Pathways to alcohol-induced brain impairment in young people: a review.
paper
Cited
Public
Unavailable
- Authors
- Hermens, Daniel F; Lagopoulos, Jim; Tobias-Webb, Juliette; De Regt, Tamara; Dore, Glenys; Juckes, Lisa; Latt, Noeline; Hickie, Ian B
- Year
- 2013
- Journal
- Cortex; a journal devoted to the study of the nervous system and behavior
- PMID
- 22789780
- DOI
- 10.1016/j.cortex.2012.05.021
Classically, disorders associated with 'alcohol-related brain damage' (ARBD) occur as a result of chronic excessive alcohol misuse and confer significant physical and psychological disability to the individual as well as to the community. These phenotypes are often difficult to detect at early stages and therefore early intervention and treatment is limited. It remains unresolved as to whether there are neurobiological markers of the early stages of such brain damage in young 'at-risk' drinkers, who probably experience 'alcohol-induced brain impairment' prior to the onset of ARBD, per se. This review focuses on neurobiological (in particular, neuropsychological and neuroimaging) markers that are associated with alcohol misuse in young people (13-24 years of age). The findings from this review suggest that a clearer understanding of alcohol misuse (particularly with regards to binge drinking) is needed. Despite this, neurocognitive profile along with supporting neuroimaging evidence appears to be particularly important in the early detection of brain changes that result from excessive alcohol use. In young alcohol misusers, these preventable and potentially reversible deficits may be progressive but if left unresolved such deficits eventually become major contributors to poor outcome (long term) and hamper adherence to treatment. We address five key themes in this review: (i) there are specific drinking patterns in young people; (ii) youth represents a critical period in brain development that is particularly vulnerable to alcohol misuse; (iii) the extent to which there are pre-existing versus alcohol-induced neurobiological changes remains unclear; (iv) vulnerability markers may be mediated by mental health and substance use comorbidities; and (v) cognitive remediation would be a likely candidate for early prevention and treatment as it could help to develop efficient meta-cognitive skills to prevent relapse in young drinkers.
No figures extracted from this document.
No chunks β full text not yet ingested.
No entities extracted from this document yet.
No uploaded files.
Not in any collection.
No citations found.
In this knowledge base
| Title | Year | PMID |
|---|---|---|
| Understanding alcohol use disorders with neuroelectrophysiology. | 2014 | 25307587 |
External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Repeated Binge-Like Alcohol Drinking Heightens Aggression in Mice | Frier MD et al. | β | 2025 | β |
| The Correlation Between Emotionality Changes and Alcohol Consumption in Young Persons: A Pilot Study. | Mitincu-Caramfil SD et al. | β | 2025 | β |
| An Examination of Bidirectional Associations Between Alcohol Use and Internalizing Symptoms Among Adolescents During the COVID-19 Pandemic. | Gohari MR et al. | β | 2024 | β |
| Ethanol binge drinking exposure during adolescence displays long-lasting motor dysfunction related to cerebellar neurostructural damage even after long-term withdrawal in female Wistar rats. | de Oliveira IG et al. | β | 2024 | β |
| Sex-specific effects of alcohol on neurobehavioral performance and endoplasmic reticulum stress: an analysis using neuron-specific MANF deficient mice. | Wen W et al. | β | 2024 | β |
| The PEERCARE peer led programme for college students: A qualitative evaluation of a "chill-out" harm reduction space. | Blanzat C et al. | β | 2024 | β |
| Binge drinking is associated with higher cortisol and lower hippocampal and prefrontal gray matter volume: Prospective association with future alcohol intake. | Fan S et al. | β | 2023 | β |
| Nicotine's effect on cognition, a friend or foe? | Wang Q et al. | β | 2023 | β |
| Successful word retraining, maintenance and transference of practice to everyday activities: A single case experimental design in early onset alcohol-induced brain damage. | Savage SA et al. | β | 2023 | β |
| The effects of binge drinking on attention in young adults. | Monds LA et al. | β | 2023 | β |
