Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice.
paper
Cited
Public
Unavailable
- Authors
- Lu, Yongke; Zhuge, Jian; Wang, Xiaodong; Bai, Jingxiang; Cederbaum, Arthur I
- Year
- 2008
- Journal
- Hepatology (Baltimore, Md.)
- PMID
- 18393316
- DOI
- 10.1002/hep.22222
Cytochrome P450 2E1 (CYP2E1) is suggested to play a role in alcoholic liver disease, which includes alcoholic fatty liver, alcoholic hepatitis, and alcoholic cirrhosis. In this study, we investigated whether CYP2E1 plays a role in experimental alcoholic fatty liver in an oral ethanol-feeding model. After 4 weeks of ethanol feeding, macrovesicular fat accumulation and accumulation of triglyceride in liver were observed in wild-type mice but not in CYP2E1-knockout mice. In contrast, free fatty acids (FFAs) were increased in CYP2E1-knockout mice but not in wild-type mice. CYP2E1 was induced by ethanol in wild-type mice, and oxidative stress induced by ethanol was higher in wild-type mice than in CYP2E1-knockout mice. Peroxisome proliferator-activated receptor alpha (PPARalpha), a regulator of fatty acid oxidation, was up-regulated in CYP2E1-knockout mice fed ethanol but not in wild-type mice. A PPARalpha target gene, acyl CoA oxidase, was decreased by ethanol in wild-type but not in CYP2E1-knockout mice. Chlormethiazole, an inhibitor of CYP2E1, lowered macrovesicular fat accumulation, inhibited oxidative stress, and up-regulated PPARalpha protein level in wild-type mice fed ethanol. The introduction of CYP2E1 to CYP2E1-knockout mice via an adenovirus restored macrovesicular fat accumulation. These results indicate that CYP2E1 contributes to experimental alcoholic fatty liver in this model and suggest that CYP2E1-derived oxidative stress may inhibit oxidation of fatty acids by preventing up-regulation of PPARalpha by ethanol, resulting in fatty liver.
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|---|---|---|---|---|
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| CYP2E1 overexpression in hepatocellular carcinoma modulates tumor invasion and migration via Wnt/Ξ²-catenin signaling pathway. | Ishteyaque S et al. | β | 2025 | β |
| Discovery of a CYP2E1 inhibitor and its therapeutic potential in severe acute pancreatitis. | Qiu J et al. | β | 2025 | β |
| [Elucidating the Mechanisms of Lipid Accumulation in the Liver and Evaluating Potential Drug Targets]. | Koga T | β | 2025 | β |
| Evaluation of the beneficial effects of pemafibrate in hypertriglyceridemia with or without alcohol drinking (PAR-CHAT: PARmodia-CHikushi Anti-dyslipidemia Trial). | Takamiya Y et al. | β | 2025 | β |
| Gardenin A alleviates alcohol-induced oxidative stress and inflammation in HepG2 and Caco2 cells via AMPK/Nrf2 pathway. | Chadha P et al. | β | 2025 | β |
| Lipopolysaccharide, arbiter of the gut-liver axis, modulates hepatic cell pathophysiology in alcoholism. | Mak KM et al. | β | 2025 | β |
| Repression of the ERRΞ³-CYP2E1 pathway by FGF4 mitigates alcohol-associated liver injury. | Wang L et al. | β | 2025 | β |
| The Pathophysiology of Alcohol-Associated Liver Disease: Focusing on Superoxide Dismutase 1 as a Therapeutic Target. | Gopal T et al. | β | 2025 | β |
| The role of bacterial outer membrane vesicles in inflammatory response of acute-on-chronic liver failure. | Qin X et al. | β | 2025 | β |
| The role of cytochrome P4502E1 in ethanol mediated diseases: a narrative update. | Zakhari S et al. | β | 2025 | β |
| Alcohol-associated liver disease: Emerging therapeutic strategies. | Mullish BH et al. | β | 2024 | β |
| Biphasic effects of ethanol consumption on N,N-dimethylformamide-induced liver injury in mice. | Zheng QX et al. | β | 2024 | β |
| Chronic Ethanol Intake Impairs Niacin Nutritional Status in Mice. | Mizutani A et al. | β | 2024 | β |
| Contributing roles of mitochondrial dysfunction and hepatocyte apoptosis in liver diseases through oxidative stress, post-translational modifications, inflammation, and intestinal barrier dysfunction. | LeFort KR et al. | β | 2024 | β |
| FXR overexpression prevents hepatic steatosis through inhibiting AIM2 inflammasome activation in alcoholic liver disease. | Li L et al. | β | 2024 | β |
