Delivering factors for reprogramming a somatic cell to pluripotency.
- Authors
- Um, Soong Ho
- Year
- 2012
- Journal
- International journal of stem cells
- PMID
- 24298349
- DOI
- 10.15283/ijsc.2012.5.1.6
- PMCID
- PMC3840986
An adult cell originates from stem cell. The stem cell is usually categorized into three species including an embryonic stem cell (ESc), an adult stem cell, and an induced stem cell (iPSc). iPSc features pluripotency, which is meant to be differentiated into any types of cells. Accordingly, it is much attractive to anyone who pursuit a regenerative medicine, owing to the potential almighty. They are simply produced by reprogramming a somatic cell via a transfer of transcription factors. The efficiency and productivity of iPS are considerably subject to delivering methods of exogenous genes into a variety of targeted mammalians. Conventional and well-run gene delivery techniques have been reviewed here. This details the methods and principles of delivery factors and provides an overview of the research, with an emphasis on their potential for use as clinical therapeutic platforms.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | 2019 | 30087005 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Inducing Pluripotency in Somatic Cells: Historical Perspective and Recent Advances. | Park J et al. | — | 2024 | → |
| Unlocking the therapeutic potential: odyssey of induced pluripotent stem cells in precision cell therapies. | Mohite P et al. | — | 2024 | → |
| Beyond youth: Understanding CAR T cell fitness in the context of immunological aging. | Noll JH et al. | — | 2023 | → |
| Cell-Permeable <i>Oct4</i> Gene Delivery Enhances Stem Cell-like Properties of Mouse Embryonic Fibroblasts. | Choi DH et al. | — | 2021 | → |
| Efficient and gentle delivery of molecules into cells with different elasticity <i>via</i> Progressive Mechanoporation. | Uvizl A et al. | — | 2021 | → |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | — | 2019 | → |
| Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience. | Mertens J et al. | — | 2016 | → |
| Enhanced Reprogramming Efficiency and Kinetics of Induced Pluripotent Stem Cells Derived from Human Duchenne Muscular Dystrophy. | Teotia P et al. | — | 2015 | → |
| Cell-penetrating peptide (CPP)-conjugated proteins is an efficient tool for manipulation of human mesenchymal stromal cells. | Jo J et al. | — | 2014 | → |