| Alcohol and the Adolescent Brain: What We've Learned and Where the Data Are Taking Us. | Tapert SF et al. | β | 2022 | β |
| A mixed-methods approach to improve the measurement of alcohol-induced blackouts: ABOM-2. | Boness CL et al. | β | 2022 | β |
| Attentional bias in alcohol drinkers: A systematic review of its link with consumption variables. | Bollen Z et al. | β | 2022 | β |
| Differential effects of alcohol-drinking patterns on the structure and function of the brain and cognitive performance in young adult drinkers: A pilot study. | Guo X et al. | β | 2022 | β |
| Effects of binge drinking during adolescence and emerging adulthood on the brain: A systematic review of neuroimaging studies. | PΓ©rez-GarcΓa JM et al. | β | 2022 | β |
| Electrophysiological resting-state hyperconnectivity and poorer behavioural regulation as predisposing profiles of adolescent binge drinking. | AntΓ³n-Toro LF et al. | β | 2022 | β |
| Exploring Contributing Factors of Solitary Drinking among Hong Kong Chinese Adolescents and Young Adults: A Descriptive Phenomenology. | Ho KY et al. | β | 2022 | β |
| Alcohol and Brain Development in Adolescents and Young Adults: A Systematic Review of the Literature and Advisory Report of the Health Council of the Netherlands. | de Goede J et al. | β | 2021 | β |
| Eye Tracking Studies Exploring Cognitive and Affective Processes among Alcohol Drinkers: a Systematic Review and Perspectives. | Maurage P et al. | β | 2021 | β |
| Pediatric thiamine deficiency disorders in high-income countries between 2000 and 2020: a clinical reappraisal. | Rakotoambinina B et al. | β | 2021 | β |
| The possible role of CREB-BDNF signaling pathway in neuroprotective effects of minocycline against alcohol-induced neurodegeneration: molecular and behavioral evidences. | Motaghinejad M et al. | β | 2021 | β |
| Visual impairment and its associated factors among medical and health sciences students at the University of Gondar, Northwest Ethiopia. | Getnet M et al. | β | 2021 | β |
| Youth Cannabis use and Legalization in Canada - Reconsidering the Fears, Myths and Facts Three Years In. | Haines-Saah RJ et al. | β | 2021 | β |
| Chronic alcohol-induced liver injury correlates with memory deficits: Role for neuroinflammation. | King JA et al. | β | 2020 | β |
| Disentangling the role of social cognition processes at early steps of alcohol abuse: The influence of affective theory of mind. | Lannoy S et al. | β | 2020 | β |
| Effect of alcohol use on the adolescent brain and behavior. | Lees B et al. | β | 2020 | β |
| Eye tracking correlates of acute alcohol consumption: A systematic and critical review. | Maurage P et al. | β | 2020 | β |
| Gamma oryzanol impairs alcohol-induced anxiety-like behavior in mice via upregulation of central monoamines associated with Bdnf and Il-1Ξ² signaling. | Akter S et al. | β | 2020 | β |
| Molecular, histological and behavioral evidences for neuroprotective effects of minocycline against nicotine-induced neurodegeneration and cognition impairment: Possible role of CREB-BDNF signaling pathway. | Motaghinejad M et al. | β | 2020 | β |
| Patterns of behavioral risk factors for non-communicable diseases in Vietnam: A narrative scoping review. | Thuy Duyen N et al. | β | 2020 | β |
| Twenty-first birthday drinking: Extreme-drinking episodes and white matter microstructural changes in the fornix and corpus callosum. | Boness CL et al. | β | 2020 | β |
| Animal models of binge drinking, current challenges to improve face validity. | Jeanblanc J et al. | β | 2019 | β |
| Behavioral and Cerebral Impairments Associated with Binge Drinking in Youth: A Critical Review. | Lannoy S et al. | β | 2019 | β |
| Decreased event-related theta power and phase-synchrony in young binge drinkers during target detection: An anatomically-constrained MEG approach. | Correas A et al. | β | 2019 | β |
| Impact of Exchange Stay on Alcohol Consumption: Longitudinal Exploration in a Large Sample of European Students. | Dormal V et al. | β | 2019 | β |
| Increased Nucleus Accumbens Volume in College Binge Drinkers - Preliminary Evidence From Manually Segmented MRI Analysis. | Sousa SS et al. | β | 2019 | β |
| Indirect and moderated effects of parent-child communication on drinking outcomes in the transition to college. | Hartman JD et al. | β | 2019 | β |