| Interaction between fatty acid oxidation and ethanol metabolism in liver. | Lu Y et al. | β | 2024 | β |
| Kaempferol and nicotiflorin ameliorated alcohol-induced liver injury in mice by miR-138-5p/SIRT1/FXR and gut microbiota. | Ge J et al. | β | 2024 | β |
| Reducing Oxidative Stress-Mediated Alcoholic Liver Injury by Multiplexed RNAi of <i>Cyp2e1, Cyp4a10</i>, and <i>Cyp4a14</i>. | Zhang Q et al. | β | 2024 | β |
| The Discovery of Gut Microbial Metabolites as Modulators of Host Susceptibility to Acetaminophen-Induced Hepatotoxicity. | Lee H et al. | β | 2024 | β |
| The Interplay between Endogenous and Foodborne Pro-Oxidants and Antioxidants in Shaping Redox Homeostasis. | Jakubek P et al. | β | 2024 | β |
| Amelioration of ethanol-induced oxidative stress and alcoholic liver disease by <i>inΒ vivo</i> RNAi targeting <i>Cyp2e1</i>. | Wang Y et al. | β | 2023 | β |
| Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease. | Kim HH et al. | β | 2023 | β |
| Class III Alcohol Dehydrogenase Plays a Key Role in the Onset of Alcohol-Related/-Associated Liver Disease as an S-Nitrosoglutathione Reductase in Mice. | Haseba T et al. | β | 2023 | β |
| Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-ΞΊB/NLRP3 Inflammasome Pathway. | Zhang F et al. | β | 2023 | β |
| Effect of Clomethiazole Vs. Clorazepate on Hepatic Fat and Serum Transaminase Activities in Alcohol-Associated Liver Disease: Results from a Randomized, Controlled Phase II Clinical Trial. | Hohmann N et al. | β | 2023 | β |
| Hepatic fibrosis: Targeting peroxisome proliferator-activated receptor alpha from mechanism to medicines. | Gong L et al. | β | 2023 | β |
| Label-Free Imaging Techniques to Evaluate Metabolic Changes Caused by Toxic Liver Injury in PCLS. | Rodimova S et al. | β | 2023 | β |
| Lutein Prevents Liver Injury and Intestinal Barrier Dysfunction in Rats Subjected to Chronic Alcohol Intake. | Zhao S et al. | β | 2023 | β |
| Pathogenesis of Alcoholic Fatty Liver a Narrative Review. | Seitz HK et al. | β | 2023 | β |
| Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease. | Yan C et al. | β | 2023 | β |
| Post-translational modifications of histone and non-histone proteins in epigenetic regulation and translational applications in alcohol-associated liver disease: Challenges and research opportunities. | Rungratanawanich W et al. | β | 2023 | β |
| The effects of carvacrol on oxidative stress, inflammation, and liver function indicators in a systemic inflammation model induced by lipopolysaccharide in rats. | Mortazavi A et al. | β | 2023 | β |
| The role of NADPH oxidase 1 in alcohol-induced oxidative stress injury of intestinal epithelial cells. | Chen L et al. | β | 2023 | β |
| Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism. | Chen X et al. | β | 2023 | β |
| Amelioration of Hepatic Steatosis by the Androgen Receptor Inhibitor EPI-001 in Mice and Human Hepatic Cells Is Associated with the Inhibition of CYP2E1. | Wang S et al. | β | 2022 | β |
| A retinoic acid receptor Ξ²2 agonist protects against alcohol liver disease and modulates hepatic expression of canonical retinoid metabolism genes. | Melis M et al. | β | 2022 | β |
| CD73-Adenosine A<sub>1</sub>R Axis Regulates the Activation and Apoptosis of Hepatic Stellate Cells Through the PLC-IP<sub>3</sub>-Ca<sup>2+</sup>/DAG-PKC Signaling Pathway. | Liu Z et al. | β | 2022 | β |
| Cirrhosis-associated immune dysfunction. | Albillos A et al. | β | 2022 | β |
| Creatine supplementation protects against diet-induced non-alcoholic fatty liver but exacerbates alcoholic fatty liver. | Marinello PC et al. | β | 2022 | β |
| Crosstalk between Oxidative Stress and Inflammatory Liver Injury in the Pathogenesis of Alcoholic Liver Disease. | Yang YM et al. | β | 2022 | β |
| CYP2E1 plays a suppressive role in hepatocellular carcinoma by regulating Wnt/Dvl2/Ξ²-catenin signaling. | Zhu L et al. | β | 2022 | β |
| Cytochrome P450 2E1-dependent hepatic ethanol metabolism induces fatty acid-binding protein 4 and steatosis. | Attal N et al. | β | 2022 | β |
| Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease. | Shi Y et al. | β | 2022 | β |
