2022 | β |
| Enteric nervous system and intestinal epithelial regulation of the gut-brain axis. | Dowling LR et al. | β | 2022 | β |
| Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer's Disease Predementia. | Souchet B et al. | β | 2022 | β |
| Exercise Training Prevents the Loss of Wall Thickness and Lowers Expression of Alzheimer's Related Proteins in 3xTg Mouse Jejunum. | Al-Nakkash L et al. | β | 2022 | β |
| Exogenous AΞ²<sub>1-42</sub> monomers improve synaptic and cognitive function in Alzheimer's disease model mice. | Duan Y et al. | β | 2022 | β |
| Fasting-mimicking diet cycles reduce neuroinflammation to attenuate cognitive decline in Alzheimer's models. | Rangan P et al. | β | 2022 | β |
| Fats, Friends or Foes: Investigating the Role of Short- and Medium-Chain Fatty Acids in Alzheimer's Disease. | Ameen AO et al. | β | 2022 | β |
| Fatty Acid-Binding Protein 3 Is a Marker of Neurodegeneration and White Matter Hyperintensity Burden in Mexican American Older Adults. | Clark AL et al. | β | 2022 | β |
| Fingolimod Rescues Memory and Improves Pathological Hallmarks in the 3xTg-AD Model of Alzheimer's Disease. | Fagan SG et al. | β | 2022 | β |
| From cradle to grave: neurogenesis, neuroregeneration and neurodegeneration in Alzheimer's and Parkinson's diseases. | Wakhloo D et al. | β | 2022 | β |
| From synapses to circuits and back: Bridging levels of understanding in animal models of Alzheimer's disease. | Chockanathan U et al. | β | 2022 | β |
| Frontotemporal Dementia and Glucose Metabolism. | Garrett LR et al. | β | 2022 | β |
| FSH blockade improves cognition in mice with Alzheimer's disease. | Xiong J et al. | β | 2022 | β |
| Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing Ξ²-amyloid load in Alzheimer's disease model. | Shen Q et al. | β | 2022 | β |
| Glatiramer Acetate Immunomodulation: Evidence of Neuroprotection and Cognitive Preservation. | Kasindi A et al. | β | 2022 | β |
| Group 1 Metabotropic Glutamate Receptors in Neurological and Psychiatric Diseases: Mechanisms and Prospective. | Su LD et al. | β | 2022 | β |
| Gut Microbiome and Mycobiome Alterations in an In Vivo Model of Alzheimer's Disease. | D'Argenio V et al. | β | 2022 | β |
| Gut Microbiota as a Hidden Player in the Pathogenesis of Alzheimer's Disease. | Choi H et al. | β | 2022 | β |
| Gut microbiota modulation in Alzheimer's disease: Focus on lipid metabolism. | Bonfili L et al. | β | 2022 | β |
| Heightened Tameness and Accelerated Handling-Habituation in 3ΓTg-AD Mice on a B6;129 Genetic Background. | Hu W et al. | β | 2022 | β |
| High-fat diet exacerbates cognitive decline in mouse models of Alzheimer's disease and mixed dementia in a sex-dependent manner. | Gannon OJ et al. | β | 2022 | β |
| Icariin Ameliorates Alzheimer's Disease Pathology by Alleviating Myelin Injury in 3βΓβTg-AD Mice. | Yu H et al. | β | 2022 | β |
| Impact of Behavioral Assessment and Re-Test as Functional Trainings That Modify Survival, Anxiety and Functional Profile (Physical Endurance and Motor Learning) of Old Male and Female 3xTg-AD Mice and NTg Mice with Normal Aging. | Castillo-Mariqueo L et al. | β | 2022 | β |
| Impact of the Flavonoid Quercetin on Ξ²-Amyloid Aggregation Revealed by Intrinsic Fluorescence. | Alghamdi A et al. | β | 2022 | β |
| Induction of Accelerated Aging in a Mouse Model. | Cai N et al. | β | 2022 | β |
| Innate Preferences Affect Results of Object Recognition Task in Wild Type and Alzheimer's Disease Mouse Models. | Tropea MR et al. | β | 2022 | β |
| Intranasal Administration of a TRAIL Neutralizing Monoclonal Antibody Adsorbed in PLGA Nanoparticles and NLC Nanosystems: An In Vivo Study on a Mouse Model of Alzheimer's Disease. | Musumeci T et al. | β | 2022 | β |
| Investigation of Anxiety- and Depressive-like Symptoms in 4- and 8-Month-Old Male Triple Transgenic Mouse Models of Alzheimer's Disease. | VΓ‘rkonyi D et al. | β | 2022 | β |
| In Vivo Preclinical Assessment of Ξ²-Amyloid-Affine [<sup>11</sup>C]C-PIB Accumulation in Aluminium-Induced Alzheimer's Disease-Resembling Hypercholesterinaemic Rat Model. | KΓ©pes Z et al. | β | 2022 | β |
| iTRAQ-Based Proteomic Analysis of APP Transgenic Mouse Urine Exosomes. | Zhou X et al. | β | 2022 | β |
| Kyphosis and bizarre patterns impair spontaneous gait performance in end-of-life mice with Alzheimer's disease pathology while gait is preserved in normal aging. | Castillo-Mariqueo L et al. | β | 2022 | β |
| Low-Dose Radiation Therapy Reduces Amyloid Load in Young 3xTg-AD Mice. | CeyzΓ©riat K et al. | β | 2022 | β |
| Luteolin alleviates cognitive impairment in Alzheimer's disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation. | Kou JJ et al. | β | 2022 | β |
| Mechanisms of Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope. | Nabi SU et al. | β | 2022 | β |
| Mechanistic Insights of Chelator Complexes with Essential Transition Metals: Antioxidant/Pro-Oxidant Activity and Applications in Medicine. | Timoshnikov VA et al. | β | 2022 | β |
| Melanocortin receptor agonist NDP-Ξ±-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice. | Daini E et al. | β | 2022 | β |
| Metabolome-wide association study on <i>ABCA7</i> indicates a role of ceramide metabolism in Alzheimer's disease. | Dehghan A et al. | β | 2022 | β |
| Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease. | Gabrielli M et al. | β | 2022 | β |
| Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk. | Lv J et al. | β | 2022 | β |
| Modulating autophagic flux via ROS-responsive targeted micelles to restore neuronal proteostasis in Alzheimer's disease. | Xu S et al. | β | 2022 | β |
| Modulation of entorhinal cortex-hippocampus connectivity and recognition memory following electroacupuncture on 3ΓTg-AD model: Evidence from multimodal MRI and electrophysiological recordings. | Lin B et al. | β | 2022 | β |
| Modulation of Gut Microbiota and Neuroprotective Effect of a Yeast-Enriched Beer. | Cecarini V et al. | β | 2022 | β |
| Morphological and biomolecular targets in retina and vitreous from Reelin-deficient mice (Reeler): Potential implications for age-related macular degeneration in Alzheimer's dementia. | Balzamino BO et al. | β | 2022 | β |
| Mouse Models of Alzheimer's Disease. | Yokoyama M et al. | β | 2022 | β |
| Mouse models of Alzheimer's disease for preclinical research. | Watamura N et al. | β | 2022 | β |
| Near-Infrared Fluorescent Probes as Imaging and Theranostic Modalities for Amyloid-Beta and Tau Aggregates in Alzheimer's Disease. | Rai H et al. | β | 2022 | β |
| Neurochemical and cognitive changes precede structural abnormalities in the TgF344-AD rat model. | Fowler CF et al. | β | 2022 | β |
| Neuroimaging of Mouse Models of Alzheimer's Disease. | Jullienne A et al. | β | 2022 | β |
