A unified approach to adjusting association tests for population admixture with arbitrary pedigree structure and arbitrary missing marker information.
paper
Cited
Public
Unavailable
- Authors
- Rabinowitz, D; Laird, N
- Year
- 2000
- Journal
- Human heredity
- PMID
- 10782012
- DOI
- 10.1159/000022918
A general approach to family-based examinations of association between marker alleles and traits is proposed. The approach is based on computing p values by comparing test statistics for association to their conditional distributions given the minimal sufficient statistic under the null hypothesis for the genetic model, sampling plan and population admixture. The approach can be applied with any test statistic, so any kind of phenotype and multi-allelic markers may be examined, and covariates may be included in analyses. By virtue of the conditioning, the approach results in correct type I error probabilities regardless of population admixture, the true genetic model and the sampling strategy. An algorithm for computing the conditional distributions is described, and the results of the algorithm for configurations of nuclear families are presented. The algorithm is applicable with all pedigree structures and all patterns of missing marker allele information.
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| Detecting multiple variants associated with disease based on sequencing data of case-parent trios. | Wang C et al. | β | 2016 | β |
| Genome-wide association study of antibody responses to Plasmodium falciparum candidate vaccine antigens. | Milet J et al. | β | 2016 | β |
| GMDR: Versatile Software for Detecting Gene-Gene and Gene-Environ- ment Interactions Underlying Complex Traits. | Xu HM et al. | β | 2016 | β |
| Test for association of common variants in GRM7 with alcohol consumption. | Melroy-Greif WE et al. | β | 2016 | β |
| Testing Allele Transmission of an SNP Set Using a Family-Based Generalized Genetic Random Field Method. | Li M et al. | β | 2016 | β |
| The role of ASTN2 variants in childhood and adult ADHD, comorbid disorders and associated personality traits. | Freitag CM et al. | β | 2016 | β |
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| ACN9 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. | Hill SY et al. | β | 2015 | β |
| A multi-SNP association test for complex diseases incorporating an optimal P-value threshold algorithm in nuclear families. | Wang YT et al. | β | 2015 | β |
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| A powerful nonparametric statistical framework for family-based association analyses. | Li M et al. | β | 2015 | β |
| A re-formulation of generalized linear mixed models to fit family data in genetic association studies. | Wang T et al. | β | 2015 | β |
| A Sequence Kernel Association Test for Dichotomous Traits in Family Samples under a Generalized Linear Mixed Model. | Yan Q et al. | β | 2015 | β |
| Associating Multivariate Quantitative Phenotypes with Genetic Variants in Family Samples with a Novel Kernel Machine Regression Method. | Yan Q et al. | β | 2015 | β |
| Association of single nucleotide polymorphism rs3792876 in SLC22A4 gene with autoimmune thyroid disease in a Chinese Han population. | Hou X et al. | β | 2015 | β |
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| Genetic Evidence for Possible Involvement of the Calcium Channel Gene CACNA1A in Autism Pathogenesis in Chinese Han Population. | Li J et al. | β | 2015 | β |
| Genotype-Based Score Test for Association Testing in Families. | Uh HW et al. | β | 2015 | β |
| Rare-Variant Kernel Machine Test for Longitudinal Data from Population and Family Samples. | Yan Q et al. | β | 2015 | β |
| Schizophrenia Related Variants in CACNA1C also Confer Risk of Autism. | Li J et al. | β | 2015 | β |
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| Synaptic P-Rex1 signaling regulates hippocampal long-term depression and autism-like social behavior. | Li J et al. | β | 2015 | β |
| A general efficient and flexible approach for genome-wide association analyses of imputed genotypes in family-based designs. | Cobat A et al. | β | 2014 | β |
| Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies. | Neumann C et al. | β | 2014 | β |
| A novel test for testing the optimally weighted combination of rare and common variants based on data of parents and affected children. | Sha Q et al. | β | 2014 | β |
| A unified GMDR method for detecting gene-gene interactions in family and unrelated samples with application to nicotine dependence. | Chen GB et al. | β | 2014 | β |
| Comparison of methods to account for relatedness in genome-wide association studies with family-based data. | Eu-Ahsunthornwattana J et al. | β | 2014 | β |
| Comparison of multilevel modeling and the family-based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data. | Wang J et al. | β | 2014 | β |
| Examination of genetic variation in GABRA2 with conduct disorder and alcohol abuse and dependence in a longitudinal study. | Melroy WE et al. | β | 2014 | β |
| Family-based association test using both common and rare variants and accounting for directions of effects for sequencing data. | Chung RH et al. | β | 2014 | β |
| Family-based association test using normal approximation to gene dropping null distribution. | Jiang Y et al. | β | 2014 | β |
| Identifying Genetic Variants for Addiction via Propensity Score Adjusted Generalized Kendall's Tau. | Jiang Y et al. | β | 2014 | β |
| Investigation of Parental Transmission of RUNX2 Single Nucleotide Polymorphism and Its Association With Nonsyndromic Cleft Lip With or Without Palate. | Jung SH et al. | β | 2014 | β |
| On family-based genome-wide association studies with large pedigrees: observations and recommendations. | Fardo DW et al. | β | 2014 | β |
| Testing gene-environment interactions in family-based association studies using trait-based ascertained samples. | Zhang W et al. | β | 2014 | β |
| Testing genetic association with rare and common variants in family data. | Chen H et al. | β | 2014 | β |
| Value of Mendelian laws of segregation in families: data quality control, imputation, and beyond. | Blue EM et al. | β | 2014 | β |
| A general framework for robust and efficient association analysis in family-based designs: quantitative and dichotomous phenotypes. | Won S et al. | β | 2013 | β |
| Analysis of family- and population-based samples using multiple linkage disequilibrium mapping. | Chiu YF et al. | β | 2013 | β |
| Association between MSX1 SNPs and nonsyndromic cleft lip with or without cleft palate in the Korean population. | Kim NY et al. | β | 2013 | β |
| Association study between genes in Reelin signaling pathway and autism identifies DAB1 as a susceptibility gene in a Chinese Han population. | Li J et al. | β | 2013 | β |
| Case-sibling studies that acknowledge unstudied parents and permit the inclusion of unmatched individuals. | Shi M et al. | β | 2013 | β |
| Dosage transmission disequilibrium test (dTDT) for linkage and association detection. | Zhang Z et al. | β | 2013 | β |
| Evaluating power and type 1 error in large pedigree analyses of binary traits. | Cummings AC et al. | β | 2013 | β |
| Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families. | Hill SY et al. | β | 2013 | β |
| Family-based association mapping in crop species. | Guo B et al. | β | 2013 | β |
