The Promise and Peril of Genetics.
paper
Primary
Public
- Authors
- Dick, Danielle M
- Year
- 2022
- Journal
- Current directions in psychological science
- PMID
- 36591341
- DOI
- 10.1177/09637214221112041
- PMCID
- PMC9802013
Human genetics is advancing at an unprecedented pace. Improvements in genotyping technology and rapidly falling costs have accelerated gene discovery. We can now comprehensively scan the genome, testing variation across millions of genetic markers, to identify specific variants associated with any outcome of interest. Large consortia consisting of hundreds of scientists are analyzing data from hundreds of thousands to millions of individuals. Multivariate methods now enable us to identify genes involved in underlying processes, to complement studies focused on specific disorders or traits. There has been an exponential increase in use of direct-to-consumer genetic feedback platforms. These advances are poised to have a widespread effect on medicine and society. However, with such rapid progress will come ethical, social, and legal challenges. Among those challenges is the need for increased efforts to enhance public understanding of the ways genes contribute to complex behavioral outcomes, and for increased diversity in the field of genetics to ensure that all people benefit from advances. Psychologists can play an important role in addressing the inevitable questions that will arise as genetics increasingly becomes mainstream.
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| # | Section | Preview |
|---|---|---|
| 20 | DNA is not Destiny | For individuals to understand and interpret genetic scores, they need to understand the complicated… |
| 21 | The Diversity Problem in Genetics | There is another problem in our field: the profound lack of representation in genetics, both among… |
| 22 | The Diversity Problem in Genetics | There are efforts underway to increase diversity in genetic studies, but remedying such extreme… |
| 23 | The Diversity Problem in Genetics | Genetics will likely make it into the clinic and mainstream before these problems are remedied, and… |
| 24 | Conclusions | The field of genetics has entered a period of rapid advancement that promises to revolutionize our… |
| 25 | Conclusions | toward answering those questions. We’ve been so excited about advances in gene discovery that we… |
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21–26 of 26
| Name | Type |
|---|---|
| ADH | gene |
| ADHD | phenotype |
| alcohol | phenotype |
| Alcohol Problems | phenotype |
| Alcohol Use | phenotype |
| Alcohol Use Disorder | phenotype |
| ALDH2 | gene |
| anxiety | phenotype |
| behavior | phenotype |
| behavioral disorders | phenotype |
| behavioral outcomes | phenotype |
| behavioral traits | phenotype |
| biobanks | cohort |
| Childhood behavior problems local | phenotype |
| complex behavioral outcomes | phenotype |
| complex health conditions and behaviors local | phenotype |
| depression | phenotype |
| Direct-to-Consumer Genetic Testing local | cohort |
| disorder | phenotype |
| dispositional genes local | gene |
| educational attainment | phenotype |
| elevated genetic risk local | phenotype |
| Emotion | phenotype |
| environmental processes local | drug |
| Externalizing-associated variants local | variant |
| externalizing behavior | phenotype |
| Externalizing genes local | gene |
| general population | cohort |
| genes | gene |
| genetic risk scores local | phenotype |
| genetic variants | cohort |
| impulsivity | phenotype |
| life outcomes local | phenotype |
| Manic depression local | phenotype |
| mental health outcomes | phenotype |
| neighborhood disadvantage | phenotype |
| Neurological condition local | phenotype |
| normal behavioral variation local | phenotype |
| Precision Medicine Initiative local | cohort |
| psychiatric disorders | phenotype |
| Psychiatric Genomics Consortium | cohort |
| psychiatric outcomes | phenotype |
| Risk and reward local | phenotype |
| self-regulation | phenotype |
| socioeconomic status | phenotype |
| substance use | phenotype |
| susceptibility genes | cohort |
| Targeted drug treatments local | drug |
| Temperamental traits local | phenotype |
| tobacco use | phenotype |
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External
| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Are polygenic scores for psychiatric and substance use outcomes "ready" for clinical application? Current state and next steps. | Dick DM et al. | — | 2026 | → |
| Returning Genetic Information About Risk for Alcohol Use Disorder to Adolescents: Findings of a Preliminary Qualitative Study of Precision Prevention. | Weitzman ER et al. | — | 2024 | → |
| The collaborative study on the genetics of alcoholism: Sample and clinical data. | Dick DM et al. | — | 2023 | → |