| Neuropathological and behavioral features of an APP/PS1/MAPT (6xTg) transgenic model of Alzheimer's disease. | Tag SH et al. | β | 2022 | β |
| No evidence of aberrant amyloid Ξ² and phosphorylated tau expression in herpes simplex virus-infected neurons of the trigeminal ganglia and brain. | Tran DN et al. | β | 2022 | β |
| Non-conducting functions of ion channels: The case of integrin-ion channel complexes. | Forzisi E et al. | β | 2022 | β |
| Ovariectomy-induced hormone deprivation aggravates AΞ²<sub>1-42</sub> deposition in the basolateral amygdala and cholinergic fiber loss in the cortex but not cognitive behavioral symptoms in a triple transgenic mouse model of Alzheimer's disease. | Farkas S et al. | β | 2022 | β |
| Oxidative stress, the immune response, synaptic plasticity, and cognition in transgenic models of Alzheimer disease. | Bello-Medina PC et al. | β | 2022 | β |
| Parkin as a Molecular Bridge Linking Alzheimer's and Parkinson's Diseases? | Checler F et al. | β | 2022 | β |
| Pathogenic tau recruits wild-type tau into brain inclusions and induces gut degeneration in transgenic SPAM mice. | Xia Y et al. | β | 2022 | β |
| PET Imaging in Preclinical Anti-AΞ² Drug Development. | SyvΓ€nen S et al. | β | 2022 | β |
| Phosphorylation of Tau at Threonine 231 in Patients With Multiple System Atrophy and in a Mouse Model. | Tanaka MT et al. | β | 2022 | β |
| Preclinical Models for Alzheimer's Disease: Past, Present, and Future Approaches. | Akhtar A et al. | β | 2022 | β |
| Progressive Vascular Abnormalities in the Aging 3xTg-AD Mouse Model of Alzheimer's Disease. | Jullienne A et al. | β | 2022 | β |
| Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease. | Mustaly-Kalimi S et al. | β | 2022 | β |
| Proteomic Profiling of Cerebrum Mitochondria, Myelin Sheath, and Synaptosome Revealed Mitochondrial Damage and Synaptic Impairments in Association with 3βΓβTg-AD Mice Model. | Shen L et al. | β | 2022 | β |
| Protopine promotes the proteasomal degradation of pathological tau in Alzheimer's disease models via HDAC6 inhibition. | Sreenivasmurthy SG et al. | β | 2022 | β |
| Ras Inhibitor Lonafarnib Rescues Structural and Functional Impairments of Synapses of AΞ²<sub>1-42</sub> Mice via Ξ±7nAChR-Dependent BDNF Upregulation. | Cai C et al. | β | 2022 | β |
| Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons. | Soloperto A et al. | β | 2022 | β |
| R-carvedilol, a potential new therapy for Alzheimer's disease. | Yao J et al. | β | 2022 | β |
| Recombinant Integrin Ξ²1 Signal Peptide Blocks Gliosis Induced by AΞ² Oligomers. | Ortiz-Sanz C et al. | β | 2022 | β |
| Regulatory role of cathepsin L in induction of nuclear laminopathy in Alzheimer's disease. | Islam MI et al. | β | 2022 | β |
| Remembering your A, B, C's: Alzheimer's disease and ABCA1. | Lewandowski CT et al. | β | 2022 | β |
| Repetitive Transcranial Magnetic Stimulation Improves Brain-Derived Neurotrophic Factor and Cholinergic Signaling in the 3xTgAD Mouse Model of Alzheimer's Disease. | McNerney MW et al. | β | 2022 | β |
| Retinal Aging in 3Γ Tg-AD Mice Model of Alzheimer's Disease. | GuimarΓ£es P et al. | β | 2022 | β |
| Reversal of Lipid Metabolism Dysregulation by Selenium and Folic Acid Co-Supplementation to Mitigate Pathology in Alzheimer's Disease. | Zhang ZH et al. | β | 2022 | β |
| Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q. | Spurrier J et al. | β | 2022 | β |
| Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies. | Limorenko G et al. | β | 2022 | β |
| Second Sphere Interactions in Amyloidogenic Diseases. | Roy M et al. | β | 2022 | β |
| Sex- and Neuropsychiatric-Dependent Circadian Alterations in Daily Voluntary Physical Activity Engagement and Patterns in Aged 3xTg-AD Mice. | Alveal-Mellado D et al. | β | 2022 | β |
| Simultaneous Alteration of the Circadian Variation of Memory, Hippocampal Synaptic Plasticity, and Metabolism in a Triple Transgenic Mouse Model of Alzheimer's Disease. | Carvalho da Silva AM et al. | β | 2022 | β |
| SOBA: Development and testing of a soluble oligomer binding assay for detection of amyloidogenic toxic oligomers. | Shea D et al. | β | 2022 | β |
| Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse AΞ² plaque pathology when injected into newborn mouse hosts. | Moore BD et al. | β | 2022 | β |
| Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model. | Lin X et al. | β | 2022 | β |
| Spatial proteomics in three-dimensional intact specimens. | Bhatia HS et al. | β | 2022 | β |
| Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model. | Hamilton LK et al. | β | 2022 | β |
| Structural Plasticity of the Hippocampus in Neurodegenerative Diseases. | Weerasinghe-Mudiyanselage PDE et al. | β | 2022 | β |
| Surfactant Protein-G in Wildtype and 3xTg-AD Mice: Localization in the Forebrain, Age-Dependent Hippocampal Dot-like Deposits and Brain Content. | Meinicke A et al. | β | 2022 | β |
| Synaptic dysfunction in early phases of Alzheimer's Disease. | Pelucchi S et al. | β | 2022 | β |
| TAPPing into the potential of inducible tau/APP transgenic mice. | Xu G et al. | β | 2022 | β |
| Targeting whole body metabolism and mitochondrial bioenergetics in the drug development for Alzheimer's disease. | Austad SN et al. | β | 2022 | β |
| Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation. | Li L et al. | β | 2022 | β |
| Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models. | Carpanini SM et al. | β | 2022 | β |
| The amyloid peptide Ξ² disrupts intercellular junctions and increases endothelial permeability in a NADPH oxidase 1-dependent manner. | Tarafdar A et al. | β | 2022 | β |
| The basal forebrain volume reduction detected by MRI does not necessarily link with the cholinergic neuronal loss in the Alzheimer's disease mouse model. | Zhou XA et al. | β | 2022 | β |
| The effect of dietary fat consumption on Alzheimer's disease pathogenesis in mouse models. | Amelianchik A et al. | β | 2022 | β |
| The effect of exercise on early sensorimotor performance alterations in the 3xTg-AD model of Alzheimer's disease. | Bareiss SK et al. | β | 2022 | β |
| The emerging role of the microbiome in Alzheimer's disease. | WasΓ©n C et al. | β | 2022 | β |
| The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. | Ring J et al. | β | 2022 | β |
| The Impact of Probiotic Supplementation on Cognitive, Pathological and Metabolic Markers in a Transgenic Mouse Model of Alzheimer's Disease. | Webberley TS et al. | β | 2022 | β |
| The lateral entorhinal cortex is a hub for local and global dysfunction in early Alzheimer's disease states. | Mandino F et al. | β | 2022 | β |
| The Neuroepigenetic Landscape of Vertebrate and Invertebrate Models of Neurodegenerative Diseases. | Sundaramoorthy TH et al. | β | 2022 | β |