| Family-based association tests for sequence data, and comparisons with population-based association tests. | Ionita-Laza I et al. | β | 2013 | β |
| Genetic association test for multiple traits at gene level. | Guo X et al. | β | 2013 | β |
| Genetic evidence for the association of the hypothalamic-pituitary-adrenal (HPA) axis with ADHD and methylphenidate treatment response. | Fortier MΓ et al. | β | 2013 | β |
| Incorporating parental information into family-based association tests. | Yu Z et al. | β | 2013 | β |
| Joint associations of 61 genetic variants in the nicotinic acetylcholine receptor genes with subclinical atherosclerosis in American Indians: a gene-family analysis. | Yang J et al. | β | 2013 | β |
| MSX1 gene and nonsyndromic oral clefts in a Southern Brazilian population. | Souza LT et al. | β | 2013 | β |
| Multiple genetic variant association testing by collapsing and kernel methods with pedigree or population structured data. | Schaid DJ et al. | β | 2013 | β |
| NCK2 is significantly associated with opiates addiction in African-origin men. | Liu Z et al. | β | 2013 | β |
| Polymorphisms in the fetal progesterone receptor and a calcium-activated potassium channel isoform are associated with preterm birth in an Argentinian population. | Mann PC et al. | β | 2013 | β |
| Rare variant analysis for family-based design. | De G et al. | β | 2013 | β |
| Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts. | Vardarajan B et al. | β | 2013 | β |
| Sequence kernel association test for quantitative traits in family samples. | Chen H et al. | β | 2013 | β |
| Sequence variants in oxytocin pathway genes and preterm birth: a candidate gene association study. | Kim J et al. | β | 2013 | β |
| Testing for direct genetic effects using a screening step in family-based association studies. | Lutz SM et al. | β | 2013 | β |
| The evidence for association of ATP2B2 polymorphisms with autism in Chinese Han population. | Yang W et al. | β | 2013 | β |
| A sparse transmission disequilibrium test for haplotypes based on Bradley-Terry graphs. | Ma L et al. | β | 2012 | β |
| Association between PAX9 single-nucleotide polymorphisms and nonsyndromic cleft lip with or without cleft palate. | Lee JK et al. | β | 2012 | β |
| Association of the -1072G/A polymorphism in the LTC4S gene with asthma in an Indian population. | Kumar A et al. | β | 2012 | β |
| ASTN1 and alcohol dependence: family-based association analysis in multiplex alcohol dependence families. | Hill SY et al. | β | 2012 | β |
| BLUP genotype imputation for case-control association testing with related individuals and missing data. | McPeek MS | β | 2012 | β |
| Differential human leucocyte allele association between psoriasis and psoriatic arthritis: a family-based association study. | Eder L et al. | β | 2012 | β |
| Effect of angiotensin II type I receptor A1166C polymorphism on benazepril action in hypertensive patients: a family-based association test study. | Zhang N et al. | β | 2012 | β |
| Evidence of gene-environment interaction for the RUNX2 gene and environmental tobacco smoke in controlling the risk of cleft lip with/without cleft palate. | Wu T et al. | β | 2012 | β |
| Examining associations between disordered eating and serotonin transporter gene polymorphisms. | Munn-Chernoff MA et al. | β | 2012 | β |
| Families or Unrelated: The Evolving Debate in Genetic Association Studies. | Fardo DW et al. | β | 2012 | β |
| Family-based association tests using genotype data with uncertainty. | Yu Z | β | 2012 | β |
| Flexible semiparametric analysis of longitudinal genetic studies by reduced rank smoothing. | Wang Y et al. | β | 2012 | β |
| Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach. | Fardo DW et al. | β | 2012 | β |
| Genetic associations of surfactant protein D and angiotensin-converting enzyme with lung disease in preterm neonates. | Ryckman KK et al. | β | 2012 | β |
| Genetic Diversity and Balancing Selection within the Human Phenylalanine Hydroxylase (PAH) Gene Region in Iranian Population. | Haghighatnia A et al. | β | 2012 | β |
| Genome-wide association study of the age of onset of childhood asthma. | Forno E et al. | β | 2012 | β |
| High-order SNP combinations associated with complex diseases: efficient discovery, statistical power and functional interactions. | Fang G et al. | β | 2012 | β |
| HLA-DMA and DMB genes in rheumatoid arthritis. | Boudjema A et al. | β | 2012 | β |
| Intra-familial tests of association between familial idiopathic scoliosis and linked regions on 9q31.3-q34.3 and 16p12.3-q22.2. | Miller NH et al. | β | 2012 | β |
| Nonparametric Covariate-Adjusted Association Tests Based on the Generalized Kendall's Tau(). | Zhu W et al. | β | 2012 | β |
| On the meta-analysis of genome-wide association studies: a robust and efficient approach to combine population and family-based studies. | Won S et al. | β | 2012 | β |
| On the statistical properties of family-based association tests in datasets containing both pedigrees and unrelated case-control samples. | Hiekkalinna T et al. | β | 2012 | β |
| On the validity of the likelihood ratio test and consistency of resulting parameter estimates in joint linkage and linkage disequilibrium analysis under improperly specified parametric models. | Hiekkalinna T et al. | β | 2012 | β |
| Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence. | Wang KS et al. | β | 2012 | β |
| Single-marker family-based association analysis conditional on parental information. | Chung RH et al. | β | 2012 | β |
| Test of association between 10 single nucleotide polymorphisms in the oxytocin receptor gene and conduct disorder. | Sakai JT et al. | β | 2012 | β |
| TGFA/Taq I polymorphism and environmental factors in non-syndromic oral clefts in Southern Brazil. | Souza LT et al. | β | 2012 | β |
| XM: association testing on the X-chromosome in case-control samples with related individuals. | Thornton T et al. | β | 2012 | β |
| A faster pedigree-based generalized multifactor dimensionality reduction method for detecting gene-gene interactions. | Chen GB et al. | β | 2011 | β |
| A flexible model for association analysis in sibships with missing genotype data. | Dudbridge F et al. | β | 2011 | β |
| A robust TDT-type association test under informative parental missingness. | Chen JH et al. | β | 2011 | β |
| Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study. | Voyiaziakis E et al. | β | 2011 | β |
| Bias due to two-stage residual-outcome regression analysis in genetic association studies. | Demissie S et al. | β | 2011 | β |
| Combining disease models to test for gene-environment interaction in nuclear families. | Hoffmann TJ et al. | β | 2011 | β |
| Converging evidence for an association of ATP2B2 allelic variants with autism in male subjects. | Carayol J et al. | β | 2011 | β |
| Correlation in chicken between the marker LEI0258 alleles and Major Histocompatibility Complex sequences. | Chazara O et al. | β | 2011 | β |
| CRISPLD2 variants including a C471T silent mutation may contribute to nonsyndromic cleft lip with or without cleft palate. | Letra A et al. | β | 2011 | β |
| Cytochrome P450 (CYP2D6) genotype is associated with elevated systolic blood pressure in preterm infants after discharge from the neonatal intensive care unit. | Dagle JM et al. | β | 2011 | β |
| Distribution of the number of false discoveries in large-scale family-based association testing with application to the association between PTPN1 and hypertension and obesity. | Wang WC et al. | β | 2011 | β |
