Recent developments in alcoholism:genetic transmission.
- Authors
- Goldman, D
- Year
- 1993
- Journal
- Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
- PMID
- 8234925
This chapter is an overview of developments in the study of genetic factors in vulnerability in alcoholism. The focus is on recent developments, including heritability studies in twins and transmission studies in families, both of which have continued to reveal evidence for a substantial role for genetic factors but also for etiologic complexity and variation in vulnerability across generations and across cultures. Studies are discussed which utilized psychophysiological and neurochemical markers for alcoholism for analysis of genetic association, transmission, and linkage. These markers include the low P300 event-related potential, sensitivity to ethanol's intoxicating and euphoric effects, platelet adenylate cyclase, and neurotransmitter metabolite concentrations. Although it is highly likely that many alcoholism-associated physiologic phenotypes are secondary traits, these approaches have increased the specificity of genetic analyses and genetic analyses are clarifying their relationship to alcoholism. For example, early efforts to study, in families, the co-occurrence of the P300 marker and alcoholism have yielded results indicating that the P300 abnormality precedes significant exposure to alcohol and that relatives of alcoholics are more likely to have this trait. In the area of animal models, two nonhuman primate species, the vervet monkey and the rhesus macaque, were shown to willingly consume alcohol to intoxicating blood levels. Also, linkage studies using the quantitative trait locus (QTL) mapping strategy were attempted for phenotypes relevant for alcoholism. The QTL strategy is theoretically capable of identifying determinant genes which contribute only a small portion of the variance. In human linkage studies, a genetic association was found to the DRD2 dopamine receptor. The DRD2 finding generated controversy, as a number of other groups failed to replicate it, and also focused attention on the advantages and pitfalls of the population association approach for detecting genes influencing behavior. The relationship of the alcohol metabolic gene variants to alcoholism was clarified by the finding that functional variants of alcohol and aldehyde dehydrogenases can act additively to determine vulnerability to alcoholism.
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| Acute alcohol withdrawal is associated with c-Fos expression in the basal ganglia and associated circuitry: C57BL/6J and DBA/2J inbred mouse strain analyses. | Kozell LB et al. | — | 2005 | → |
| Acoustic startle reactivity during acute alcohol withdrawal in rats that differ in genetic predisposition toward alcohol drinking: effect of stimulus characteristics. | Chester JA et al. | — | 2004 | → |
| Alcohol addiction research: from animal models to clinics. | Spanagel R | — | 2003 | → |
| Auditory P3 in female alcoholics. | Suresh S et al. | — | 2003 | → |
| Candidate genes for alcohol dependence: animal studies. | Schumann G et al. | — | 2003 | → |
| EEG low-voltage alpha and alpha power in African American young adults: relation to family history of alcoholism. | Ehlers CL et al. | — | 2003 | → |
| Spectral analyses of sleep EEG in depressed offspring of fathers with or without a positive history of alcohol abuse or dependence: a pilot study. | Dahl RE et al. | — | 2003 | → |
| Congenic mapping of alcohol and pentobarbital withdrawal liability loci to a <1 centimorgan interval of murine chromosome 4: identification of Mpdz as a candidate gene. | Fehr C et al. | — | 2002 | → |
| Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults. | Ehlers CL et al. | — | 2001 | → |
| Effects of age and parental history of alcoholism on EEG findings in mission Indian children and adolescents. | Ehlers CL et al. | — | 2001 | → |
| Mismatch negativity in subjects at high risk for alcoholism. | Zhang XL et al. | — | 2001 | → |
| Genetics of alcoholism and substance abuse. | Enoch MA et al. | — | 1999 | → |
| Interaction between the functional polymorphisms of the alcohol-metabolism genes in protection against alcoholism. | Chen CC et al. | — | 1999 | → |
| Ethanol reward and aversion in mice bred for sensitivity to ethanol withdrawal. | Chester JA et al. | — | 1998 | → |
| PROP taster status and parental history of alcohol dependence. | Kranzler HR et al. | — | 1998 | → |
| Quantitative trait loci involved in genetic predisposition to acute alcohol withdrawal in mice. | Buck KJ et al. | — | 1997 | → |
| Withdrawal strategies for outpatients. Alcohol, benzodiazepine, barbiturate, and opiate addictions. | Mezciems PE | — | 1996 | → |
| Quantitative Trait Loci Mapping. | Grisel JE et al. | — | 1995 | → |
| Strategies for mapping and identifying quantitative trait loci specifying behavioral responses to alcohol. | Buck KJ | — | 1995 | → |