| The Role of Astrocytes in Synapse Loss in Alzheimer's Disease: A Systematic Review. | Hulshof LA et al. | β | 2022 | β |
| The role of histone modifications: from neurodevelopment to neurodiseases. | Park J et al. | β | 2022 | β |
| The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases. | DeMaio A et al. | β | 2022 | β |
| Theta and gamma oscillatory dynamics in mouse models of Alzheimer's disease: A path to prospective therapeutic intervention. | Mehak SF et al. | β | 2022 | β |
| The three sisters of fate: Genetics, pathophysiology and outcomes of animal models of neurodegenerative diseases. | Klonarakis M et al. | β | 2022 | β |
| Thiamine insufficiency induces Hypoxia Inducible Factor-1Ξ± as an upstream mediator for neurotoxicity and AD-like pathology. | Valle ML et al. | β | 2022 | β |
| Translating pharmacology models effectively to predict therapeutic benefit. | Dudal S et al. | β | 2022 | β |
| Treadmill Exercise Prevents Decline in Spatial Learning and Memory in 3ΓTg-AD Mice through Enhancement of Structural Synaptic Plasticity of the Hippocampus and Prefrontal Cortex. | Mu L et al. | β | 2022 | β |
| Unraveling the Gordian knot: genetics and the troubled road to effective therapeutics for Alzheimer's disease. | Restifo LL | β | 2022 | β |
| X-ray multiscale 3D neuroimaging to quantify cellular aging and neurodegeneration postmortem in a model of Alzheimer's disease. | Barbone GE et al. | β | 2022 | β |
| 3ΓTg-AD Mice Overexpressing Phospholipid Transfer Protein Improves Cognition Through Decreasing Amyloid-Ξ² Production and Tau Hyperphosphorylation. | Wang WZ et al. | β | 2021 | β |
| Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. | Park J et al. | β | 2021 | β |
| Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease. | Han J et al. | β | 2021 | β |
| A brain proteomic signature of incipient Alzheimer's disease in young <i>APOE</i> Ξ΅4 carriers identifies novel drug targets. | Roberts JA et al. | β | 2021 | β |
| Accumulation ofΒ amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains. | Vaillant-Beuchot L et al. | β | 2021 | β |
| Activation of Apoptosis in a Ξ²B1-CTGF Transgenic Mouse Model. | Weiss M et al. | β | 2021 | β |
| Administration of anti-ERMAP antibody ameliorates Alzheimer's disease in mice. | Liu H et al. | β | 2021 | β |
| Adult Hippocampal Neurogenesis in Aging and Alzheimer's Disease. | Babcock KR et al. | β | 2021 | β |
| Advances in Genetics and Epigenetic Alterations in Alzheimer's Disease: A Notion for Therapeutic Treatment. | Rabaneda-Bueno R et al. | β | 2021 | β |
| A freeze-and-thaw-induced fragment of the microtubule-associated protein tau in rat brain extracts: implications for the biochemical assessment of neurotoxicity. | Vasconcelos IC et al. | β | 2021 | β |
| Age and gender differences for the behavioral phenotypes of 3xTg alzheimer's disease mice. | Pairojana T et al. | β | 2021 | β |
| Age- and sex-dependent alterations in the peripheral immune system in the 3xTg-AD mouse model of Alzheimer's disease: Increased proportion of CD3+CD4-CD8- double-negative T cells in the blood. | Nava Catorce M et al. | β | 2021 | β |
| Age-related impairment of cerebral blood flow response to K<sub>ATP</sub> channel opener in Alzheimer's disease mice with presenilin-1 mutation. | Liu D et al. | β | 2021 | β |
| Aging induces abnormal accumulation of AΞ² in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain. | Koinuma S et al. | β | 2021 | β |
| A High Fat/Cholesterol Diet Recapitulates Some Alzheimer's Disease-Like Features in Mice: Focus on Hippocampal Mitochondrial Dysfunction. | Mancini G et al. | β | 2021 | β |
| Alzheimer's Disease and Diabetes Mellitus in Comparison: The Therapeutic Efficacy of the Vanadium Compound. | He Z et al. | β | 2021 | β |
| Alzheimer's Disease Animal Models: Elucidation of Biomarkers and Therapeutic Approaches for Cognitive Impairment. | Nakai T et al. | β | 2021 | β |
| Alzheimer's disease: a tale of two diseases? | Nardini E et al. | β | 2021 | β |
| Alzheimer's disease genetic risk and sleep phenotypes in healthy young men: association with more slow waves and daytime sleepiness. | Muto V et al. | β | 2021 | β |
| Alzheimer's Disease, Sleep Disordered Breathing, and Microglia: Puzzling out a Common Link. | Ulland TK et al. | β | 2021 | β |
| Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain. | Valverde A et al. | β | 2021 | β |
| Amyloid and Tau Induce Cell Death Independently of TSPO Polymerization and Density Changes. | Tournier BB et al. | β | 2021 | β |
| Amyloid-Driven Tau Accumulation on Mitochondria Potentially Leads to Cognitive Deterioration in Alzheimer's Disease. | Cuadrado-Tejedor M et al. | β | 2021 | β |
| Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer's Disease, Parkinson's Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis. | Nguyen PH et al. | β | 2021 | β |
| Amyloids: The History of Toxicity and Functionality. | Yakupova EI et al. | β | 2021 | β |
| Amyloid Ξ² and Amyloid Precursor Protein Synergistically Suppress Large-Conductance Calcium-Activated Potassium Channel in Cortical Neurons. | Yamamoto K et al. | β | 2021 | β |
| Anhydroexfoliamycin, a <i>Streptomyces</i> Secondary Metabolite, Mitigates Microglia-Driven Inflammation. | Gegunde S et al. | β | 2021 | β |
| An improved and simplified protocol to combine Golgi-Cox staining with immunofluorescence and transmission electron microscopy techniques. | Pedrazzoli M et al. | β | 2021 | β |
| A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies. | Zheng J et al. | β | 2021 | β |
| An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity? | Sciaccaluga M et al. | β | 2021 | β |
| Assessment of the Effects of Altered Amyloid-Beta Clearance on Behavior following Repeat Closed-Head Brain Injury in Amyloid-Beta Precursor Protein Humanized Mice. | Maigler KC et al. | β | 2021 | β |
| A Tau-Driven Adverse Outcome Pathway Blueprint Toward Memory Loss in Sporadic (Late-Onset) Alzheimer's Disease with Plausible Molecular Initiating Event Plug-Ins for Environmental Neurotoxicants. | Tsamou M et al. | β | 2021 | β |
| ATP Synthase and Mitochondrial Bioenergetics Dysfunction in Alzheimer's Disease. | Patro S et al. | β | 2021 | β |
| Auditory sensory deprivation induced by noise exposure exacerbates cognitive decline in a mouse model of Alzheimer's disease. | Paciello F et al. | β | 2021 | β |
| Beneficial Effects of Citrus-Derived Polymethoxylated Flavones for Central Nervous System Disorders. | Matsuzaki K et al. | β | 2021 | β |
| Berberine Improves Behavioral and Cognitive Deficits in a Mouse Model of Alzheimer's Disease via Regulation of Ξ²-Amyloid Production and Endoplasmic Reticulum Stress. | Liang Y et al. | β | 2021 | β |
