Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain.
paper
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- Authors
- Schwenk, Jochen; Baehrens, David; Haupt, Alexander; Bildl, Wolfgang; Boudkkazi, Sami; Roeper, Jochen; Fakler, Bernd; Schulte, Uwe
- Year
- 2014
- Journal
- Neuron
- PMID
- 25242221
- DOI
- 10.1016/j.neuron.2014.08.044
Native AMPA receptors (AMPARs) in the mammalian brain are macromolecular complexes whose functional characteristics vary across the different brain regions and change during postnatal development or in response to neuronal activity. The structural and functional properties of the AMPARs are determined by their proteome, the ensemble of their protein building blocks. Here we use high-resolution quantitative mass spectrometry to analyze the entire pool of AMPARs affinity-isolated from distinct brain regions, selected sets of neurons, and whole brains at distinct stages of postnatal development. These analyses show that the AMPAR proteome is dynamic in both space and time: AMPARs exhibit profound region specificity in their architecture and the constituents building their core and periphery. Likewise, AMPARs exchange many of their building blocks during postnatal development. These results provide a unique resource and detailed contextual data sets for the analysis of native AMPAR complexes and their role in excitatory neurotransmission.
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External
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| Modular composition and dynamics of native GABAB receptors identified by high-resolution proteomics. | Schwenk J et al. | β | 2016 | β |
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| PRRT2: from Paroxysmal Disorders to Regulation of Synaptic Function. | Valtorta F et al. | β | 2016 | β |
| PRRT2 Is a Key Component of the Ca(2+)-Dependent Neurotransmitter Release Machinery. | Valente P et al. | β | 2016 | β |
| Review on the role of AMPA receptor nano-organization and dynamic in the properties of synaptic transmission. | Compans B et al. | β | 2016 | β |
| Specification of synaptic connectivity by cell surface interactions. | de Wit J et al. | β | 2016 | β |
| Unconventional secretory processing diversifies neuronal ion channel properties. | Hanus C et al. | β | 2016 | β |
| ABHD17 proteins are novel protein depalmitoylases that regulate N-Ras palmitate turnover and subcellular localization. | Lin DT et al. | β | 2015 | β |
| Auxiliary Subunit GSG1L Acts to Suppress Calcium-Permeable AMPA Receptor Function. | McGee TP et al. | β | 2015 | β |
| Development- and age-related alterations in the expression of AMPA receptor subunit GluR2 and its trafficking proteins in the hippocampus of male mouse brain. | Pandey SP et al. | β | 2015 | β |
| Novel Regulation of the Synthesis of Ξ±-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Subunit GluA1 by Carnitine Palmitoyltransferase 1C (CPT1C) in the Hippocampus. | FadΓ³ R et al. | β | 2015 | β |
| Quantitative isoform-profiling of highly diversified recognition molecules. | Schreiner D et al. | β | 2015 | β |
| Regional Specializations of the PAZ Proteomes Derived from Mouse Hippocampus, Olfactory Bulb and Cerebellum. | Weingarten J et al. | β | 2015 | β |
| Structure, Dynamics, and Allosteric Potential of Ionotropic Glutamate Receptor N-Terminal Domains. | Krieger J et al. | β | 2015 | β |
| Synaptic localization of neurotransmitter receptors: comparing mechanisms for AMPA and GABAA receptors. | Martenson JS et al. | β | 2015 | β |
| The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. | Savas JN et al. | β | 2015 | β |