| Evidence for association between Disrupted-in-Schizophrenia 1 (DISC1) gene polymorphisms and autism in Chinese Han population: a family-based association study. | Zheng F et al. | β | 2011 | β |
| Family-based association analysis of alcohol dependence in the COGA sample and replication in the Australian twin-family study. | Wang KS et al. | β | 2011 | β |
| Family-based designs for genome-wide association studies. | Ott J et al. | β | 2011 | β |
| General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect. | Obermann-Borst SA et al. | β | 2011 | β |
| Genome-wide copy number variation analysis in attention-deficit/hyperactivity disorder: association with neuropeptide Y gene dosage in an extended pedigree. | Lesch KP et al. | β | 2011 | β |
| HLA-C, CSTA and DS12346 susceptibility alleles confer over 100-fold increased risk of developing psoriasis: evidence of gene interaction. | Vasilopoulos Y et al. | β | 2011 | β |
| IGF-1 gene polymorphisms in Polish families with high-grade myopia. | Rydzanicz M et al. | β | 2011 | β |
| Mutations in the TSGA14 gene in families with autism spectrum disorders. | Korvatska O et al. | β | 2011 | β |
| No association of polymorphisms in the CDK5, NDEL1, and LIS1 with autism in Chinese Han population. | Wang L et al. | β | 2011 | β |
| Perspectives on genome-wide multi-stage family-based association studies. | Van Steen K | β | 2011 | β |
| Polymorphisms in programmed death-1 gene are not associated with chronic HBV infection in Chinese patients. | Lv F et al. | β | 2011 | β |
| Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. | Jiang Y et al. | β | 2011 | β |
| PSEUDOMARKER: a powerful program for joint linkage and/or linkage disequilibrium analysis on mixtures of singletons and related individuals. | Hiekkalinna T et al. | β | 2011 | β |
| Role of UBE3A and ATP10A genes in autism susceptibility region 15q11-q13 in an Italian population: a positive replication for UBE3A. | Guffanti G et al. | β | 2011 | β |
| Single-nucleotide polymorphisms in the KCNN3 gene associate with preterm birth. | Day LJ et al. | β | 2011 | β |
| Statistical Analysis in Genetic Studies of Mental Illnesses. | Zhang H | β | 2011 | β |
| Unbiased and locally efficient estimation of genetic effect on quantitative trait in the presence of population admixture. | Wang Y et al. | β | 2011 | β |
| Use of principal components to aggregate rare variants in case-control and family-based association studies in the presence of multiple covariates. | Kazma R et al. | β | 2011 | β |
| Validity and power of association testing in family-based sampling designs: evidence for and against the common wisdom. | Knight S et al. | β | 2011 | β |
| A doubly robust test for gene-environment interaction in family-based studies of affected offspring. | Moerkerke B et al. | β | 2010 | β |
| An Association Test for Multiple Traits Based on the Generalized Kendall's Tau. | Zhang H et al. | β | 2010 | β |
| An evaluation of inflammatory gene polymorphisms in sibships discordant for premature coronary artery disease: the GRACE-IMMUNE study. | Brown BD et al. | β | 2010 | β |
| An omnibus test for family-based association studies with multiple SNPs and multiple phenotypes. | Lasky-Su J et al. | β | 2010 | β |
| Association between genes on chromosome 4p16 and non-syndromic oral clefts in four populations. | Ingersoll RG et al. | β | 2010 | β |
| A three-stage approach for genome-wide association studies with family data for quantitative traits. | Chen MH et al. | β | 2010 | β |
| CAPL: a novel association test using case-control and family data and accounting for population stratification. | Chung RH et al. | β | 2010 | β |
| Efficiency robust statistics for genetic linkage and association studies under genetic model uncertainty. | Joo J et al. | β | 2010 | β |
| Evidence of gene-environment interaction for the IRF6 gene and maternal multivitamin supplementation in controlling the risk of cleft lip with/without cleft palate. | Wu T et al. | β | 2010 | β |
| FAM-MDR: a flexible family-based multifactor dimensionality reduction technique to detect epistasis using related individuals. | Cattaert T et al. | β | 2010 | β |
| Gene by environment interaction and ambient air pollution. | Romieu I et al. | β | 2010 | β |
| Gene-environment interaction tests for family studies with quantitative phenotypes: A review and extension to longitudinal measures. | Moreno-Macias H et al. | β | 2010 | β |
| Genetic variants of human urea transporter-2 are associated with metabolic syndrome in Asian population. | Tsai HJ et al. | β | 2010 | β |
| Genome-wide TDT analysis in French-Canadian families with Tourette syndrome. | RiviΓ¨re JB et al. | β | 2010 | β |
| Incorporating covariates into multipoint association mapping in the case-parent design. | Chiu YF et al. | β | 2010 | β |
| Inferring haplotype/disease association by joint use of case-parents trios and case-parent pairs. | Hu YQ et al. | β | 2010 | β |
| Mothers' dopamine receptor polymorphism modulates the relation between infant fussiness and sensitive parenting. | Kaitz M et al. | β | 2010 | β |
| On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. | Lasky-Su J et al. | β | 2010 | β |
| On the genome-wide analysis of copy number variants in family-based designs: methods for combining family-based and population-based information for testing dichotomous or quantitative traits, or completely ascertained samples. | Murphy A et al. | β | 2010 | β |
| Parametric model-based statistics for possible genotyping errors and sample stratification in sibling-pair SNP data. | Korostishevsky M et al. | β | 2010 | β |
| Parsing the effects of individual SNPs in candidate genes with family data. | Hoffmann TJ et al. | β | 2010 | β |
| Prioritizing GWAS results: A review of statistical methods and recommendations for their application. | Cantor RM et al. | β | 2010 | β |
| ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. | Thornton T et al. | β | 2010 | β |
| Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. | Chen AC et al. | β | 2010 | β |
| Statistical challenges for genome-wide association studies of suicidality using family data. | Lasky-Su J et al. | β | 2010 | β |
| Taste genes associated with dental caries. | Wendell S et al. | β | 2010 | β |
| Testing for genetic association in the presence of linkage and gene-covariate interactions. | Callegaro A et al. | β | 2010 | β |
| Test of association between GABRA2 (SNP rs279871) and adolescent conduct/alcohol use disorders utilizing a sample of clinic referred youth with serious substance and conduct problems, controls and available first degree relatives. | Sakai JT et al. | β | 2010 | β |
| The identification of colon cancer susceptibility genes by using genome-wide scans. | Daley D | β | 2010 | β |
| Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome. | Locke AE et al. | β | 2010 | β |
| Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes. | Sherva R et al. | β | 2010 | β |
| A case-control and a family-based association study revealing an association between CYP2E1 polymorphisms and nasopharyngeal carcinoma risk in Cantonese. | Jia WH et al. | β | 2009 | β |
| Analytical Approaches and Population Types for Finding and Utilizing QTL in Complex Plant Populations | Sneller CH et al. | β | 2009 | β |