| Ginsenoside Rc Modulates SIRT6-NRF2 Interaction to Alleviate Alcoholic Liver Disease. | Pan Z et al. | β | 2022 | β |
| <i>Levilactobacillus brevis</i> MG5311 Alleviates Ethanol-Induced Liver Injury by Suppressing Hepatic Oxidative Stress in C57BL/6 Mice. | Jung H et al. | β | 2022 | β |
| Mice lacking Ξ±4 nicotinic acetylcholine receptors are protected against alcohol-associated liver injury. | Watson WH et al. | β | 2022 | β |
| Roxadustat, a Hypoxia-Inducible Factor 1Ξ± Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease. | Gao Y et al. | β | 2022 | β |
| The impact of legacy and novel perfluoroalkyl substances on human cytochrome P450: An in vitro study on the inhibitory potential and underlying mechanisms. | Amstutz VH et al. | β | 2022 | β |
| The Preliminary Results for Evaluating Cocoa Butter's Hepatoprotective Effects against Lipid Accumulation and Inflammation in Adult Male Rats Chronically Fed Ethanol. | Chang HY et al. | β | 2022 | β |
| Withaferin A alleviates ethanol-induced liver injury by inhibiting hepatic lipogenesis. | Hamada K et al. | β | 2022 | β |
| Activation of PPARΞ±-catalase pathway reverses alcoholic liver injury via upregulating NAD synthesis and accelerating alcohol clearance. | Yue R et al. | β | 2021 | β |
| A mini-review of the rodent models for alcoholic liver disease: shortcomings, application, and future prospects. | Liu SX et al. | β | 2021 | β |
| A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age. | McMahan RH et al. | β | 2021 | β |
| Anti-Oxidant and Anti-Inflammatory Effects of Lipopolysaccharide from <i>Rhodobacter sphaeroides</i> against Ethanol-Induced Liver and Kidney Toxicity in Experimental Rats. | Mehanna ET et al. | β | 2021 | β |
| Curcumin Can be Acts as Effective agent for Prevent or Treatment of Alcohol-induced Toxicity in Hepatocytes: An Illustrated Mechanistic Review. | Salehi E et al. | β | 2021 | β |
| Cytochrome P450 2F2 (CYP2F2) negatively regulates browning in 3T3-L1 white adipocytes. | Dang TTH et al. | β | 2021 | β |
| Ellagic Acid Prevents Binge Alcohol-Induced Leaky Gut and Liver Injury through Inhibiting Gut Dysbiosis and Oxidative Stress. | Kim DH et al. | β | 2021 | β |
| Hepatoprotection by Ginsenoside Rg1 in alcoholic liver disease. | Yang C et al. | β | 2021 | β |
| <i>Cannabis sativa</i> L. (var. <i>indica</i>) Exhibits Hepatoprotective Effects by Modulating Hepatic Lipid Profile and Mitigating Gluconeogenesis and Cholinergic Dysfunction in Oxidative Hepatic Injury. | Erukainure OL et al. | β | 2021 | β |
| Metformin and Probiotics Interplay in Amelioration of Ethanol-Induced Oxidative Stress and Inflammatory Response in an <i>In Vitro</i> and <i>In Vivo</i> Model of Hepatic Injury. | Patel F et al. | β | 2021 | β |
| Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA study. | Yoshimura Y et al. | β | 2021 | β |
| PPARΞ± agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase. | Chen X et al. | β | 2021 | β |
| PPARΞ± agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. | Xu Y et al. | β | 2021 | β |
| Raphani Semen (<i>Raphanus sativus</i> L.) Ameliorates Alcoholic Fatty Liver Disease by Regulating De Novo Lipogenesis. | Park WY et al. | β | 2021 | β |
| Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway. | Ishida K et al. | β | 2021 | β |
| The History of Alcoholic Liver Disease: From an Unrecognized Disease to One of the Most Frequent Diseases in Hepatology. | Seitz HK et al. | β | 2021 | β |
| Translational Approaches with Antioxidant Phytochemicals against Alcohol-Mediated Oxidative Stress, Gut Dysbiosis, Intestinal Barrier Dysfunction, and Fatty Liver Disease. | Ballway JW et al. | β | 2021 | β |
| UDP-glucuronosyltransferases mediate coffee-associated reduction of liver fibrosis in bile duct ligated humanized transgenic <i>UGT1A</i> mice. | Landerer S et al. | β | 2021 | β |
| Alcohol-induced Hsp90 acetylation is a novel driver of liver sinusoidal endothelial dysfunction and alcoholic liver disease | Yang Y et al. | β | 2020 | β |
| Autophagy mitigates ethanol-induced mitochondrial dysfunction and oxidative stress in esophageal keratinocytes. | Chandramouleeswaran PM et al. | β | 2020 | β |
| Drug targeting CYP2E1 for the treatment of early-stage alcoholic steatohepatitis. | Diesinger T et al. | β | 2020 | β |