| Berberine Improves Cognitive Impairment by Simultaneously Impacting Cerebral Blood Flow and Ξ²-Amyloid Accumulation in an APP/tau/PS1 Mouse Model of Alzheimer's Disease. | Ye C et al. | β | 2021 | β |
| Binding of Amyloid Ξ²(1-42)-Calmodulin Complexes to Plasma Membrane Lipid Rafts in Cerebellar Granule Neurons Alters Resting Cytosolic Calcium Homeostasis. | Poejo J et al. | β | 2021 | β |
| Biomarkers to Evaluate Androgen Deprivation Therapy for Prostate Cancer and Risk of Alzheimer's Disease and Neurodegeneration: Old Drugs, New Concerns. | Achard V et al. | β | 2021 | β |
| Bis(ethylmaltolato)oxidovanadium (IV) alleviates neuronal apoptosis through regulating peroxisome proliferator-activated receptor Ξ³ in a triple transgenic animal model of Alzheimer's disease. | He Z et al. | β | 2021 | β |
| Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease. | Park JS et al. | β | 2021 | β |
| Cerebrovascular phenotypes in mouse models of Alzheimer's disease. | Szu JI et al. | β | 2021 | β |
| Changes in 24 h Rhythmicity of Spontaneous Locomotor Activity in the Triple Transgenic Mouse for Alzheimer's Disease (3xTg-AD) in a Jet Lag Protocol: Correlations with Retinal Sensitivity. | GonzΓ‘lez-Luna IA et al. | β | 2021 | β |
| Changes in the brain transcriptome after DNA AΞ²42 trimer immunization in a 3xTg-AD mouse model. | Lambracht-Washington D et al. | β | 2021 | β |
| Cholinergic neurodegeneration in Alzheimer disease mouse models. | Shekari A et al. | β | 2021 | β |
| Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3. | GimΓ©nez-Llort L et al. | β | 2021 | β |
| Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers. | Gaetani L et al. | β | 2021 | β |
| Collusion of Ξ±-Synuclein and AΞ² aggravating co-morbidities in a novel prion-type mouse model. | Lloyd GM et al. | β | 2021 | β |
| Combined Model of Aggregation and Network Diffusion Recapitulates Alzheimer's Regional Tau-Positron Emission Tomography. | Raj A et al. | β | 2021 | β |
| Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer's Disease. | Tureckova J et al. | β | 2021 | β |
| Computational Interspecies Translation Between Alzheimer's Disease Mouse Models and Human Subjects Identifies Innate Immune Complement, TYROBP, and TAM Receptor Agonist Signatures, Distinct From Influences of Aging. | Lee MJ et al. | β | 2021 | β |
| Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. | Oakley DH et al. | β | 2021 | β |
| Curcugreen Treatment Prevented Splenomegaly and Other Peripheral Organ Abnormalities in 3xTg and 5xFAD Mouse Models of Alzheimer's Disease. | Manna J et al. | β | 2021 | β |
| Current Developments on the Role of Ξ±<sub>1</sub>-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism. | Perez DM | β | 2021 | β |
| Deconstructing Alzheimer's Disease: How to Bridge the Gap between Experimental Models and the Human Pathology? | Vignon A et al. | β | 2021 | β |
| Development of grape polyphenols as multi-targeting strategies for Alzheimer's disease. | El Gaamouch F et al. | β | 2021 | β |
| Differential effects of chronic immunosuppression on behavioral, epigenetic, and Alzheimer's disease-associated markers in 3xTg-AD mice. | Kapadia M et al. | β | 2021 | β |
| Diffusion MRI detects basal forebrain cholinergic abnormalities in the 3xTg-AD mouse model of Alzheimer's disease. | Falangola MF et al. | β | 2021 | β |
| Dipeptidyl peptidase 4 contributes to Alzheimer's disease-like defects in a mouse model and is increased in sporadic Alzheimer's disease brains. | Valverde A et al. | β | 2021 | β |
| Disruption of metabolic, sleep, and sensorimotor functional outcomes in a female transgenic mouse model of Alzheimer's disease. | Nwafor DC et al. | β | 2021 | β |
| Does Alzheimer's disease stem in the gastrointestinal system? | Khodabakhsh P et al. | β | 2021 | β |
| Dopaminergic dysfunction in the 3xTg-AD mice model of Alzheimer's disease. | Gloria Y et al. | β | 2021 | β |
| Effects of dietary restriction on metabolic and cognitive health. | Souza Matos M et al. | β | 2021 | β |
| Enhancing GABAergic signaling ameliorates aberrant gamma oscillations of olfactory bulb in AD mouse models. | Chen M et al. | β | 2021 | β |
| Evaluating Effects of Glatiramer Acetate Treatment on Amyloid Deposition and Tau Phosphorylation in the 3xTg Mouse Model of Alzheimer's Disease. | Dionisio-Santos DA et al. | β | 2021 | β |
| Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer's Disease. | Chen YA et al. | β | 2021 | β |
| Evidence of the Cellular Senescence Stress Response in Mitotically Active Brain Cells-Implications for Cancer and Neurodegeneration. | Gillispie GJ et al. | β | 2021 | β |
| Exposure of Mesenchymal Stem Cells to an Alzheimer's Disease Environment Enhances Therapeutic Effects. | Park SE et al. | β | 2021 | β |
| Expression of Low Level of VPS35-mCherry Fusion Protein Diminishes Vps35 Depletion Induced Neuron Terminal Differentiation Deficits and Neurodegenerative Pathology, and Prevents Neonatal Death. | Zhao Y et al. | β | 2021 | β |
| Extracellular Vesicles From 3xTg-AD Mouse and Alzheimer's Disease Patient Astrocytes Impair Neuroglial and Vascular Components. | GonzΓ‘lez-Molina LA et al. | β | 2021 | β |
| Formulated Chinese medicine Shaoyao Gancao Tang reduces NLRP1 and NLRP3 in Alzheimer's disease cell and mouse models for neuroprotection and cognitive improvement. | Chiu YJ et al. | β | 2021 | β |
| FOXO and related transcription factors binding elements in the regulation of neurodegenerative disorders. | Oli V et al. | β | 2021 | β |
| Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics. | Salvan P et al. | β | 2021 | β |
| From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum. | Ouellette J et al. | β | 2021 | β |
| Generation of a humanized AΞ² expressing mouse demonstrating aspects of Alzheimer's disease-like pathology. | Baglietto-Vargas D et al. | β | 2021 | β |
| Genetically modified large animal models for investigating neurodegenerative diseases. | Yang W et al. | β | 2021 | β |
| Genetic deletion of Ξ±7 nicotinic acetylcholine receptors induces an age-dependent Alzheimer's disease-like pathology. | Tropea MR et al. | β | 2021 | β |
| Genetic Insights into Alzheimer's Disease. | Latimer CS et al. | β | 2021 | β |
| Genotype Load Modulates Amyloid Burden and Anxiety-Like Patterns in Male 3xTg-AD Survivors despite Similar Neuro-Immunoendocrine, Synaptic and Cognitive Impairments. | Muntsant A et al. | β | 2021 | β |
| GPR40 Agonist Ameliorate Pathological Neuroinflammation of Alzheimer's Disease via the Modulation of Gut Microbiota and Immune System, a Mini-Review. | Chen J et al. | β | 2021 | β |
| Group 2 innate lymphoid cells are numerically and functionally deficient in the triple transgenic mouse model of Alzheimer's disease. | Fung ITH et al. | β | 2021 | β |
