Increased association of brain protein kinase C with the receptor for activated C kinase-1 (RACK1) in bipolar affective disorder.
- Authors
- Wang, H; Friedman, E
- Year
- 2001
- Journal
- Biological psychiatry
- PMID
- 11543740
- DOI
- 10.1016/s0006-3223(01)01147-7
BACKGROUND: Membrane protein kinase C (PKC) activity is increased in frontal cortex of subjects with bipolar affective disorder, and lithium was demonstrated to inhibit PKC translocation to membranes. Protein kinase C is anchored to the membrane via the receptor for activated C kinase-1 (RACK1), suggesting that interactions between these proteins may be altered in bipolar disease. METHODS: The levels of RACK1 coimmunoprecipitating with PKC isozymes were compared in homogenates of frontal cortex slices from postmortem bipolar subjects and matched control subjects. RESULTS: Receptor for activated C kinase-1 was located exclusively in membranes and, in control brains, the levels of RACK1 that coimmunoprecipitated with most PKC isozymes were increased by stimulation with the PKC activator, phorbol 12-myristate, 13-acetate (PMA). The association of RACK1 with membrane gammaPKC and zetaPKC was increased under basal conditions in bipolar relative to control brains. Stimulation with PMA increased the amount of RACK1 that coimmunoprecipitated with the alpha, beta, gamma, delta, and varepsilonPKC isozymes, but not zetaPKC, in bipolar tissues over that elicited in control tissues. CONCLUSIONS: These data suggest that the increased association of RACK1 with PKC isozymes may be responsible for the increases in membrane PKC and in its activation that were previously observed in frontal cortex of bipolar affective disorder brains.
No figures extracted from this document.
No chunks — full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
No citations found.
In this knowledge base
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| The ribosome-associated protein RACK1 represses Kir4.1 translation in astrocytes and influences neuronal activity. | Oudart M et al. | — | 2023 | → |
| Translational regulation by RACK1 in astrocytes represses KIR4.1 expression and regulates neuronal activity | Oudart M et al. | — | 2022 | — |
| Molecular Mechanisms Linking ALS/FTD and Psychiatric Disorders, the Potential Effects of Lithium. | Limanaqi F et al. | — | 2019 | → |
| Rack1 Controls Parallel Fiber-Purkinje Cell Synaptogenesis and Synaptic Transmission. | Yang H et al. | — | 2019 | → |
| Using human stem cells as a model system to understand the neural mechanisms of alcohol use disorders: Current status and outlook. | Scarnati MS et al. | — | 2019 | → |
| Valproate for acute mania. | Jochim J et al. | — | 2019 | → |
| RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in rats. | Ni H et al. | — | 2018 | → |
| Application of induced pluripotent stem cells to understand neurobiological basis of bipolar disorder and schizophrenia. | Liu YN et al. | — | 2017 | → |
| RACK1 regulates neural development. | Kershner L et al. | — | 2017 | → |
| Role of Protein Kinase C in Bipolar Disorder: A Review of the Current Literature. | Saxena A et al. | — | 2017 | → |
| Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. | Mertens J et al. | — | 2015 | → |
| Tamoxifen use for the management of mania: a review of current preclinical evidence. | Armani F et al. | — | 2014 | → |
| Second messenger/signal transduction pathways in major mood disorders: moving from membrane to mechanism of action, part II: bipolar disorder. | Niciu MJ et al. | — | 2013 | → |
| Successful combined therapy with tamoxifen and lithium in a paradoxical sleep deprivation-induced mania model. | Armani F et al. | — | 2012 | → |
| RACK1, A multifaceted scaffolding protein: Structure and function. | Adams DR et al. | — | 2011 | → |
| Structure of the RACK1 dimer from Saccharomyces cerevisiae. | Yatime L et al. | — | 2011 | → |
| Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain. | Wang HY et al. | — | 2009 | → |
| GABA(A) receptors and their associated proteins: implications in the etiology and treatment of schizophrenia and related disorders. | Charych EI et al. | — | 2009 | → |
| Importance of steroid receptor coactivators in the modulation of steroid action on brain and behavior. | Charlier TD | — | 2009 | → |
| Protein kinase C inhibitors: rationale for use and potential in the treatment of bipolar disorder. | Zarate CA et al. | — | 2009 | → |
| The plasmodium receptor for activated C kinase protein inhibits Ca(2+) signaling in mammalian cells. | Sartorello R et al. | — | 2009 | → |
| Distribution and expression of protein kinase C interactive protein (PKCI/HINT1) in mouse central nervous system (CNS). | Liu Q et al. | — | 2008 | → |
| Human receptor for activated protein kinase C1 associates with polyglutamine aggregates and modulates polyglutamine toxicity. | Lam W et al. | — | 2008 | → |
| Nociceptive and behavioural sensitisation by protein kinase Cepsilon signalling in the CNS. | Van Kolen K et al. | — | 2008 | → |
| Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment. | McNamara RK et al. | — | 2008 | → |
| Verapamil augmentation of lithium treatment improves outcome in mania unresponsive to lithium alone: preliminary findings and a discussion of therapeutic mechanisms. | Mallinger AG et al. | — | 2008 | → |
| Intracellular signaling pathways pave roads to recovery for mood disorders. | Tanis KQ et al. | — | 2007 | → |
| Differential effect of serum from bipolar versus schizophrenic patients on spontaneous acetylcholine release at mammalian neuromuscular junction. | Veggetti MI et al. | — | 2006 | → |
| Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness. | McNamara RK et al. | — | 2006 | → |
| RACK1 has the nerve to act: structure meets function in the nervous system. | Sklan EH et al. | — | 2006 | → |
| Lithium and bipolar mood disorder: the inositol-depletion hypothesis revisited. | Harwood AJ | — | 2005 | → |
| Lithium and valproic acid treatments reduce PKC activation and receptor-G protein coupling in platelets of bipolar manic patients. | Hahn CG et al. | — | 2005 | → |
| Microarray analysis of differentially expressed genes in rat frontal cortex under chronic risperidone treatment. | Chen ML et al. | — | 2005 | → |
| Protein kinase C signal transduction regulation in physiological and pathological aging. | Battaini F et al. | — | 2005 | → |
| RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release. | Patterson RL et al. | — | 2004 | → |
| Serotonin-mediated phosphorylation of extracellular regulated kinases in platelets of patients with panic disorder versus controls. | Martini C et al. | — | 2004 | → |
| Affective disorders, antidepressant drugs and brain metabolism. | Moretti A et al. | — | 2003 | → |
| Altered 5-HT-induced calcium response in the presence of staurosporine in blood platelets from bipolar disorder patients. | Suzuki K et al. | — | 2003 | → |
| Cloning, expression and genomic structure of a novel human GNB2L1 gene, which encodes a receptor of activated protein kinase C (RACK). | Wang S et al. | — | 2003 | → |
| Molecular basis of lithium action: integration of lithium-responsive signaling and gene expression networks. | Lenox RH et al. | — | 2003 | → |
| Protein kinase C isoforms as therapeutic targets in nervous system disease states. | Battaini F | — | 2001 | → |