| An association study of 22 candidate genes in psoriasis families reveals shared genetic factors with other autoimmune and skin disorders. | Oudot T et al. | β | 2009 | β |
| Approaches to the identification of susceptibility genes. | Collins A | β | 2009 | β |
| Assessment of Alzheimer's disease case-control associations using family-based methods. | Schjeide BM et al. | β | 2009 | β |
| Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. | Chen AC et al. | β | 2009 | β |
| Association study of a single nucleotide polymorphism in the exon 2 region of toll-like receptor 9 (TLR9) gene with susceptibility to systemic lupus erythematosus among Chinese. | Xu CJ et al. | β | 2009 | β |
| Association study of SHANK3 gene polymorphisms with autism in Chinese Han population. | Qin J et al. | β | 2009 | β |
| Choline transporter gene variation is associated with attention-deficit hyperactivity disorder. | English BA et al. | β | 2009 | β |
| Combining unrelated family studies to improve the power of genetic association test. | Cheng KF | β | 2009 | β |
| Comparison of a unified analysis approach for family and unrelated samples with the transmission-disequilibrium test to study associations of hypertension in the Framingham Heart Study. | Sun X et al. | β | 2009 | β |
| Determination of genetic predisposition to patent ductus arteriosus in preterm infants. | Dagle JM et al. | β | 2009 | β |
| DNA variants in coding region of EFHC1: SNPs do not associate with juvenile myoclonic epilepsy. | Bai D et al. | β | 2009 | β |
| Estimation and testing of gene-environment interactions in family-based association studies. | Cordell HJ | β | 2009 | β |
| Evidence for sex-specific associations between variation in acid phosphatase locus 1 (ACP1) and insulin sensitivity in Mexican-Americans. | Shu YH et al. | β | 2009 | β |
| Family-based association analysis of S100A8 genetic polymorphisms with aggressive periodontitis. | Ren XY et al. | β | 2009 | β |
| Family-based association of FKBP5 in bipolar disorder. | Willour VL et al. | β | 2009 | β |
| Family-based association study of Neuregulin 1 with psychotic bipolar disorder. | Goes FS et al. | β | 2009 | β |
| Family-Based Association Tests with longitudinal measurements: handling missing data. | Ding X et al. | β | 2009 | β |
| Family-based genome-wide association study for simulated data of Framingham Heart Study. | Xu H et al. | β | 2009 | β |
| Gene-environment interaction tests for dichotomous traits in trios and sibships. | Hoffmann TJ et al. | β | 2009 | β |
| Genetic association tests: a method for the joint analysis of family and case-control data. | Gray-McGuire C et al. | β | 2009 | β |
| Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. | Wang JC et al. | β | 2009 | β |
| Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results. | Marazita ML et al. | β | 2009 | β |
| Genome-wide association analyses of quantitative traits: the GAW16 experience. | Ghosh S | β | 2009 | β |
| Genome-wide association studies and the genetic dissection of complex traits. | Sebastiani P et al. | β | 2009 | β |
| Impact of population stratification on family-based association tests with longitudinal measurements. | Ding X et al. | β | 2009 | β |
| Lack of association of interferon regulatory factor 1 with severe malaria in affected child-parental trio studies across three African populations. | Mangano VD et al. | β | 2009 | β |
| Maximizing the Power of Genome-Wide Association Studies: A Novel Class of Powerful Family-Based Association Tests. | Won S et al. | β | 2009 | β |
| Nicotine withdrawal sensitivity, linkage to chr6q26, and association of OPRM1 SNPs in the SMOking in FAMilies (SMOFAM) sample. | Hardin J et al. | β | 2009 | β |
| On combining triads and unrelated subjects data in candidate gene studies: an application to data on testicular cancer. | Hsu L et al. | β | 2009 | β |
| On quality control measures in genome-wide association studies: a test to assess the genotyping quality of individual probands in family-based association studies and an application to the HapMap data. | Fardo DW et al. | β | 2009 | β |
| On the adjustment for covariates in genetic association analysis: a novel, simple principle to infer direct causal effects. | Vansteelandt S et al. | β | 2009 | β |
| On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. | Won S et al. | β | 2009 | β |
| PRKCA: a positional candidate gene for body mass index and asthma. | Murphy A et al. | β | 2009 | β |
| Robust QTL fine mapping by applying a quantitative transmission disequilibrium test to the Mendelian sampling term. | Simianer H et al. | β | 2009 | β |
| Searching for genes for cleft lip and/or palate based on breakpoint analysis of a balanced translocation t(9;17)(q32;q12). | Machida J et al. | β | 2009 | β |
| Sex chromosomes and genetic association studies. | Clayton DG | β | 2009 | β |
| Tests of association for quantitative traits in nuclear families using principal components to correct for population stratification. | Zhang L et al. | β | 2009 | β |
| The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. | Israel S et al. | β | 2009 | β |
| Transforming growth factor-beta receptor-3 is associated with pulmonary emphysema. | Hersh CP et al. | β | 2009 | β |
| Univariate/multivariate genome-wide association scans using data from families and unrelated samples. | Zhang L et al. | β | 2009 | β |
| Uterine leiomyomata and decreased height: a common HMGA2 predisposition allele. | Hodge JC et al. | β | 2009 | β |
| Variation in IGF2BP2 interacts with adiposity to alter insulin sensitivity in Mexican Americans. | Li X et al. | β | 2009 | β |
| A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies. | Lou XY et al. | β | 2008 | β |
| Age-at-onset linkage analysis in Caribbean Hispanics with familial late-onset Alzheimer's disease. | Lee JH et al. | β | 2008 | β |
| Analyses of the National Institute on Aging Late-Onset Alzheimer's Disease Family Study: implication of additional loci. | Lee JH et al. | β | 2008 | β |
| An extension of the regression of offspring on mid-parent to test for association and estimate locus-specific heritability: the revised ROMP method. | Roy-Gagnon MH et al. | β | 2008 | β |
| Application of association mapping to understanding the genetic diversity of plant germplasm resources. | Abdurakhmonov IY et al. | β | 2008 | β |
| A single nucleotide polymorphism (A --> G) in intron 3 of IFNgamma gene is associated with asthma. | Kumar A et al. | β | 2008 | β |
| Association of GSK3B with Alzheimer disease and frontotemporal dementia. | Schaffer BA et al. | β | 2008 | β |
| Association of the ENGRAILED 2 (EN2) gene with autism in Chinese Han population. | Wang L et al. | β | 2008 | β |
| Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. | Dehghan A et al. | β | 2008 | β |
| Chromosome 17q12 variants contribute to risk of early-onset prostate cancer. | Levin AM et al. | β | 2008 | β |
| Chromosome 8q24 markers: risk of early-onset and familial prostate cancer. | Beebe-Dimmer JL et al. | β | 2008 | β |
| Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism. | Maussion G et al. | β | 2008 | β |
| Differential parental transmission of markers in RUNX2 among cleft case-parent trios from four populations. | Sull JW et al. | β | 2008 | β |
| Disease associations and family-based tests. | Ewens WJ et al. | β | 2008 | β |