| Emerging Roles of SIRT1 in Alcoholic Liver Disease. | Ren R et al. | β | 2020 | β |
| Free radicals, antioxidants, nuclear factor-E2-related factor-2 and liver damage. | Ramos-Tovar E et al. | β | 2020 | β |
| Hepatoprotective Effects of Steamed and Freeze-Dried Mature Silkworm Larval Powder against Ethanol-Induced Fatty Liver Disease in Rats. | Lee DY et al. | β | 2020 | β |
| High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARΞ±: a new model for steatohepatitis-associated fibrosis. | Chen X et al. | β | 2020 | β |
| Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver. | Ramos-Tovar E et al. | β | 2020 | β |
| Oxidative stress-dependent frataxin inhibition mediated alcoholic hepatocytotoxicity through ferroptosis. | Liu J et al. | β | 2020 | β |
| Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-Induced Osteopenia and Steatosis in Rats. | Ham JR et al. | β | 2020 | β |
| Roles of peroxisome proliferator-activated receptor Ξ± in the pathogenesis of ethanol-induced liver disease. | Meng FG et al. | β | 2020 | β |
| Chronic intake of high-dose of blueberry leaf extract does not augment the harmful effects of ethanol in rats. | Yamasaki K et al. | β | 2019 | β |
| Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis. | Zhong F et al. | β | 2019 | β |
| Cryptotanshinone from the <i>Salvia miltiorrhiza</i> Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways. | Nagappan A et al. | β | 2019 | β |
| CYP1A2 contributes to alcohol-induced abnormal lipid metabolism through the PTEN/AKT/SREBP-1c pathway. | Zhu Q et al. | β | 2019 | β |
| CYP2A6 is associated with obesity: studies in human samples and a high fat diet mouse model. | Wang K et al. | β | 2019 | β |
| Drug-induced liver injury in obesity and nonalcoholic fatty liver disease. | Allard J et al. | β | 2019 | β |
| Dysfunctional Immune Response in Acute-on-Chronic Liver Failure: It Takes Two to Tango. | Martin-Mateos R et al. | β | 2019 | β |
| Establishment of a p-nitrophenol oxidation-based assay for the analysis of CYP2E1 activity in intact hepatocytes in vitro. | Mahli A et al. | β | 2019 | β |
| Experimental Applications of <i>in situ</i> Liver Perfusion Machinery for the Study of Liver Disease. | Choi WM et al. | β | 2019 | β |
| Fermented ginseng, GBCK25, ameliorates steatosis and inflammation in nonalcoholic steatohepatitis model. | Choi N et al. | β | 2019 | β |
| Inhibitory effect of chlormethiazole on the toxicokinetics of diethylnitrosamine in normal and hepatofibrotic rats. | Wang G et al. | β | 2019 | β |
| Orally administration of <i>Neolentinus lepideus</i> extracts attenuated ethanol induced accumulation of hepatic lipid in mice. | Park KM et al. | β | 2019 | β |
| Regulatory T cells suppress excessive lipid accumulation in alcoholic liver disease. | Wang H et al. | β | 2019 | β |
| Schisandra fruits for the management of drug-induced liver injury in China: A review. | Zhu P et al. | β | 2019 | β |
| Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice. | Chen X et al. | β | 2019 | β |
| A Blend of Extracts from Houttuynia cordata, Nelumbo nucifera, and Camellia sinensis Protects Against Ethanol-Induced Liver Damage in C57BL/6 Mice. | You Y et al. | β | 2018 | β |
| Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti- inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu. | Sowmya K et al. | β | 2018 | β |
| Carcinogenic Etheno DNA Adducts in Alcoholic Liver Disease: Correlation with Cytochrome P-4502E1 and Fibrosis. | Mueller S et al. | β | 2018 | β |
| Confounding influence of tamoxifen in mouse models of Cre recombinase-induced gene activity or modulation. | Hammad S et al. | β | 2018 | β |
| Cytochrome P450s and Alcoholic Liver Disease. | Lu Y et al. | β | 2018 | β |
| Engineered Animal Models Designed for Investigating Ethanol Metabolism, Toxicity and Cancer. | Marshall S et al. | β | 2018 | β |
| Evaluating the effect of diallyl sulfide on regulation of inflammatory mRNA expression in 3T3L1 adipocytes and RAW 264.7 macrophages during ethanol treatment. | Kema VH et al. | β | 2018 | β |
| Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress. | Nagappan A et al. | β | 2018 | β |