| Adolescent Binge Drinking. | Chung T et al. | β | 2018 | β |
| Behavioral and Brain Activity Indices of Cognitive Control Deficits in Binge Drinkers. | Molnar SM et al. | β | 2018 | β |
| Binge Drinking and the Young Brain: A Mini Review of the Neurobiological Underpinnings of Alcohol-Induced Blackout. | Hermens DF et al. | β | 2018 | β |
| Binge drinking in young people: protocol for a systematic review of neuropsychological, neurophysiological and neuroimaging studies. | Lees B et al. | β | 2018 | β |
| Binge drinking is associated with reduced quality of life in young students: A pan-European study. | Dormal V et al. | β | 2018 | β |
| Electrophysiological correlates of emotional crossmodal processing in binge drinking. | Lannoy S et al. | β | 2018 | β |
| "Freshman's week": characteristics associated with participation and experiencing adverse effects. | Erevik EK et al. | β | 2018 | β |
| Heavy alcohol use in adolescence is associated with altered cortical activity: a combined TMS-EEG study. | Kaarre O et al. | β | 2018 | β |
| Neurobiological Effects of Binge Drinking Help in Its Detection and Differential Diagnosis from Alcohol Dependence. | Waszkiewicz N et al. | β | 2018 | β |
| Alcohol screening among young people: a prospective study from the Swiss Sentinel Surveillance System (Sentinella) of physicians' a priori opinions. | Wenger-Bonny C et al. | β | 2017 | β |
| Associations between alcohol-use and depression symptoms in adolescence: Examining gender differences and pathways over time. | Danzo S et al. | β | 2017 | β |
| Binging at the campus: Motivations and impulsivity influence binge drinking profiles in university students. | Lannoy S et al. | β | 2017 | β |
| College Binge Drinking Associated with Decreased Frontal Activation to Negative Emotional Distractors during Inhibitory Control. | Cohen-Gilbert JE et al. | β | 2017 | β |
| Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats. | Motaghinejad M et al. | β | 2017 | β |
| Differential impairments across attentional networks in binge drinking. | Lannoy S et al. | β | 2017 | β |
| Gray Matter Abnormalities in the Inhibitory Circuitry of Young Binge Drinkers: A Voxel-Based Morphometry Study. | Sousa SS et al. | β | 2017 | β |
| Neural correlates of correct and failed response inhibition in heavy versus light social drinkers: an fMRI study during a go/no-go task by healthy participants. | Campanella S et al. | β | 2017 | β |
| Patterns of Alcohol Consumption in Spanish University Alumni: Nine Years of Follow-Up. | GΓ³mez P et al. | β | 2017 | β |
| Preserved Crossmodal Integration of Emotional Signals in Binge Drinking. | Lannoy S et al. | β | 2017 | β |
| GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. | Tomasini MC et al. | β | 2016 | β |
| Landolphia owariensis Attenuates Alcohol-induced Cerebellar Neurodegeneration: Significance of Neurofilament Protein Alteration in the Purkinje Cells. | Oyinbo CA et al. | β | 2016 | β |
| Migraine Triggers and Oxidative Stress: A Narrative Review and Synthesis. | Borkum JM | β | 2016 | β |
| Personality profile of binge drinking in university students is modulated by sex. A study using the Alternative Five Factor Model. | Adan A et al. | β | 2016 | β |
| Prefrontal mechanisms of comorbidity from a transdiagnostic and ontogenic perspective. | Macdonald AN et al. | β | 2016 | β |
| Sexually dimorphic brain volume interaction in college-aged binge drinkers. | Kvamme TL et al. | β | 2016 | β |
| The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review. | Iorfino F et al. | β | 2016 | β |
| Up-Regulation of PKR Signaling Pathway by Ethanol Displays an Age of Onset-Dependent Relationship. | Duncan JW et al. | β | 2016 | β |
| Accessibility of Catering Service Venues and Adolescent Drinking in Beijing, China. | Lu S et al. | β | 2015 | β |
| Adolescent Heavy Drinking Does Not Affect Maturation of Basic Executive Functioning: Longitudinal Findings from the TRAILS Study. | Boelema SR et al. | β | 2015 | β |
| Age at first use of alcohol predicts the risk of heavy alcohol use in early adulthood: a longitudinal study in the United States. | Liang W et al. | β | 2015 | β |
| [Alcohol use in young adolescents. A survey in French secondary schools]. | Bailly D et al. | β | 2015 | β |