| Evidence of association between brain-derived neurotrophic factor gene and bipolar disorder. | Liu L et al. | β | 2008 | β |
| Family-Based Association Testing of OCD-associated SNPs of SLC1A1 in an autism sample. | Brune CW et al. | β | 2008 | β |
| Family-based methods for linkage and association analysis. | Laird NM et al. | β | 2008 | β |
| Family study designs in the age of genome-wide association studies: experience from the Framingham Heart Study. | Cupples LA | β | 2008 | β |
| Genetic susceptibility and haplotype analysis between Fcgamma receptor IIB and IIIA gene with systemic lupus erythematosus in Chinese population. | Pan F et al. | β | 2008 | β |
| Genomics and genome-wide association studies: an integrative approach to expression QTL mapping. | Degnan JH et al. | β | 2008 | β |
| Heterogeneous association between engrailed-2 and autism in the CPEA network. | Brune CW et al. | β | 2008 | β |
| IL10 polymorphisms are associated with airflow obstruction in severe alpha1-antitrypsin deficiency. | Demeo DL et al. | β | 2008 | β |
| Kernel-based association test. | Yang HC et al. | β | 2008 | β |
| Lack of association of VDR gene polymorphisms with thyroid autoimmune disorders: familial and case/control studies. | Maalej A et al. | β | 2008 | β |
| Likelihood-based association analysis for nuclear families and unrelated subjects with missing genotype data. | Dudbridge F | β | 2008 | β |
| Linkage disequilibrium analyses within chromosome 19p in multiple sclerosis. | Vyshkina T et al. | β | 2008 | β |
| Macrophage migration inhibitory factor and autism spectrum disorders. | Grigorenko EL et al. | β | 2008 | β |
| Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. | Al-Kateb H et al. | β | 2008 | β |
| No association between the DRD3 Ser9Gly polymorphism and schizophrenia. | Fathalli F et al. | β | 2008 | β |
| On the analysis of copy-number variations in genome-wide association studies: a translation of the family-based association test. | Ionita-Laza I et al. | β | 2008 | β |
| Ordered-subset analysis (OSA) for family-based association mapping of complex traits. | Chung RH et al. | β | 2008 | β |
| Polymorphisms of the IL12B and IL23R genes are associated with psoriasis. | Nair RP et al. | β | 2008 | β |
| Power, validity, bias and robustness of family-based association analysis methods in the presence of linkage for late onset diseases. | Nsengimana J et al. | β | 2008 | β |
| QTL for the heritable inverted teat defect in pigs. | Jonas E et al. | β | 2008 | β |
| Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles. | Tiwari HK et al. | β | 2008 | β |
| Screening and replication using the same data set: testing strategies for family-based studies in which all probands are affected. | Murphy A et al. | β | 2008 | β |
| Testing and estimating gene-environment interactions in family-based association studies. | Vansteelandt S et al. | β | 2008 | β |
| Testing association in the presence of linkage using the GRE and multiple markers. | Jonasdottir G et al. | β | 2008 | β |
| Transmission disequilibrium testing of the chromosome 15q11-q13 region in autism. | Kim SJ et al. | β | 2008 | β |
| Two MTHFR polymorphisms, maternal B-vitamin intake, and CHDs. | van Driel LM et al. | β | 2008 | β |
| A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. | Riley BM et al. | β | 2007 | β |
| A logistic mixture model for a family-based association study. | Xing G et al. | β | 2007 | β |
| A multi-marker test based on family data in genome-wide association study. | Zhang Z et al. | β | 2007 | β |
| An entropy-based genome-wide transmission/disequilibrium test. | Zhao J et al. | β | 2007 | β |
| A new multimarker test for family-based association studies. | Rakovski CS et al. | β | 2007 | β |
| A new transmission test for affected sib-pair families. | Xu H et al. | β | 2007 | β |
| Approaches to handling incomplete data in family-based association testing. | Van Steen K et al. | β | 2007 | β |
| A region of 35 kb containing the trace amine associate receptor 6 (TAAR6) gene is associated with schizophrenia in the Irish study of high-density schizophrenia families. | Vladimirov V et al. | β | 2007 | β |
| Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. | Levin AM et al. | β | 2007 | β |
| Association between IRF6 and nonsyndromic cleft lip with or without cleft palate in four populations. | Park JW et al. | β | 2007 | β |
| Association of autism with polymorphisms in the paired-like homeodomain transcription factor 1 (PITX1) on chromosome 5q31: a candidate gene analysis. | Philippi A et al. | β | 2007 | β |
| Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects. | Yue W et al. | β | 2007 | β |
| Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. | Jacob S et al. | β | 2007 | β |
| Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. | Nelson TL et al. | β | 2007 | β |
| A unified framework for linkage and association analysis of quantitative traits. | Dupuis J et al. | β | 2007 | β |
| Case-control association testing with related individuals: a more powerful quasi-likelihood score test. | Thornton T et al. | β | 2007 | β |
| Common genetic variation within the low-density lipoprotein receptor-related protein 6 and late-onset Alzheimer's disease. | De Ferrari GV et al. | β | 2007 | β |
| Common variation in the BRCA1 gene and prostate cancer risk. | Douglas JA et al. | β | 2007 | β |
| Density-based clustering in haplotype analysis for association mapping. | Igo RP et al. | β | 2007 | β |
| DTNBP1 (Dystrobrevin binding protein 1) and schizophrenia: association evidence in the 3' end of the gene. | Duan J et al. | β | 2007 | β |
| EFBAT: exact family-based association tests. | Schneiter K et al. | β | 2007 | β |
| Evaluation of fetal and maternal genetic variation in the progesterone receptor gene for contributions to preterm birth. | Ehn NL et al. | β | 2007 | β |
| Evidence for an association of the dopamine D5 receptor gene on age at onset of attention deficit hyperactivity disorder. | Lasky-Su J et al. | β | 2007 | β |
| Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. | Sisodiya SM et al. | β | 2007 | β |
| Genetic variation in the hypothalamic-pituitary-adrenocortical axis regulatory factor, T-box 19, and the angry/hostility personality trait. | Wasserman D et al. | β | 2007 | β |
| Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. | Yang Q et al. | β | 2007 | β |
| Gln50Ter polymorphism of Fcgamma receptor IIB gene associated with genetic susceptibility to human systemic lupus erythematosus in Chinese populations. | Pan F et al. | β | 2007 | β |
| Haplotype-based score test for linkage in nuclear families. | Nam CM et al. | β | 2007 | β |
| Impaired FGF signaling contributes to cleft lip and palate. | Riley BM et al. | β | 2007 | β |
| Joint modeling of linkage and association using affected sib-pair data. | Chen MH et al. | β | 2007 | β |
| Linkage and association of myocilin (MYOC) polymorphisms with high myopia in a Chinese population. | Tang WC et al. | β | 2007 | β |
| Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. | Steffen KM et al. | β | 2007 | β |
| Mixed-effects logistic approach for association following linkage scan for complex disorders. | Xu H et al. | β | 2007 | β |
| On dichotomizing phenotypes in family-based association tests: quantitative phenotypes are not always the optimal choice. | Fardo D et al. | β | 2007 | β |
| Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma. | Gao L et al. | β | 2007 | β |