| Hepatoprotective effects of garlic against ethanol-induced liver injury: A mini-review. | Guan MJ et al. | β | 2018 | β |
| Impairment of Akt activity by CYP2E1 mediated oxidative stress is involved in chronic ethanol-induced fatty liver. | Zeng T et al. | β | 2018 | β |
| Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. | Hartmann P et al. | β | 2018 | β |
| Nicotine enhances alcoholic fatty liver in mice: Role of CYP2A5. | Chen X et al. | β | 2018 | β |
| Nrf2 in alcoholic liver disease. | Sun J et al. | β | 2018 | β |
| Pomegranate prevents binge alcohol-induced gut leakiness and hepatic inflammation by suppressing oxidative and nitrative stress. | Cho YE et al. | β | 2018 | β |
| Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. | Yokoyama A et al. | β | 2018 | β |
| SUMOylation regulates cytochrome P450 2E1 expression and activity in alcoholic liver disease. | Tomasi ML et al. | β | 2018 | β |
| Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease. | Zhao N et al. | β | 2018 | β |
| The safety evaluation of food flavouring substances: the role of metabolic studies. | Smith RL et al. | β | 2018 | β |
| Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARΞ±-FGF21 axis. | Chen X et al. | β | 2017 | β |
| Alcoholic Liver Disease: from CYP2E1 to CYP2A5. | Leung TM et al. | β | 2017 | β |
| Anti-steatotic and anti-inflammatory effects of Hovenia dulcis Thunb. extracts in chronic alcohol-fed rats. | Choi RY et al. | β | 2017 | β |
| Combined Catalase and ADH Inhibition Ameliorates Ethanol-Induced Myocardial Dysfunction Despite Causing Oxidative Stress in Conscious Female Rats. | Yao F et al. | β | 2017 | β |
| Cytochrome P450-2E1 promotes fast food-mediated hepatic fibrosis. | Abdelmegeed MA et al. | β | 2017 | β |
| Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of Ξ±-endosulfan and dioxin in HepaRG human cells. | Attignon EA et al. | β | 2017 | β |
| Fructose 1, 6-diphosphate prevents alcohol-induced liver injury through inhibiting oxidative stress and promoting alcohol metabolism in mice. | Li L et al. | β | 2017 | β |
| Ginsenosides from stems and leaves of ginseng prevent ethanol-induced lipid accumulation in human L02 hepatocytes. | Hu CF et al. | β | 2017 | β |
| <i>Schisandra sphenanthera</i> extract (Wuzhi Tablet) protects against chronic-binge and acute alcohol-induced liver injury by regulating the NRF2-ARE pathway in mice. | Zeng X et al. | β | 2017 | β |
| Protective effect of wild Corni fructus methanolic extract against acute alcoholic liver injury in mice. | Jiang Z et al. | β | 2017 | β |
| Protective Effects of Diallyl Sulfide Against Ethanol-Induced Injury in Rat Adipose Tissue and Primary Human Adipocytes. | Kema VH et al. | β | 2017 | β |
| Role of CYP2E1 in Mitochondrial Dysfunction and Hepatic Injury by Alcohol and Non-Alcoholic Substances. | Abdelmegeed MA et al. | β | 2017 | β |
| The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARΞ± down-regulation. | Na S et al. | β | 2017 | β |
| The regulatory effects of fish oil and chitosan on hepatic lipogenic signals in high-fat diet-induced obese rats. | Chiu CY et al. | β | 2017 | β |
| Alcohol Upregulation of CYP2A5: Role of Reactive Oxygen Species. | Lu Y et al. | β | 2016 | β |
| Critical Roles of Kupffer Cells in the Pathogenesis of Alcoholic Liver Disease: From Basic Science to Clinical Trials. | Zeng T et al. | β | 2016 | β |
| Cytochrome P450-2E1 promotes aging-related hepatic steatosis, apoptosis and fibrosis through increased nitroxidative stress. | Abdelmegeed MA et al. | β | 2016 | β |
| Decreased hepatic iron in response to alcohol may contribute to alcohol-induced suppression of hepcidin. | Varghese J et al. | β | 2016 | β |
| Hepatoprotective effects of hoveniae semen cum fructus extracts in ethanol intoxicated mice. | Cho I et al. | β | 2016 | β |
| Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | Tilg H et al. | β | 2016 | β |
| Low-<i>Ο</i>3 Fatty Acid and Soy Protein Attenuate Alcohol-Induced Fatty Liver and Injury by Regulating the Opposing Lipid Oxidation and Lipogenic Signaling Pathways. | Reyes-Gordillo K et al. | β | 2016 | β |
| Mechanism of Hepatocyte Apoptosis. | Cao L et al. | β | 2016 | β |
