An evaluation of the full level of response to alcohol model of heavy drinking and problems in COGA offspring.
- Authors
- Schuckit, Marc A; Smith, Tom L; Danko, George P; Trim, Ryan; Bucholz, Kathleen K; Edenberg, Howard J; Hesselbrock, Victor; Kramer, John J; Dick, Danielle M
- Year
- 2009
- Journal
- Journal of studies on alcohol and drugs
- PMID
- 19371495
- DOI
- 10.15288/jsad.2009.70.436
- PMCID
- PMC2670749
OBJECTIVE: The low level of response (LR) to alcohol is an endophenotype related to heavier drinking and alcohol problems. Structural equation models (SEMs) indicate LR affects alcohol outcomes (ALCOUT) both directly and through mediation by drinking in peers (PEER), alcohol expectancies (EXPECT), and drinking to cope with stress (COPE), with some variation depending on the sample tested. This article presents the first full test of this LR-based model in young subjects from the Collaborative Study on the Genetics of Alcoholism (COGA). METHOD: Data were generated from 325 12- to 22-year-old (47.4% male) drinking offspring from COGA families, using the Self-Report of the Effects of Alcohol questionnaire to determine LR early in the drinking career and a validated, structured interview for demography and alcohol use/problem patterns. Standardized questionnaires were used to measure PEER, EXPECT, and COPE, with the model tested through the maximum likelihood estimation for analyses of the variance/covariance matrix using both Amos and Mplus. RESULTS: The SEM yielded good fit characteristics and explained 59% of the variance, with LR relating both directly to ALCOUT and as partially mediated by PEER and COPE. Although GENDER related to both LR and ALCOUT in the model, and AGE related to ALCOUT, the SEM results were invariant across both AGE and GENDER, with generally similar invariant results regarding the presence or absence of an alcohol-use disorder diagnosis. CONCLUSIONS: The results support the applicability of the LR-based model of heavy drinking and alcohol problems in the COGA offspring, a group with different demography compared with the two other samples of adolescents tested to date. The modest differences observed across samples will be evaluated in future research to enhance understanding of how the model operates across socioeconomic groups.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Evaluations of potential sex differences in alcohol use and problems in 454 offspring from the San Diego Prospective Study. | Schuckit MA et al. | — | 2025 | → |
| Where alcohol use disorder meets interoception: A meta-analytic view on structural and functional neuroimaging data. | Muehlhan M et al. | — | 2024 | → |
| Alexithymia and Alcohol Use: Evaluating the Role of Interoceptive Sensibility with the Revised Multidimensional Assessment of Interoceptive Awareness. | Lyvers M et al. | — | 2023 | → |
| Evidence for an alcohol-related "harm paradox" in individuals with internalizing disorders: Test and replication in two independent community samples. | Anker JJ et al. | — | 2023 | → |
| The Self-Rated Effects of Alcohol Are Related to Presystemic Metabolism of Alcohol. | Bramness JG et al. | — | 2023 | → |
| AUD Risk, Diagnoses, and Course in a Prospective Study Across Two Generations: Implications for Prevention. | Schuckit MA | — | 2022 | → |
| Characterising patterns of alcohol use among heavy drinkers: A cluster analysis utilising alcohol biosensor data. | Gunn RL et al. | — | 2021 | → |
| The synergistic effect between interoceptive accuracy and alcohol use disorder status on pain sensitivity. | Jakubczyk A et al. | — | 2021 | → |
| Transfer of incentive salience from a first-order alcohol cue to a novel second-order alcohol cue among individuals at risk for alcohol use disorder: electrophysiological evidence. | Fleming KA et al. | — | 2021 | → |
| Translating preclinical models of alcohol seeking and consumption into the human laboratory using intravenous alcohol self-administration paradigms. | Cyders MA et al. | — | 2021 | → |
| Association Between Interoception and Emotion Regulation in Individuals With Alcohol Use Disorder. | Jakubczyk A et al. | — | 2019 | → |
| Intergenerational continuity in alcohol misuse: Maternal alcohol use disorder and the sequelae of maternal and family functioning. | Johnson AK et al. | — | 2019 | → |
| Interoceptive accuracy and interoceptive sensibility in individuals with alcohol use disorder-Different phenomena with different clinical correlations? | Jakubczyk A et al. | — | 2019 | → |
| Predictors of Increases in Alcohol Problems and Alcohol Use Disorders in Offspring in the San Diego Prospective Study. | Schuckit MA et al. | — | 2019 | → |
| Post-GWAS in Psychiatric Genetics: A Developmental Perspective on the "Other" Next Steps. | Dick DM et al. | — | 2018 | → |
| Alcohol Misuse Across the Lifespan: Insights from Developmental Studies in Behavior Genetics. | Savage JE et al. | — | 2017 | → |
| A Prospective Comparison of How the Level of Response to Alcohol and Impulsivity Relate to Future DSM-IV Alcohol Problems in the COGA Youth Panel. | Schuckit MA et al. | — | 2017 | → |