| High-fat diet-induced atherosclerosis promotes neurodegeneration in the triple transgenic (3 Γ Tg) mouse model of Alzheimer's disease associated with chronic platelet activation. | Wang M et al. | β | 2021 | β |
| High-Fat Diet Modulates Hepatic Amyloid Ξ² and Cerebrosterol Metabolism in the Triple Transgenic Mouse Model of Alzheimer's Disease. | Bosoi CR et al. | β | 2021 | β |
| Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice. | Criado-Marrero M et al. | β | 2021 | β |
| Hydrogen sulfide is neuroprotective in Alzheimer's disease by sulfhydrating GSK3Ξ² and inhibiting Tau hyperphosphorylation. | Giovinazzo D et al. | β | 2021 | β |
| Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in App<sup>NL-G-F</sup>, App<sup>NL-F</sup>, and 3xTg-AD mouse models. | Pauls E et al. | β | 2021 | β |
| Identification of retinoblastoma binding protein 7 (Rbbp7) as a mediator against tau acetylation and subsequent neuronal loss in Alzheimer's disease and related tauopathies. | Dave N et al. | β | 2021 | β |
| IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease. | Brigas HC et al. | β | 2021 | β |
| <i>Mayday</i> sustains trans-synaptic BMP signaling required for synaptic maintenance with age. | Sidisky JM et al. | β | 2021 | β |
| Impairment of visual cortical plasticity by amyloid-beta species. | William CM et al. | β | 2021 | β |
| Induced Pluripotent Stem Cell-Derived Neural Precursors Improve Memory, Synaptic and Pathological Abnormalities in a Mouse Model of Alzheimer's Disease. | Armijo E et al. | β | 2021 | β |
| IntelliCage Automated Behavioral Phenotyping Reveals Behavior Deficits in the 3xTg-AD Mouse Model of Alzheimer's Disease Associated With Brain Weight. | Winslow W et al. | β | 2021 | β |
| Interaction between AΞ² and Tau in the Pathogenesis of Alzheimer's Disease. | Zhang H et al. | β | 2021 | β |
| Intermittent Hypoxic Conditioning Rescues Cognition and Mitochondrial Bioenergetic Profile in the Triple Transgenic Mouse Model of Alzheimer's Disease. | Correia SC et al. | β | 2021 | β |
| Intranasal Paclitaxel Alters Alzheimer's Disease Phenotypic Features in 3xTg-AD Mice. | Cross DJ et al. | β | 2021 | β |
| Intravenous administration of mesenchymal stem cells reduces Tau phosphorylation and inflammation in the 3xTg-AD mouse model of Alzheimer's disease. | Neves AF et al. | β | 2021 | β |
| In Vivo Microdialysis in Mice Captures Changes in Alzheimer's Disease Cerebrospinal Fluid Biomarkers Consistent with Developing Pathology. | Bjorkli C et al. | β | 2021 | β |
| Is Ξ³-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99? | Checler F et al. | β | 2021 | β |
| Levetiracetam Treatment Normalizes Levels of Presynaptic Endocytosis Machinery and Restores Nonamyloidogenic APP Processing in <i>App</i> Knock-in Mice. | Rao NR et al. | β | 2021 | β |
| Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model. | Liu Y et al. | β | 2021 | β |
| Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes. | Li Z et al. | β | 2021 | β |
| Magnetic Resonance Imaging in Animal Models of Alzheimer's Disease Amyloidosis. | Ni R | β | 2021 | β |
| Maintained memory and long-term potentiation in a mouse model of Alzheimer's disease with both amyloid pathology and human tau. | Tulloch J et al. | β | 2021 | β |
| Manipulation of EGFR-Induced Signaling for the Recruitment of Quiescent Neural Stem Cells in the Adult Mouse Forebrain. | Cochard LM et al. | β | 2021 | β |
| Mass spectrometry analysis of tau and amyloid-beta in iPSC-derived models of Alzheimer's disease and dementia. | Arber C et al. | β | 2021 | β |
| Metallobiology and therapeutic chelation of biometals (copper, zinc and iron) in Alzheimer's disease: Limitations, and current and future perspectives. | Fasae KD et al. | β | 2021 | β |
| Methyl-Beta-Cyclodextrin Restores K<sub>IR</sub> Channel Function in Brain Endothelium of Female Alzheimer's Disease Mice. | Hakim MA et al. | β | 2021 | β |
| Microfluidic Platforms to Unravel Mysteries of Alzheimer's Disease: How Far Have We Come? | Prasanna P et al. | β | 2021 | β |
| Microglia in Neuroinflammation and Neurodegeneration: From Understanding to Therapy. | Muzio L et al. | β | 2021 | β |
| Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice. | Quintana DD et al. | β | 2021 | β |
| Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle. | Morris JK et al. | β | 2021 | β |
| Mitochondrial dysfunction in neurodegenerative diseases: A focus on iPSC-derived neuronal models. | Trombetta-Lima M et al. | β | 2021 | β |
| Modified Snake Ξ±-Neurotoxin Averts Ξ²-Amyloid Binding to Ξ±7 Nicotinic Acetylcholine Receptor and Reverses Cognitive Deficits in Alzheimer's Disease Mice. | Fonar G et al. | β | 2021 | β |
| Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer's Disease. | GonzΓ‘lez de San RomΓ‘n E et al. | β | 2021 | β |
| MTH1 and OGG1 maintain a low level of 8-oxoguanine in Alzheimer's brain, and prevent the progression of Alzheimer's pathogenesis. | Oka S et al. | β | 2021 | β |
| Neuroinflammation in Alzheimer's Disease. | Onyango IG et al. | β | 2021 | β |
| Neuronal and Astrocytic Extracellular Vesicle Biomarkers in Blood Reflect Brain Pathology in Mouse Models of Alzheimer's Disease. | Delgado-Peraza F et al. | β | 2021 | β |
| Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein. | Park J et al. | β | 2021 | β |
| Neuronal Network Excitability in Alzheimer's Disease: The Puzzle of Similar versus Divergent Roles of Amyloid Ξ² and Tau. | Kazim SF et al. | β | 2021 | β |
| Neurotrophic Treatment Initiated During Early Postnatal Development Prevents the Alzheimer-Like Behavior and Synaptic Dysfunction. | Wei W et al. | β | 2021 | β |
| Novel Monoclonal Antibodies Against Mouse C1q: Characterisation and Development of a Quantitative ELISA for Mouse C1q. | Byrne RAJ et al. | β | 2021 | β |
| Olfactory dysfunction in the 3xTg-AD model of Alzheimer's disease. | Mitrano DA et al. | β | 2021 | β |
| Olfactory Signatures in the Food Finding Test in Mice With Normal and Alzheimer's Disease-Pathological Aging With Special Concerns on the Effects of Social Isolation. | MarΓn-Pardo D et al. | β | 2021 | β |
| Partial Inhibition of Mitochondrial Complex I Reduces Tau Pathology and Improves Energy Homeostasis and Synaptic Function in 3xTg-AD Mice. | Stojakovic A et al. | β | 2021 | β |
| Positron Emission Tomography in Animal Models of Alzheimer's Disease Amyloidosis: Translational Implications. | Ni R | β | 2021 | β |
| Positron Emission Tomography in Animal Models of Tauopathies. | Cao L et al. | β | 2021 | β |
| Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease. | Kim J | β | 2021 | β |