| Molecular changes in hepatic metabolism and transport in cirrhosis and their functional importance. | Dietrich CG et al. | β | 2016 | β |
| New therapeutic targets in alcoholic hepatitis. | Arsene D et al. | β | 2016 | β |
| Role of Transcription Factors in Steatohepatitis and Hypertension after Ethanol: The Epicenter of Metabolism. | Ansari RA et al. | β | 2016 | β |
| The effect of 17Ξ²-estradiol on sex-dimorphic cytochrome P450 expression patterns induced by hyperoxia in the liver of male CBA/H mice. | Ε afranko Ε½M et al. | β | 2016 | β |
| Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice. | Hong F et al. | β | 2015 | β |
| Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1. | Seitz HK et al. | β | 2015 | β |
| Alcohol Dehydrogenase-1B (rs1229984) and Aldehyde Dehydrogenase-2 (rs671) Genotypes Are Strong Determinants of the Serum Triglyceride and Cholesterol Levels of Japanese Alcoholic Men. | Yokoyama A et al. | β | 2015 | β |
| Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity. | Lu Y et al. | β | 2015 | β |
| Dual effect of red wine on liver redox status: a concise and mechanistic review. | Silva P et al. | β | 2015 | β |
| Excessive bile acid activated NF-kappa B and promoted the development of alcoholic steatohepatitis in farnesoid X receptor deficient mice. | Wu WB et al. | β | 2015 | β |
| Free fatty acids enhance the oxidative damage induced by ethanol metabolism in an in vitro model. | HernΓ‘ndez I et al. | β | 2015 | β |
| Hepatoprotective effect of kaempferol against alcoholic liver injury in mice. | Wang M et al. | β | 2015 | β |
| Identification of cytochrome CYP2E1 as critical mediator of synergistic effects of alcohol and cellular lipid accumulation in hepatocytes in vitro. | Mahli A et al. | β | 2015 | β |
| Interleukin-32Ξ³ attenuates ethanol-induced liver injury by the inhibition of cytochrome P450 2E1 expression and inflammatory responses. | Lee DH et al. | β | 2015 | β |
| Ligustrazine prevents alcohol-induced liver injury by attenuating hepatic steatosis and oxidative stress. | Lu C et al. | β | 2015 | β |
| Microbiota Protects Mice Against Acute Alcohol-Induced Liver Injury. | Chen P et al. | β | 2015 | β |
| Molecular mechanisms of the microsomal mixed function oxidases and biological and pathological implications. | Cederbaum AI | β | 2015 | β |
| Myeloperoxidase formation of PAF receptor ligands induces PAF receptor-dependent kidney injury during ethanol consumption. | Latchoumycandane C et al. | β | 2015 | β |
| Nrf2-mediated antioxidant response by ethanolic extract of Sida cordifolia provides protection against alcohol-induced oxidative stress in liver by upregulation of glutathione metabolism. | Rejitha S et al. | β | 2015 | β |
| Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice. | Cao YW et al. | β | 2015 | β |
| Transgenic mouse models for alcohol metabolism, toxicity, and cancer. | Heit C et al. | β | 2015 | β |
| Update on Alcoholic Hepatitis. | Torok NJ | β | 2015 | β |
| A cross-omics toxicological evaluation of drinking water treated with different processes. | Shi P et al. | β | 2014 | β |
| Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease. | Wu W et al. | β | 2014 | β |
| Alcoholic Ketosis: Prevalence, Determinants, and Ketohepatitis in Japanese Alcoholic Men. | Yokoyama A et al. | β | 2014 | β |
| Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1Ξ±-dependent apoptosis pathway in mice and humans. | Yun JW et al. | β | 2014 | β |
| Chronic liver inflammation: clinical implications beyond alcoholic liver disease. | Park BJ et al. | β | 2014 | β |
| CMZ reversed chronic ethanol-induced disturbance of PPAR-Ξ± possibly by suppressing oxidative stress and PGC-1Ξ± acetylation, and activating the MAPK and GSK3Ξ² pathway. | Zeng T et al. | β | 2014 | β |
| Emodin ameliorates ethanol-induced fatty liver injury in mice. | Liu Y et al. | β | 2014 | β |
| Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver. | Liu J | β | 2014 | β |
| Ethanol plus the Jo2 Fas agonistic antibody-induced liver injury is attenuated in mice with partial ablation of argininosuccinate synthase. | Lu Y et al. | β | 2014 | β |