| Mediation of effects of the level of response to alcohol and impulsivity 15 years later in 36-year-old men: Implications for prevention efforts. | Schuckit MA et al. | — | 2017 | → |
| Hypothetical evaluations of positive and negative alcohol consequences in adolescents across various levels of drinking experience. | Merrill JE et al. | — | 2016 | → |
| Psychometric validation of measures of alcohol expectancies, retrospective subjective response, and positive drinking consequences for use with adolescents. | Morean ME et al. | — | 2016 | → |
| The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes. | Trela CJ et al. | — | 2016 | → |
| The ontogeny of ethanol aversion. | Saalfield J et al. | — | 2016 | → |
| Adaptation of Subjective Responses to Alcohol is Affected by an Interaction of GABRA2 Genotype and Recent Drinking. | Kosobud AE et al. | — | 2015 | → |
| Differences in subjective response to alcohol by gender, family history, heavy episodic drinking, and cigarette use: refining and broadening the scope of measurement. | Morean ME et al. | — | 2015 | → |
| Endophenotypes for Alcohol Use Disorder: An Update on the Field. | Salvatore JE et al. | — | 2015 | → |
| Integrating basic research with prevention/intervention to reduce risky substance use among college students. | Dick DM et al. | — | 2015 | → |
| Quantifying alcohol consumption: Self-report, transdermal assessment, and prediction of dependence symptoms. | Simons JS et al. | — | 2015 | → |
| Adolescent alcohol use: risks and consequences. | Marshall EJ | — | 2014 | → |
| Contribution of time of drinking onset and family history of alcohol problems in alcohol and drug use behaviors in Argentinean college students. | Pilatti A et al. | — | 2014 | → |
| Effect of sex on ethanol consumption and conditioned taste aversion in adolescent and adult rats. | Schramm-Sapyta NL et al. | — | 2014 | → |
| Alcohol stress response dampening during imminent versus distal, uncertain threat. | Hefner KR et al. | — | 2013 | → |
| Genetics of alcohol dependence and social work research: do they mix? | Hesselbrock MN et al. | — | 2013 | → |
| How bad could it be? Alcohol dampens stress responses to threat of uncertain intensity. | Bradford DE et al. | — | 2013 | → |
| Relationships among independent major depressions, alcohol use, and other substance use and related problems over 30 years in 397 families. | Schuckit MA et al. | — | 2013 | → |
| Stability of scores and correlations with drinking behaviors over 15 years for the Self-Report of the Effects of Alcohol Questionnaire. | Schuckit MA et al. | — | 2013 | → |
| The Subjective Effects of Alcohol Scale: development and psychometric evaluation of a novel assessment tool for measuring subjective response to alcohol. | Morean ME et al. | — | 2013 | → |
| Comparison across two generations of prospective models of how the low level of response to alcohol affects alcohol outcomes. | Schuckit MA et al. | — | 2012 | → |
| fMRI differences between subjects with low and high responses to alcohol during a stop signal task. | Schuckit MA et al. | — | 2012 | → |
| Sex differences in how a low sensitivity to alcohol relates to later heavy drinking. | Schuckit MA et al. | — | 2012 | → |
| Structuring a college alcohol prevention program on the low level of response to alcohol model: a pilot study. | Schuckit MA et al. | — | 2012 | → |
| Subjective and neural responses to intravenous alcohol in young adults with light and heavy drinking patterns. | Gilman JM et al. | — | 2012 | → |
| The longitudinal prediction of alcohol consumption-related harms among young adults. | Little K et al. | — | 2012 | → |
| Alcohol dose effects on stress response to cued threat vary by threat intensity. | Moberg CA et al. | — | 2011 | → |
| A prospective evaluation of how a low level of response to alcohol predicts later heavy drinking and alcohol problems. | Schuckit MA et al. | — | 2011 | → |
| Conversation with Marc Schuckit. | Schuckit M | — | 2011 | → |
| Do executive and reactive disinhibition mediate the effects of familial substance use disorders on adolescent externalizing outcomes? | Handley ED et al. | — | 2011 | → |
| Testing a level of response to alcohol-based model of heavy drinking and alcohol problems in 1,905 17-year-olds. | Schuckit MA et al. | — | 2011 | → |
| Acute ethanol effects on brain activation in low- and high-level responders to alcohol. | Trim RS et al. | — | 2010 | → |
| Comparing structural equation models that use different measures of the level of response to alcohol. | Schuckit MA et al. | — | 2010 | → |
| Genetic variation and brain gene expression in rodent models of alcoholism implications for medication development. | Björk K et al. | — | 2010 | → |
| Persistent high alcohol consumption in alcohol-preferring (P) rats results from a lack of normal aversion to alcohol. | Rezvani AH et al. | — | 2010 | → |
| Trajectories of alcohol consumption following liver transplantation. | DiMartini A et al. | — | 2010 | → |
| The relationships of the level of response to alcohol and additional characteristics to alcohol use disorders across adulthood: a discrete-time survival analysis. | Trim RS et al. | — | 2009 | → |