| Preservation of Retinal Function Through Synaptic Stabilization in Alzheimer's Disease Model Mouse Retina by Lycium Barbarum Extracts. | Liu J et al. | β | 2021 | β |
| Preserved Thermal Pain in 3xTg-AD Mice With Increased Sensory-Discriminative Pain Sensitivity in Females but Affective-Emotional Dimension in Males as Early Sex-Specific AD-Phenotype Biomarkers. | CaΓ±ete T et al. | β | 2021 | β |
| Preventive Effects of Continuous Betaine Intake on Cognitive Impairment and Aberrant Gene Expression in Hippocampus of 3xTg Mouse Model of Alzheimer's Disease. | Ibi D et al. | β | 2021 | β |
| Principles of brain aging: Status and challenges of modeling human molecular changes in mice. | Kluever V et al. | β | 2021 | β |
| Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals. | Hark TJ et al. | β | 2021 | β |
| RAPGEF2 mediates oligomeric AΞ²-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease. | Jang YN et al. | β | 2021 | β |
| Redox Homeostasis and Prospects for Therapeutic Targeting in Neurodegenerative Disorders. | Akanji MA et al. | β | 2021 | β |
| Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol. | Wang H et al. | β | 2021 | β |
| Regulation of microglia population dynamics throughout development, health, and disease. | Hammond BP et al. | β | 2021 | β |
| Relevance of transgenic mouse models for Alzheimer's disease. | Tai LM et al. | β | 2021 | β |
| Remodeling of projections from ventral hippocampus to prefrontal cortex in Alzheimer's mice. | Xu F et al. | β | 2021 | β |
| Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model. | Tournissac M et al. | β | 2021 | β |
| Retinal Changes in Transgenic Mouse Models of Alzheimer's Disease. | Guo L et al. | β | 2021 | β |
| Retinoid X receptor activation promotes re-myelination in a very old triple transgenic mouse model of Alzheimer's disease. | Santos-Gil DF et al. | β | 2021 | β |
| Rosmarinic acid suppresses tau phosphorylation and cognitive decline by downregulating the JNK signaling pathway. | Yamamoto S et al. | β | 2021 | β |
| Selective Regional Loss of Cortical Synapses Lacking Presynaptic Mitochondria in the 5xFAD Mouse Model. | Seo NY et al. | β | 2021 | β |
| Sex-Dependent End-of-Life Mental and Vascular Scenarios for Compensatory Mechanisms in Mice with Normal and AD-Neurodegenerative Aging. | Muntsant A et al. | β | 2021 | β |
| Sex-Dependent Signatures, Time Frames and Longitudinal Fine-Tuning of the Marble Burying Test in Normal and AD-Pathological Aging Mice. | Santana-Santana M et al. | β | 2021 | β |
| Sex differences in the neuropathological hallmarks of Alzheimer's disease: focus on cognitively intact elderly individuals. | Hu YT et al. | β | 2021 | β |
| Sex-specific alterations in NAD+ metabolism in 3xTg Alzheimer's disease mouse brain assessed by quantitative targeted LC-MS. | van der Velpen V et al. | β | 2021 | β |
| Sexual Dimorphism in the 3xTg-AD Mouse Model and Its Impact on Pre-Clinical Research. | Dennison JL et al. | β | 2021 | β |
| Social Nesting, Animal Welfare, and Disease Monitoring. | GimΓ©nez-Llort L et al. | β | 2021 | β |
| Sources and triggers of oxidative damage in neurodegeneration. | Angelova PR | β | 2021 | β |
| Spatial Memory and Gut Microbiota Alterations Are Already Present in Early Adulthood in a Pre-clinical Transgenic Model of Alzheimer's Disease. | Bello-Medina PC et al. | β | 2021 | β |
| Spatial memory deficiency early in 6xTg Alzheimer's disease mouse model. | Kang S et al. | β | 2021 | β |
| SPG302 Reverses Synaptic and Cognitive Deficits Without Altering Amyloid or Tau Pathology in a Transgenic Model of Alzheimer's Disease. | Trujillo-Estrada L et al. | β | 2021 | β |
| Strategic Modification of Gut Microbiota through Oral Bacteriotherapy Influences Hypoxia Inducible Factor-1Ξ±: Therapeutic Implication in Alzheimer's Disease. | Bonfili L et al. | β | 2021 | β |
| Subcommissural Organ-Spondin-Derived Peptide Restores Memory in a Mouse Model of Alzheimer's Disease. | Le Douce J et al. | β | 2021 | β |
| Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice. | Schob S et al. | β | 2021 | β |
| Synapses, Microglia, and Lipids in Alzheimer's Disease. | Paasila PJ et al. | β | 2021 | β |
| Synaptic dysregulation and hyperexcitability induced by intracellular amyloid beta oligomers. | Fernandez-Perez EJ et al. | β | 2021 | β |
| Synaptic Mitochondria: An Early Target of Amyloid-Ξ² and Tau in Alzheimer's Disease. | Torres AK et al. | β | 2021 | β |
| Systematic Phenotyping and Characterization of the 3xTg-AD Mouse Model of Alzheimer's Disease. | Javonillo DI et al. | β | 2021 | β |
| Systems-based proteomics to resolve the biology of Alzheimer's disease beyond amyloid and tau. | Rayaprolu S et al. | β | 2021 | β |
| Targeted metabolomics study of early pathological features in hippocampus of triple transgenic Alzheimer's disease male mice. | Zhao Y et al. | β | 2021 | β |
| Targeting increased levels of APP in Down syndrome: Posiphen-mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model. | Chen XQ et al. | β | 2021 | β |
| Targeting Microglia-Synapse Interactions in Alzheimer's Disease. | Piccioni G et al. | β | 2021 | β |
| Targeting MicroRNA-485-3p Blocks Alzheimer's Disease Progression. | Koh HS et al. | β | 2021 | β |
| Targeting the miRNA-155/TNFSF10 network restrains inflammatory response in the retina in a mouse model of Alzheimer's disease. | Burgaletto C et al. | β | 2021 | β |
| Tau Pathology Profile Across a Parietal-Hippocampal Brain Network Is Associated With Spatial Reorientation Learning and Memory Performance in the 3xTg-AD Mouse. | Stimmell AC et al. | β | 2021 | β |
| Tau phosphorylation and cochlear apoptosis cause hearing loss in 3ΓTg-AD Mouse Model of Alzheimer's Disease. | Wang SE et al. | β | 2021 | β |
| Tau Seeding Mouse Models with Patient Brain-Derived Aggregates. | Robert A et al. | β | 2021 | β |
| Telomerase Reverse Transcriptase Preserves Neuron Survival and Cognition in Alzheimer's Disease Models. | Shim HS et al. | β | 2021 | β |
| Tetrahydrobiopterin Improves Recognition Memory in the Triple-Transgenic Mouse Model of Alzheimer's Disease, Without Altering Amyloid-Ξ² and Tau Pathologies. | Fanet H et al. | β | 2021 | β |
| The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice. | Varinthra P et al. | β | 2021 | β |
| The Amyloid-Ξ² Pathway in Alzheimer's Disease. | Hampel H et al. | β | 2021 | β |
| The bioactivity of neuronal-derived nitric oxide in aging and neurodegeneration: Switching signaling to degeneration. | Ledo A et al. | β | 2021 | β |
| The clinical use of curcumin on neurological disorders: An updated systematic review of clinical trials. | Mohseni M et al. | β | 2021 | β |
| The complexity of Alzheimer's disease: an evolving puzzle. | Ferrari C et al. | β | 2021 | β |