| Inhibition of cytochrome P4502E1 by chlormethiazole attenuated acute ethanol-induced fatty liver. | Chen YY et al. | β | 2014 | β |
| Methodology to assay CYP2E1 mixed function oxidase catalytic activity and its induction. | Cederbaum AI | β | 2014 | β |
| Multifactorial comparative proteomic study of cytochrome P450 2E1 function in chronic alcohol administration. | Wang Y et al. | β | 2014 | β |
| Pathogenesis of alcoholic liver disease: role of oxidative metabolism. | Ceni E et al. | β | 2014 | β |
| Sulforaphane induces Nrf2 and protects against CYP2E1-dependent binge alcohol-induced liver steatosis. | Zhou R et al. | β | 2014 | β |
| The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts. | Linhart K et al. | β | 2014 | β |
| Absence of receptor interacting protein kinase 3 prevents ethanol-induced liver injury. | Roychowdhury S et al. | β | 2013 | β |
| Ascorbic acid is superior to silymarin in the recovery of ethanol-induced inflammatory reactions in hepatocytes of guinea pigs. | Abhilash PA et al. | β | 2013 | β |
| CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis. | Abdelmegeed MA et al. | β | 2013 | β |
| Cytochrome P4502E1 inhibitor, chlormethiazole, decreases lipopolysaccharide-induced inflammation in rat Kupffer cells with ethanol treatment. | Ye Q et al. | β | 2013 | β |
| Cytochrome P450 2E1: its clinical aspects and a brief perspective on the current research scenario. | Dey A | β | 2013 | β |
| Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1Ξ± in vivo. | Wang X et al. | β | 2013 | β |
| Deletion of circadian gene Per1 alleviates acute ethanol-induced hepatotoxicity in mice. | Wang T et al. | β | 2013 | β |
| Estrogen-related receptor Ξ³ controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol. | Kim DK et al. | β | 2013 | β |
| Impairment of autophagy: from hereditary disorder to drug intoxication. | Aki T et al. | β | 2013 | β |
| Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. | Shearn CT et al. | β | 2013 | β |
| Inhibition of autophagy promotes CYP2E1-dependent toxicity in HepG2 cells via elevated oxidative stress, mitochondria dysfunction and activation of p38 and JNK MAPK. | Wu D et al. | β | 2013 | β |
| Mouse model of chronic and binge ethanol feeding (the NIAAA model). | Bertola A et al. | β | 2013 | β |
| Nicotine enhances ethanol-induced fat accumulation and collagen deposition but not inflammation in mouse liver. | Lu Y et al. | β | 2013 | β |
| Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO. | Tang Y et al. | β | 2013 | β |
| Roles of cytochrome P4502E1 gene polymorphisms and the risks of alcoholic liver disease: a meta-analysis. | Zeng T et al. | β | 2013 | β |
| The activation of HO-1/Nrf-2 contributes to the protective effects of diallyl disulfide (DADS) against ethanol-induced oxidative stress. | Zeng T et al. | β | 2013 | β |
| The role of cytochrome P450 2E1 in ethanol-mediated carcinogenesis. | Seitz HK et al. | β | 2013 | β |
| Additive effects of mitochondrion-targeted cytochrome CYP2E1 and alcohol toxicity on cytochrome c oxidase function and stability of respirosome complexes. | Bansal S et al. | β | 2012 | β |
| Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. | Wu D et al. | β | 2012 | β |
| Characterization of 4-HNE modified L-FABP reveals alterations in structural and functional dynamics. | Smathers RL et al. | β | 2012 | β |
| Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. | Abdelmegeed MA et al. | β | 2012 | β |
| CYP2E1 Sensitizes the Liver to LPS- and TNF Ξ±-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases. | Cederbaum AI et al. | β | 2012 | β |
| Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats. | Ye Q et al. | β | 2012 | β |
| Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver. | Yang L et al. | β | 2012 | β |
| Early growth response-1 contributes to steatosis development after acute ethanol administration. | Donohue TM et al. | β | 2012 | β |
| Ethanol-induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. | Tang H et al. | β | 2012 | β |
| Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway. | Lu Y et al. | β | 2012 | β |
| Garlic oil alleviated ethanol-induced fat accumulation via modulation of SREBP-1, PPAR-Ξ±, and CYP2E1. | Zeng T et al. | β | 2012 | β |