| Polymorphisms in the neuronal isoform of tryptophan hydroxylase 2 are associated with bipolar disorder in French Canadian pedigrees. | Harvey M et al. | β | 2007 | β |
| Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. | Levin AM et al. | β | 2007 | β |
| Testing association in the presence of linkage--a powerful score for binary traits. | Jonasdottir G et al. | β | 2007 | β |
| The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. | Cupples LA et al. | β | 2007 | β |
| The involvement of upstream stimulatory factor 1 in Dutch patients with familial combined hyperlipidemia. | van der Vleuten GM et al. | β | 2007 | β |
| The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease. | Rogaeva E et al. | β | 2007 | β |
| The PPARgamma Pro12Ala polymorphism is not associated with body mass index or waist circumference among Hispanics from Colorado. | Nelson TL et al. | β | 2007 | β |
| The role of DTNBP1, NRG1, and AKT1 in the genetics of schizophrenia in Finland. | Turunen JA et al. | β | 2007 | β |
| The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. | Matthews AG et al. | β | 2007 | β |
| Vitamin D receptor gene polymorphisms and susceptibility M. tuberculosis in native Paraguayans. | Wilbur AK et al. | β | 2007 | β |
| X-APL: an improved family-based test of association in the presence of linkage for the X chromosome. | Chung RH et al. | β | 2007 | β |
| A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia. | Li C et al. | β | 2006 | β |
| A graphical assessment of p-values from sliding window haplotype tests of association to identify asthma susceptibility loci on chromosome 11q. | Mathias RA et al. | β | 2006 | β |
| Allowing for missing data at highly polymorphic genes when testing for maternal, offspring and maternal-fetal genotype incompatibility effects. | Hsieh HJ et al. | β | 2006 | β |
| A mutation in RYK is a genetic factor for nonsyndromic cleft lip and palate. | Watanabe A et al. | β | 2006 | β |
| Analysis of candidate genes on chromosome 2 in oral cleft case-parent trios from three populations. | Beaty TH et al. | β | 2006 | β |
| Analysis of chromosome 5q31-32 and psoriasis: confirmation of a susceptibility locus but no association with SNPs within SLC22A4 and SLC22A5. | Friberg C et al. | β | 2006 | β |
| Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: no evidence for association despite adequate power and evidence for linkage. | Stuart P et al. | β | 2006 | β |
| Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. | Barden N et al. | β | 2006 | β |
| An efficient family-based association test using multiple markers. | Xu X et al. | β | 2006 | β |
| Association between the 5HT1B receptor gene (HTR1B) and the inattentive subtype of ADHD. | Smoller JW et al. | β | 2006 | β |
| Association of Fcgamma receptor IIB gene polymorphism with genetic susceptibility to systemic lupus erythematosus in Chinese populations--a family-based association study. | Pan F et al. | β | 2006 | β |
| Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. | Shibata N et al. | β | 2006 | β |
| Contributions of PTCH gene variants to isolated cleft lip and palate. | Mansilla MA et al. | β | 2006 | β |
| Detection of genes for ordinal traits in nuclear families and a unified approach for association studies. | Zhang H et al. | β | 2006 | β |
| Eotaxin polymorphisms and serum total IgE levels in children with asthma. | Raby BA et al. | β | 2006 | β |
| European population substructure: clustering of northern and southern populations. | Seldin MF et al. | β | 2006 | β |
| Evaluation of a methylenetetrahydrofolate-dehydrogenase 1958G>A polymorphism for neural tube defect risk. | De Marco P et al. | β | 2006 | β |
| Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. | Kaufman KM et al. | β | 2006 | β |
| Family-based association test for time-to-onset data with time-dependent differences between the hazard functions. | Jiang H et al. | β | 2006 | β |
| Family-based association tests for ordinal traits adjusting for covariates. | Wang X et al. | β | 2006 | β |
| Family-based association tests suggest linkage between surfactant protein B (SP-B) (and flanking region) and respiratory distress syndrome (RDS): SP-B haplotypes and alleles from SP-B-linked loci are risk factors for RDS. | Floros J et al. | β | 2006 | β |
| Family-based designs in the age of large-scale gene-association studies. | Laird NM et al. | β | 2006 | β |
| Genetic association tests based on ranks (GATOR) for quantitative traits with and without censoring. | Allen AS et al. | β | 2006 | β |
| Improvement of mapping accuracy by unifying linkage and association analysis. | Lou XY et al. | β | 2006 | β |
| Improving the power of association tests for quantitative traits in family studies. | Diao G et al. | β | 2006 | β |
| Major histocompatibility complex class I chain-related gene A polymorphisms and extended haplotypes are associated with familial alopecia areata. | Barahmani N et al. | β | 2006 | β |
| New complexities in the genetics of stuttering: significant sex-specific linkage signals. | Suresh R et al. | β | 2006 | β |
| N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels. | Martucci L et al. | β | 2006 | β |
| PedGenie: an analysis approach for genetic association testing in extended pedigrees and genealogies of arbitrary size. | Allen-Brady K et al. | β | 2006 | β |
| Polymorphisms in the novel gene acyloxyacyl hydroxylase (AOAH) are associated with asthma and associated phenotypes. | Barnes KC et al. | β | 2006 | β |
| Polymorphisms in the protein tyrosine phosphatase (PTPN22) gene is not associated with autoimmune thyroid in a large affected Tunisian family. | Chabchoub G et al. | β | 2006 | β |
| Role of interferon-gamma gene polymorphisms in susceptibility to IgA nephropathy: a family-based association study. | Schena FP et al. | β | 2006 | β |
| Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. | Nair RP et al. | β | 2006 | β |
| T-bet polymorphisms are associated with asthma and airway hyperresponsiveness. | Raby BA et al. | β | 2006 | β |
| The adrenergic receptor alpha-2A gene (ADRA2A) and neuropsychological executive functions as putative endophenotypes for childhood ADHD. | Waldman ID et al. | β | 2006 | β |
| The APL test: extension to general nuclear families and haplotypes and examination of its robustness. | Chung RH et al. | β | 2006 | β |
| The functional "KL-VS" variant of KLOTHO is not associated with type 2 diabetes in 5028 UK Caucasians. | Freathy RM et al. | β | 2006 | β |
| Validity, efficiency, and robustness of a family-based test of association. | Lewinger JP et al. | β | 2006 | β |
| Variants in the gene encoding C3 are associated with asthma and related phenotypes among African Caribbean families. | Barnes KC et al. | β | 2006 | β |
| Variants of the SFTPA1 and SFTPA2 genes and susceptibility to tuberculosis in Ethiopia. | Malik S et al. | β | 2006 | β |
| Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men. | Hsu YH et al. | β | 2006 | β |
| A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. | Jiang S et al. | β | 2005 | β |
| A haplotype similarity based transmission/disequilibrium test under founder heterogeneity. | Yu K et al. | β | 2005 | β |
| A method for identifying genes related to a quantitative trait, incorporating multiple siblings and missing parents. | Kistner EO et al. | β | 2005 | β |