| The effect of sodium channels on neurological/neuronal disorders: A systematic review. | Bagheri S et al. | β | 2021 | β |
| The informed road map to prevention of Alzheimer Disease: A call to arms. | McDade E et al. | β | 2021 | β |
| The Many Faces of Post-Ischemic Tau Protein in Brain Neurodegeneration of the Alzheimer's Disease Type. | Pluta R et al. | β | 2021 | β |
| The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice. | Di J et al. | β | 2021 | β |
| The Neuroprotective Beta Amyloid Hexapeptide Core Reverses Deficits in Synaptic Plasticity in the 5xFAD APP/PS1 Mouse Model. | Forest KH et al. | β | 2021 | β |
| The Non-receptor Tyrosine Kinase Pyk2 in Brain Function and Neurological and Psychiatric Diseases. | de Pins B et al. | β | 2021 | β |
| The Potential Role of Herpes Simplex Virus Type 1 and Neuroinflammation in the Pathogenesis of Alzheimer's Disease. | Laval K et al. | β | 2021 | β |
| Therapeutic B-cell depletion reverses progression of Alzheimer's disease. | Kim K et al. | β | 2021 | β |
| The Relevance of Amyloid Ξ²-Calmodulin Complexation in Neurons and Brain Degeneration in Alzheimer's Disease. | Poejo J et al. | β | 2021 | β |
| The role of amyloids in Alzheimer's and Parkinson's diseases. | Salahuddin P et al. | β | 2021 | β |
| The Role of Melatonin on Behavioral Changes and Concomitant Oxidative Stress in icvAΞ²<sub>1-42</sub> Rat Model with Pinealectomy. | Tzoneva R et al. | β | 2021 | β |
| The translocator protein ligands as mitochondrial functional modulators for the potential anti-Alzheimer agents. | Kim T et al. | β | 2021 | β |
| Three month inhalation exposure to low-level PM2.5 induced brain toxicity in an Alzheimer's disease mouse model. | Lee SH et al. | β | 2021 | β |
| Topographical Overlapping of the Amyloid-Ξ² and Tau Pathologies in the Default Mode Network Predicts Alzheimer's Disease with Higher Specificity. | Hojjati SH et al. | β | 2021 | β |
| Training protocol for probabilistic Pavlovian conditioning in mice using an open-source head-fixed setup. | HegedΓΌs P et al. | β | 2021 | β |
| Translational Modeling of Psychomotor Function in Normal and AD-Pathological Aging With Special Concerns on the Effects of Social Isolation. | Castillo-Mariqueo L et al. | β | 2021 | β |
| Transmission of cerebral amyloid pathology by peripheral administration of misfolded AΞ² aggregates. | Morales R et al. | β | 2021 | β |
| TRPV1-Mediated Microglial Autophagy Attenuates Alzheimer's Disease-Associated Pathology and Cognitive Decline. | Wang C et al. | β | 2021 | β |
| Unbiased high-content screening reveals AΞ²- and tau-independent synaptotoxic activities in human brain homogenates from Alzheimer's patients and high-pathology controls. | Jiang H et al. | β | 2021 | β |
| Using stable isotope labeling to advance our understanding of Alzheimer's disease etiology and pathology. | Hark TJ et al. | β | 2021 | β |
| Variability in sub-threshold signaling linked to Alzheimer's disease emerges with age and amyloid plaque deposition in mouse ventral CA1 pyramidal neurons. | Russo ML et al. | β | 2021 | β |
| Vascular smooth muscle cell dysfunction contribute to neuroinflammation and Tau hyperphosphorylation in Alzheimer disease. | Aguilar-Pineda JA et al. | β | 2021 | β |
| What is the gold standard model for Alzheimer's disease drug discovery and development? | Cacabelos R et al. | β | 2021 | β |
| Whole Blood Transcriptome Characterization of 3xTg-AD Mouse and Its Modulation by Transcranial Direct Current Stimulation (tDCS). | Magri C et al. | β | 2021 | β |
| 9R, the cholinesterase and amyloid beta aggregation dual inhibitor, as a multifunctional agent to improve cognitive deficit and neuropathology in the triple-transgenic Alzheimer's disease mouse model. | Ju Y et al. | β | 2020 | β |
| Acetylation of AMPA Receptors Regulates Receptor Trafficking and Rescues Memory Deficits in Alzheimer's Disease. | O'Connor M et al. | β | 2020 | β |
| A Curcumin Analog Exhibits Multiple Biologic Effects on the Pathogenesis of Alzheimer's Disease and Improves Behavior, Inflammation, and Ξ²-Amyloid Accumulation in a Mouse Model. | Su IJ et al. | β | 2020 | β |
| Age-Dependent Decline in Synaptic Mitochondrial Function Is Exacerbated in Vulnerable Brain Regions of Female 3xTg-AD Mice. | Espino de la Fuente-MuΓ±oz C et al. | β | 2020 | β |
| Allopregnanolone Promotes Neuronal and Oligodendrocyte Differentiation In Vitro and In Vivo: Therapeutic Implication for Alzheimer's Disease. | Chen S et al. | β | 2020 | β |
| Altered Expression of Glial Gap Junction Proteins Cx43, Cx30, and Cx47 in the 5XFAD Model of Alzheimer's Disease. | Angeli S et al. | β | 2020 | β |
| Alzheimer's Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research. | Pistollato F et al. | β | 2020 | β |
| Animal Models of Metabolic Disorders in the Study of Neurodegenerative Diseases: An Overview. | de Bem AF et al. | β | 2020 | β |
| An Isoquinolinium Dual Inhibitor of Cholinesterases and Amyloid Ξ² Aggregation Mitigates Neuropathological Changes in a Triple-Transgenic Mouse Model of Alzheimer's Disease. | Ju Y et al. | β | 2020 | β |
| A Novel Concept is Needed for Combating Alzheimer's Disease and NeuroHIV. | Hu XT | β | 2020 | β |
| A novel structure associated with aging is augmented in the DPP6-KO mouse brain. | Lin L et al. | β | 2020 | β |
| An Overview of Astrocyte Responses in Genetically Induced Alzheimer's Disease Mouse Models. | Spanos F et al. | β | 2020 | β |
| Anti-AΞ² antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathology. | Laversenne V et al. | β | 2020 | β |
| Astrocytic palmitoylethanolamide pre-exposure exerts neuroprotective effects in astrocyte-neuron co-cultures from a triple transgenic mouse model of Alzheimer's disease. | Beggiato S et al. | β | 2020 | β |
| Both Amyloid-Ξ² Peptide and Tau Protein Are Affected by an Anti-Amyloid-Ξ² Antibody Fragment in Elderly 3xTg-AD Mice. | Roda AR et al. | β | 2020 | β |
| Bridging the Gap Between Fluid Biomarkers for Alzheimer's Disease, Model Systems, and Patients. | Bjorkli C et al. | β | 2020 | β |
| Ca<sup>2+</sup> Dyshomeostasis Disrupts Neuronal and Synaptic Function in Alzheimer's Disease. | McDaid J et al. | β | 2020 | β |
| Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model. | FernΓ‘ndez-PΓ©rez EJ et al. | β | 2020 | β |
| Characterization and Discovery of a Selective Small-Molecule Modulator of Mitochondrial Complex I Targeting a Unique Binding Site. | Green JC et al. | β | 2020 | β |
| Cognitive Impairment in the 3xTg-AD Mouse Model of Alzheimer's Disease is Affected by AΞ²-ImmunoTherapy and Cognitive Stimulation. | Roda AR et al. | β | 2020 | β |
| Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease. | Chen C et al. | β | 2020 | β |