| Genetic determinants of alcoholic liver disease. | Stickel F et al. | β | 2012 | β |
| Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis. | Shi X et al. | β | 2012 | β |
| Lipid droplet accumulation and impaired fat efflux in polarized hepatic cells: consequences of ethanol metabolism. | McVicker BL et al. | β | 2012 | β |
| Oxidative stress and inflammation: essential partners in alcoholic liver disease. | Ambade A et al. | β | 2012 | β |
| Oxidative stress and liver disease. | Zhu R et al. | β | 2012 | β |
| The type of dietary fat modulates intestinal tight junction integrity, gut permeability, and hepatic toll-like receptor expression in a mouse model of alcoholic liver disease. | Kirpich IA et al. | β | 2012 | β |
| Alcohol and lipid traffic don't mix. | McNiven MA et al. | β | 2011 | β |
| Alcoholic liver disease: pathogenesis and new therapeutic targets. | Gao B et al. | β | 2011 | β |
| Ethanol induction of CYP2A5: permissive role for CYP2E1. | Lu Y et al. | β | 2011 | β |
| Hepatocyte-specific hypoxia-inducible factor-1Ξ± is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. | Nath B et al. | β | 2011 | β |
| Identification of a cytochrome P4502E1/Bid/C1q-dependent axis mediating inflammation in adipose tissue after chronic ethanol feeding to mice. | Sebastian BM et al. | β | 2011 | β |
| Mechanisms of the inflammatory reaction implicated in alcoholic hepatitis: 2011 update. | Voican CS et al. | β | 2011 | β |
| Pathogenesis of alcoholic hepatitis: Role of inflammatory signaling and oxidative stress. | Jampana SC et al. | β | 2011 | β |
| Pathways of liver injury in alcoholic liver disease. | Tilg H et al. | β | 2011 | β |
| Polymorphism of N-acetyltransferase 2 gene and the susceptibility to alcoholic liver cirrhosis: interaction with smoking. | Yang KC et al. | β | 2011 | β |
| Alcoholic steatohepatitis. | Stickel F et al. | β | 2010 | β |
| Chronic alcohol-induced liver injury and oxidant stress are decreased in cytochrome P4502E1 knockout mice and restored in humanized cytochrome P4502E1 knock-in mice. | Lu Y et al. | β | 2010 | β |
| Chronic ethanol consumption results in atypical liver injury in copper/zinc superoxide dismutase deficient mice. | Curry-McCoy TV et al. | β | 2010 | β |
| CYP2E1 enhances ethanol-induced lipid accumulation but impairs autophagy in HepG2 E47 cells. | Wu D et al. | β | 2010 | β |
| CYP2E1 potentiation of LPS and TNFΞ±-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction. | Lu Y et al. | β | 2010 | β |
| Focus on: Alcohol and the liver. | Szabo G et al. | β | 2010 | β |
| Interleukin-22 treatment ameliorates alcoholic liver injury in a murine model of chronic-binge ethanol feeding: role of signal transducer and activator of transcription 3. | Ki SH et al. | β | 2010 | β |
| Long-term ethanol exposure causes human liver cancer cells to become resistant to mitomycin C treatment through the inactivation of bad-mediated apoptosis. | Huang CS et al. | β | 2010 | β |
| Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. | Powell CL et al. | β | 2010 | β |
| Rat strain differences in susceptibility to alcohol-induced chronic liver injury and hepatic insulin resistance. | Denucci SM et al. | β | 2010 | β |
| Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity. | Cederbaum AI | β | 2010 | β |
| Alcoholic hepatitis. | Lucey MR et al. | β | 2009 | β |
| Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. | Wang X et al. | β | 2009 | β |
| Ethanol and liver: recent advances in the mechanisms of ethanol-induced hepatosteatosis. | Zeng T et al. | β | 2009 | β |
| Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. | Cohen JI et al. | β | 2009 | β |
| Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice. | Roychowdhury S et al. | β | 2009 | β |
| Molecular mechanisms of alcoholic fatty liver. | Purohit V et al. | β | 2009 | β |
| Role of oxidative stress in alcohol-induced liver injury. | Cederbaum AI et al. | β | 2009 | β |
| Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. | Machida K et al. | β | 2009 | β |
| Ethanol intoxication increases hepatic N-lysyl protein acetylation. | Picklo MJ | β | 2008 | β |