| Analysis of binary traits: testing association in the presence of linkage. | Jonasdottir G et al. | β | 2005 | β |
| Analysis of the RELN gene as a genetic risk factor for autism. | Skaar DA et al. | β | 2005 | β |
| Application of family-based association testing to assess the genotype-phenotype association involved in complex traits using single-nucleotide polymorphisms. | Wang MH et al. | β | 2005 | β |
| Association of defensin beta-1 gene polymorphisms with asthma. | Levy H et al. | β | 2005 | β |
| Autism and the serotonin transporter: the long and short of it. | Devlin B et al. | β | 2005 | β |
| Brain-derived neurotrophic factor variants are associated with childhood-onset mood disorder: confirmation in a Hungarian sample. | Strauss J et al. | β | 2005 | β |
| CAA insertion polymorphism in the 3'UTR of Nogo gene on 2p14 is not associated with schizophrenia. | Xiong L et al. | β | 2005 | β |
| COGA phenotypes and linkages on chromosome 2. | Wiener HW et al. | β | 2005 | β |
| Comparing strategies for association mapping in samples with related individuals. | Bourgain C | β | 2005 | β |
| Comparison of family-based association tests in chromosome regions selected by linkage-based confidence intervals. | Lewinger JP et al. | β | 2005 | β |
| Comparison of genotype- and haplotype-based approaches for fine-mapping of alcohol dependence using COGA data. | Pinnaduwage D et al. | β | 2005 | β |
| Complex trait mapping in isolated populations: Are specific statistical methods required? | Bourgain C et al. | β | 2005 | β |
| Construction of endophenotypes for complex diseases in the presence of heterogeneity. | Chen CH et al. | β | 2005 | β |
| Covariate adjustment in family-based association studies. | Whittemore AS et al. | β | 2005 | β |
| Data mining. | Cupples LA et al. | β | 2005 | β |
| Exact family-based association tests for biallelic data. | Schneiter K et al. | β | 2005 | β |
| Exploiting gene-environment independence in family-based case-control studies: increased power for detecting associations, interactions and joint effects. | Chatterjee N et al. | β | 2005 | β |
| Family-based association between Alzheimer's disease and variants in UBQLN1. | Bertram L et al. | β | 2005 | β |
| Fine mapping by linkage and association in nuclear family and case-control designs. | Bull SB et al. | β | 2005 | β |
| Further evidence for LBP-1c/CP2/LSF association in Alzheimer's disease families. | Bertram L et al. | β | 2005 | β |
| Genetic variants of the T-cell immunoglobulin mucin 1 but not the T-cell immunoglobulin mucin 3 gene are associated with asthma in an African American population. | Gao PS et al. | β | 2005 | β |
| Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. | Yang Q et al. | β | 2005 | β |
| Genomic screening and replication using the same data set in family-based association testing. | Van Steen K et al. | β | 2005 | β |
| Genomic screening in family-based association testing. | Murphy A et al. | β | 2005 | β |
| Haplotype sharing transmission/disequilibrium tests that allow for genotyping errors. | Sha Q et al. | β | 2005 | β |
| Haplotypes of the WNK1 gene associate with blood pressure variation in a severely hypertensive population from the British Genetics of Hypertension study. | Newhouse SJ et al. | β | 2005 | β |
| Haplotypes within genes of beta-chemokines in 17q11 are associated with multiple sclerosis: a second phase study. | Vyshkina T et al. | β | 2005 | β |
| Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia. | Sanders AR et al. | β | 2005 | β |
| Identifying genetic variation affecting a complex trait in simulated data: a comparison of meta-analysis with pooled data analysis. | Wu X et al. | β | 2005 | β |
| Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. | Douglas JA et al. | β | 2005 | β |
| Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population. | Sharma S et al. | β | 2005 | β |
| Medical sequencing of candidate genes for nonsyndromic cleft lip and palate. | Vieira AR et al. | β | 2005 | β |
| PBAT: a comprehensive software package for genome-wide association analysis of complex family-based studies. | Van Steen K et al. | β | 2005 | β |
| Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. | Wu S et al. | β | 2005 | β |
| Power and related statistical properties of conditional likelihood score tests for association studies in nuclear families with parental genotypes. | Li Z et al. | β | 2005 | β |
| Robust trend tests for genetic association in case-control studies using family data. | Tian X et al. | β | 2005 | β |
| Software for quantitative trait analysis. | Almasy L et al. | β | 2005 | β |
| Surrogate phenotype definition for alcohol use disorders: a genome-wide search for linkage and association. | Rosenberger A et al. | β | 2005 | β |
| Testing association and linkage using affected-sib-parent study designs. | Millstein J et al. | β | 2005 | β |
| The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder. | Smoller JW et al. | β | 2005 | β |
| The insulin gene variable number tandem repeat and risk of type 2 diabetes in a population-based sample of families and unrelated men and women. | Meigs JB et al. | β | 2005 | β |
| Upstream stimulatory factor 1 associated with familial combined hyperlipidemia, LDL cholesterol, and triglycerides. | Coon H et al. | β | 2005 | β |
| Use of susceptibility scoring in conjunction with the genotypic transmission disequilibrium test. | Benke KS et al. | β | 2005 | β |
| A common haplotype of the nicotine acetylcholine receptor alpha 4 subunit gene is associated with vulnerability to nicotine addiction in men. | Feng Y et al. | β | 2004 | β |
| Alleles of a reelin CGG repeat do not convey liability to autism in a sample from the CPEA network. | Devlin B et al. | β | 2004 | β |
| Association of Fcgamma receptor IIA, but not IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family-based association study in Caucasians. | Kyogoku C et al. | β | 2004 | β |
| Association of vitamin D receptor gene polymorphisms with childhood and adult asthma. | Raby BA et al. | β | 2004 | β |
| Beta2 adrenergic receptor gene Arg16Gly polymorphism is associated with therapeutic efficacy of benazepril on essential hypertension in Chinese. | Huang G et al. | β | 2004 | β |
| Case/pseudocontrol analysis in genetic association studies: A unified framework for detection of genotype and haplotype associations, gene-gene and gene-environment interactions, and parent-of-origin effects. | Cordell HJ et al. | β | 2004 | β |
| D919G polymorphism of methionine synthase gene is associated with blood pressure response to benazepril in Chinese hypertensive patients. | Zhang Y et al. | β | 2004 | β |
| Epistatic interaction between beta2-adrenergic receptor and neuropeptide Y genes influences LDL-cholesterol in hypertension. | Tomaszewski M et al. | β | 2004 | β |
| Evidence of association between FKBP1B and thyroid autoimmune disorders in a large Tunisian family. | Maalej A et al. | β | 2004 | β |
| Genomewide linkage scan for myopia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 22q12. | Stambolian D et al. | β | 2004 | β |
| IL10 gene polymorphisms are associated with asthma phenotypes in children. | Lyon H et al. | β | 2004 | β |
| Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate. | Zucchero TM et al. | β | 2004 | β |
| Linkage of bipolar affective disorder on chromosome 8q24: follow-up and parametric analysis. | Avramopoulos D et al. | β | 2004 | β |
| Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. | Marazita ML et al. | β | 2004 | β |
| New approach to association testing in case-parent designs under informative parental missingness. | Chen YH | β | 2004 | β |
| No association between a previously reported OLR1 3' UTR polymorphism and Alzheimer's disease in a large family sample. | Bertram L et al. | β | 2004 | β |
| No evidence for linkage or association of neuregulin-1 (NRG1) with disease in the Irish study of high-density schizophrenia families (ISHDSF). | Thiselton DL et al. | β | 2004 | β |
| PBAT: tools for family-based association studies. | Lange C et al. | β | 2004 | β |
| PEN2 is not a genetic risk factor for Alzheimer's disease in a large family sample. | Bertram L et al. | β | 2004 | β |
| Polymorphisms in the trace amine receptor 4 (TRAR4) gene on chromosome 6q23.2 are associated with susceptibility to schizophrenia. | Duan J et al. | β | 2004 | β |
| Sequence variants of the gene encoding chemoattractant receptor expressed on Th2 cells (CRTH2) are associated with asthma and differentially influence mRNA stability. | Huang JL et al. | β | 2004 | β |
| Targeted scan of fifteen regions for nonsyndromic cleft lip and palate in Filipino families. | Schultz RE et al. | β | 2004 | β |
| Tests of gene-environment interaction for case-parent triads with general environmental exposures. | Lake SL et al. | β | 2004 | β |
| Accounting for linkage in family-based tests of association with missing parental genotypes. | Martin ER et al. | β | 2003 | β |
| A new powerful non-parametric two-stage approach for testing multiple phenotypes in family-based association studies. | Lange C et al. | β | 2003 | β |
| Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition. | Smoller JW et al. | β | 2003 | β |
| Disease associations and family-based tests. | Ewens WJ et al. | β | 2003 | β |
| Environmental and genetic determinants of tobacco use: methodology for a multidisciplinary, longitudinal family-based investigation. | Swan GE et al. | β | 2003 | β |
| Family-based association study of markers on chromosome 22 in schizophrenia using African-American, European-American, and Chinese families. | Takahashi S et al. | β | 2003 | β |
| From genomics to proteomics: new directions in molecular neuropsychiatry. | Eisener AF et al. | β | 2003 | β |
| Genetic association tests for family data with missing parental genotypes: a comparison. | Whittemore AS et al. | β | 2003 | β |
| Informative missingness in genetic association studies: case-parent designs. | Allen AS et al. | β | 2003 | β |
| Modest evidence for linkage and possible confirmation of association between NOTCH4 and schizophrenia in a large Veterans Affairs Cooperative Study sample. | Skol AD et al. | β | 2003 | β |
| No association between marker D10S1423 and Alzheimer's disease. | Bertram L et al. | β | 2003 | β |
| Power evaluations for family-based tests of association with incomplete parental genotypes. | Yang Q et al. | β | 2003 | β |
| Small babies receive the cardiovascular protective apolipoprotein epsilon 2 allele less frequently than expected. | Infante-Rivard C et al. | β | 2003 | β |
| Transmission/disequilibrium test based on haplotype sharing for tightly linked markers. | Zhang S et al. | β | 2003 | β |
| Using the noninformative families in family-based association tests: a powerful new testing strategy. | Lange C et al. | β | 2003 | β |
| 5HT1Dbeta Receptor gene implicated in the pathogenesis of Obsessive-Compulsive Disorder: further evidence from a family-based association study. | Mundo E et al. | β | 2002 | β |
| Allele sharing and allelic association I: sib pair tests with increased power. | Lazzeroni LC | β | 2002 | β |
| Association mapping, using a mixture model for complex traits. | Zhu X et al. | β | 2002 | β |
| Association of angiotensin-converting enzyme polymorphisms with systemic lupus erythematosus and nephritis: analysis of 644 SLE families. | Parsa A et al. | β | 2002 | β |
| Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. | Serretti A et al. | β | 2002 | β |
| Genetic association mapping at the crossroads: which test and why? Overview and practical guidelines. | Schulze TG et al. | β | 2002 | β |
| Genome scan of three quantitative traits in schizophrenia pedigrees. | Wilcox MA et al. | β | 2002 | β |
| No evidence for linkage of liability to autism to HOXA1 in a sample from the CPEA network. | Devlin B et al. | β | 2002 | β |
| On a general class of conditional tests for family-based association studies in genetics: the asymptotic distribution, the conditional power, and optimality considerations. | Lange C et al. | β | 2002 | β |
| PARK3 influences age at onset in Parkinson disease: a genome scan in the GenePD study. | DeStefano AL et al. | β | 2002 | β |
| Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypes. | Raby BA et al. | β | 2002 | β |
| Power and design considerations for a general class of family-based association tests: quantitative traits. | Lange C et al. | β | 2002 | β |
| Power calculations for a general class of family-based association tests: dichotomous traits. | Lange C et al. | β | 2002 | β |
| Testing candidate genes for non-syndromic oral clefts using a case-parent trio design. | Beaty TH et al. | β | 2002 | β |
| Tests for genetic association using family data. | Shih MC et al. | β | 2002 | β |
| A chronology of fine-scale gene mapping by linkage disequilibrium. | Lazzeroni LC | β | 2001 | β |
| Comparison of the QTDT analysis for IgE in the CSGA data set. | Page GP et al. | β | 2001 | β |
| Correcting for a potential bias in the pedigree disequilibrium test. | Martin ER et al. | β | 2001 | β |
| Family-based association tests for qualitative and quantitative traits using single-nucleotide polymorphism and microsatellite data. | Wilk JB et al. | β | 2001 | β |
| Family-based tests of association in the presence and absence of known linkage. | Bertram L et al. | β | 2001 | β |
| Genetic association analysis of behavioral inhibition using candidate loci from mouse models. | Smoller JW et al. | β | 2001 | β |
| Genomic control, a new approach to genetic-based association studies. | Devlin B et al. | β | 2001 | β |
| Joint tests of linkage and association for quantitative traits. | Allison DB et al. | β | 2001 | β |
| Lack of linkage and association between autoimmune thyroid diseases and the CTLA-4 gene in a large Tunisian family. | Maalej A et al. | β | 2001 | β |
| Reconstructing parental genotypes when testing for linkage in the presence of association. | Knapp M | β | 2001 | β |
| Transmission/disequilibrium test meets measured haplotype analysis: family-based association analysis guided by evolution of haplotypes. | Seltman H et al. | β | 2001 | β |
| Evidence for genetic linkage of Alzheimer's disease to chromosome 10q. | Bertram L et al. | β | 2000 | β |
| Family-based association studies. | Zhao H | β | 2000 | β |
| Family-based tests of association and linkage that use unaffected sibs, covariates, and interactions. | Lunetta KL et al. | β | 2000 | β |
| Family-based tests of association in the presence of linkage. | Lake SL et al. | β | 2000 | β |
| Implementing a unified approach to family-based tests of association. | Laird NM et al. | β | 2000 | β |
| The transmission/disequilibrium test and parental-genotype reconstruction for X-chromosomal markers. | Horvath S et al. | β | 2000 | β |