Neurobiological mechanisms of control in alcohol use disorder - Moving towards mechanism-based non-invasive brain stimulation treatments.
- Authors
- Ghin, Filippo; Beste, Christian; Stock, Ann-Kathrin
- Year
- 2022
- Journal
- Neuroscience and biobehavioral reviews
- PMID
- 34942268
- DOI
- 10.1016/j.neubiorev.2021.12.031
Alcohol use disorder (AUD) is characterized by excessive habitual drinking and loss of control over alcohol intake despite negative consequences. Both of these aspects foster uncontrolled drinking and high relapse rates in AUD patients. Yet, common interventions mostly focus on the phenomenological level, and prioritize the reduction of craving and withdrawal symptoms. Our review provides a mechanistic understanding of AUD and suggests alternative therapeutic approaches targeting the mechanisms underlying dysfunctional alcohol-related behaviours. Specifically, we explain how repeated drinking fosters the development of rigid drinking habits and is associated with diminished cognitive control. These behavioural and cognitive effects are then functionally related to the neurobiochemical effects of alcohol abuse. We further explain how alterations in fronto-striatal network activity may constitute the neurobiological correlates of these alcohol-related dysfunctions. Finally, we discuss limitations in current pharmacological AUD therapies and suggest non-invasive brain stimulation (like TMS and tDCS interventions) as a potential addition/alternative for modulating the activation of both cortical and subcortical areas to help re-establish the functional balance between controlled and automatic behaviour.
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In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | 2026 | 41657495 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state. | Richard CD et al. | — | 2026 | → |
| Localized Nonablative Neuromodulatory Irradiation of the Nucleus Accumbens Ameliorates Voluntary Excessive Alcohol Consumption in Miniature Pigs. | Yeh CI et al. | — | 2026 | → |
| Shared neural network dysfunctions in treatment-resistant major depression and alcohol use disorder: Resting-state fMRI evidence and implications for neuromodulation. | Tien Y et al. | — | 2026 | → |
| Alcohol use disorder is associated with altered frontomedial phase-amplitude coupling strength during resting state | Richard C et al. | — | 2025 | — |
| Chronic alcohol-induced brain states limit propagation of direct cortical stimulation. | Habelt B et al. | — | 2025 | → |
| Distinct Alpha Connectivity Patterns During Response Inhibition in Alcohol Use Disorder. | Ghin F et al. | — | 2025 | → |
| Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neuropsychiatric Symptoms in Substance Use Disorder (SUD)-A Review and Insights into Possible Mechanisms of Action. | Chmiel J et al. | — | 2025 | → |
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| Neurobiological Mechanisms of Action of Transcranial Direct Current Stimulation (tDCS) in the Treatment of Substance Use Disorders (SUDs)-A Review. | Chmiel J et al. | — | 2025 | → |
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| On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder. | Ghin F et al. | — | 2022 | → |