| Alterations in serum microRNA in humans with alcohol use disorders impact cell proliferation and cell death pathways and predict structural and functional changes in brain. | Ignacio C et al. | β | 2015 | β |
| Associations of Truancy, Perceived School Performance, and Mental Health With Alcohol Consumption Among Adolescents. | Holtes M et al. | β | 2015 | β |
| A Systematic Review of School-Based Alcohol and other Drug Prevention Programs. | Agabio R et al. | β | 2015 | β |
| Cognitive dysfunction and functional disability in alcohol-dependent adults with or without a comorbid affective disorder. | Lee RS et al. | β | 2015 | β |
| Drinking patterns and the association between socio-demographic factors and adolescents' alcohol use in three metropolises in China. | Lu S et al. | β | 2015 | β |
| Electrophysiological correlates of problematic Internet use: Critical review and perspectives for future research. | D'Hondt F et al. | β | 2015 | β |
| Internet Use and Adolescent Binge Drinking: Findings from the Monitoring the Future Study. | Mu KJ et al. | β | 2015 | β |
| Weaknesses in executive functioning predict the initiating of adolescents' alcohol use. | Peeters M et al. | β | 2015 | β |
| Alcohol use assessment in young adult cancer survivors. | Breitenbach K et al. | β | 2014 | β |
| Beyond inhibition: a dual-process perspective to renew the exploration of binge drinking. | Lannoy S et al. | β | 2014 | β |
| Binge alcohol consumption in emerging adults: anterior cingulate cortical "thinness" is associated with alcohol use patterns. | Mashhoon Y et al. | β | 2014 | β |
| Binge drinking and the differential influence of ethanol on cognitive control subprocesses: a novel field of neurotoxicology. | Stock AK et al. | β | 2014 | β |
| Binge drinking in adolescents: a review of neurophysiological and neuroimaging research. | Petit G et al. | β | 2014 | β |
| Binge drinking, reflection impulsivity, and unplanned sexual behavior: impaired decision-making in young social drinkers. | Townshend JM et al. | β | 2014 | β |
| Evolution of the binge drinking pattern in college students: neurophysiological correlates. | LΓ³pez-Caneda E et al. | β | 2014 | β |
| Impact of alcohol use on inhibitory control (and vice versa) during adolescence and young adulthood: a review. | LΓ³pez-Caneda E et al. | β | 2014 | β |
| Larger mid-dorsolateral prefrontal gray matter volume in young binge drinkers revealed by voxel-based morphometry. | Doallo S et al. | β | 2014 | β |
| Neurocognitive deficits, craving, and abstinence among alcohol-dependent individuals following detoxification. | Naim-Feil J et al. | β | 2014 | β |
| Should the legal age for alcohol purchase be raised to 21? | Toumbourou JW et al. | β | 2014 | β |
| Stress and alcohol interactions: animal studies and clinical significance. | Spanagel R et al. | β | 2014 | β |
| The impact of alcohol and tobacco use on in vivo glutathione in youth with bipolar disorder: an exploratory study. | Chitty KM et al. | β | 2014 | β |
| Understanding alcohol use disorders with neuroelectrophysiology. | Rangaswamy M et al. | β | 2014 | β |
| Alcohol and immunology: Summary of the 2012 Alcohol and Immunology Research Interest Group (AIRIG) meeting. | Ippolito JA et al. | β | 2013 | β |
| Behavioral self-concept as predictor of teen drinking behaviors. | Dudovitz RN et al. | β | 2013 | β |
| Clinical classification in mental health at the cross-roads: which direction next? | Hickie IB et al. | β | 2013 | β |
| Effects of a persistent binge drinking pattern of alcohol consumption in young people: a follow-up study using event-related potentials. | LΓ³pez-Caneda E et al. | β | 2013 | β |
| Increased cortical activity in binge drinkers during working memory task: a preliminary assessment through a functional magnetic resonance imaging study. | Campanella S et al. | β | 2013 | β |
| Neuropsychological functioning is compromised in binge drinking young adults with depression. | Hermens DF et al. | β | 2013 | β |
| Pathways to alcohol-induced brain impairment in young people: a review by Hermens et al., 2013. | Maurage P et al. | β | 2013 | β |
| Pathways to alcohol-induced brain impairment in young people: a review by Hermens et al., 2013: reply. | Hermens DF et al. | β | 2013 | β |