| Dickkopf-related protein-1 inhibition attenuates amyloid-beta pathology associated to Alzheimer's disease. | Menet R et al. | β | 2020 | β |
| Digging Signatures in 13-Month-Old 3xTg-AD Mice for Alzheimer's Disease and Its Disruption by Isolation Despite Social Life Since They Were Born. | Gimenez-Llort L et al. | β | 2020 | β |
| Does Impairment of Adult Neurogenesis Contribute to Pathophysiology of Alzheimer's Disease? A Still Open Question. | Li Puma DD et al. | β | 2020 | β |
| Dysfunction of Mitochondrial Ca<sup>2+</sup> Regulatory Machineries in Brain Aging and Neurodegenerative Diseases. | Jung H et al. | β | 2020 | β |
| Embryonic proteoglycans regulate monoamines in the rat frontal cortex and hippocampus in Alzheimer's disease-like pathology. | Chavushyan V et al. | β | 2020 | β |
| Environment and Gene Association With Obesity and Their Impact on Neurodegenerative and Neurodevelopmental Diseases. | Flores-Dorantes MT et al. | β | 2020 | β |
| Epigenetic basis of Alzheimer disease. | Tecalco-Cruz AC et al. | β | 2020 | β |
| Evaluating Circadian Dysfunction in Mouse Models of Alzheimer's Disease: Where Do We Stand? | Sheehan PW et al. | β | 2020 | β |
| Evidence for aggregation-independent, PrP<sup>C</sup>-mediated AΞ² cellular internalization. | Foley AR et al. | β | 2020 | β |
| Exercise-mediated alteration of hippocampal Dicer mRNA and miRNAs is associated with lower BACE1 gene expression and AΞ²<sup>1-42</sup> in female 3xTg-AD mice. | Dungan CM et al. | β | 2020 | β |
| Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in. | Chiasseu M et al. | β | 2020 | β |
| Heat therapy: possible benefits for cognitive function and the aging brain. | Von Schulze AT et al. | β | 2020 | β |
| Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer's disease. | Coninx E et al. | β | 2020 | β |
| IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease. | Escrig A et al. | β | 2020 | β |
| Impact of Social Isolation on the Behavioral, Functional Profiles, and Hippocampal Atrophy Asymmetry in Dementia in Times of Coronavirus Pandemic (COVID-19): A Translational Neuroscience Approach. | Muntsant A et al. | β | 2020 | β |
| Influence of Woodsmoke Exposure on Molecular Mechanisms Underlying Alzheimer's Disease: Existing Literature and Gaps in Our Understanding. | Schuller A et al. | β | 2020 | β |
| Inhibition of Colony-Stimulating Factor 1 Receptor by PLX3397 Prevents Amyloid Beta Pathology and Rescues Dopaminergic Signaling in Aging 5xFAD Mice. | Son Y et al. | β | 2020 | β |
| Intermittent fasting promotes adult hippocampal neuronal differentiation by activating GSK-3Ξ² in 3xTg-AD mice. | Li W et al. | β | 2020 | β |
| Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic Mice. | Houben S et al. | β | 2020 | β |
| Label-free X-ray estimation of brain amyloid burden. | Dahal E et al. | β | 2020 | β |
| Manganese Exposure Aggravates Ξ²-Amyloid Pathology by Microglial Activation. | Lin G et al. | β | 2020 | β |
| Microglia facilitate loss of perineuronal nets in the Alzheimer's disease brain. | Crapser JD et al. | β | 2020 | β |
| MicroRNA-138 Overexpression Alters AΞ²42 Levels and Behavior in Wildtype Mice. | Boscher E et al. | β | 2020 | β |
| Neuron Loss in Alzheimer's Disease: Translation in Transgenic Mouse Models. | Wirths O et al. | β | 2020 | β |
| Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer's Disease. | Broderick TL et al. | β | 2020 | β |
| Neuroprotective effects of p62(SQSTM1)-engineered lactic acid bacteria in Alzheimer's disease: a pre-clinical study. | Cecarini V et al. | β | 2020 | β |
| Neurotoxicity of different amyloid beta subspecies in mice and their interaction with isoflurane anaesthesia. | Borgstedt L et al. | β | 2020 | β |
| Pathogenic Tau Causes a Toxic Depletion of Nuclear Calcium. | Mahoney R et al. | β | 2020 | β |
| Phosphorylated AΞ² peptides in human Down syndrome brain and different Alzheimer's-like mouse models. | Kumar S et al. | β | 2020 | β |
| Plasma BDNF Levels Following Transcranial Direct Current Stimulation Allow Prediction of Synaptic Plasticity and Memory Deficits in 3ΓTg-AD Mice. | Cocco S et al. | β | 2020 | β |
| POSCAbilities: The Application of the Prion Organotypic Slice Culture Assay to Neurodegenerative Disease Research. | Pineau H et al. | β | 2020 | β |
| Preclinical models of disease and multimorbidity with focus upon cardiovascular disease and dementia. | Shabir O et al. | β | 2020 | β |
| Prenatal to early postnatal neurotrophic treatment prevents Alzheimer-like behavior and pathology in mice. | Wei W et al. | β | 2020 | β |
| Presenilin-2 and Calcium Handling: Molecules, Organelles, Cells and Brain Networks. | Pizzo P et al. | β | 2020 | β |
| Rodent Models of Amyloid-Beta Feature of Alzheimer's Disease: Development and Potential Treatment Implications. | Poon CH et al. | β | 2020 | β |
| Role of Kalirin and mouse strain in retention of spatial memory training in an Alzheimer's disease model mouse line. | Russo-Savage L et al. | β | 2020 | β |
| Role of sex and high-fat diet in metabolic and hypothalamic disturbances in the 3xTg-AD mouse model of Alzheimer's disease. | Robison LS et al. | β | 2020 | β |
| Role of tau protein in Alzheimer's disease: The prime pathological player. | Muralidar S et al. | β | 2020 | β |
| Role of the metabolism of branched-chain amino acids in the development of Alzheimer's disease and other metabolic disorders. | Polis B et al. | β | 2020 | β |
| Sex-dependent alterations in the physiology of entorhinal cortex neurons in old heterozygous 3xTg-AD mice. | Arsenault D et al. | β | 2020 | β |
| Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease. | Owlett L et al. | β | 2020 | β |
| Synergy between amyloid-Ξ² and tau in Alzheimer's disease. | Busche MA et al. | β | 2020 | β |
| Telomere length and oxidative stress variations in a murine model of Alzheimer's disease progression. | MartΓnez-GonzΓ‘lez K et al. | β | 2020 | β |
| The continuum between neurodegeneration, brain plasticity, and movement: a critical appraisal. | Schirinzi T et al. | β | 2020 | β |
| The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer's Disease. | Sorgdrager F et al. | β | 2020 | β |
| Transcriptional, Behavioral and Biochemical Profiling in the 3xTg-AD Mouse Model Reveals a Specific Signature of Amyloid Deposition and Functional Decline in Alzheimer's Disease. | Yin W et al. | β | 2020 | β |
| Ubiquitin, Autophagy and Neurodegenerative Diseases. | Watanabe Y et al. | β | 2020 | β |
| Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease. | Shen Y et al. | β | 2020 | β |
| Yuan-Hu Zhi Tong Prescription Mitigates Tau Pathology and Alleviates Memory Deficiency in the Preclinical Models of Alzheimer's Disease. | Iyaswamy A et al. | β | 2020 | β |